高尿酸血症与冠状动脉病变的相关性研究进展
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摘要
高尿酸血症(hyperuricemia,HUA)是嘌呤代谢障碍引起的代谢性疾病,它不仅可引起痛风、肾病、代谢综合征等疾病,还可通过一系列病理生理途径对冠状动脉造成影响。随着人口老龄化进程的加快,冠状动脉病变(coronary artery disease,CAD)发病率逐年升高,严重危害人类健康。高尿酸血症是冠状动脉病变的危险因素,控制高尿酸血症,可以降低冠状动脉病变的发病率和死亡率。然而,到目前为止,高尿酸血症与冠状动脉病变的机制尚未完全揭示。本研究旨在对近年来高尿酸血症与冠状动脉病变的相关性的角度做一综述。
Hyperuricemia(HUA) is a metabolic disease caused by sputum metabolism disorder. It can not only cause gout, kidney disease, metabolic syndrome and other diseases, but also affect coronary arteries through a series of pathophysiological pathways. With the acceleration of the aging process, the incidence of coronary artery disease(CAD)has increased year by year, seriously endangering human health. HUA is a risk factor for coronary artery disease, which controls hyperuricemia and can reduce the incidence and mortality of coronary artery disease. However, the mechanisms of hyperuricemia and coronary artery disease have not been fully revealed so far. This study is intended to review the relationship between hyperuricemia and coronary artery disease in recent years.
Hyperuricemia(HUA) is a metabolic disease caused by sputum metabolism disorder. It can not only cause gout, kidney disease, metabolic syndrome and other diseases, but also affect coronary arteries through a series of pathophysiological pathways. With the acceleration of the aging process, the incidence of coronary artery disease(CAD)has increased year by year, seriously endangering human health. HUA is a risk factor for coronary artery disease, which controls hyperuricemia and can reduce the incidence and mortality of coronary artery disease. However, the mechanisms of hyperuricemia and coronary artery disease have not been fully revealed so far. This study is intended to review the relationship between hyperuricemia and coronary artery disease in recent years.
引文
[1]陈伟伟,高润霖,刘力生,等.《中国心血管病报告2017》概要[J].中国循环杂志, 2018, 33(1):1-8.
[2] LOZANO R, NAGHAVI M, FOREMAN K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and2010:a systematic analysis for the Global Burden of Disease Study2010[J]. Lancet, 2012, 380(9859):2095-2128.
[3] WU J, QIU L, CHENG XQ, et al. Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population[J]. Sci Rep, 2017, 7(1):5456.
[4] MERRIMAN TR. An update on the genetic architecture of hyperuricemia and gout[J]. Arthritis Res Ther, 2015, 17:98.
[5] BRAGA F, PASQUALETTI S, FERRARO S, et al. Hyperuricemia as risk factor for coronary heart disease incidence and mortality in the general population:a systematic review and meta-analysis[J]. Clin Chem Lab Med, 2016, 54(1):7-15.
[6] EKICI B, KUTUK U, ALHAN A, et al. The relationship between serum uric acid levels and angiographic severity of coronary heart disease[J]. Kardiol Pol, 2015, 73(7):533-538.
[7] LAN M, LIU B, HE Q. Evaluation of the association between hyperuricemia and coronary artery disease:A STROBE-compliant article[J]. Medicine(Baltimore), 2018, 97(44):e12926.
[8] BATTAGGIA A, SCALISI A, PUCCETTI L. Hyperuricemia does not seem to be an independent risk factor for coronary heart disease[J].Clin Chem Lab Med, 2018, 56(3):e59-e62.
[9] LI M, HU X, FAN Y, et al. Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysis[J]. Sci Rep, 2016, 6:19520.
[10] ZHANG C, JIANG L, XU L, et al. Implications of hyperuricemia in severe coronary artery disease[J]. Am J Cardiol, 2019, 123(4):558-564.
[11] KUWABARA M, NIWA K, NISHI Y, et al. Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension[J]. Hypertens Res,2014, 37(8):785-789.
[12] LOEFFLER LF, NAVAS-ACIEN A, BRADY TM, et al. Uric acid level and elevated blood pressure in US adolescents:National Health and Nutrition Examination Survey, 1999-2006[J]. Hypertension,2012, 59(4):811-817.
[13] HUANG J, SUN Y, NIU K, et al. Does elevated serum uric acid level predict the hypertension incidence? A Chinese prospective cohort study[J]. Clin Exp Hypertens, 2015, 37(6):498-504.
[14] KUROCZYCKA-SANIUTYCZ E, WASILEWSKA A, SULIK A, et al. Urinary angiotensinogen as a marker of intrarenal angiotensinⅡactivity in adolescents with primary hypertension[J]. Pediatr Nephrol,2013, 28(7):1113-1119.
[15] SANCHEZ-LOZADA LG, SOTO V, TAPIA E, et al. Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia[J]. Am J Physiol Renal Physiol, 2008, 295(4):F1134-F1141.
[16] LIU-BRYAN R. Intracellular innate immunity in gouty arthritis:role of NALP3 inflammasome[J]. Immunol Cell Biol, 2010, 88(1):20-23.
[17] FACCHINI F, CHEN YD, HOLLENBECK CB, et al. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration[J]. JAMA, 1991,266(21):3008-3011.
[18] JOHNSON RJ, NAKAGAWA T, SANCHEZ-LOZADA LG, et al.Sugar, uric acid, and the etiology of diabetes and obesity[J]. Diabetes, 2013, 62(10):3307-3315.
[19] KRISHNAN E, PANDYA BJ, CHUNG L, et al. Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes:a15-year follow-up study[J]. Am J Epidemiol, 2012, 176(2):108-116.
[20] CICERCHI C, LI N, KRATZER J, et al. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation:evolutionary implications of the uricase loss in hominids[J]. FASEB J, 2014, 28(8):3339-3350.
[21] LI C, HSIEH MC, CHANG SJ. Metabolic syndrome, diabetes, and hyperuricemia[J]. Curr Opin Rheumatol, 2013, 25(2):210-216.
[22] SAUTIN YY, NAKAGAWA T, ZHARIKOV S, et al. Adverse effects of the classic antioxidant uric acid in adipocytes:NADPH oxidase-mediated oxidative/nitrosative stress[J]. Am J Physiol Cell Physiol, 2007, 293(2):C584-C596.
[23] JALAL DI, JABLONSKI KL, MCFANN K, et al. Vascular endothelial function is not related to serum uric acid in healthy adults[J]. Am J Hypertens, 2012, 25(4):407-413.
[24] GHAEMI-OSKOUIE F, SHI Y. The role of uric acid as an endogenous danger signal in immunity and inflammation[J]. Curr Rheumatol Rep, 2011,13(2):160-166.
[25] ZHI L, YUZHANG Z, TIANLIANG H, et al. High uric acid induces insulin resistance in cardiomyocytes in vitro and in vivo[J]. PLoS One, 2016, 11(2):e147737.
[26] PENG TC, WANG CC, KAO TW, et al. Relationship between hyperuricemia and lipid profiles in US adults[J]. Biomed Res Int, 2015,2015:127596.
[27] SAH SK, KHATIWADA S, PANDEY S, et al. Association of high-sensitivity C-reactive protein and uric acid with the metabolic syndrome components[J]. Springerplus, 2016, 5:269.
[28] BALDWIN W, MCRAE S, MAREK G, et al. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome[J]. Diabetes, 2011,60(4):1258-1269.
[29] LANASPA MA, SANCHEZ-LOZADA LG, CICERCHI C, et al. Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver[J]. PLo S One, 2012, 7(10):e47948.
[30] LANASPA MA, CICERCHI C, GARCIA G, et al. Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver[J]. PLoS One, 2012, 7(11):e48801.
[31] JOHNSON RJ, NAKAGAWA T, SANCHEZ-LOZADA LG, et al.Sugar, uric acid, and the etiology of diabetes and obesity[J]. Diabetes, 2013, 62(10):3307-3315.
[32] FORD ES, LI C, COOK S, et al. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents[J].Circulation, 2007, 115(19):2526-2532.
[33] QASEEM A, HARRIS RP, FORCIEA MA. Management of acute and recurrent gout:a clinical practice guideline from the American College of physicians[J]. Ann Intern Med, 2017, 166(1):58-68.
[34]高尿酸血症相关疾病诊疗多学科共识专家组.中国高尿酸血症相关疾病诊疗多学科专家共识[J].中华内科杂志, 2017, 56(3):235-248.
[35]王昱,张卓莉. 2016年欧洲抗风湿病联盟关于痛风治疗的建议:基于循证医学的证据[J].中华临床免疫和变态反应杂志, 2017, 11(1):95-98.
[2] LOZANO R, NAGHAVI M, FOREMAN K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and2010:a systematic analysis for the Global Burden of Disease Study2010[J]. Lancet, 2012, 380(9859):2095-2128.
[3] WU J, QIU L, CHENG XQ, et al. Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population[J]. Sci Rep, 2017, 7(1):5456.
[4] MERRIMAN TR. An update on the genetic architecture of hyperuricemia and gout[J]. Arthritis Res Ther, 2015, 17:98.
[5] BRAGA F, PASQUALETTI S, FERRARO S, et al. Hyperuricemia as risk factor for coronary heart disease incidence and mortality in the general population:a systematic review and meta-analysis[J]. Clin Chem Lab Med, 2016, 54(1):7-15.
[6] EKICI B, KUTUK U, ALHAN A, et al. The relationship between serum uric acid levels and angiographic severity of coronary heart disease[J]. Kardiol Pol, 2015, 73(7):533-538.
[7] LAN M, LIU B, HE Q. Evaluation of the association between hyperuricemia and coronary artery disease:A STROBE-compliant article[J]. Medicine(Baltimore), 2018, 97(44):e12926.
[8] BATTAGGIA A, SCALISI A, PUCCETTI L. Hyperuricemia does not seem to be an independent risk factor for coronary heart disease[J].Clin Chem Lab Med, 2018, 56(3):e59-e62.
[9] LI M, HU X, FAN Y, et al. Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysis[J]. Sci Rep, 2016, 6:19520.
[10] ZHANG C, JIANG L, XU L, et al. Implications of hyperuricemia in severe coronary artery disease[J]. Am J Cardiol, 2019, 123(4):558-564.
[11] KUWABARA M, NIWA K, NISHI Y, et al. Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension[J]. Hypertens Res,2014, 37(8):785-789.
[12] LOEFFLER LF, NAVAS-ACIEN A, BRADY TM, et al. Uric acid level and elevated blood pressure in US adolescents:National Health and Nutrition Examination Survey, 1999-2006[J]. Hypertension,2012, 59(4):811-817.
[13] HUANG J, SUN Y, NIU K, et al. Does elevated serum uric acid level predict the hypertension incidence? A Chinese prospective cohort study[J]. Clin Exp Hypertens, 2015, 37(6):498-504.
[14] KUROCZYCKA-SANIUTYCZ E, WASILEWSKA A, SULIK A, et al. Urinary angiotensinogen as a marker of intrarenal angiotensinⅡactivity in adolescents with primary hypertension[J]. Pediatr Nephrol,2013, 28(7):1113-1119.
[15] SANCHEZ-LOZADA LG, SOTO V, TAPIA E, et al. Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia[J]. Am J Physiol Renal Physiol, 2008, 295(4):F1134-F1141.
[16] LIU-BRYAN R. Intracellular innate immunity in gouty arthritis:role of NALP3 inflammasome[J]. Immunol Cell Biol, 2010, 88(1):20-23.
[17] FACCHINI F, CHEN YD, HOLLENBECK CB, et al. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration[J]. JAMA, 1991,266(21):3008-3011.
[18] JOHNSON RJ, NAKAGAWA T, SANCHEZ-LOZADA LG, et al.Sugar, uric acid, and the etiology of diabetes and obesity[J]. Diabetes, 2013, 62(10):3307-3315.
[19] KRISHNAN E, PANDYA BJ, CHUNG L, et al. Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes:a15-year follow-up study[J]. Am J Epidemiol, 2012, 176(2):108-116.
[20] CICERCHI C, LI N, KRATZER J, et al. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation:evolutionary implications of the uricase loss in hominids[J]. FASEB J, 2014, 28(8):3339-3350.
[21] LI C, HSIEH MC, CHANG SJ. Metabolic syndrome, diabetes, and hyperuricemia[J]. Curr Opin Rheumatol, 2013, 25(2):210-216.
[22] SAUTIN YY, NAKAGAWA T, ZHARIKOV S, et al. Adverse effects of the classic antioxidant uric acid in adipocytes:NADPH oxidase-mediated oxidative/nitrosative stress[J]. Am J Physiol Cell Physiol, 2007, 293(2):C584-C596.
[23] JALAL DI, JABLONSKI KL, MCFANN K, et al. Vascular endothelial function is not related to serum uric acid in healthy adults[J]. Am J Hypertens, 2012, 25(4):407-413.
[24] GHAEMI-OSKOUIE F, SHI Y. The role of uric acid as an endogenous danger signal in immunity and inflammation[J]. Curr Rheumatol Rep, 2011,13(2):160-166.
[25] ZHI L, YUZHANG Z, TIANLIANG H, et al. High uric acid induces insulin resistance in cardiomyocytes in vitro and in vivo[J]. PLoS One, 2016, 11(2):e147737.
[26] PENG TC, WANG CC, KAO TW, et al. Relationship between hyperuricemia and lipid profiles in US adults[J]. Biomed Res Int, 2015,2015:127596.
[27] SAH SK, KHATIWADA S, PANDEY S, et al. Association of high-sensitivity C-reactive protein and uric acid with the metabolic syndrome components[J]. Springerplus, 2016, 5:269.
[28] BALDWIN W, MCRAE S, MAREK G, et al. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome[J]. Diabetes, 2011,60(4):1258-1269.
[29] LANASPA MA, SANCHEZ-LOZADA LG, CICERCHI C, et al. Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver[J]. PLo S One, 2012, 7(10):e47948.
[30] LANASPA MA, CICERCHI C, GARCIA G, et al. Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver[J]. PLoS One, 2012, 7(11):e48801.
[31] JOHNSON RJ, NAKAGAWA T, SANCHEZ-LOZADA LG, et al.Sugar, uric acid, and the etiology of diabetes and obesity[J]. Diabetes, 2013, 62(10):3307-3315.
[32] FORD ES, LI C, COOK S, et al. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents[J].Circulation, 2007, 115(19):2526-2532.
[33] QASEEM A, HARRIS RP, FORCIEA MA. Management of acute and recurrent gout:a clinical practice guideline from the American College of physicians[J]. Ann Intern Med, 2017, 166(1):58-68.
[34]高尿酸血症相关疾病诊疗多学科共识专家组.中国高尿酸血症相关疾病诊疗多学科专家共识[J].中华内科杂志, 2017, 56(3):235-248.
[35]王昱,张卓莉. 2016年欧洲抗风湿病联盟关于痛风治疗的建议:基于循证医学的证据[J].中华临床免疫和变态反应杂志, 2017, 11(1):95-98.