肠膜明串珠菌产葡聚糖与低聚糖及其产物应用研究进展
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摘要
肠膜明串珠菌是一类益生乳酸菌,在其生长代谢过程中,能生成葡聚糖蔗糖酶。葡聚糖蔗糖酶在一定条件下能以蔗糖为唯一底物将其转化为葡聚糖,而当有受体如麦芽糖存在时,则生成低聚糖。综述了肠膜明串珠菌产葡聚糖与低聚糖的合成机理,国内外研究现状及其功能性应用,并对发展前景进行了展望。
Leuconostoc mesenteroides is a kind of probiotic Lactic acid bacteria,which can produce dextransucrase during its growth and metabolism. Dextransucrase can be converted to glucan with sucrose as the sole substrate under certain conditions.When there is a receptor such as maltose, dextransucrase catalyzes the formation of oligosaccharides.We make a reviewed about the synthesis mechanism of glucan and oligosaccharides produced by Leuconostoc mesenteroides, its functional application and research status at home and abroad. Finally, we look forward to its development prospects.
Leuconostoc mesenteroides is a kind of probiotic Lactic acid bacteria,which can produce dextransucrase during its growth and metabolism. Dextransucrase can be converted to glucan with sucrose as the sole substrate under certain conditions.When there is a receptor such as maltose, dextransucrase catalyzes the formation of oligosaccharides.We make a reviewed about the synthesis mechanism of glucan and oligosaccharides produced by Leuconostoc mesenteroides, its functional application and research status at home and abroad. Finally, we look forward to its development prospects.
引文
[1]张志霞.青藏高原部分地区不同分离样品肠膜明串珠菌的多位点序列分型研究[D].郑州大学,2016.
[2]董智芳.利用肠膜明串珠菌发酵合成葡聚糖及动力学研究[D].广西民族大学,2010.
[3]钱林生,邱录贵,秦铁军等.肠膜明串珠菌[M].北京:中国医学科学院血液研究所,1985:2-10.
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[6] ISHIDA R, SAKAGUCHI K, MATSUZAKI C, et al. Levansucrase from Leuconostoc mesenteroides NTM048 produces a levan exopolysaccharide with immunomodulating activity[J]. Biotechnology letters,2016, 38(4):681-687.
[7]李莉,魏小雁,张彦斌,等.培养基成分对肠膜明串珠菌肠膜亚种合成葡聚糖的影响[J].中国乳品工业,2009,37(06):16-19.
[8] SKORY C D, C?TéG L. Secreted expression of Leuconostoc mesenteroides glucansucrase in Lactococcus lactis for the production of insoluble glucans[J]. Applied microbiology and biotechnology, 2015, 99(23):10001-10010.
[9]范娟,张安,常聪,等.一株肠膜明串珠菌的分离筛选及其合成葡聚糖培养条件的优化[J].食品科技,2017,42(01):2-6.
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[14] MAJUMDER A, BHANDARI S, PURAMA R K, et al. Enhanced production of a novel dextran from Leuconostoc mesenteroides NRRL B-640 by Response Surface Methodology[J]. Annals of microbiology, 2009, 59(2):309-315.
[15]李冰,张建法,蒋鹏举.真菌硬葡聚糖的生产及在油田上的应用[J].微生物学通报,2003(05):99-102.
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[17] CHUNG C H, DAY D F. Glucooligosaccharides from Leuconostoc mesenteroides B-742(ATCC 13146):a potential prebiotic[J]. Journal of Industrial Microbiology and Biotechnology, 2002, 29(4):196-199.
[18] KOEPSELL H J, TSUCHIYA H M, HMELLMAN N N, et al. Enzymatic synthesis of dextran acceptor specificity and chain initiation[J]. Journal of Biological Chemistry, 1953, 200(2):793-801.
[19]高莉莉.肠膜明串珠菌发酵生成低聚糖的研究[D].北京林业大学,2009.
[20] KOTHARI D, BARUAH R, GOYAL A. Immobilization of glucansucrase for the production of gluco-oligosaccharides from Leuconostoc mesenteroides[J]. Biotechnology letters, 2012, 34(11):2101-2106.
[21] MILLER A W, ROBYT J F. Stabilization of dextransucrase from Leuconostoc mesenteroides NRRL B-512F by nonionic detergents,poly(ethylene glycol)and high-molecular-weight dextran[J]. Biochimica et Biophysica Acta(BBA)-Protein Structure and Molecular Enzymology, 1984, 785(3):89-96.
[22]张寅,干苏灵,张柏林.肠膜明串珠菌6055生产低聚葡萄糖的研究[J].食品工业科技,2014,35(09):150-155.
[23] PEREIRA A M, COSTA F A A, RODRIGUES M I, et al. In vitro synthesis of oligosaccharides by acceptor reaction of dextransucrase from Leuconostoc mesenteroides[J]. Biotechnology letters, 1998, 20(4):397-401.
[24] MOLLY K, SMET I D, NOLLET L, et al. Effect of lactobacilli on the ecology of the gastro-intestinal microbiota cultured in the SHIME reactor[J]. Microbial ecology in health and disease, 1996, 9(2):79-89.
[25] NAGENDRA R, VISWANATHA S, KUMAR S A, et al. Effect of feeding milk formula containing lactulose to infants on faecal bifidobacterial flora[J]. Nutrition Research, 1995, 15(1):15-24.
[26] PACK, M Y."Effect of Temperature on Growth and Diacetyl Production by Aroma Bacteria in Single-and Mixed-Strain Lactic Cultures1."Journal of Dairy Science 51.3(1968):339-344.
[27] KAPLAN H, HUTKINS R W. Fermentation of fructooligosaccharides by lactic acid bacteria and bifidobacteria[J]. Applied and Environmental Microbiology, 2000, 66(6):2682-2684.
[28] VEDAMUTHU E R. The dairy Leuconostoc:use in dairy products[J]. Journal of Dairy Science, 1994, 77(9):2725-2737.
[29] NGUYEN T T H, SEO Y S, CHO J Y, et al. Synthesis of oligosaccharide-containing orange juice using glucansucrase[J]. Biotechnology and bioprocess engineering, 2015, 20(3):447-452.
[2]董智芳.利用肠膜明串珠菌发酵合成葡聚糖及动力学研究[D].广西民族大学,2010.
[3]钱林生,邱录贵,秦铁军等.肠膜明串珠菌[M].北京:中国医学科学院血液研究所,1985:2-10.
[4]陈代杰,金飞燕.生物高分子(第五卷多糖Ⅰ-原核生物多糖)[M].北京:化学工业出版社,2004:305-320.
[5]宗明,金中淦,徐兰,等.乳酸细菌葡聚糖蔗糖酶的研究应用与进展[J].检验医学教育,2005(02):30-32.
[6] ISHIDA R, SAKAGUCHI K, MATSUZAKI C, et al. Levansucrase from Leuconostoc mesenteroides NTM048 produces a levan exopolysaccharide with immunomodulating activity[J]. Biotechnology letters,2016, 38(4):681-687.
[7]李莉,魏小雁,张彦斌,等.培养基成分对肠膜明串珠菌肠膜亚种合成葡聚糖的影响[J].中国乳品工业,2009,37(06):16-19.
[8] SKORY C D, C?TéG L. Secreted expression of Leuconostoc mesenteroides glucansucrase in Lactococcus lactis for the production of insoluble glucans[J]. Applied microbiology and biotechnology, 2015, 99(23):10001-10010.
[9]范娟,张安,常聪,等.一株肠膜明串珠菌的分离筛选及其合成葡聚糖培养条件的优化[J].食品科技,2017,42(01):2-6.
[10] SAWALE S D, LELE S S. Statistical optimization of media for dextran production by Leuconostoc sp., isolated from fermented idli batter[J]. Food Science and Biotechnology, 2010, 19(2):471-478.
[11]王英,黄开红,李思睿,等.产葡聚糖明串珠菌的分离鉴定及发酵条件研究[J].食品与生物技术学报,2012,31(07):727-732.
[12] CHOROMANSKA A, KULBACKA J, HARASYM J, et al. Highand low-molecular weight oat beta-glucan reveals antitumor activity in human epithelial lung cancer[J]. Pathology&Oncology Research,2017:1-10.
[13] SALES V S D F, LIMA A M D S, MELCHUNA K M,et al. Effects of beta-glucan in a mice model of vaginitis by candida albicans[C]//World Allergy Organization Journal. BioMed Central, 2015, 8(1):A227.
[14] MAJUMDER A, BHANDARI S, PURAMA R K, et al. Enhanced production of a novel dextran from Leuconostoc mesenteroides NRRL B-640 by Response Surface Methodology[J]. Annals of microbiology, 2009, 59(2):309-315.
[15]李冰,张建法,蒋鹏举.真菌硬葡聚糖的生产及在油田上的应用[J].微生物学通报,2003(05):99-102.
[16]李婧.利用肠膜明串珠菌代谢生产低聚葡萄糖的研究[D].北京林业大学,2010.
[17] CHUNG C H, DAY D F. Glucooligosaccharides from Leuconostoc mesenteroides B-742(ATCC 13146):a potential prebiotic[J]. Journal of Industrial Microbiology and Biotechnology, 2002, 29(4):196-199.
[18] KOEPSELL H J, TSUCHIYA H M, HMELLMAN N N, et al. Enzymatic synthesis of dextran acceptor specificity and chain initiation[J]. Journal of Biological Chemistry, 1953, 200(2):793-801.
[19]高莉莉.肠膜明串珠菌发酵生成低聚糖的研究[D].北京林业大学,2009.
[20] KOTHARI D, BARUAH R, GOYAL A. Immobilization of glucansucrase for the production of gluco-oligosaccharides from Leuconostoc mesenteroides[J]. Biotechnology letters, 2012, 34(11):2101-2106.
[21] MILLER A W, ROBYT J F. Stabilization of dextransucrase from Leuconostoc mesenteroides NRRL B-512F by nonionic detergents,poly(ethylene glycol)and high-molecular-weight dextran[J]. Biochimica et Biophysica Acta(BBA)-Protein Structure and Molecular Enzymology, 1984, 785(3):89-96.
[22]张寅,干苏灵,张柏林.肠膜明串珠菌6055生产低聚葡萄糖的研究[J].食品工业科技,2014,35(09):150-155.
[23] PEREIRA A M, COSTA F A A, RODRIGUES M I, et al. In vitro synthesis of oligosaccharides by acceptor reaction of dextransucrase from Leuconostoc mesenteroides[J]. Biotechnology letters, 1998, 20(4):397-401.
[24] MOLLY K, SMET I D, NOLLET L, et al. Effect of lactobacilli on the ecology of the gastro-intestinal microbiota cultured in the SHIME reactor[J]. Microbial ecology in health and disease, 1996, 9(2):79-89.
[25] NAGENDRA R, VISWANATHA S, KUMAR S A, et al. Effect of feeding milk formula containing lactulose to infants on faecal bifidobacterial flora[J]. Nutrition Research, 1995, 15(1):15-24.
[26] PACK, M Y."Effect of Temperature on Growth and Diacetyl Production by Aroma Bacteria in Single-and Mixed-Strain Lactic Cultures1."Journal of Dairy Science 51.3(1968):339-344.
[27] KAPLAN H, HUTKINS R W. Fermentation of fructooligosaccharides by lactic acid bacteria and bifidobacteria[J]. Applied and Environmental Microbiology, 2000, 66(6):2682-2684.
[28] VEDAMUTHU E R. The dairy Leuconostoc:use in dairy products[J]. Journal of Dairy Science, 1994, 77(9):2725-2737.
[29] NGUYEN T T H, SEO Y S, CHO J Y, et al. Synthesis of oligosaccharide-containing orange juice using glucansucrase[J]. Biotechnology and bioprocess engineering, 2015, 20(3):447-452.