天然多糖的硫酸化修饰对其生物活性影响研究进展
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摘要
多糖是广泛存在于生物体内的一类生物活性大分子,因其具有多种生物活性,已引起国内外学者的高度关注。近年来研究发现,通过硫酸化修饰,可以改善多糖的生物活性,使其具有其他天然多糖无法比拟的生物活性。本文对多糖的硫酸化修饰方法及其生物活性进行综述,为今后开展硫酸化多糖的深入研究及开发应用提供参考。
Polysaccharides are a class of important bioactive molecules widely found in organisms. It has many biological activities,which attracted the attention of scholars at home and abroad.In recent years,researcher had found that the activities of polysaccharide could be improved by sulfation modification. Compared with other natural polysaccharide,sulfated polysaccharide have more medicinal activities. This article reviewed the research progress of the bioactivities of sulfated polysaccharide and provided a reference for the further research and application of sulfated polysaccharide in the future.
Polysaccharides are a class of important bioactive molecules widely found in organisms. It has many biological activities,which attracted the attention of scholars at home and abroad.In recent years,researcher had found that the activities of polysaccharide could be improved by sulfation modification. Compared with other natural polysaccharide,sulfated polysaccharide have more medicinal activities. This article reviewed the research progress of the bioactivities of sulfated polysaccharide and provided a reference for the further research and application of sulfated polysaccharide in the future.
引文
[1]许凤清,吴皓.海带多糖的研究进展[J].中国中医药信息杂志,2005,12(6):106-108.
[2]Zvyagintseva T N,Shevchenko N M.Water-soluble polysaccharides of some far-eastern brown seaweeds.Distribution,structure,and their dependence on the developmental conditions[J].Journal of Experimental Marine Biology and Ecology,2003,294:1-13.
[3]Xie J H,Liu X,Shen M Y,et al.Purification,physicochemical characterisation and anticancer activity of a polysaccharide from Cyclocarya paliurus leaves[J].Food Chemistry,2013,136(3-4):1453-1460.
[4]Cosgrove D J.Growth of the plant cell wall[J].Nat Rev Mol Cell Biol,2005,6(11):850-861.
[5]Kulicke W M,Lettau A I,Thielking H.Correlation between immunological activity,molar mass,and molecular structure of different(1→3)-beta-D-glucans[J].Carbohydrate Research,1997,297(2):135.
[6]Chaidedgumjorn A,Toyoda H,Woo E R,et al.Effect of(1→3)-and(1→4)-linkages of fully sulfated polysaccharides on their anticoagulant activity[J].Carbohydrate Research,2002,337(10):925-33.
[7]曲瑾郁,任大明.蛹虫草多糖的化学修饰及体外抗氧化能力[J].食品科学,2011,32(15):58-61.
[8]Jiang J,Meng F Y,He Z,et al.Sulfated modification of longan polysaccharide and its immunomodulatory and antitumor activity in vitro[J].International Journal of Biological Macromolecules,2014,67(6):323-329.
[9]Sun Z,He Y,Liang Z,et al.Sulfation of(1→3)-β--glucan from the fruiting bodies of Russula virescens and antitumor activities of the modifiers[J].Carbohydrate Polymers,2009,77(3):628-633.
[10]Zhu Z Y,Liu Y,Si C L,et al.Sulfated modification of the polysaccharide from Cordyceps gunnii,mycelia and its biological activities[J].Carbohydrate Polymers,2013,92(1):872-876.
[11]Wang L,Li X,Chen Z.Sulfated modification of the polysaccharides obtained from defatted rice bran and their antitumor activities[J].International Journal of Biological Macromolecules,2009,44(2):211.
[12]Lu X,Mo X,Guo H,et al.Sulfation modification and anticoagulant activity of the polysaccharides obtained from persimmon(Diospyros kaki L.)fruits[J].International Journal of Biological Macromolecules,2012,51(5):1189-95.
[13]Lu Y,Wang D,Hu Y,et al.Sulfated modification of epimedium polysaccharide and effects of the modifiers on cellular infectivity of IBDV[J].Chinese Journal of Animal&Veterinary Sciences,2008,71(2):180-186.
[14]Zhao X,Hu Y,Wang D,et al.Optimization of sulfated modification conditions of tremella polysaccharide and effects of modifiers on cellular infectivity of NDV[J].International Journal of Biological Macromolecules,2011,49(1):44-49.
[15]Wei D,Wei Y,Cheng W,et al.Sulfated modification,characterization and antitumor activities of Radix hedysari,polysaccharide[J].International Journal of Biological Macromolecules,2012,51(4):471-476.
[16]Zhang Z,Liu Z,Tao X,et al.Characterization and sulfated modification of an exopolysaccharide from Lactobacillus plantarum ZDY2013 and its biological activities[J].Carbohydrate Polymers,2016,153:25-33.
[17]孔倩,周婷,葛佳,等.南瓜多糖硫酸酯化修饰与结构稳定性关系研究[J].食品科技,2009(4):160-163.
[18]谢明勇,王之珺,谢建华.多糖的硫酸化修饰及其结构与生物活性关系研究进展[J].中国食品学报,2015,15(2):2-8.
[19]申进文,冯雅岚,余海尤,等.硫酸化分级香菇多糖抗氧化活性研究[J].菌物学报,2010,29(3):449-453.
[20]许春平,赵珊珊,杨琛琛,等.烤烟多糖的硫酸化修饰及抗氧化活性[J].烟草科技,2015,48(7):42-45.
[21]刘玉凤,贾淑颖,刘飞飞,等.不同取代度的硫酸化肠浒苔多糖抗氧化活性研究[J].食品工业科技,2016,37(19):142-147,152.
[22]Wang J,Guo H,Zhang J,et al.Sulfated modification,characterization and structure-antioxidant relationships of Artemisia sphaerocephala,polysaccharides[J].Carbohydrate Polymers,2010,81(4):897-905.
[23]Xie J H,Wang Z J,Shen M Y,et al.Sulfated modification,characterization and antioxidant activities of polysaccharide from Cyclocarya paliurus[J].Food Hydrocolloids,2015,53:7-15.
[24]Xu Y,Shen S,Wei Y,et al.Sulfated modification of the polysaccharide from Sphallerocarpus gracilis,and its antioxidant activities[J].International Journal of Biological Macromolecules,2016,87:180.
[25]Du Z,Shi F,Liu D,et al.Anticoagulant activity of a sulfated Lachnum polysaccharide in mice with a state of hypercoagulability[J].Bioorganic&Medicinal Chemistry Letters,2016,26(22):5550-5556.
[26]Matsubara K,Matsuura Y,Bacic A,et al.Anticoagulant properties of a sulfated galactan preparation from a marine green alga,Codium cylin-dricum[J].Int J of Biol Macromol,2001,28(5):395.
[27]Wang J M,Hu Y L,Wang D Y,et al.Sulfated modification can enhance the immune-enhancing activity of Lycium barbarum polysaccharides[J].Cellular Immunology,2010,263(2):219-223.
[28]郭龙,杨英来,杨涛,等.高硫代度红芪多糖硫酸酯的制备及体外抗凝血活性研究[J].药学学报,2013,48(11):1665-1670.
[29]杨曦明,范聪,李慧萍,等.白树花多糖硫酸酯的抗凝血活性研究[J].中国实验诊断学,2010,14(7):1031-1034.
[30]赵锐,郭彩霞,张鸥,等.玉米芯多糖及其硫酸酯抗凝血活性及其机制[J].吉林大学学报(医学版),2012,38(1):62-66.
[31]张汇,王君巧,聂少平,等.黑灵芝葡聚糖高活性硫酸化产物的制备及分离纯化[J].食品科学,2013,34(23):128-132.
[32]卢可可,张月巧,袁娅,等.硫酸化修饰多糖抗肿瘤活性构效关系及分子机制研究进展[J].食品科学,2014,35(23):297-302.
[33]王君敏,薛敬礼,葛蓓蕾,等.枸杞多糖及其硫酸酯体外免疫及抗肿瘤活性[J].郑州大学学报(医学版),2015,50(6):809-813.
[34]刘玉红.茶藨子木层孔菌多糖硫酸酯的制备与体外抗肿瘤活性[J].中国医院药学杂志,2014,34(7):509-512.
[35]杨柳.岩藻多糖硫酸酯的抗肿瘤活性筛选和初步机理研究[D].山东:山东大学微生物与生药化学,2012.
[36]Li W,Li X X,Chen Z X.Sulfated modification of the polysaccharides obtained from defatted rice bran and their antitumor activities[J].International Journal of Biological Macromolecules,2009,44(2):211.
[37]Yoshida O,Nakashima H,Yoshida T,et al.Sulfation of the immunomodulating polysaccharide lentinan:A novel strategy for antivirals to Human immunodeficiency virus(HIV)[J].Biochem Pharmacol,1998,37(15):2887-2981.
[38]蒋岩,陈春英,裴丽健,等.硫酸酯化箬叶多糖抗HIV-1机制的初步研究[J].中华实验和临床病毒学杂志,2000,14(1):56-59.
[39]王欢,张能英,李海英,等.硫酸化修饰对党参多糖体外抗I型单纯疱疹病毒的影响[J].中国科技论文,2015,10(6):706-709.
[40]Zhao X,Hu Y,Wang D,et al.Optimization of sulfated modification conditions of tremella polysaccharide and effects o modifiers on cellular infectivity of NDV[J].International Journa of Biological Macromolecules,2011,49(1):44-49.
[2]Zvyagintseva T N,Shevchenko N M.Water-soluble polysaccharides of some far-eastern brown seaweeds.Distribution,structure,and their dependence on the developmental conditions[J].Journal of Experimental Marine Biology and Ecology,2003,294:1-13.
[3]Xie J H,Liu X,Shen M Y,et al.Purification,physicochemical characterisation and anticancer activity of a polysaccharide from Cyclocarya paliurus leaves[J].Food Chemistry,2013,136(3-4):1453-1460.
[4]Cosgrove D J.Growth of the plant cell wall[J].Nat Rev Mol Cell Biol,2005,6(11):850-861.
[5]Kulicke W M,Lettau A I,Thielking H.Correlation between immunological activity,molar mass,and molecular structure of different(1→3)-beta-D-glucans[J].Carbohydrate Research,1997,297(2):135.
[6]Chaidedgumjorn A,Toyoda H,Woo E R,et al.Effect of(1→3)-and(1→4)-linkages of fully sulfated polysaccharides on their anticoagulant activity[J].Carbohydrate Research,2002,337(10):925-33.
[7]曲瑾郁,任大明.蛹虫草多糖的化学修饰及体外抗氧化能力[J].食品科学,2011,32(15):58-61.
[8]Jiang J,Meng F Y,He Z,et al.Sulfated modification of longan polysaccharide and its immunomodulatory and antitumor activity in vitro[J].International Journal of Biological Macromolecules,2014,67(6):323-329.
[9]Sun Z,He Y,Liang Z,et al.Sulfation of(1→3)-β--glucan from the fruiting bodies of Russula virescens and antitumor activities of the modifiers[J].Carbohydrate Polymers,2009,77(3):628-633.
[10]Zhu Z Y,Liu Y,Si C L,et al.Sulfated modification of the polysaccharide from Cordyceps gunnii,mycelia and its biological activities[J].Carbohydrate Polymers,2013,92(1):872-876.
[11]Wang L,Li X,Chen Z.Sulfated modification of the polysaccharides obtained from defatted rice bran and their antitumor activities[J].International Journal of Biological Macromolecules,2009,44(2):211.
[12]Lu X,Mo X,Guo H,et al.Sulfation modification and anticoagulant activity of the polysaccharides obtained from persimmon(Diospyros kaki L.)fruits[J].International Journal of Biological Macromolecules,2012,51(5):1189-95.
[13]Lu Y,Wang D,Hu Y,et al.Sulfated modification of epimedium polysaccharide and effects of the modifiers on cellular infectivity of IBDV[J].Chinese Journal of Animal&Veterinary Sciences,2008,71(2):180-186.
[14]Zhao X,Hu Y,Wang D,et al.Optimization of sulfated modification conditions of tremella polysaccharide and effects of modifiers on cellular infectivity of NDV[J].International Journal of Biological Macromolecules,2011,49(1):44-49.
[15]Wei D,Wei Y,Cheng W,et al.Sulfated modification,characterization and antitumor activities of Radix hedysari,polysaccharide[J].International Journal of Biological Macromolecules,2012,51(4):471-476.
[16]Zhang Z,Liu Z,Tao X,et al.Characterization and sulfated modification of an exopolysaccharide from Lactobacillus plantarum ZDY2013 and its biological activities[J].Carbohydrate Polymers,2016,153:25-33.
[17]孔倩,周婷,葛佳,等.南瓜多糖硫酸酯化修饰与结构稳定性关系研究[J].食品科技,2009(4):160-163.
[18]谢明勇,王之珺,谢建华.多糖的硫酸化修饰及其结构与生物活性关系研究进展[J].中国食品学报,2015,15(2):2-8.
[19]申进文,冯雅岚,余海尤,等.硫酸化分级香菇多糖抗氧化活性研究[J].菌物学报,2010,29(3):449-453.
[20]许春平,赵珊珊,杨琛琛,等.烤烟多糖的硫酸化修饰及抗氧化活性[J].烟草科技,2015,48(7):42-45.
[21]刘玉凤,贾淑颖,刘飞飞,等.不同取代度的硫酸化肠浒苔多糖抗氧化活性研究[J].食品工业科技,2016,37(19):142-147,152.
[22]Wang J,Guo H,Zhang J,et al.Sulfated modification,characterization and structure-antioxidant relationships of Artemisia sphaerocephala,polysaccharides[J].Carbohydrate Polymers,2010,81(4):897-905.
[23]Xie J H,Wang Z J,Shen M Y,et al.Sulfated modification,characterization and antioxidant activities of polysaccharide from Cyclocarya paliurus[J].Food Hydrocolloids,2015,53:7-15.
[24]Xu Y,Shen S,Wei Y,et al.Sulfated modification of the polysaccharide from Sphallerocarpus gracilis,and its antioxidant activities[J].International Journal of Biological Macromolecules,2016,87:180.
[25]Du Z,Shi F,Liu D,et al.Anticoagulant activity of a sulfated Lachnum polysaccharide in mice with a state of hypercoagulability[J].Bioorganic&Medicinal Chemistry Letters,2016,26(22):5550-5556.
[26]Matsubara K,Matsuura Y,Bacic A,et al.Anticoagulant properties of a sulfated galactan preparation from a marine green alga,Codium cylin-dricum[J].Int J of Biol Macromol,2001,28(5):395.
[27]Wang J M,Hu Y L,Wang D Y,et al.Sulfated modification can enhance the immune-enhancing activity of Lycium barbarum polysaccharides[J].Cellular Immunology,2010,263(2):219-223.
[28]郭龙,杨英来,杨涛,等.高硫代度红芪多糖硫酸酯的制备及体外抗凝血活性研究[J].药学学报,2013,48(11):1665-1670.
[29]杨曦明,范聪,李慧萍,等.白树花多糖硫酸酯的抗凝血活性研究[J].中国实验诊断学,2010,14(7):1031-1034.
[30]赵锐,郭彩霞,张鸥,等.玉米芯多糖及其硫酸酯抗凝血活性及其机制[J].吉林大学学报(医学版),2012,38(1):62-66.
[31]张汇,王君巧,聂少平,等.黑灵芝葡聚糖高活性硫酸化产物的制备及分离纯化[J].食品科学,2013,34(23):128-132.
[32]卢可可,张月巧,袁娅,等.硫酸化修饰多糖抗肿瘤活性构效关系及分子机制研究进展[J].食品科学,2014,35(23):297-302.
[33]王君敏,薛敬礼,葛蓓蕾,等.枸杞多糖及其硫酸酯体外免疫及抗肿瘤活性[J].郑州大学学报(医学版),2015,50(6):809-813.
[34]刘玉红.茶藨子木层孔菌多糖硫酸酯的制备与体外抗肿瘤活性[J].中国医院药学杂志,2014,34(7):509-512.
[35]杨柳.岩藻多糖硫酸酯的抗肿瘤活性筛选和初步机理研究[D].山东:山东大学微生物与生药化学,2012.
[36]Li W,Li X X,Chen Z X.Sulfated modification of the polysaccharides obtained from defatted rice bran and their antitumor activities[J].International Journal of Biological Macromolecules,2009,44(2):211.
[37]Yoshida O,Nakashima H,Yoshida T,et al.Sulfation of the immunomodulating polysaccharide lentinan:A novel strategy for antivirals to Human immunodeficiency virus(HIV)[J].Biochem Pharmacol,1998,37(15):2887-2981.
[38]蒋岩,陈春英,裴丽健,等.硫酸酯化箬叶多糖抗HIV-1机制的初步研究[J].中华实验和临床病毒学杂志,2000,14(1):56-59.
[39]王欢,张能英,李海英,等.硫酸化修饰对党参多糖体外抗I型单纯疱疹病毒的影响[J].中国科技论文,2015,10(6):706-709.
[40]Zhao X,Hu Y,Wang D,et al.Optimization of sulfated modification conditions of tremella polysaccharide and effects o modifiers on cellular infectivity of NDV[J].International Journa of Biological Macromolecules,2011,49(1):44-49.