老年住院患者抑郁症状与血液生化指标的关系
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摘要
目的:研究老年住院患者抑郁症状与常见血液生化指标的相关关系,探讨发生抑郁症状的危险因素。方法:选取在老年内科住院治疗的年龄≥60岁患者共201例,进行血液生化检测和老年抑郁量表简化版(GDS-15)筛查。GDS-15评分≤5分为无抑郁组,评分>5分为抑郁症状组,比较两组间血液生化指标的差别,用多重线性回归分析老年住院患者抑郁症状的相关因素。结果:抑郁症状组血清总蛋白[(60.7±4.3) g/Lvs.(63.5±5.6) g/L]和血红蛋白[(121.6±20.1) g/L vs.(129.7±19.4) g/L]低于无抑郁组患者(均P<0.05);无抑郁组和抑郁症状组患者的年龄、体质量指数、血糖、血脂等指标的差异无统计学意义(P>0.05)。多重线性回归分析显示总蛋白是GDS-15评分的预测因素(标准化偏回归系数β=-0.42,P<0.05)。结论:伴有抑郁症状的老年内科住院患者总蛋白和血红蛋白水平较低,总蛋白低是抑郁症状的可疑危险因素。
Objective:To investigate the relationship between the depressive symptoms and blood biochemical indexes in elderly inpatients.Methods:Totally 201 inpatients without depression were enrolled in this study.Blood tests and the Geriatric Depression Scale-5(GDS-15) were performed on all of the patients.The patients were divided into non-depressive symptoms group and depressive symptoms group according to GDS-15 score.Differences between two groups were compared,and multiple linear regression analysis was used to screen for risk factors by SPSS 22.0.Results:Serum total protein(TP) [(60.7±4.3) vs.(63.5±5.6) g/L] and hemoglobin [(121.6±20.1) vs.(129.7±19.4) g/L] were lower in the depressive symptoms group than in the non-depressive symptoms group(Ps<0.05).There were no differences between the two groups in age,BMI,fasting blood glucose,total cholesterol,triglyceride,high density lipoprotein cholesterol and low density lipoprotein cholesterol(Ps>0.05).Multiple linear regression analysis showed that TP was the predictive variable for GDS-15 score(β=-0.4,P<0.05).Conclusion:Serum total protein and hemoglobin levels in patients with depressive symptoms may be significant lower than those in patients without depressive symptom.There is association between serum total protein and depressive symptoms.
Objective:To investigate the relationship between the depressive symptoms and blood biochemical indexes in elderly inpatients.Methods:Totally 201 inpatients without depression were enrolled in this study.Blood tests and the Geriatric Depression Scale-5(GDS-15) were performed on all of the patients.The patients were divided into non-depressive symptoms group and depressive symptoms group according to GDS-15 score.Differences between two groups were compared,and multiple linear regression analysis was used to screen for risk factors by SPSS 22.0.Results:Serum total protein(TP) [(60.7±4.3) vs.(63.5±5.6) g/L] and hemoglobin [(121.6±20.1) vs.(129.7±19.4) g/L] were lower in the depressive symptoms group than in the non-depressive symptoms group(Ps<0.05).There were no differences between the two groups in age,BMI,fasting blood glucose,total cholesterol,triglyceride,high density lipoprotein cholesterol and low density lipoprotein cholesterol(Ps>0.05).Multiple linear regression analysis showed that TP was the predictive variable for GDS-15 score(β=-0.4,P<0.05).Conclusion:Serum total protein and hemoglobin levels in patients with depressive symptoms may be significant lower than those in patients without depressive symptom.There is association between serum total protein and depressive symptoms.
引文
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[15]陈健,李建生,陈香宇.食管运动功能与抑郁障碍分析[J].中华消化杂志,2006,26 (4):269-270.
[16]Chuang CS,Yang TY,Muo CH,et al.Hyperlipidemia,stain use and the risk of developing depression:a nationwide retrospective cohort study [J].Gen Hosp Psychiatry,2014,36(5):497-501.
[17]Bova M,Carnevali L,Cicero AF,et al.Psychosocial factors and metabolic parameters:is there any association in elderly people? The Massa Lombarda Project[J].Aging Ment Health,2010,14(7):801-806.
[18]Liu T,Zhong S,Liao X,et al.A meta-analysis of oxidative stress markers in depression[J].PLos One,2015,10(10):1-17.
[2] 苏晓丽,徐彩霞,马琴,等.老年冠心病患者抑郁情况及影响因素[J].中国老年学杂志.2017,37(12):5976-5978.
[3] 刘粹,康岚,黄成兵,等.住院脑卒中患者抑郁障碍现况调查[J].中国心理卫生杂志,2013,27(2):93-97.
[4] Sheikh JI,Yesavage JA.Geriatric depression scale (GDS):recent evidence and development of a shorter version [J].Clin Gerontol,1986,5(1):5165-5173.
[5] 唐丹.简版老年抑郁量表 (GDS-15)在中国老年人中的使用[J].中国临床心理学杂志,2013,21(3):402-405.
[6] Dick B,Harm WJ.van Marwijk HW,et al.Test-Characteristics of the GDS-15 in screening for major depression in elderly patients in general practice[J].Clin Geront,2006,29(1):1-9.
[7] 黄风佳,张秀丽,曾秀芳,等.老年高血压抑郁症状的发生率及干预的效果研究[J].中国城乡企业卫生,2018,6(6):24-26.
[8] 常婷利.老年慢性病住院患者的抑郁情绪调查和应对方式分析 [J].临床医药文献杂志,2018,5(12):179-180.
[9] 戴必兵,彭义升,李娟.老年人抑郁症状与情绪调节策越的横断面研究[J].中国心理卫生杂志,2014,28(3):192-196.
[10]朱彩云,王国栋,刘鑫,等.老年住院患者抑郁发病率[J].中国老年学杂志,2017,37(3):1249-1250.
[11]Jackson JC,Pandharipande PP,Girard TD,et al.Depression,post-traumatic stress disorder,and functional disability in survivors of critical illness in the Brain-ICU sthdy:a longitudinal cohort study[J].Lancet Respir Med,2014,2(5):369-379.
[12]Vulser H,Wiernik E,Hoertel N,et al.Association between depression and anemia in otherwise healthy adults [J].Acta Psychiatr Scand,2016,134(2):150-160.
[13]MarcelliniF,Giuli C,Papa R,et al.Phychosocial and biochemical interactions in aging:preliminary results from an Italian old sample of "ZINCAGE" project[J].Arch Gernot Geriatr,2007,44(Suppl 1):259-269.
[14]You F,Yang X,Ye S.The significance of routine biochemical markers in patients with major depressive disorder [J].SCI Rep,2016.6(1):34402.
[15]陈健,李建生,陈香宇.食管运动功能与抑郁障碍分析[J].中华消化杂志,2006,26 (4):269-270.
[16]Chuang CS,Yang TY,Muo CH,et al.Hyperlipidemia,stain use and the risk of developing depression:a nationwide retrospective cohort study [J].Gen Hosp Psychiatry,2014,36(5):497-501.
[17]Bova M,Carnevali L,Cicero AF,et al.Psychosocial factors and metabolic parameters:is there any association in elderly people? The Massa Lombarda Project[J].Aging Ment Health,2010,14(7):801-806.
[18]Liu T,Zhong S,Liao X,et al.A meta-analysis of oxidative stress markers in depression[J].PLos One,2015,10(10):1-17.