阻塞性睡眠呼吸暂停低通气综合征与呼吸系统疾病相关发病机制的研究进展
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摘要
<正>睡眠呼吸暂停低通气综合征在临床上可分为三种类型,即阻塞性、中枢性、混合性,其中阻塞性占50%～70%,是最常见的睡眠呼吸暂停综合征类型[1]。阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)是指每夜睡眠中呼吸暂停反复发作在30次以上,或睡眠呼吸暂停/低通气指数(apnea-hypopnea index,AHI)≥5次/h[2]。依据2003年中华医学会呼吸病学分会睡眠呼吸疾病学组制定的《阻塞性睡眠呼吸暂停低通气综合征诊治指南
引文
1刘建红.阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版)解析[A].中国睡眠研究会睡眠呼吸专业委员会.2015年全国睡眠呼吸学术年会论文汇编[C].中国睡眠研究会睡眠呼吸专业委员会:中国睡眠研究会,2015:6.
2 Simiakakis M,Kapsimalis F,Chaligiannis E,et al. Lack of effect of sleep apnea on oxidative stress in obstructive sleep apnea syndrome(OSAS)patients[J]. PLoS One,2012,7(6):e39172.
3 Eckert DJ,Malhotra A. Pathophysiology of adult obstructive sleep apnea[J]. Proc Am Thorac Soc,2008,5(2):144-153.
4 Lu D,Li N,Yao X,et al. Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome[J]. Bosn J Basic Med Sci,2017,17(1):47-53.
5 Ram S,Seirawan H,Kumar SK,et al. Prevalence and impact of sleep disorders and sleep habits in the United States[J]. Sleep Breath,2010,14(1):63-70.
6 Tufik S,Santos-Silva R,Taddei JA,et al. Obstructive sleep apnea syndrome in the Sao Paulo epidemiologic sleep study[J]. Sleep Med,2010,11(5):441-446.
7 Peppard PE,Young T,Barnet JH,et al. Increased prevalence of sleep-disordered breathing in adults[J]. Am J Epidemiol,2013,177(9):1006-1014.
8 Semenza GL,Prabhakar NR. HIF-1-dependent respiratory,cardiovascular,and redox responses to chronic intermittent hypoxia[J]. Antioxid Redox Signal,2007,9(9):1391-1396.
9 Vgontzas AN,Papanicolaou DA,Bixler EO,et al. Elevation of plasma cytokines in disorders of excessive daytime sleepiness:role of sleep disturbance and obesity[J]. J Clin Endocrinol Metab,1997,82(5):1313-1316.
10 Vgontzas AN,Papanicolaou DA,Bixler EO,et al. Sleep apnea and daytime sleepiness and fatigue:relation to visceral obesity,insulin resistance,and hypercytokinemia[J]. J Clin Endocrinol Metab,2000,85(3):1151-1158.
11 Wu ZH,Yang XP,Niu X,et al. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease:a meta-analysis[J]. Sleep Breath,2018,doi:10. 1007/s11325-018 -1691-x.
12 汤泰秦.胃食管反流性疾病与呼吸系统疾病(综述)[J].暨南大学学报(自然科学与医学版),2001(04):88-92.
13 Jaimchariyatam N,Tantipornsinchai W,Desudchit T,et al. Association between respiratory events and nocturnal gastroesophageal reflux events in patients with coexisting obstructive sleep apnea and gastroesophageal reflux disease[J]. Sleep Med,2016,22:33-38.
14 Pasricha PJ. Effect of sleep on gastroesophageal physiology and airway protective mechanisms[J]. Am J Med,2003,115 Suppl 3A,114s-118 s.
15 Meier-Ewert HK,Ridker PM,Rifai N,et al. Effect of sleep loss on C-Reactive protein,an inflammatory marker of cardiovascular risk[J]. J Am Coll Cardiol,2004,43(4):678-683.
16 Vgontzas AN,Zoumakis E,Bixler EO,et al. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines[J]. J Clin Endocrinol Metab,2004,89(5):2119-2126.
17 Irwin MR,Wang M,Campomayor CO,et al. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation[J]. Arch Intern Med,2006,166(16):1756-1762.
18 Feng J,Zhang D,Chen B. Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea[J]. Sleep Breath,2012,16(2):283-294.
19 Gozal D,Kheirandish-Gozal L. Cardiovascular morbidity in obstructive sleep apnea:oxidative stress,inflammation,and much more[J].Am J Respir Crit Care Med,2008,177(4):369-375.
20 Jelic S,Padeletti M,Kawut SM,et al. Inflammation,oxidative stress,and repair capacity of the vascular endothelium in obstructive sleep apnea[J]. Circulation,2008,117(17):2270-2278.
21 Ignarro LJ,Buga GM,Wood KS,et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide[J].Proc Natl Acad Sci USA,1987,84(24):9265-9269.
22 Murad F. Cyclic guanosine monophosphate as a mediator of vasodilation[J]. J Clin Invest,1986,78(1):1-5.
23 Trachsel S,Hambraeus-Jonzon K,Bergquist M,et al. No redistribution of lung blood flow by inhaled nitric oxide in endotoxemic piglets pretreated with an endothelin receptor antagonist[J]. J Appl Physiol(1985),2015,118(6):768-775.
24 张静静,王岗,李满祥.内皮-间充质转化在肺动脉高压发病机制中的研究进展[J].中国病理生理杂志,2018,34(9):1724-1728.
25 Ranchoux B,Antigny F,Rucker-Martin C,et al. Endothelial-tomesenchymal transition in pulmonary hypertension[J]. Circulation,2015,131(11):1006-1018.
26 Good RB,Gilbane AJ,Trinder SL,et al. Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary arterial hypertension[J]. Am J Pathol,2015,185(7):1850-1858.
27 Alkhalil M,Schulman E,Getsy J. Obstructive sleep apnea syndrome and asthma:what are the links?[J]. J Clin Sleep Med,2009,5(1):71-78.
28 魏进萍,赵国厚,袁开芬,等.阻塞性睡眠呼吸低通气障碍综合征与支气管哮喘的相关性[J].中国老年保健医学,2017,15(4):75-77.
29 杨贤,关巍,冯喜英.睡眠呼吸暂停低通气综合征与特发性肺纤维化关系的研究进展[J].中国保健营养,2016,26(7):62.
30 Eisele HJ,Markart P,Schulz R. Obstructive sleep apnea,oxidative stress,and cardiovascular disease:Evidence from human studies[J]. Oxid Med Cell Longev,2015,2015:608438.
31 王秋林,王浩毅,王树人.氧化应激状态的评价[J].中国病理生理杂志,2005,21(10):2069-2074.
32 Lévy P,Ryan S,Oldenburg O,et al. Sleep apnoea and the heart[J]. Eur Respir Rev,2013,22(129):333-352.
33 高淑磊.血清8-OHdG、MnSOD与高血压及阻塞性睡眠呼吸暂停低通气综合征[J].中国老年学杂志,2013,33(19):4939-4943.
34 Lavie L. Obstructive sleep apnoea syndrome-an oxidative stress disorder[J]. Sleep Medicine Reviews,2003,7(1):35-51.
35 Peng YJ,Overholt JL,Kline D,et al. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia:Implications for recurrent apneas[J]. Proc Natl Acad Sci USA,2003,100(17):10073-10078.
36 Ramanathan L,Gozal D,Siegel JM. Antioxidant responses to chronic hypoxia in the rat cerebellum and pons[J]. J Neurochem,2005,93(1):47-52.
37 张福业,孟秋云,赵廷利,等.阻塞性睡眠呼吸暂停低通气综合征患者凝血纤溶的变化[J].泰山医学院学报,2011,32(7):489-491.
38 von Knel R,Loredo JS,Ancoli-Israel S,et al. Association between sleep apnea severity and blood coagulability:treatment effects of nasal continuous positive airway pressure[J]. Sleep Breathing,2006,10(3):139-146.
39 Zamarrón C,Ricoy J,Riveiro A,et al. Plasminogen Activator Inhibitor-1in Obstructive Sleep Apnea Patients with and without Hypertension[J]. Lung,2008,186(3):151-156.
40 Imagawa S,Yamaguchi Y,Higuchi M,et al. Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome[J]. Blood,2001,98(4):1255-1257.
41 侯微微,刘双,谢江,等.阻塞性睡眠呼吸暂停低通气综合征与肺血栓栓塞症影响因素的Logistic研究[J].心肺血管病杂志,2014,33(1):72-75.
42 Peled N,Kassirer M,Kramer MR,et al. Increased erythrocyte adhesiveness and aggregation in obstructive sleep apnea syndrome[J]. Thromb Res,2008,121(5):631-636.
43 Barros D,García-Río F. Obstructive sleep apnea and dyslipidemia.From animal models to clinical evidence[J]. Sleep,2018,doi:10.1093/sleep/zsy236.
44 Pratt-Ubunama MN,Nishizaka MK,Boedefeld RL,et al. Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension[J]. Chest,2007,131(2):453-459.
45 李琳,金光华,郎金琦,等. OSAHS与深静脉血栓-肺血栓栓塞相关性研究进展[J].临床耳鼻咽喉头颈外科杂志,2017,31(15):1214-1217.
46 叶亮,李庆云,李敏.慢性间歇低氧与交感神经异常兴奋的研究进展[J].中国呼吸与危重监护杂志,2009,8(6):609-611.
47 Yuan G,Nanduri J,Bhasker CR,et al. Ca2+/Calmodulin Kinasedependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia[J]. J Biol Chem,2005,280(6):4321-8328.
48 Kumar GK,Rai V,Sharma SD,et al. Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress[J]. J Physiol,2006,575(1):229-239.
49 Leuenberger UA,Hogeman CS,Quraishi SA,et al. Short-term intermittent hypoxia enhances sympathetic responses to continuous hypoxia in humans[J]. J Appl Physiol(1985),2007,103(3):835-842.
50 韦华清,兰枝东,韦岑,等.阻塞性睡眠呼吸暂停低通气综合征对心脏的影响[J].临床心血管病杂志,2013,29(1):57-59.
51 Denjean A,Roux C,Herve P,et al. Mild isocapnic hypoxia enhances the bronchial response to methacholine in asthmatic subjects[J]. Am Rev Respir Dis,1988,138(4):789-793.
52 Rodríguez-Téllez M. Supra-oesophageal manifestations of gastro-oesophageal reflux disease[J]. Drugs,2005,65 Suppl 1:67-73.
53 Wu DN,Yamauchi K,Kobayashi H,et al. Effects of esophageal acid perfusion on cough responsiveness in patients with bronchial asthma[J]. Chest,2002,122(2):505-509.
54 王建丽,张立强.美国内科医师学院关于阻塞性睡眠呼吸暂停低通气综合征诊疗指南解读[J].临床内科杂志,2015,32(6):431-432.
2 Simiakakis M,Kapsimalis F,Chaligiannis E,et al. Lack of effect of sleep apnea on oxidative stress in obstructive sleep apnea syndrome(OSAS)patients[J]. PLoS One,2012,7(6):e39172.
3 Eckert DJ,Malhotra A. Pathophysiology of adult obstructive sleep apnea[J]. Proc Am Thorac Soc,2008,5(2):144-153.
4 Lu D,Li N,Yao X,et al. Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome[J]. Bosn J Basic Med Sci,2017,17(1):47-53.
5 Ram S,Seirawan H,Kumar SK,et al. Prevalence and impact of sleep disorders and sleep habits in the United States[J]. Sleep Breath,2010,14(1):63-70.
6 Tufik S,Santos-Silva R,Taddei JA,et al. Obstructive sleep apnea syndrome in the Sao Paulo epidemiologic sleep study[J]. Sleep Med,2010,11(5):441-446.
7 Peppard PE,Young T,Barnet JH,et al. Increased prevalence of sleep-disordered breathing in adults[J]. Am J Epidemiol,2013,177(9):1006-1014.
8 Semenza GL,Prabhakar NR. HIF-1-dependent respiratory,cardiovascular,and redox responses to chronic intermittent hypoxia[J]. Antioxid Redox Signal,2007,9(9):1391-1396.
9 Vgontzas AN,Papanicolaou DA,Bixler EO,et al. Elevation of plasma cytokines in disorders of excessive daytime sleepiness:role of sleep disturbance and obesity[J]. J Clin Endocrinol Metab,1997,82(5):1313-1316.
10 Vgontzas AN,Papanicolaou DA,Bixler EO,et al. Sleep apnea and daytime sleepiness and fatigue:relation to visceral obesity,insulin resistance,and hypercytokinemia[J]. J Clin Endocrinol Metab,2000,85(3):1151-1158.
11 Wu ZH,Yang XP,Niu X,et al. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease:a meta-analysis[J]. Sleep Breath,2018,doi:10. 1007/s11325-018 -1691-x.
12 汤泰秦.胃食管反流性疾病与呼吸系统疾病(综述)[J].暨南大学学报(自然科学与医学版),2001(04):88-92.
13 Jaimchariyatam N,Tantipornsinchai W,Desudchit T,et al. Association between respiratory events and nocturnal gastroesophageal reflux events in patients with coexisting obstructive sleep apnea and gastroesophageal reflux disease[J]. Sleep Med,2016,22:33-38.
14 Pasricha PJ. Effect of sleep on gastroesophageal physiology and airway protective mechanisms[J]. Am J Med,2003,115 Suppl 3A,114s-118 s.
15 Meier-Ewert HK,Ridker PM,Rifai N,et al. Effect of sleep loss on C-Reactive protein,an inflammatory marker of cardiovascular risk[J]. J Am Coll Cardiol,2004,43(4):678-683.
16 Vgontzas AN,Zoumakis E,Bixler EO,et al. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines[J]. J Clin Endocrinol Metab,2004,89(5):2119-2126.
17 Irwin MR,Wang M,Campomayor CO,et al. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation[J]. Arch Intern Med,2006,166(16):1756-1762.
18 Feng J,Zhang D,Chen B. Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea[J]. Sleep Breath,2012,16(2):283-294.
19 Gozal D,Kheirandish-Gozal L. Cardiovascular morbidity in obstructive sleep apnea:oxidative stress,inflammation,and much more[J].Am J Respir Crit Care Med,2008,177(4):369-375.
20 Jelic S,Padeletti M,Kawut SM,et al. Inflammation,oxidative stress,and repair capacity of the vascular endothelium in obstructive sleep apnea[J]. Circulation,2008,117(17):2270-2278.
21 Ignarro LJ,Buga GM,Wood KS,et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide[J].Proc Natl Acad Sci USA,1987,84(24):9265-9269.
22 Murad F. Cyclic guanosine monophosphate as a mediator of vasodilation[J]. J Clin Invest,1986,78(1):1-5.
23 Trachsel S,Hambraeus-Jonzon K,Bergquist M,et al. No redistribution of lung blood flow by inhaled nitric oxide in endotoxemic piglets pretreated with an endothelin receptor antagonist[J]. J Appl Physiol(1985),2015,118(6):768-775.
24 张静静,王岗,李满祥.内皮-间充质转化在肺动脉高压发病机制中的研究进展[J].中国病理生理杂志,2018,34(9):1724-1728.
25 Ranchoux B,Antigny F,Rucker-Martin C,et al. Endothelial-tomesenchymal transition in pulmonary hypertension[J]. Circulation,2015,131(11):1006-1018.
26 Good RB,Gilbane AJ,Trinder SL,et al. Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary arterial hypertension[J]. Am J Pathol,2015,185(7):1850-1858.
27 Alkhalil M,Schulman E,Getsy J. Obstructive sleep apnea syndrome and asthma:what are the links?[J]. J Clin Sleep Med,2009,5(1):71-78.
28 魏进萍,赵国厚,袁开芬,等.阻塞性睡眠呼吸低通气障碍综合征与支气管哮喘的相关性[J].中国老年保健医学,2017,15(4):75-77.
29 杨贤,关巍,冯喜英.睡眠呼吸暂停低通气综合征与特发性肺纤维化关系的研究进展[J].中国保健营养,2016,26(7):62.
30 Eisele HJ,Markart P,Schulz R. Obstructive sleep apnea,oxidative stress,and cardiovascular disease:Evidence from human studies[J]. Oxid Med Cell Longev,2015,2015:608438.
31 王秋林,王浩毅,王树人.氧化应激状态的评价[J].中国病理生理杂志,2005,21(10):2069-2074.
32 Lévy P,Ryan S,Oldenburg O,et al. Sleep apnoea and the heart[J]. Eur Respir Rev,2013,22(129):333-352.
33 高淑磊.血清8-OHdG、MnSOD与高血压及阻塞性睡眠呼吸暂停低通气综合征[J].中国老年学杂志,2013,33(19):4939-4943.
34 Lavie L. Obstructive sleep apnoea syndrome-an oxidative stress disorder[J]. Sleep Medicine Reviews,2003,7(1):35-51.
35 Peng YJ,Overholt JL,Kline D,et al. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia:Implications for recurrent apneas[J]. Proc Natl Acad Sci USA,2003,100(17):10073-10078.
36 Ramanathan L,Gozal D,Siegel JM. Antioxidant responses to chronic hypoxia in the rat cerebellum and pons[J]. J Neurochem,2005,93(1):47-52.
37 张福业,孟秋云,赵廷利,等.阻塞性睡眠呼吸暂停低通气综合征患者凝血纤溶的变化[J].泰山医学院学报,2011,32(7):489-491.
38 von Knel R,Loredo JS,Ancoli-Israel S,et al. Association between sleep apnea severity and blood coagulability:treatment effects of nasal continuous positive airway pressure[J]. Sleep Breathing,2006,10(3):139-146.
39 Zamarrón C,Ricoy J,Riveiro A,et al. Plasminogen Activator Inhibitor-1in Obstructive Sleep Apnea Patients with and without Hypertension[J]. Lung,2008,186(3):151-156.
40 Imagawa S,Yamaguchi Y,Higuchi M,et al. Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome[J]. Blood,2001,98(4):1255-1257.
41 侯微微,刘双,谢江,等.阻塞性睡眠呼吸暂停低通气综合征与肺血栓栓塞症影响因素的Logistic研究[J].心肺血管病杂志,2014,33(1):72-75.
42 Peled N,Kassirer M,Kramer MR,et al. Increased erythrocyte adhesiveness and aggregation in obstructive sleep apnea syndrome[J]. Thromb Res,2008,121(5):631-636.
43 Barros D,García-Río F. Obstructive sleep apnea and dyslipidemia.From animal models to clinical evidence[J]. Sleep,2018,doi:10.1093/sleep/zsy236.
44 Pratt-Ubunama MN,Nishizaka MK,Boedefeld RL,et al. Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension[J]. Chest,2007,131(2):453-459.
45 李琳,金光华,郎金琦,等. OSAHS与深静脉血栓-肺血栓栓塞相关性研究进展[J].临床耳鼻咽喉头颈外科杂志,2017,31(15):1214-1217.
46 叶亮,李庆云,李敏.慢性间歇低氧与交感神经异常兴奋的研究进展[J].中国呼吸与危重监护杂志,2009,8(6):609-611.
47 Yuan G,Nanduri J,Bhasker CR,et al. Ca2+/Calmodulin Kinasedependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia[J]. J Biol Chem,2005,280(6):4321-8328.
48 Kumar GK,Rai V,Sharma SD,et al. Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress[J]. J Physiol,2006,575(1):229-239.
49 Leuenberger UA,Hogeman CS,Quraishi SA,et al. Short-term intermittent hypoxia enhances sympathetic responses to continuous hypoxia in humans[J]. J Appl Physiol(1985),2007,103(3):835-842.
50 韦华清,兰枝东,韦岑,等.阻塞性睡眠呼吸暂停低通气综合征对心脏的影响[J].临床心血管病杂志,2013,29(1):57-59.
51 Denjean A,Roux C,Herve P,et al. Mild isocapnic hypoxia enhances the bronchial response to methacholine in asthmatic subjects[J]. Am Rev Respir Dis,1988,138(4):789-793.
52 Rodríguez-Téllez M. Supra-oesophageal manifestations of gastro-oesophageal reflux disease[J]. Drugs,2005,65 Suppl 1:67-73.
53 Wu DN,Yamauchi K,Kobayashi H,et al. Effects of esophageal acid perfusion on cough responsiveness in patients with bronchial asthma[J]. Chest,2002,122(2):505-509.
54 王建丽,张立强.美国内科医师学院关于阻塞性睡眠呼吸暂停低通气综合征诊疗指南解读[J].临床内科杂志,2015,32(6):431-432.