屈螺酮炔雌醇片联合新生化颗粒治疗药物流产后组织残留对血清激素及炎症因子影响
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摘要
目的:探讨屈螺酮炔雌醇片联合新生化颗粒对药物流产后组织物残留患者血清激素及炎症因子的影响。方法:选取2015年6月—2018年1月本院收治的药物流产后组织残留妇女160例,按随机数字表法分为观察组与对照组各80例。对照组应用米非司酮片治疗,观察组应用屈螺酮炔雌醇片和新生化颗粒治疗。比较两组治疗效果。测定治疗前后血清雌二醇(E_2)、孕酮(P)、■-绒毛膜促性腺激素(■-hCG)和超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子■(TNF-■)。结果:观察组治疗成功率(100%)高于对照组(93.8%),阴道出血量、出血时间及首次月经恢复时间均低于对照组,首次月经干净后子宫内膜厚度高于对照组(均P<0.05)。治疗后观察组血清■-hCG及P水平均低于对照组, E_2水平高于对照组,血清hs-CRP、IL-6及TNF-■水平低于对照组(均P<0.05)。结论:屈螺酮炔雌醇片联合新生化颗粒治疗药物流产后宫内组织物残留,可能与调节性激素及降低清炎性因子水平有关。
Objective: To investigate the influence of drospirenone and ethinylestradiol tablets combined with Xinshenghua granule for treating patients with intrauterine residue after medical abortion on their serum hormones levels and inflammatory factors. Methods: 160 patients with intrauterine residue after medical abortion were enrolled and were randomly divided into the observation group and the control group(80 cases in each group) from June 2015 to January 2018. The patients in the control group were treated by mifepristone tablets, and patients in the observation group were treated with drospirenone and ethinylestradiol tablets combined with Xinshenghua granule. The efficacy of patients was compared between the two groups. The levels of serum sex hormone, such as estradiol(E_2), progesterone(P), ■-chorionic gonadotropin(■-hCG), and inflammatory factors, such as hypersensitive C-reactive protein(hs-CRP), interleukins-6(IL-6), tumor necrosis factor alpha(TNF-■) of all patients were measured before and after treatment. Results: The treatment success rate of patients in the observation group was 100%, which was significant higher than that(93.8%) of patients in the control group(P<0.05). The amount of vaginal bleeding, the duration of vaginal bleeding, and the time of first menstrual recovery of patients in the observation group were significant lower than those of patients in the control group, while the endometrial thickness after the first menstrual recovery was significantly higher than that of patients in the control group(P<0.05). After treatment, the serum levels of ■-hCG, P, hs-CRP, IL-6 and TNF-■of patients in the observation group were significant lower than those of patients in the control group, while the E_2 level was significant higher than those of patients in the control group(P<0.05). Conclusion: The drospirenone and ethinylestradiol tablets combined with Xinshenghua granule for treating patients with intrauterine residue after medical abortion has good effectiveness, which may be related to regulating hormones and decreasing serum inflammatory factor levels.
Objective: To investigate the influence of drospirenone and ethinylestradiol tablets combined with Xinshenghua granule for treating patients with intrauterine residue after medical abortion on their serum hormones levels and inflammatory factors. Methods: 160 patients with intrauterine residue after medical abortion were enrolled and were randomly divided into the observation group and the control group(80 cases in each group) from June 2015 to January 2018. The patients in the control group were treated by mifepristone tablets, and patients in the observation group were treated with drospirenone and ethinylestradiol tablets combined with Xinshenghua granule. The efficacy of patients was compared between the two groups. The levels of serum sex hormone, such as estradiol(E_2), progesterone(P), ■-chorionic gonadotropin(■-hCG), and inflammatory factors, such as hypersensitive C-reactive protein(hs-CRP), interleukins-6(IL-6), tumor necrosis factor alpha(TNF-■) of all patients were measured before and after treatment. Results: The treatment success rate of patients in the observation group was 100%, which was significant higher than that(93.8%) of patients in the control group(P<0.05). The amount of vaginal bleeding, the duration of vaginal bleeding, and the time of first menstrual recovery of patients in the observation group were significant lower than those of patients in the control group, while the endometrial thickness after the first menstrual recovery was significantly higher than that of patients in the control group(P<0.05). After treatment, the serum levels of ■-hCG, P, hs-CRP, IL-6 and TNF-■of patients in the observation group were significant lower than those of patients in the control group, while the E_2 level was significant higher than those of patients in the control group(P<0.05). Conclusion: The drospirenone and ethinylestradiol tablets combined with Xinshenghua granule for treating patients with intrauterine residue after medical abortion has good effectiveness, which may be related to regulating hormones and decreasing serum inflammatory factor levels.
引文
[1] 潘惠兰.桃红四物汤加减配合米索前列醇治疗药物流产术后蜕膜组织残留疗效观察[J].陕西中医,2014,35(3):266-267.
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[3] 况玉兰,罗小琴,齐艳虹.米非司酮治疗人工流产术后宫腔残留的临床观察[J].中国计划生育学杂志,2014,22(2):122-123.
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[5] 邹倩,王燕,熊俊,等.不同方案治疗流产后宫腔残留的疗效观察[J].中国计划生育学杂志,2016,24(7):479-481.
[6] 付丽,王祥燕.人工流产术后残留保守治疗效果的影响因素[J].中国计划生育和妇产科,2015,(2):47-49.
[7] 况玉兰,罗小琴,齐艳虹.米非司酮治疗人工流产术后宫腔残留的临床观察[J].中国计划生育学杂志,2014,22(2):122-123.
[8] 姚小林,胡建国,潘丽华.经阴道超声检测子宫薄型内膜的子宫动脉和子宫螺旋动脉血流动力学改变[J].临床超声医学杂志,2014,16(2):129-130.
[9] 金兰英,吕英,邵明君等.屈螺酮炔雌醇片治疗流产后宫内残留的疗效分析[J].中国现代医生,2016,54(23):46-49.
[10] 赵现立,刘朝阳,谭宏伟,等.屈螺酮炔雌醇片预防稽留流产清宫术后宫腔粘连初步研究[J].中国工程科学,2015,17(6):13-15.
[11] 黎柳明.人工流产术后口服戊酸雌二醇与屈螺酮炔雌醇片修复子宫内膜的效果对比研究[J].广西医学,2016,38(8):1159-1161.
[12] 辜转荣.新生化颗粒联合鲜益母草胶囊改善药物流产后急性出血的效果[J].实用临床医药杂志,2018,22(7):114-116.
[13] 孙俊杰,刘小利,汤远霞,等.丹莪妇康煎膏对药物流产后组织物残留患者临床症状及血清生化指标的影响[J].中国妇幼保健,2018,33(2):397-399.
[14] 张建英,楚更五,刘秀萍,等 .当归散对正常和缩宫素处理大鼠子宫活动力的影响 [J].中国实验方剂学杂志,2011,17(7):201-203.
[15] 钟立甲,张文泉,华永丽,等 .代谢组学方法评价当归不同炮制品挥发油抗大鼠急性炎症作用的研究 [J].中国中药杂志,2016,41 (11) :2061-2069.
[2] 董瑞侠,高玉兰.经阴道彩色多普勒超声检测药物流产后宫内残留物以及残留组织血流动力学情况[J].医学综述,2017,23(2):379-381.
[3] 况玉兰,罗小琴,齐艳虹.米非司酮治疗人工流产术后宫腔残留的临床观察[J].中国计划生育学杂志,2014,22(2):122-123.
[4] 程利南,车焱.现代计划生育学[M].上海:复旦大学出版社,2014:260-265.
[5] 邹倩,王燕,熊俊,等.不同方案治疗流产后宫腔残留的疗效观察[J].中国计划生育学杂志,2016,24(7):479-481.
[6] 付丽,王祥燕.人工流产术后残留保守治疗效果的影响因素[J].中国计划生育和妇产科,2015,(2):47-49.
[7] 况玉兰,罗小琴,齐艳虹.米非司酮治疗人工流产术后宫腔残留的临床观察[J].中国计划生育学杂志,2014,22(2):122-123.
[8] 姚小林,胡建国,潘丽华.经阴道超声检测子宫薄型内膜的子宫动脉和子宫螺旋动脉血流动力学改变[J].临床超声医学杂志,2014,16(2):129-130.
[9] 金兰英,吕英,邵明君等.屈螺酮炔雌醇片治疗流产后宫内残留的疗效分析[J].中国现代医生,2016,54(23):46-49.
[10] 赵现立,刘朝阳,谭宏伟,等.屈螺酮炔雌醇片预防稽留流产清宫术后宫腔粘连初步研究[J].中国工程科学,2015,17(6):13-15.
[11] 黎柳明.人工流产术后口服戊酸雌二醇与屈螺酮炔雌醇片修复子宫内膜的效果对比研究[J].广西医学,2016,38(8):1159-1161.
[12] 辜转荣.新生化颗粒联合鲜益母草胶囊改善药物流产后急性出血的效果[J].实用临床医药杂志,2018,22(7):114-116.
[13] 孙俊杰,刘小利,汤远霞,等.丹莪妇康煎膏对药物流产后组织物残留患者临床症状及血清生化指标的影响[J].中国妇幼保健,2018,33(2):397-399.
[14] 张建英,楚更五,刘秀萍,等 .当归散对正常和缩宫素处理大鼠子宫活动力的影响 [J].中国实验方剂学杂志,2011,17(7):201-203.
[15] 钟立甲,张文泉,华永丽,等 .代谢组学方法评价当归不同炮制品挥发油抗大鼠急性炎症作用的研究 [J].中国中药杂志,2016,41 (11) :2061-2069.