Box-Behnken 效应面法优化薏苡仁破壁饮片成型工艺
|
摘要
目的:优化薏苡仁破壁饮片成型工艺。方法:以干燥方法、干燥温度、干燥时间、乙醇浓度、料液比、制粒筛网目数为考察对象,以成型率为评价指标,利用3因素3水平Box-Behnken效应面法优化薏苡仁破壁饮片成型工艺。结果:效应面法优选出的最佳成型工艺为:电热鼓风干燥,干燥温度为60℃,干燥时间为70min,乙醇浓度为29.5%,料液比为0.44:1,制粒筛网为35目。制备的薏苡仁破壁饮片成型率平均值为91.21%,与模型方程理论预测值(89.72%)的偏差为0.82%,吸湿率为9.89%,临界相对湿度75%,休止角34.46±0.100,松密度(0.4770±0.003)g·mL~(-1),振实密度(0.4934±0.004)g·mL~(-1),压缩指数(4±0.000)%。结论:Box-Behnken效应面法可用于薏苡仁破壁饮片成型工艺参数的优化,制备的破壁饮片质量达标,为其生产提供参考。
Objective:To optimize molding technics of ultrafine granular powder of Coix seed.Methods:The variables were optimized by Box-Behnken Design(BBD) by response surface method.The drying method,drying temperature,drying time,ethanol concentration,liquid ratio and grain sieve mesh were chosen as independent variables and the particle molding rate was chosen as dependent variables.Results:The optimal molding technics were as follows:The drying method was electrothermal blowing dry box.The drying temperature was at 60 ℃ and the drying time was 70 min.The ethanol concentration was 29.5% and the liquid ratio was 0.44:1.The grain sieve mesh was 35 meshs.The average value of particle molding rate was 91.21%.Its deviation from the theoretical prediction value(89.72%) of the model equation was about 0.82%.The moisture absorption rate was 9.89%.The critical relative humidity was 75%.The angle of repose was 34.46±0.100 and the bulk density was(0.4770±0.003)g·mL~(-1).The tap density was(0.4934±0.004) g·mL~(-1) and the compression exponent was(4±0.000)%.Conclusion:The box-Behnken design-response surface method is suitable for optimizing the molding technics of ultrafine granular powder of Coix seed,which can reach the stantdards of the ultrafine granular powder of herbal medicine and provide the reference for its production.
Objective:To optimize molding technics of ultrafine granular powder of Coix seed.Methods:The variables were optimized by Box-Behnken Design(BBD) by response surface method.The drying method,drying temperature,drying time,ethanol concentration,liquid ratio and grain sieve mesh were chosen as independent variables and the particle molding rate was chosen as dependent variables.Results:The optimal molding technics were as follows:The drying method was electrothermal blowing dry box.The drying temperature was at 60 ℃ and the drying time was 70 min.The ethanol concentration was 29.5% and the liquid ratio was 0.44:1.The grain sieve mesh was 35 meshs.The average value of particle molding rate was 91.21%.Its deviation from the theoretical prediction value(89.72%) of the model equation was about 0.82%.The moisture absorption rate was 9.89%.The critical relative humidity was 75%.The angle of repose was 34.46±0.100 and the bulk density was(0.4770±0.003)g·mL~(-1).The tap density was(0.4934±0.004) g·mL~(-1) and the compression exponent was(4±0.000)%.Conclusion:The box-Behnken design-response surface method is suitable for optimizing the molding technics of ultrafine granular powder of Coix seed,which can reach the stantdards of the ultrafine granular powder of herbal medicine and provide the reference for its production.
引文
[1] 国家药典委员会.中华人民共和国药典:一部[S].北京:中国医药科技出版,2015:376-377.
[2] 胡少华,肖小年,易醒,等.薏苡仁的研究新进展[J].时珍国医国药,2009,20(5):1059-1060.
[3] 韩旭,高洁,韩冰冰,等.中药薏苡仁现代临床研究进展[J].陕西中医,2014,35(9):1270-1271.
[4] 成金乐,赖智填,彭丽华.中药破壁饮片研究[J].世界科学技术—中医药现代化,2014,16(2):254-262.
[5] 赫光中,果秋婷.Box-Behnken效应面法优化胃爽颗粒剂成型工艺[J].中南药学,2013,11(7):498-501.
[6] 尚雅文,龚慕辛,翟永松,等.星点设计-效应面法优选糖肾宁颗粒的成型工艺[J].中国实验方剂学杂志,2015,21(16):14-18.
[7] 徐霞,顾清,杨帝顺,等.用Box-Behnken效应面法优化芩梅颗粒的制备工艺[J].药学服务与研究,2016,16(3):207-210.
[8] 王念明,张定堃,杨明,等.超微粉碎对黄芩粉体学性质的影响[J].中药材,2013,36(4):640-644.
[9] 范凌云,王振恒,余琰,等.不同粒径三黄粉粉体学性质及体外溶出度比较[J].中国中医药信息杂志,2015,22(9):91-94.
[10] 袁劲松,汤翠娥,王奇成.粉体休止角α对散剂混合工艺指导作用的探讨[J].中国药房,1994,6(6):14-15.
[11] 江亦川,杨敏.乳糖粉体学性质的初步探讨[J].今日药学,2002,12(4):19-22.
[12] 成金乐,彭丽华,邓雯.中智中药破壁饮片量效关系初探[J].世界中医药,2016,11(3):529-532.
[13] 邓雯,谢果,杨泽锐,等.中药破壁饮片安全性研究进展及思考[J].中国现代中药,2015,17(12):1340-1344.
[2] 胡少华,肖小年,易醒,等.薏苡仁的研究新进展[J].时珍国医国药,2009,20(5):1059-1060.
[3] 韩旭,高洁,韩冰冰,等.中药薏苡仁现代临床研究进展[J].陕西中医,2014,35(9):1270-1271.
[4] 成金乐,赖智填,彭丽华.中药破壁饮片研究[J].世界科学技术—中医药现代化,2014,16(2):254-262.
[5] 赫光中,果秋婷.Box-Behnken效应面法优化胃爽颗粒剂成型工艺[J].中南药学,2013,11(7):498-501.
[6] 尚雅文,龚慕辛,翟永松,等.星点设计-效应面法优选糖肾宁颗粒的成型工艺[J].中国实验方剂学杂志,2015,21(16):14-18.
[7] 徐霞,顾清,杨帝顺,等.用Box-Behnken效应面法优化芩梅颗粒的制备工艺[J].药学服务与研究,2016,16(3):207-210.
[8] 王念明,张定堃,杨明,等.超微粉碎对黄芩粉体学性质的影响[J].中药材,2013,36(4):640-644.
[9] 范凌云,王振恒,余琰,等.不同粒径三黄粉粉体学性质及体外溶出度比较[J].中国中医药信息杂志,2015,22(9):91-94.
[10] 袁劲松,汤翠娥,王奇成.粉体休止角α对散剂混合工艺指导作用的探讨[J].中国药房,1994,6(6):14-15.
[11] 江亦川,杨敏.乳糖粉体学性质的初步探讨[J].今日药学,2002,12(4):19-22.
[12] 成金乐,彭丽华,邓雯.中智中药破壁饮片量效关系初探[J].世界中医药,2016,11(3):529-532.
[13] 邓雯,谢果,杨泽锐,等.中药破壁饮片安全性研究进展及思考[J].中国现代中药,2015,17(12):1340-1344.