外泌体在卵巢癌转移及诊疗中的研究进展
摘要
卵巢癌是常见的妇科恶性肿瘤,死亡率居女性生殖道肿瘤之首。长久以来,对卵巢癌转移机理的研究一直聚焦于肿瘤细胞与机体之间的相互作用。而近年来,外泌体被发现在肿瘤细胞及肿瘤微环境物质之间可以进行信息传递,这为肿瘤转移研究领域开辟了新的思路。外泌体是细胞分泌的脂质双分子层结构的纳米级囊泡,广泛参与细胞间信息传递和物质交换等多种病理生理过程。外泌体不仅能够反映分泌细胞的生理和功能状态,在调控肿瘤的发生、发展、侵袭及转移中也发挥了重要作用。本文将对外泌体在卵巢癌转移机制及诊疗中的研究进展做一综述。
引文
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4 Hingorani S.Intercepting Cancer Communiques:Exosomes as Heralds of Malignancy.Cancer Cell,2015,28:151-153.
5 Zhang Y,Wang XF.A niche role for cancer exosomes in metastasis.Nat Cell Biol,2015,17:709-711.
6 Sung BH,Ketova T,Hoshino D,et al.Directional cell movement through tissues is controlled by exosome secretion.Nat Commun,2015,6:7164.
7 Buck AH,Coakley G,Simbari F,et al.Erratum:Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.Nat Commun,2014,5:5488.
8 Losh J,Vanhoof A.Gateway arch to the rna exosome.Cell,2015,162:940-941.
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10 Desrochers LM,Antonyak MA,Cerione RA.Extracellular vesicles:satellites of information transfer in cancer and stem cell biology.Dev Cell,2016,37:301-309.
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15 Taylor DD,Gercel-Taylor C.MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.Gynecol Oncol,2008,110:13-21.
16 Syn N,Wang L,Sethi G,et al.Exosome-mediated metastasis:from epithelial-mesenchymal transition to escape from immunosurveillance.Trends Pharmacol Sci,2016,37:606-617.
17 Tominaga N,Yoshioka Y,Ochiya T.A novel platform for cancer therapy using extracellular vesicles.Adv Drug Deliv Rev,2015,95:50-55.
18 Gallart-Palau X,Serra A,Sze SK.Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR.Mol Neurodegener,2016,11:41.
19 Liu Y,Cao X.Organotropic metastasis:role of tumor exosomes.Cell Res,2016,26:149-150.
20 Cho JA,Park H,Lim KH,et al.Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts.Gynecol Oncol,2011,123:379-386.
21 King HW,Michael MZ,Gleadle JM.Hypoxic enhancement of exosome release by breast cancer cells.Bmc Cancer,2012,12:421.
22 Taylor DD,Gerel TC.Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects.Br J Cancer,2005,92:305 -311.
23 Peng P,Yan Y,Keng S.Exosomes in the ascites of ovarian cancer patients:Origin and effects on anti-tumor immunity.Oncol Rep,2011,25:749-762.
24 Luo Z,Wang Q,Lau WB,et al.Tumor microenvironment:The culprit for ovarian cancer metastasis?.Cancer Lett,2016,377:174-182.
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27 Lu J,Getz G,Miska EA,et al.MicroRNA expression profiles classify human cancers.Nature,2005,435:834-838.
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