中药治疗肺炎支原体感染的实验研究进展
|
摘要
肺炎支原体是儿童社区获得性呼吸道感染的主要病原体,发病率有逐年上升趋势。其容易引起哮喘及慢性咳嗽,且可引起肺外并发症,甚至导致重症肺炎、难治性肺炎支原体肺炎。近年来,越来越多的报道显示,中药对肺炎支原体具有一定的抑制作用,且可调节免疫,改善循环,降低耐药性,预防复发。文章旨在对近30年来,中医药对抗肺炎支原体感染的实验研究作一综述。
Mycoplasma pneumoniae is the main pathogens in children with community acquired respiratory tract infections and the incidence rate is increasing year by year. It is easy to cause asthma and chronic cough,and can lead to extra-pulmonary complications,and even severe pneumonia,refractory mycoplasma pneumoniae pneumonia. In recent years,more and more reports have shown that traditional Chinese medicine has an inhibitory effect on mycoplasma pneumoniae,which can regulate immunity,improve circulation,reduce drug resistance and prevent recurrence. This paper aims to review the experimental study of traditional Chinese medicine against mycoplasma pneumoniae infection in the past 30 years.
Mycoplasma pneumoniae is the main pathogens in children with community acquired respiratory tract infections and the incidence rate is increasing year by year. It is easy to cause asthma and chronic cough,and can lead to extra-pulmonary complications,and even severe pneumonia,refractory mycoplasma pneumoniae pneumonia. In recent years,more and more reports have shown that traditional Chinese medicine has an inhibitory effect on mycoplasma pneumoniae,which can regulate immunity,improve circulation,reduce drug resistance and prevent recurrence. This paper aims to review the experimental study of traditional Chinese medicine against mycoplasma pneumoniae infection in the past 30 years.
引文
[1]辛德莉,马红秋,侯安存,等.热毒净不同剂型对肺炎支原体的体外抑制试验研究[J].中国实验方剂学杂志,2004,10(5):43-45.
[2]洪丽君,李逸伟.中西医结合治疗小儿支原体肺炎636例[J].中国中医药科技,2002,9(3):158.
[3]姜永红,虞坚尔,姜之炎,等.清肺通络方对支原体肺炎影响的实验研究[J].中医学报,2014,29(4):487-489.
[4]王伟明,张俊威,许庆瑞,等.芩百浓缩丸体内外抗肺炎支原体作用的实验研究[J].中草药,2008,39(5):742-745.
[5]石玉祥,张永英,焦万红.复方青黛散对丝状支原体PG株的体外抑菌试验和临床应用效果[J].黑龙江畜牧兽医,2008(11):83-85.
[6]辛德莉,刘玉华,侯安存,等.蛭丹化瘀口服液体外抑制病原微生物的实验研究[J].北京中医,2004,23(1):45-46.
[7]张俊威,王伟明,石景玉,等.芩百粉针体外抗肺炎支原体作用的实验研究[J].黑龙江医药,2009,22(2):176-177.
[8]孙艳平,焦晓黎,吴秉纯. 8味中药提取物体外抗肺炎支原体的实验研究[J].陕西中医,2008,29(6):727-728.
[9]张俊威,姚琳,蒙艳丽,等.桔梗总皂苷体外抗肺炎支原体作用实验研究[J].中华中医药学刊,2013,31(4):868-870.
[10]辛德莉,侯安存,李靖,等.中药莪术油对肺炎支原体地方株的体外抑制实验研究[J].临床和实验医学杂志,2003,2(4):228-230.
[11]孙艳平,董秀华.黄芩苷体外诱导肺炎支原体耐药的实验研究[J].中医药信息,2010,27(4):115-116.
[12]Hassan J,Irwin F,Dooley S,et al. Mycoplasma pneumoniae infection in a pediatric population:analysis of soluble immune markers as rosk fatorsfor asthma[J]. Hun Immunol,2008,69(12):851-855.
[13]JIANG Yonghong,YU Jianer,GUO Aihua,et al. Ameliorative effects of Qingfei Tongluo formula on experimental mycoplasmal pneumonia in mice[J]. Journal of Natural Medicines,2016,70(2):145-151.
[14]徐嘉辉.大桑菊合剂对儿童耐大环内酯肺炎支原体肺炎的疗效及作用机制[D].广州:广州中医药大学,2016.
[15]李继昌,王伟明,张红娟.呼畅清肺浓缩丸对肺炎支原体鼠免疫功能影响的研究[J].中国中药杂志,2005,30(5):366-369.
[16]郭铁军,周振华,黄灼宏,等.连休蜈蚣地龙汤对支原体肺炎患儿免疫功能的影响[J].新中医,2007,39(1):19-21.
[17]李素云,李亚,李建生,等.毒素清颗粒对支原体肺炎老龄大鼠免疫功能和细胞因子的影响[J].中国实验方剂学杂志,2012,18(21):222-225.
[18]鲁艳芳,袁军,刘红艳,等.理肺通络方对支原体肺炎大鼠肺组织IL-4、IFN-γ基因表达的影响[J].中国中医药科技,2007,14(5):331-332.
[19]张涵,索绪斌,张云凌,等.芩百清肺浓缩丸对肺炎支原体感染BALB/c小鼠. LRP3炎性体的影响[J].中国病原生物学杂志,2017,12(10):943-946.
[20]姜永红,姜之炎,虞坚尔.清肺通络方对MPP小鼠Th17细胞信号途径调控作用的研究[J].世界中西医结合杂志,2013,8(10):994-996.
[21]包立民.阿奇霉素联合鱼腥草素钠治疗小儿呼吸道支原体感染的临床观察[J].时珍国医国药,2006,17(3):415.
[22]Faulkner CB,Davidosn MK,Davis JK,et al. Acute mycoplasma pulmonis Infection associated with coagulopathy in C3H/He N mice[J].Laboratory animal science,1995,45(4):368-372.
[23]XIAO Zhen,JIANG Yonghong,GAO Xuan,et al. Comparison of the ameliorative effects of Qingfei Tongluo formula and azithromycin on Mycoplasma pneumoniae pneumonia[J]. Journal of Natural Medicines,2017,71(4):685-692.
[24]刘晓红,侯安存,辛德莉,等.蛭丹化瘀口服液对支原体感染小鼠肺炎的影响[J].中国中西医结合杂志,2003,23(6):441-444.
[25]卞菊,姜之炎.活血化瘀中药治疗小儿肺炎的研究现状[J].中国中西医结合儿科学,2012,4(1):38-39.
[26]刘晓红,李贵,方慧秋.抗毒通瘀合剂治疗支原体肺炎大鼠的实验研究[J].中国实验方剂学杂志,1998,4(1):16
[27]苏启生,苏丽芬.参麦注射液联合血必净注射液治疗小儿重症肺炎并心衰45例[J].中国中医急症,2011,20(10):1677-1678.
[28]陈德明,卢伟,钱树新.宁肺片洽疗小儿肺炎的临床与实验研究[J].中医杂志,1988(9):26-27.
[29]鲁艳芳,向希雄,刘红艳,等.理肺通络合剂对肺炎支原体肺炎模型肺组织损伤的影响[J].中医儿科杂志,2006,2(5):19-23.
[30]李燕宁,吴金勇,孙晓虹,等.支原体颗粒抗小儿肺炎支原体感染的实验研究[J].中医儿科杂志,2005,1(2):12-16.
[31]于东游.阿奇霉素联合川芎嗪治疗小儿支原体肺炎的疗效观察[J].临床合理用药,2010,3(17):51-52.
[32]蔡菊英,刘慧清,陈玉勤,等.阿奇霉素联合香丹注射液治疗小儿支原体肺炎疗效观察[J].中国冶金工业医学杂志,2008,25(6):690-691.
[33]Onozuka D,Chaves LF. Climate variability and nonstation-ary dynamics of Mycoplasma pneumoniae pneumonia in Ja-pan[J]. PLo S One,2014,9(4):954-957.
[34]刘云宁,李小凤,班旭霞,等.中药抗菌成分及其抗菌机制的研究进展[J].环球中医药,2015,8(8):1012-1017.
[2]洪丽君,李逸伟.中西医结合治疗小儿支原体肺炎636例[J].中国中医药科技,2002,9(3):158.
[3]姜永红,虞坚尔,姜之炎,等.清肺通络方对支原体肺炎影响的实验研究[J].中医学报,2014,29(4):487-489.
[4]王伟明,张俊威,许庆瑞,等.芩百浓缩丸体内外抗肺炎支原体作用的实验研究[J].中草药,2008,39(5):742-745.
[5]石玉祥,张永英,焦万红.复方青黛散对丝状支原体PG株的体外抑菌试验和临床应用效果[J].黑龙江畜牧兽医,2008(11):83-85.
[6]辛德莉,刘玉华,侯安存,等.蛭丹化瘀口服液体外抑制病原微生物的实验研究[J].北京中医,2004,23(1):45-46.
[7]张俊威,王伟明,石景玉,等.芩百粉针体外抗肺炎支原体作用的实验研究[J].黑龙江医药,2009,22(2):176-177.
[8]孙艳平,焦晓黎,吴秉纯. 8味中药提取物体外抗肺炎支原体的实验研究[J].陕西中医,2008,29(6):727-728.
[9]张俊威,姚琳,蒙艳丽,等.桔梗总皂苷体外抗肺炎支原体作用实验研究[J].中华中医药学刊,2013,31(4):868-870.
[10]辛德莉,侯安存,李靖,等.中药莪术油对肺炎支原体地方株的体外抑制实验研究[J].临床和实验医学杂志,2003,2(4):228-230.
[11]孙艳平,董秀华.黄芩苷体外诱导肺炎支原体耐药的实验研究[J].中医药信息,2010,27(4):115-116.
[12]Hassan J,Irwin F,Dooley S,et al. Mycoplasma pneumoniae infection in a pediatric population:analysis of soluble immune markers as rosk fatorsfor asthma[J]. Hun Immunol,2008,69(12):851-855.
[13]JIANG Yonghong,YU Jianer,GUO Aihua,et al. Ameliorative effects of Qingfei Tongluo formula on experimental mycoplasmal pneumonia in mice[J]. Journal of Natural Medicines,2016,70(2):145-151.
[14]徐嘉辉.大桑菊合剂对儿童耐大环内酯肺炎支原体肺炎的疗效及作用机制[D].广州:广州中医药大学,2016.
[15]李继昌,王伟明,张红娟.呼畅清肺浓缩丸对肺炎支原体鼠免疫功能影响的研究[J].中国中药杂志,2005,30(5):366-369.
[16]郭铁军,周振华,黄灼宏,等.连休蜈蚣地龙汤对支原体肺炎患儿免疫功能的影响[J].新中医,2007,39(1):19-21.
[17]李素云,李亚,李建生,等.毒素清颗粒对支原体肺炎老龄大鼠免疫功能和细胞因子的影响[J].中国实验方剂学杂志,2012,18(21):222-225.
[18]鲁艳芳,袁军,刘红艳,等.理肺通络方对支原体肺炎大鼠肺组织IL-4、IFN-γ基因表达的影响[J].中国中医药科技,2007,14(5):331-332.
[19]张涵,索绪斌,张云凌,等.芩百清肺浓缩丸对肺炎支原体感染BALB/c小鼠. LRP3炎性体的影响[J].中国病原生物学杂志,2017,12(10):943-946.
[20]姜永红,姜之炎,虞坚尔.清肺通络方对MPP小鼠Th17细胞信号途径调控作用的研究[J].世界中西医结合杂志,2013,8(10):994-996.
[21]包立民.阿奇霉素联合鱼腥草素钠治疗小儿呼吸道支原体感染的临床观察[J].时珍国医国药,2006,17(3):415.
[22]Faulkner CB,Davidosn MK,Davis JK,et al. Acute mycoplasma pulmonis Infection associated with coagulopathy in C3H/He N mice[J].Laboratory animal science,1995,45(4):368-372.
[23]XIAO Zhen,JIANG Yonghong,GAO Xuan,et al. Comparison of the ameliorative effects of Qingfei Tongluo formula and azithromycin on Mycoplasma pneumoniae pneumonia[J]. Journal of Natural Medicines,2017,71(4):685-692.
[24]刘晓红,侯安存,辛德莉,等.蛭丹化瘀口服液对支原体感染小鼠肺炎的影响[J].中国中西医结合杂志,2003,23(6):441-444.
[25]卞菊,姜之炎.活血化瘀中药治疗小儿肺炎的研究现状[J].中国中西医结合儿科学,2012,4(1):38-39.
[26]刘晓红,李贵,方慧秋.抗毒通瘀合剂治疗支原体肺炎大鼠的实验研究[J].中国实验方剂学杂志,1998,4(1):16
[27]苏启生,苏丽芬.参麦注射液联合血必净注射液治疗小儿重症肺炎并心衰45例[J].中国中医急症,2011,20(10):1677-1678.
[28]陈德明,卢伟,钱树新.宁肺片洽疗小儿肺炎的临床与实验研究[J].中医杂志,1988(9):26-27.
[29]鲁艳芳,向希雄,刘红艳,等.理肺通络合剂对肺炎支原体肺炎模型肺组织损伤的影响[J].中医儿科杂志,2006,2(5):19-23.
[30]李燕宁,吴金勇,孙晓虹,等.支原体颗粒抗小儿肺炎支原体感染的实验研究[J].中医儿科杂志,2005,1(2):12-16.
[31]于东游.阿奇霉素联合川芎嗪治疗小儿支原体肺炎的疗效观察[J].临床合理用药,2010,3(17):51-52.
[32]蔡菊英,刘慧清,陈玉勤,等.阿奇霉素联合香丹注射液治疗小儿支原体肺炎疗效观察[J].中国冶金工业医学杂志,2008,25(6):690-691.
[33]Onozuka D,Chaves LF. Climate variability and nonstation-ary dynamics of Mycoplasma pneumoniae pneumonia in Ja-pan[J]. PLo S One,2014,9(4):954-957.
[34]刘云宁,李小凤,班旭霞,等.中药抗菌成分及其抗菌机制的研究进展[J].环球中医药,2015,8(8):1012-1017.