年龄和月经状态对成年女性骨盆骨髓ADC值的影响
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摘要
目的探讨年龄和月经状态对成年女性骨盆骨髓ADC值的影响。方法回顾性分析124例成年女性骨盆骨髓ADC值,其中未绝经组51例,32例年龄>40岁,19例≤40岁;绝经组73例,27例年龄>60岁,46例≤60岁。比较不同月经状态及不同年龄女性之间骨盆骨髓ADC值的差异。结果未绝经组女性骨盆骨髓ADC值高于绝经组(P<0.001);未绝经组中,≤40岁者ADC值高于>40岁者(P<0.001);绝经组≤60岁ADC值与>60岁比较差异无统计学意义(P>0.05)。女性骨盆骨髓ADC值整体上与年龄呈负相关(rs=-0.581,P<0.001),未绝经女性二者呈负相关(rs=-0.301,P=0.032),而绝经后女性二者无显著相关(P>0.05)。结论成年女性骨盆骨髓ADC值随年龄增长而下降,这种趋势在绝经前女性中尤为显著。
Objective To explore the impact of age and menstrual status on ADC value of pelvic bone marrow in adult women.Methods ADC data of pelvic bone marrow in 124 adult women were retrospectively analyzed,including 51 premenopausal women (premenopausal group,32aged>40and 19 aged ≤40year_s)and 73 postmenopausal women (postmenopausal group,27aged>60and 46 aged ≤60year_s).ADC values of pelvic bone marrow in different age and menstrual status of adult women were compared.Results ADC value of pelvic bone marrow in premenopausal group was higher than that in postmenopausal group (P<0.001).In premenopausal group,ADC values in patients aged≤40year_s were higher than those >40year_s (P<0.001).In postmenopausal group,no significant difference of ADC value was found between women≤60year_s and>60year_s (P>0.05).ADC value of women's pelvic bone marrow showed negative correlation with age (r_s =-0.581,P <0.001),and similar linear correlation was found in premenopausal group (r_s=-0.301,P=0.032),whereas no significant correlation was detected between age and ADC value in postmenopausal women (P>0.05).Conclusion ADC value of pelvic bone marrow in adult women decrease with aging,and the tendency is more pronounced in premenopausal women.
Objective To explore the impact of age and menstrual status on ADC value of pelvic bone marrow in adult women.Methods ADC data of pelvic bone marrow in 124 adult women were retrospectively analyzed,including 51 premenopausal women (premenopausal group,32aged>40and 19 aged ≤40year_s)and 73 postmenopausal women (postmenopausal group,27aged>60and 46 aged ≤60year_s).ADC values of pelvic bone marrow in different age and menstrual status of adult women were compared.Results ADC value of pelvic bone marrow in premenopausal group was higher than that in postmenopausal group (P<0.001).In premenopausal group,ADC values in patients aged≤40year_s were higher than those >40year_s (P<0.001).In postmenopausal group,no significant difference of ADC value was found between women≤60year_s and>60year_s (P>0.05).ADC value of women's pelvic bone marrow showed negative correlation with age (r_s =-0.581,P <0.001),and similar linear correlation was found in premenopausal group (r_s=-0.301,P=0.032),whereas no significant correlation was detected between age and ADC value in postmenopausal women (P>0.05).Conclusion ADC value of pelvic bone marrow in adult women decrease with aging,and the tendency is more pronounced in premenopausal women.
引文
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[14]BiffarA,Dietrich O,Sourbron S,et al.Diffusion and perfusion imaging of bone marrow.Eur J Radiol,2010,76(3):323-328.
[15]Chen WT,Shih TT,Chen RC,et al.Vertebral bone marrow perfusion evaluated with dynamic contrast-enhanced MRimaging:Significance of aging and sex.Radiology,2001,220(1):213-218.
[2]Justesen J,Stenderup K,Ebbesen EN,et al.Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis.Biogerontology,2001,2(3):165-171.
[3]Koyama H,Yoshihara H,Kotera M,et al.The quantitative diagnostic capability of routine MR imaging and diffusionweighted imaging in osteoporosis patients.Clin Imaging,2013,37(5):925-929.
[4]Herrmann J,Krstin N,Schoennagel BP,et al.Age-related distribution of vertebral bone-marrow diffusivity.Eur J Radiol,2012,81(12):4046-4049.
[5]Jie H,Hao F,Na LX.Vertebral bone marrow diffusivity in healthy adults at 3T diffusion-weighted imaging.Acta Radiologica,2016,57(10):1238-1243.
[6]Griffith JF,Yeung DK,Ma HT,et al.Bone marrow fat content in the elderly:A reversal of sex difference seen in younger subjects.J Mag Reson Imaging,2012,36(1):225-230.
[7]Nonomura Y,Yasumoto M,Yoshimura R,et al.Relationship between bone marrow cellularity and apparent diffusion coefficient.J Magn Reson Imaging,2001,13(5):757-760.
[8]徐贤,马林,安宁豫,等.健康成人骨髓全身磁共振扩散加权成像研究.中国医学影像学杂志,2013,21(6):401-405.
[9]何丽,刘斋,祁宇轩,等.DWI在骨质疏松症诊断中的应用价值.实用放射学杂志,2017,33(3):478-480.
[10]何杰,方浩,李晓娜,等.腰椎MR扩散加权成像对骨质疏松的定量诊断价值.临床放射学杂志,2015,34(5):763-767.
[11]徐贤,张金山,马林,等.3.0T磁共振全身扩散加权成像的正常表现和初步临床研究.中国医学影像技术,2007,23(6):793-796.
[12]Cui FZ,Cui JL,Wang SL,et al.Signal characteristics of normal adult bone marrow in whole-body diffusion-weighted imaging.Acta Radiol,2016,57(10):1230-1237.
[13]胡亮,董越,程凡容,等.健康成人骨盆骨髓扩散加权成像性别、年龄间差异及相关性研究.临床放射学杂志,2016,35(11):1725-1729.
[14]BiffarA,Dietrich O,Sourbron S,et al.Diffusion and perfusion imaging of bone marrow.Eur J Radiol,2010,76(3):323-328.
[15]Chen WT,Shih TT,Chen RC,et al.Vertebral bone marrow perfusion evaluated with dynamic contrast-enhanced MRimaging:Significance of aging and sex.Radiology,2001,220(1):213-218.