代谢组学在颅脑创伤中的应用研究进展
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摘要
颅脑创伤是人类致残、致死的主要原因之一。由于受伤机制和脑组织的复杂性,颅脑创伤可诱发广泛的病理生理学改变。代谢组学可提供颅脑创伤患者单一时间点生理、生化状态的"瞬时快照"。目前,高通量、高灵敏度的代谢组学分析工具能够检测和定量小浓度的代谢物,使客观化、精细化评估颅脑创伤成为可能。本文就代谢组学的概况及其在颅脑创伤诊疗、预后评估等方面的研究进展做一综述。
引文
[1]张赛.努力推进我国重型颅脑创伤的规范化救治[J].中华神经外科杂志,2018,34(2):109-112.
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[15]Kochanek PM,Jackson TC,Ferguson NM,et al.Emerging therapies in traumatic brain injury[J].Semin Neurol,2015,35(1):83-100.
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[19]Kraus MF,Susmaras T,Caughlin BP,et al.White matter integrity and cognition in chronic traumatic brain injury:a diffusion tensor imaging study[J].Brain,2007,130(10):2 508-2 519.
[20]Hartonen M,Mattila I,RuskeepaaAL,et al.Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry[J].J Chromatogr A,2013,1 293:142-149.
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[24]Crack PJ,Zhang M,Morganti-Kossmann MC,et al.Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes[J].J Neuroinflammation,2014,11:37.
[25]Abdullah L,Evans JE,Ferguson S,et al.Lipidomic analyses identify injury-specific phospholipid changes 3 mo after traumatic brain injury[J].FASEB J,2014,28(12):5 311-5 321.
[26]Marino S,Zei E,Battaglini M,et al.Acute metabolic brain changes following traumatic brain injury and their relevance to clinical severity and outcome[J].J Neurol Neurosurg Psyhiatry,2007,78(5):501-507.
[27]Barkhoudarian G,Hovda DA,Giza C.The molecular pathophysiology of concussive brain injury-an update[J].Phys Med Rehabil Clin N Am,2016,27(2):373-393.
[28]Dumas ME,Davidovic L.Metabolic profiling and phenotyping of central nervous system diseases:metabolites bring insights into brain dysfunctions[J].J Neuroimmune Pharmacol,2015,10(3):402-424.
[29]Glenn TC,Hirt D,Mendez G,et al.Metabolomic analysis of cerebral spinal fluid from patients with severe brain injury[J].Acta Neurochir Suppl,2013,118:115-119.
[30]Jeter CB,Hergenroeder GW,Ward NH 3rd,et al.Human mild traumatic brain injury decreases circulating branchedchain amino acids and their metabolite levels[J].J Neurotrauma,2013,30(8):671-679.
[31]Ottens AK,Stafflinger JE,Griffin HE,et al.Post-acute brain injury urinary signature:a new resource for molecular diagnostics[J].J Neurotrauma,2014,31(8):782-788.
[32]Yi L,Shi S,Wang Y,et al.Serum metabolic profiling reveals altered metabolic pathways in patients with post-traumatic cognitive impairments[J].Sci Rep,2016,6:21320.
[33]Van Gool AJ,Henry B,Sprengers ED.From biomarker strategies to biomarker activities and back[J].Drug Discov Today,2010,15(3/4):121-126.
[34]Shan R,Szmydynger-Chodobska J,Warren OU,et al.A new panel of blood biomarkers for the diagnosis of mild traumatic brain injury/concussion in adults[J].J Neurotrauma,2016,33(1):49-57.
[35]Martensson J,Martling CR,Bell M.Novel biomarkers of acute kidney injury and failure:clinical applicability[J].Br J Anaesth,2012,109(6):843-850.
[36]Drucker E,Krapfenbauer K.Pitfalls and limitations in translation from biomarker discovery to clinical utility in predictive and personalised medicine[J].EPMA J,2013,4(1):7.
[37]Nicholson JK,Holmes E,Wilson ID.Gut microorganisms,mammalian metabolism and personalized health care[J].Nat Rev Microbiol,2005,3(5):431-438.
[2]Feigin VL,Theadom A,Barker-Collo S,et al.Incidence of traumatic brain injury in New Zealand:a population-based study[J].Lancet Neurol,2013,12(1):53-64.
[3]Maas AR,Menon DK,Adelson PD,et al.Traumatic brain injury:integrated approaches to improve prevention,clinical care,and research[J].Lancet Neurol,2017,16(12):987-1 048.
[4]Nicholson JK,Lindon JC,Holmes E.'Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J].Xenobiotica,1999,29(11):1 181-1 189.
[5]Villas-B8as SG,Mas S,Akesson M,et al.Mass spectrometry in metabolome analysis[J].Mass Spectrom Rev,2005,24(5):613-646.
[6]Tang J.Microbial metabolomics[J].Curr Genomics,2011,12(6):391-403.
[7]Aldridge BB,Rhee KY.Microbial metabolomics:innovation,application,insight[J].Curr Opin Microbiol,2014,19:90-96.
[8]Barkal LJ,Theberge AB,Guo CJ,et al.Microbial metabolomics in open microscale platforms[J].Nat Commun,2016,7:10610.
[9]Theodoridis GA,Gika HG,Want EJ,et al.Liquid chromatography-mass spectrometry based global metabolite profiling:a review[J].Anal Chim Acta,2012,711:7-16.
[10]Zhang A,Sun H,Wang P,et al.Modern analytical techniques in metabolomics analysis[J].Analyst,2012,137(2):293-300.
[11]Biedermann M,Grob K.On-line coupled high performance liquid chromatography-gas chromatography for the analysis of contamination by mineral oil.Part 2:migration from paperboard into dry foods:interpretation of chromatograms[J].J Chromatogr A,2012,1 255:76-99.
[12]Zhou B,Xiao JF,Tuli L,et al.LC-MS-based metabolomics[J].Mol Biosyst,2012,8(2):470-481.
[13]Mikami T,Aoki M,Kimura T.The application of mass spectrometry to proteomics and metabolomics in biomarker discovery and drug development[J].Curr Mol Pharmacol,2012,5(2):301-316.
[14]Mashego MR,Rumbold K,De Mey M,et al.Microbial metabolomics:past,present and future methodologies[J].Biotechnol Lett,2007,29(1):1-16.
[15]Kochanek PM,Jackson TC,Ferguson NM,et al.Emerging therapies in traumatic brain injury[J].Semin Neurol,2015,35(1):83-100.
[16]Kulbe JR,Geddes JW.Current status of fluid biomarkers in mild traumatic brain injury[J].Exp Neurol,2016,275(Pt 3):334-352.
[17]Taylor DD,Gercel-Taylor C.Exosome platform for diagnosis and monitoring of traumatic brain injury[J].Philos Trans RSoc Lond B Bio Sci,2014,369(1 652).pii:20130503.
[18]Yokobori S,Hosein K,Burks S,et al.Biomarkers for the clinical differential diagnosis in traumatic brain injury--a systematic review[J].CNS Neurosci Ther,2013,19(8):556-565.
[19]Kraus MF,Susmaras T,Caughlin BP,et al.White matter integrity and cognition in chronic traumatic brain injury:a diffusion tensor imaging study[J].Brain,2007,130(10):2 508-2 519.
[20]Hartonen M,Mattila I,RuskeepaaAL,et al.Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry[J].J Chromatogr A,2013,1 293:142-149.
[21]Furukawa H,Singh SK,Mancusso R,et al.Subunit arrangement and function in NMDA receptors[J].Nature,2005,438(7 065):185-192.
[22]Barkhoudarian G,Hovda DA,Giza CC.The molecular pathophysiology of concussive brain injury[J].Clin Sports Med,2011,30(1):33-48.
[23]张赛,符锋.重型颅脑创伤规范化救治策略[J].中华神经创伤外科电子杂志,2018,4(2):122-124.
[24]Crack PJ,Zhang M,Morganti-Kossmann MC,et al.Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes[J].J Neuroinflammation,2014,11:37.
[25]Abdullah L,Evans JE,Ferguson S,et al.Lipidomic analyses identify injury-specific phospholipid changes 3 mo after traumatic brain injury[J].FASEB J,2014,28(12):5 311-5 321.
[26]Marino S,Zei E,Battaglini M,et al.Acute metabolic brain changes following traumatic brain injury and their relevance to clinical severity and outcome[J].J Neurol Neurosurg Psyhiatry,2007,78(5):501-507.
[27]Barkhoudarian G,Hovda DA,Giza C.The molecular pathophysiology of concussive brain injury-an update[J].Phys Med Rehabil Clin N Am,2016,27(2):373-393.
[28]Dumas ME,Davidovic L.Metabolic profiling and phenotyping of central nervous system diseases:metabolites bring insights into brain dysfunctions[J].J Neuroimmune Pharmacol,2015,10(3):402-424.
[29]Glenn TC,Hirt D,Mendez G,et al.Metabolomic analysis of cerebral spinal fluid from patients with severe brain injury[J].Acta Neurochir Suppl,2013,118:115-119.
[30]Jeter CB,Hergenroeder GW,Ward NH 3rd,et al.Human mild traumatic brain injury decreases circulating branchedchain amino acids and their metabolite levels[J].J Neurotrauma,2013,30(8):671-679.
[31]Ottens AK,Stafflinger JE,Griffin HE,et al.Post-acute brain injury urinary signature:a new resource for molecular diagnostics[J].J Neurotrauma,2014,31(8):782-788.
[32]Yi L,Shi S,Wang Y,et al.Serum metabolic profiling reveals altered metabolic pathways in patients with post-traumatic cognitive impairments[J].Sci Rep,2016,6:21320.
[33]Van Gool AJ,Henry B,Sprengers ED.From biomarker strategies to biomarker activities and back[J].Drug Discov Today,2010,15(3/4):121-126.
[34]Shan R,Szmydynger-Chodobska J,Warren OU,et al.A new panel of blood biomarkers for the diagnosis of mild traumatic brain injury/concussion in adults[J].J Neurotrauma,2016,33(1):49-57.
[35]Martensson J,Martling CR,Bell M.Novel biomarkers of acute kidney injury and failure:clinical applicability[J].Br J Anaesth,2012,109(6):843-850.
[36]Drucker E,Krapfenbauer K.Pitfalls and limitations in translation from biomarker discovery to clinical utility in predictive and personalised medicine[J].EPMA J,2013,4(1):7.
[37]Nicholson JK,Holmes E,Wilson ID.Gut microorganisms,mammalian metabolism and personalized health care[J].Nat Rev Microbiol,2005,3(5):431-438.