硫酸化多糖抗肿瘤研究进展
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摘要
硫酸化多糖是糖羟基上含有硫酸根的多糖,可经天然提取或硫酸化的化学修饰而得到。近年的研究证明硫酸化多糖呈现了不同程度的抗肿瘤活性,尤其是与化学修饰前相比其抗肿瘤活性显著增强,引起广泛的关注。本文对近几年国内外与天然硫酸化多糖和化学合成硫酸化多糖抗肿瘤活性相关的研究进行综述。
Sulfated polysaccharides are with hydroxyl group containing sulfate radicals,which can be obtained by natural extraction or chemical modification of sulfation. Recent studies have shown that sulfated polysaccharides exhibit different levels of antitumor activity,especially in comparison with those before chemical modification; therefore,they have attracted wide attention. This article briefly reviewed the domestic and foreign researches on the antitumor effects of natural sulfated polysaccharides and chemical synthesized sulfated polysaccharides in recent years.
Sulfated polysaccharides are with hydroxyl group containing sulfate radicals,which can be obtained by natural extraction or chemical modification of sulfation. Recent studies have shown that sulfated polysaccharides exhibit different levels of antitumor activity,especially in comparison with those before chemical modification; therefore,they have attracted wide attention. This article briefly reviewed the domestic and foreign researches on the antitumor effects of natural sulfated polysaccharides and chemical synthesized sulfated polysaccharides in recent years.
引文
1陈万青,郑荣寿,张思维.2012年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2016,25(1):1-8
2 Zong AZ,Cao HZ,Wang FS,et al.Anticancer polysaccharides from natural resources:A review of recent research[J].Carbohydrate Polymers,2012,9(4):1395-1410
3 Liu QM,Xu SS,Li L,et al.In vitro and in vivo immunomodulatory activity of sulfated polysaccharide from Porphyra haitanensis[J].Carbohydrate Polymers,2017,165:189-196
4 周本宏,谭珺,张婵.硫酸酯化天麻多糖的制备及其抗氧化活性[J].中国医院药学杂志,2017,37(17):1685-1691
5 Wu LJ,Wang W,Zhang XS,et al.Anti-HBV activity and mechanism of marine-derived polyguluronate sulfate(PGS)in vitro[J].Carbohydrate Polymers,2016,143(5):139-148
6 Tang L,Chen YC,Jiang ZB,et al.Purification,partial characterization and bioactivity of sulfated polysaccharides from Grateloupia livida[J].International Journal of Biological Macromolecules,2017,94:642-652
7 Lu MK,Lin TY,Chao CH,et al.Molecular mechanism of antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor receptor degradation[J].International Journal of Biological Macromolecules,2017,95:1144-1152
8 周本宏,谭珺,曾茂林.硫酸酯化天麻多糖对皮质酮诱导的PC12细胞损伤的保护作用[J].中国药师,2017,20(6):1005-1008
9 Ngoa DH,Kim SK.Sulfated polysaccharides as bioactive agents from marine algae[J].International Journal of Biological Macromolecules,2013,62:70-75
10 Han Y,Wu J,Liu TT,et al.Separation,characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida[J].International Journal of Biological Macromolecules,2016,83:42-49
11 杨晓丹.裙带菜褐藻多糖硫酸酯对SMMC-7721肿瘤细胞凋亡的诱及对BEL-7402的迁移抑制作用[D].大连:大连医科大学硕士学位论文,2010
12 Jose GM,Kurup GM.The efficacy of sulfated polysaccharides from Padina tetrastromatica in modulating the immune functions of RAW 264.7 cells[J].Biomedicine&Pharmacotherapy,2017,88:677-683
13 Suresh V,Senthilkumar N.Separation,purification and preliminary characterization of sulfated polysaccharides from Sargassum plagiophyllum and its in vitro anticancer and antioxidant activity[J].Process Biochemistry,2013,48:364-373
14 马伟伟,李丽,周革非.海黍子硫酸多糖体外免疫与抗肿瘤活性[J].食品科学.2013,34(7):270-274
15 Cheng JJ,Chao CH,Chang PC,et al.Studies on anti-inflammatory activity of sulfated polysaccharides from cultivated fungi Antrodia cinnamomea[J],Food Hydrocolloids,2016,53:37-45
16 Lu MK,Lin TY,Chao CH,et al.Molecular mechanism of antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor receptor degradation[J].International Journal of Biological Macromolecules,2017,95:1142-1152
17 Choi JH,Han EH,Hwang YP,et al.Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgarisvia the inhibition of NF-kappa B-dependent MMP-9expression[J].Food Chem Toxicol,2010,48(2):564-571
18 王雅楠,曹蕊,朱聪.夏枯草硫酸多糖对肝癌血管生成的作用及机制研究[J].中国肿瘤临床,2014,41(12):758-761
19 Xiong SL,Li AL,Huang N,et al.Antioxidant and immunoregulatory activity of different polysaccharide fractions from tuber of Ophiopogon japonicus[J].Carbohydrate Polymers,2011(86):1273-1280
20 Yu M,Ji YB,Qi Z,et al.Anti-tumor Activity of Sulfated Polysaccharides from Sargassum Fusiforme[J]Saudi Pharmaceutical Journal,2017,25(4):464-468
21 王凯,綦慧敏,李玉磊.孔石莼多糖及其硫酸酯化衍生物抗肿瘤活性的体外实验研究[J].中国海洋药物,2014,33(2):19-23
22 Sun ZC,Huang K,Fu XR.A chemically sulfated polysaccharide derived from Ganoderma lucidum induces mitochondrial-mediated apoptosis in human osteosarcoma MG63 cells[J].Tumor Biol,2014,35(10):9919-9926
23 彭悦云.灵芝多糖硫酸酯抗肿瘤活性的研究[D].成都.成都中医药大学硕士学位论文,2011
24 谈新提,王艺峰,张俐娜.化学修饰的茯苓多糖抗肿瘤效应的组织学观察[J].武汉大学学报,2004,25(6):652-655
25 陈群,王爱云,焦庆才.茯苓多糖硫酸酯的制备与鉴定及其增强小鼠NK细胞活性[J].食用菌学报,2009,16(3):48-52
26 王爱云,陈群,李成付.茯苓多糖修饰物抗肿瘤作用及其机制研究[J].中草药,2009,40(2):268-271
27 Lin YL,Zhang LN,Chen L.Molecular mass and antitumor activities of sulfated derivatives of-glucan from Poria cocos mycelia[J].International Journal of Biological Macromolecules,2004,34(5):289-294
28 Wang HL,Jean FL,Zhang YN.In vivo immunological activity of carboxymethylated sulfated(1→3)-d-glucan from sclerotium of Poria cocos[J].International Journal of Biological Macromolecules,2015,79:511-517
29 Shi BJ,Nie XH,Chen LZ.Anticancer activities of a chemically sulfated polysaccharide obtained from Grifola frondosa and its combination with 5-Fluorouracil against human gastric carcinoma cells[J].Carbohydrate Polymers,2007,68(4):687-692
30 程代,陈媛媛,孟梦.一种硫酸酯化灰树花多糖的免疫活性研究[J].食品研究与开发,2016,37(22):39-43
31 Kubo M,Liu YH,Ishida M,et al.A new spiroindene pigment from the medicinal fungus phellinus ribis[J].Chem Pharm Bull,2014,62(1):122-124
32 刘玉红.茶藨子木层孔菌多糖硫酸酯的制备与体外抗肿瘤活性[J].中国医院药学杂志,2014,34(7):509-512
33 刘玉红,张文玉,刘玉国.茶藨子木层孔菌多糖硫酸酯的体内抗肿瘤作用与机制[J].中国医院药学杂志,2015,35(11):985-989
34 Zhang YD,Wu W,Kang LH.Effect of Aconitum coreanum polysaccharide and its sulphated derivative on the migration of human breast cancer MDA-MB-435Scell[J].International Journal of Biological Macromolecules,2017,103:477-483
35 吴素珍,李加林,陈水亲,等.硫酸酯化当归多糖抗肿瘤实验研究[J].时珍国医国药,2012,23(2):319-320
36 吴素珍,李加林,陈水亲,等.硫酸酯化当归多糖制备及抗肿瘤活性的考察[J].中国医院药学杂志,2013,33(22):1832-1835
37 Wang L,Li YL,Zhu LD,et al.Antitumor activities and immunomodulatory of rice bran polysaccharides and its sulfates in vitro[J].International Journal of Biological Macromolecules,2016,88:424-432
38 朱丽丹,王莉,徐逸木.米糠多糖及硫酸酯化米糠多糖的体外免疫应答和抗肿瘤活性研究[J].中国粮油学报.2015,30(3):35-40
39陈晓庆,郑少燕,陈庆奇.硫酸酯化枸杞多糖及其抗肿瘤活性研究[J].轻工科技,2016,5:22-24
2 Zong AZ,Cao HZ,Wang FS,et al.Anticancer polysaccharides from natural resources:A review of recent research[J].Carbohydrate Polymers,2012,9(4):1395-1410
3 Liu QM,Xu SS,Li L,et al.In vitro and in vivo immunomodulatory activity of sulfated polysaccharide from Porphyra haitanensis[J].Carbohydrate Polymers,2017,165:189-196
4 周本宏,谭珺,张婵.硫酸酯化天麻多糖的制备及其抗氧化活性[J].中国医院药学杂志,2017,37(17):1685-1691
5 Wu LJ,Wang W,Zhang XS,et al.Anti-HBV activity and mechanism of marine-derived polyguluronate sulfate(PGS)in vitro[J].Carbohydrate Polymers,2016,143(5):139-148
6 Tang L,Chen YC,Jiang ZB,et al.Purification,partial characterization and bioactivity of sulfated polysaccharides from Grateloupia livida[J].International Journal of Biological Macromolecules,2017,94:642-652
7 Lu MK,Lin TY,Chao CH,et al.Molecular mechanism of antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor receptor degradation[J].International Journal of Biological Macromolecules,2017,95:1144-1152
8 周本宏,谭珺,曾茂林.硫酸酯化天麻多糖对皮质酮诱导的PC12细胞损伤的保护作用[J].中国药师,2017,20(6):1005-1008
9 Ngoa DH,Kim SK.Sulfated polysaccharides as bioactive agents from marine algae[J].International Journal of Biological Macromolecules,2013,62:70-75
10 Han Y,Wu J,Liu TT,et al.Separation,characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida[J].International Journal of Biological Macromolecules,2016,83:42-49
11 杨晓丹.裙带菜褐藻多糖硫酸酯对SMMC-7721肿瘤细胞凋亡的诱及对BEL-7402的迁移抑制作用[D].大连:大连医科大学硕士学位论文,2010
12 Jose GM,Kurup GM.The efficacy of sulfated polysaccharides from Padina tetrastromatica in modulating the immune functions of RAW 264.7 cells[J].Biomedicine&Pharmacotherapy,2017,88:677-683
13 Suresh V,Senthilkumar N.Separation,purification and preliminary characterization of sulfated polysaccharides from Sargassum plagiophyllum and its in vitro anticancer and antioxidant activity[J].Process Biochemistry,2013,48:364-373
14 马伟伟,李丽,周革非.海黍子硫酸多糖体外免疫与抗肿瘤活性[J].食品科学.2013,34(7):270-274
15 Cheng JJ,Chao CH,Chang PC,et al.Studies on anti-inflammatory activity of sulfated polysaccharides from cultivated fungi Antrodia cinnamomea[J],Food Hydrocolloids,2016,53:37-45
16 Lu MK,Lin TY,Chao CH,et al.Molecular mechanism of antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor receptor degradation[J].International Journal of Biological Macromolecules,2017,95:1142-1152
17 Choi JH,Han EH,Hwang YP,et al.Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgarisvia the inhibition of NF-kappa B-dependent MMP-9expression[J].Food Chem Toxicol,2010,48(2):564-571
18 王雅楠,曹蕊,朱聪.夏枯草硫酸多糖对肝癌血管生成的作用及机制研究[J].中国肿瘤临床,2014,41(12):758-761
19 Xiong SL,Li AL,Huang N,et al.Antioxidant and immunoregulatory activity of different polysaccharide fractions from tuber of Ophiopogon japonicus[J].Carbohydrate Polymers,2011(86):1273-1280
20 Yu M,Ji YB,Qi Z,et al.Anti-tumor Activity of Sulfated Polysaccharides from Sargassum Fusiforme[J]Saudi Pharmaceutical Journal,2017,25(4):464-468
21 王凯,綦慧敏,李玉磊.孔石莼多糖及其硫酸酯化衍生物抗肿瘤活性的体外实验研究[J].中国海洋药物,2014,33(2):19-23
22 Sun ZC,Huang K,Fu XR.A chemically sulfated polysaccharide derived from Ganoderma lucidum induces mitochondrial-mediated apoptosis in human osteosarcoma MG63 cells[J].Tumor Biol,2014,35(10):9919-9926
23 彭悦云.灵芝多糖硫酸酯抗肿瘤活性的研究[D].成都.成都中医药大学硕士学位论文,2011
24 谈新提,王艺峰,张俐娜.化学修饰的茯苓多糖抗肿瘤效应的组织学观察[J].武汉大学学报,2004,25(6):652-655
25 陈群,王爱云,焦庆才.茯苓多糖硫酸酯的制备与鉴定及其增强小鼠NK细胞活性[J].食用菌学报,2009,16(3):48-52
26 王爱云,陈群,李成付.茯苓多糖修饰物抗肿瘤作用及其机制研究[J].中草药,2009,40(2):268-271
27 Lin YL,Zhang LN,Chen L.Molecular mass and antitumor activities of sulfated derivatives of-glucan from Poria cocos mycelia[J].International Journal of Biological Macromolecules,2004,34(5):289-294
28 Wang HL,Jean FL,Zhang YN.In vivo immunological activity of carboxymethylated sulfated(1→3)-d-glucan from sclerotium of Poria cocos[J].International Journal of Biological Macromolecules,2015,79:511-517
29 Shi BJ,Nie XH,Chen LZ.Anticancer activities of a chemically sulfated polysaccharide obtained from Grifola frondosa and its combination with 5-Fluorouracil against human gastric carcinoma cells[J].Carbohydrate Polymers,2007,68(4):687-692
30 程代,陈媛媛,孟梦.一种硫酸酯化灰树花多糖的免疫活性研究[J].食品研究与开发,2016,37(22):39-43
31 Kubo M,Liu YH,Ishida M,et al.A new spiroindene pigment from the medicinal fungus phellinus ribis[J].Chem Pharm Bull,2014,62(1):122-124
32 刘玉红.茶藨子木层孔菌多糖硫酸酯的制备与体外抗肿瘤活性[J].中国医院药学杂志,2014,34(7):509-512
33 刘玉红,张文玉,刘玉国.茶藨子木层孔菌多糖硫酸酯的体内抗肿瘤作用与机制[J].中国医院药学杂志,2015,35(11):985-989
34 Zhang YD,Wu W,Kang LH.Effect of Aconitum coreanum polysaccharide and its sulphated derivative on the migration of human breast cancer MDA-MB-435Scell[J].International Journal of Biological Macromolecules,2017,103:477-483
35 吴素珍,李加林,陈水亲,等.硫酸酯化当归多糖抗肿瘤实验研究[J].时珍国医国药,2012,23(2):319-320
36 吴素珍,李加林,陈水亲,等.硫酸酯化当归多糖制备及抗肿瘤活性的考察[J].中国医院药学杂志,2013,33(22):1832-1835
37 Wang L,Li YL,Zhu LD,et al.Antitumor activities and immunomodulatory of rice bran polysaccharides and its sulfates in vitro[J].International Journal of Biological Macromolecules,2016,88:424-432
38 朱丽丹,王莉,徐逸木.米糠多糖及硫酸酯化米糠多糖的体外免疫应答和抗肿瘤活性研究[J].中国粮油学报.2015,30(3):35-40
39陈晓庆,郑少燕,陈庆奇.硫酸酯化枸杞多糖及其抗肿瘤活性研究[J].轻工科技,2016,5:22-24