阿托伐他汀治疗脑小血管病性认知功能障碍的临床效果
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摘要
目的研究阿托伐他汀治疗脑小血管病性认知功能障碍的临床效果。方法选取我院2017年2月至2018年2月收治的脑血小管病性认知功能障碍患者86例为研究对象,给予患者阿托伐他汀治疗。评估其治疗效果、血脂指标及认知能力。结果 86例患者的总有效率为93.02%。治疗后,患者的TG、Lp(a)、LDL-C及FFA水平均显著低于治疗前(P<0.05)。治疗后,患者的MoCA评分与ADL评分均显著高于治疗前(P<0.05)。结论阿托伐他汀能显著改善脑小血管病性认知功能障碍患者的各项血脂指标水平,提高其认知能力,疗效显著。
Objective To study the clinical effect of atorvastatin in the treatment of cognitive dysfunction caused by cerebral small vessel disease. Methods Eighty-six patients with cognitive dysfunction caused by cerebral small vessel disease admitted in our hospital from February 2017 to February 2018 were selected as the study objects and treated with atorvastatin. The therapeutic effect, blood lipid indexes and cognitive ability of patients were evaluated. Results The total effective rate of treatment in 86 patients was 93.02%. After treatment, the levels of TG, Lp(a), LDL-C and FFA were significantly lower than those before treatment(P<0.05). After treatment, the scores of MoCA and ADL of patients were significantly higher than those before treatment(P<0.05). Conclusion Atorvastatin can significantly improve the levels of blood lipid indexes in patients with cognitive dysfunction caused by cerebral small vessel disease, and improve their cognitive ability, which has a remarkable effect.
Objective To study the clinical effect of atorvastatin in the treatment of cognitive dysfunction caused by cerebral small vessel disease. Methods Eighty-six patients with cognitive dysfunction caused by cerebral small vessel disease admitted in our hospital from February 2017 to February 2018 were selected as the study objects and treated with atorvastatin. The therapeutic effect, blood lipid indexes and cognitive ability of patients were evaluated. Results The total effective rate of treatment in 86 patients was 93.02%. After treatment, the levels of TG, Lp(a), LDL-C and FFA were significantly lower than those before treatment(P<0.05). After treatment, the scores of MoCA and ADL of patients were significantly higher than those before treatment(P<0.05). Conclusion Atorvastatin can significantly improve the levels of blood lipid indexes in patients with cognitive dysfunction caused by cerebral small vessel disease, and improve their cognitive ability, which has a remarkable effect.
引文
[1]孔祥增,王彦永,王晓,等.不同类型脑小血管病患者认知功能损害特征及危险因素分析[J].中国全科医学,2017,20(5):543-548.
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[7]毕学超,高峰,王真,等.血脂与脑小腔隙灶及白质疏松的相关性研究[J].河北医学,2016,22(5):778-781.
[8]卢蓉.低密度脂蛋白胆固醇与脑小血管病的相关性分析[J].中西医结合心脑血管病杂志,2017,15(12):1524-1527.
[9]郑东升.不同剂量阿托伐他汀治疗冠心病慢性心力衰竭疗效分析[J].中西医结合心血管病电子杂志,2016,4(31):94.
[10]黄金稳.不同剂量阿托伐他汀治疗冠心病慢性心力衰竭疗效分析[J].临床医学研究与实践,2017,2(22):63-64.
[2]缪欢欢,谢瑞满.脑小血管病相关认知功能障碍的研究进展[J].老年医学与保健,2017,23(5):439-441.
[3]武建朝,张娜,陈晓虹.阿托伐他汀治疗脑小血管病伴发认知功能损害的效果观察[J].广西医科大学学报,2018,35(1):84-87.
[4]中华医学会神经病学分会.中国脑小血管病诊治共识[J].中华神经科杂志,2015,48(10):838-844.
[5]李文艳,邢晓娜,陈晓虹.脑小血管病与认知损害[J].国际脑血管病杂志,2016,24(10):945-950.
[6]董林菲,王峥,王娜,等.神经心理量表结合海马体积诊断早期Alzheimer's病的研究[J].临床神经病学杂志,2017,30(3):204-208.
[7]毕学超,高峰,王真,等.血脂与脑小腔隙灶及白质疏松的相关性研究[J].河北医学,2016,22(5):778-781.
[8]卢蓉.低密度脂蛋白胆固醇与脑小血管病的相关性分析[J].中西医结合心脑血管病杂志,2017,15(12):1524-1527.
[9]郑东升.不同剂量阿托伐他汀治疗冠心病慢性心力衰竭疗效分析[J].中西医结合心血管病电子杂志,2016,4(31):94.
[10]黄金稳.不同剂量阿托伐他汀治疗冠心病慢性心力衰竭疗效分析[J].临床医学研究与实践,2017,2(22):63-64.