摘要
背景:诊断骨质疏松症主要依靠骨密度测量,骨密度与遗传、环境、脂肪分布等多项因素有关。目前双能X射线骨密度仪和定量CT为测量骨密度的主要方法。目的:探讨定量CT测量青年人群腰椎骨密度与脂肪分布的关系。方法:严格按照筛选方案,选择北京市区、北京郊区20-40岁青年志愿者262名,所有志愿者对测量方案均知情同意。利用定量CT测量L2-L4椎体骨密度及L4椎体中间层面腹内脂肪面积、皮下脂肪面积及腹部总脂肪面积,采用Pearson相关及多元线性回归分析法对骨密度及相关脂肪指标进行相关性分析。结果与结论:①北京地区青年人群腹内脂肪面积与骨密度呈负相关(P <0.05);②而皮下脂肪面积、腹部总脂肪面积与骨密度无相关性;③建议测量青年人群腰椎松质骨骨密度,控制青年人群过度肥胖,以利于骨质疏松的预防和早期诊断工作。
BACKGROUND: Bone mineral density is used for the diagnosis of osteoporosis, and bone mineral density is related to genetic, environment and fat distribution factors. Dual energy X-ray absorptiometry and quantitative CT are main methods of measuring bone mineral density.OBJECTIVE: To investigate the relationship between lumbar spine bone mineral density and fat distribution in young adults by quantitative CT.METHODS: Totally 262 young adults aged 20-40 years in Beijing urban and suburb areas were screened based on inclusion and exclusion criteria, and all volunteers provided written informed consents. Quantitative CT was used to measure the intra-abdominal fat area, subcutaneous fat area and total abdominal fat area of L2-L4 bone mineral density and L4 vertebrae. The relationship between bone mineral density and fat distribution was analyzed by Pearson correlation analysis and multivariate linear regression.RESULTS AND CONCLUSION:(1) The area of intra-abdominal fat was negatively correlated with bone mineral density in young adults in Beijing(P < 0.05).(2) The area of subcutaneous fat and total abdominal fat were not correlated with bone mineral density.(3) Therefore, it is suggested to measure the bone mineral density of lumbar spondylous bone in young people and control obesity, so as to prevent osteoporosis and make early diagnosis.
引文
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