大脑星形胶质细胞TRPV4通道在神经血管耦合中的作用研究进展
摘要
<正>大脑的正常生理功能依赖于神经活动与血流动力学之间的紧密配合,这种机制称为神经血管耦合,其对于神经元兴奋所致的大脑局部血流的分配具有重要意义。神经血管耦合的构成包括神经元、星形胶质细胞和血管,神经活动释放的神经递质与星形胶质细胞上
引文
[1]Dunn KM,Hill-Eubanks DC,Liedtke WB,et al.TRPV4channels stimulate Ca2+-induced Ca2+release in astrocyticend feet and amplify neurovascular coupling responses[J].Proc Natl Acad Sci USA,2013,110(15):6157-6162.
[2]黄海燕,张世忠.神经血管耦合中钙信号调节机制的研究进展[J].广东医学,2016,37(6):947-949.
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[4]Muoio V,Persson PB,Sendeski MM.The neurovascularunit-concept review[J].Acta Physiol(Oxf),2014,210(4):790-798.
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[6]Koehler RC,Gebremedhin D,Harder DR.Role of astro-cytes in cerebrovascular regulation[J].J Appl Physiol,2006,100(1):307-317.
[7]Straub SV,Nelson MT.Astrocytic calcium signaling:theinformation currency coupling neuronal activity to the ce-rebral microcirculation[J].Trends Cardiovasc Med,2007,17(6):183-190.
[8]Metea MR,Newman EA.Glial cells dilate and constrictblood vessels:a mechanism of neurovascular coupling[J].J Neurosci,2006,26(11):2862-2870.
[9]Straub SV,Bonev AD,Wilkerson MK,et al.Dynamic ino-sitol trisphosphate-mediated calcium signals within astro-cytic endfeet underlie vasodilation of cerebral arterioles[J].J Gen Physiol,2006,128(6):659-669.
[10]Parri HR,Crunelli V.The role of Ca2+in the generationof spontaneous astrocytic Ca2+oscillations[J].Neurosci-ence,2003,120(4):979-992.
[11]Girouard H,Bonev AD,Hannah RM,et al.Astrocytic endfoot Ca2+and BK channels determine both arteriolar dila-tion and constriction[J].Proc Natl Acad Sci USA,2010,107(8):3811-3816.
[12]Takano T,Tian GF,Peng W,et al.Astrocyte-mediatedcontrol of cerebral blood flow[J].Nat Neurosci,2006,9(2):260-267.
[13]Harteneck C,Plant TD,Schultz G.From worm to man:three subfamilies of TRP channels[J].Trends Neurosci,2000,23(4):159-166.
[14]Kamakura T,Kondo M,Koyama Y,et al.Functional Ex-pression of an Osmosensitive Cation Channel,TransientReceptor Potential Vanilloid 4,in Rat Vestibular Ganglia[J].Audiol Neurootol,2016,21(4):268-274.
[15]Marwaha L,Bansal Y,Singh R,et al.TRP channels:po-tential drug target for neuropathic pain[J].Inflammophar-macology,2016,24(6):305-317.
[16]Wissenbach U,Bodding M,Freichel M,et al.Trp12,anovel Trp related protein from kidney[J].FEBS Left,2000,485(2-3):127-134.
[17]Vriens J,Watanabe H,Janssens A,et al.Cells welling;heat,and chemical agonists use distinct pathways for theactivation of the cat ion channel TRPV4[J].Proc NatlAcad Sci U S A,2004,101(1):396-401.
[18]Filosa JA,Bonev AD,Straub SV,et al.Local potassiumsignaling couples neuronal activity to vasodilationin thebrain[J].Nat Neurosci,2006,9(11):1397-1403.
[19]Wissenbach U,Bodding M,Freichel M,et al.Trp12,anovel Trp related protein from kidney[J].FEBS Lett,2000,485(2-3):127-134.
[20]Liedtke W,Choe Y,Marti-Renom MA,et al.Vanilloid re-ceptor-related osmotically activated channel(VR-OAC),a candidate vertebrate osmoreceptor[J].Cell,2000,103(3):525-535.
[21]okabe T,Fukumi-Tominaga T,Yonemura S,et al.TheTRPV4 channel contributes to intercellular junction for-mation in keratinocytes[J].J Biol Chem,2010,285(24):18749-18758.
[22]Anna Garcia-Elias,Sanela Mrkonjic,Carole Jung,et al.The TRPV4 Channel[J].Handb Exp Pharmacol,2014,222:293-319.
[23]Arniges M,Fernandez JM,Albrecht N,et al.HumanTRPV4 channel splice variants revealed a key role of an-kyrin domains in multimerization and trafficking[J].J Bi-ol Chem,2006,281(13):1580-1586.
[24]Vazquez E,Valverde MA.A review of TRP channelssplicing[J].Semin Cell Dev Biol,2006,17(6):607-617.
[25]Suresh K,Servinsky L,Reyes J,et al.Hydrogen peroxideinduced calcium influx in lung microvascular endothelialcells involves TRPV4[J].Am J Physiol Lung Cell MolPhysiol,2015,309(12):1467-1477.
[26]Everaerts W,Nilius B,Owsianik G.The vanilloid tran-sient receptorpotential channel TRPV4:from structure todisease[J].Prog Biophys Mol Biol,2010,103(1):2-17.
[27]Verma P,Kumar A,Goswami C.TRPV4–mediated chan-nel opathies[J].Channels(Austin),2010,4(4):319-328.
[28]Liedtke W,Choe Y,Marti-Renom MA,et al.Vanilloid re-ceptor-related osmotically activated channel(VR-OAC),a candidate vertebrate osmoreceptor[J].Cell,2000,103(3):525-535.
[29]Nilius B,Prenen J,Wissenhach U,et al.Differential acti-vation of the volume-sensitive cation channel TRP12(OTRPC4)and volume-regulated anion currents inHEK-293 cells[J].Pflugers Archiv:Eur J Physiol,2001,443(2):227-233.
[30]Nilius B,Vriens J,Prenen J,et al.TRPV4 calcium en-trychannel:a paradigm for gating diversity[J].Am JPhysiol Cell Physiol,2004,286:C 195-C 205.
[31]Vennekens R,Owsianik G,Nilius B.Vanilloid transientreceptor potential cation channels:an overview[J].CurrPharm Des,2008,14(1):18-31.
[32]Vriens J,Appendino G,Nilius B.Pharmacology of vanil-loid transient receptor potential cation channels[J].MolPharmacol,2009,75(6):1262-1279.
[33]Plant TD,Strotmann R.TRPV4:A Multifunctional Nonse-lective Cation Channel with Complex Regulation[J].Handb Exp Pharmacol,2007,179:189-205.
[34]Kanju P,Liedtke W.Pleiotropic function of TRPV4 ionchannels in the central nervous system[J].Exp Physiol,2016,101(12):1472-1476.
[35]Shibasaki K,Suzuki M,Mizuno A,et al.Effects of bodytemperature on neural activity in the hippocampus:regu-lation of resting membrane potentials by transient recep-tor potential vanilloid 4[J].J Neurosci,2007,27:1566-1575.
[36]Baets J,De Jonghe P.TRPV4 neuropathies:calciumchannel inhibition as atherapeutic target?[J]Neurology,2011,76(10):856-857.
[37]Liu L,Chen L,Liedtke W,et al.Changes in osmolalitysensitize the response to capsaicin in trigeminal sensoryneurons[J].J Neurophysiol,2007,97(3):2001-2015.
[38]Lin L,Liu C,Chen L,et al.Hypotonicity modulates tetro-dotoxin-sensitive sodium current in trigeminal ganglionneurons[J].Mol Pain,2011,7:27-32.
[39]Chen L,Liu C,Liu L,et al.Changes in osmolality modu-late sodium voltage-gated channels in trigerninal gangli-on neurons[J].Neurosci Res,2009,64:199-207.
[40]Chen L,Liu C,Liu L.The modulation of voltage-gatedpotassiunm channels by anisotonicity in trigeminal gangli-on neurons[J].Neuroscience,2008,1,54:482-295.
[41]Chen L,Liu C,Liu L.Changes in Osmolality Modulate Voltage-gated Calcium Channels in Trigeminal GanglionNeurons[J].Brain Res,2008,1208:56-66.
[42]Chen L,Liu C,Liu L.Osmolality-induced tuning of ac-tion potentials intrigeminal ganglion neurons[J].NeurosciLett,2009,452:79-83.
[43]Pryazhnikov E,Khiroug L.Sub-micromolar increase in[Ca2+]itriggers delayed exocytosis of ATP in cultured as-trocytes[J].Glia,2008,56(1):38-49.
[44]Zonta M,Angulo MC,Gobbo S,et al.Neuron-to-astrocytesignaling is central to the dynamic control of brain mi-crocirculation[J].Nat Neurosci,2003,6(1):43-50.
[45]Straub SV,Nelson MT.Astrocytic calcium signaling:Theinformation currency coupling neuronal activity to the ce-rebral microcirculation[J].Trends Cardiovasc Med,2007,17(6):183-190.
[46]Girouard H,Bonev AD,Hannah RM,et al.Astrocyticend-foot Ca2+and BK channels determine both arteriolar dila-tion and constriction[J].Proc Natl Acad Sci USA,2010,107(8):3811-3816.
[47]Li L,Yin J,Liu C,et al.Hypertonic stimulation inhibitssynaptic transmission in hippocampal slices through de-creasing pre-synaptic voltage-gated calcium current[J].Neurosci Lett,2012,507:l06-111.
[48]李林.TRPV4受体在脑缺血再灌注损伤中的作用及其分子机制研究[D].南京医科大学博士学位论文,2014.
[49]Bubolz AH,Mendoza SA,Zheng X,et al.Activation of en-dothelial TRPV4 mediates flow-induced dilation in hu-man coronary arterioles:role of Ca2+entry and mitochon-drial ROS signaling[J].Am J Physiol Heart Circ Physi-ol,2012,302:H634-H642.
[50]王大磊,刘晓莉,乔德才.大鼠力竭运动中丘脑底核和皮层神经元电活动的变化[J].中国应用生理学杂志,2011,27(4):427-431.
[51]李裕和.运动性脑缺氧与中枢疲劳[J].广州体育学院学报,1997,17(2):49-52.
[2]黄海燕,张世忠.神经血管耦合中钙信号调节机制的研究进展[J].广东医学,2016,37(6):947-949.
[3]Lo EH,Dalkara T,Moskowiz MA.Mechanisms,challengesand opportunities in stroke[J].Nat Rev Neurosci,2003,4(5):399-415.
[4]Muoio V,Persson PB,Sendeski MM.The neurovascularunit-concept review[J].Acta Physiol(Oxf),2014,210(4):790-798.
[5]Filosa JA,Iddings JA.Astrocyte regulation of cerebralvascular tone[J].Am J Physiol Heart Circ Physiol,2013,305(5):609-619.
[6]Koehler RC,Gebremedhin D,Harder DR.Role of astro-cytes in cerebrovascular regulation[J].J Appl Physiol,2006,100(1):307-317.
[7]Straub SV,Nelson MT.Astrocytic calcium signaling:theinformation currency coupling neuronal activity to the ce-rebral microcirculation[J].Trends Cardiovasc Med,2007,17(6):183-190.
[8]Metea MR,Newman EA.Glial cells dilate and constrictblood vessels:a mechanism of neurovascular coupling[J].J Neurosci,2006,26(11):2862-2870.
[9]Straub SV,Bonev AD,Wilkerson MK,et al.Dynamic ino-sitol trisphosphate-mediated calcium signals within astro-cytic endfeet underlie vasodilation of cerebral arterioles[J].J Gen Physiol,2006,128(6):659-669.
[10]Parri HR,Crunelli V.The role of Ca2+in the generationof spontaneous astrocytic Ca2+oscillations[J].Neurosci-ence,2003,120(4):979-992.
[11]Girouard H,Bonev AD,Hannah RM,et al.Astrocytic endfoot Ca2+and BK channels determine both arteriolar dila-tion and constriction[J].Proc Natl Acad Sci USA,2010,107(8):3811-3816.
[12]Takano T,Tian GF,Peng W,et al.Astrocyte-mediatedcontrol of cerebral blood flow[J].Nat Neurosci,2006,9(2):260-267.
[13]Harteneck C,Plant TD,Schultz G.From worm to man:three subfamilies of TRP channels[J].Trends Neurosci,2000,23(4):159-166.
[14]Kamakura T,Kondo M,Koyama Y,et al.Functional Ex-pression of an Osmosensitive Cation Channel,TransientReceptor Potential Vanilloid 4,in Rat Vestibular Ganglia[J].Audiol Neurootol,2016,21(4):268-274.
[15]Marwaha L,Bansal Y,Singh R,et al.TRP channels:po-tential drug target for neuropathic pain[J].Inflammophar-macology,2016,24(6):305-317.
[16]Wissenbach U,Bodding M,Freichel M,et al.Trp12,anovel Trp related protein from kidney[J].FEBS Left,2000,485(2-3):127-134.
[17]Vriens J,Watanabe H,Janssens A,et al.Cells welling;heat,and chemical agonists use distinct pathways for theactivation of the cat ion channel TRPV4[J].Proc NatlAcad Sci U S A,2004,101(1):396-401.
[18]Filosa JA,Bonev AD,Straub SV,et al.Local potassiumsignaling couples neuronal activity to vasodilationin thebrain[J].Nat Neurosci,2006,9(11):1397-1403.
[19]Wissenbach U,Bodding M,Freichel M,et al.Trp12,anovel Trp related protein from kidney[J].FEBS Lett,2000,485(2-3):127-134.
[20]Liedtke W,Choe Y,Marti-Renom MA,et al.Vanilloid re-ceptor-related osmotically activated channel(VR-OAC),a candidate vertebrate osmoreceptor[J].Cell,2000,103(3):525-535.
[21]okabe T,Fukumi-Tominaga T,Yonemura S,et al.TheTRPV4 channel contributes to intercellular junction for-mation in keratinocytes[J].J Biol Chem,2010,285(24):18749-18758.
[22]Anna Garcia-Elias,Sanela Mrkonjic,Carole Jung,et al.The TRPV4 Channel[J].Handb Exp Pharmacol,2014,222:293-319.
[23]Arniges M,Fernandez JM,Albrecht N,et al.HumanTRPV4 channel splice variants revealed a key role of an-kyrin domains in multimerization and trafficking[J].J Bi-ol Chem,2006,281(13):1580-1586.
[24]Vazquez E,Valverde MA.A review of TRP channelssplicing[J].Semin Cell Dev Biol,2006,17(6):607-617.
[25]Suresh K,Servinsky L,Reyes J,et al.Hydrogen peroxideinduced calcium influx in lung microvascular endothelialcells involves TRPV4[J].Am J Physiol Lung Cell MolPhysiol,2015,309(12):1467-1477.
[26]Everaerts W,Nilius B,Owsianik G.The vanilloid tran-sient receptorpotential channel TRPV4:from structure todisease[J].Prog Biophys Mol Biol,2010,103(1):2-17.
[27]Verma P,Kumar A,Goswami C.TRPV4–mediated chan-nel opathies[J].Channels(Austin),2010,4(4):319-328.
[28]Liedtke W,Choe Y,Marti-Renom MA,et al.Vanilloid re-ceptor-related osmotically activated channel(VR-OAC),a candidate vertebrate osmoreceptor[J].Cell,2000,103(3):525-535.
[29]Nilius B,Prenen J,Wissenhach U,et al.Differential acti-vation of the volume-sensitive cation channel TRP12(OTRPC4)and volume-regulated anion currents inHEK-293 cells[J].Pflugers Archiv:Eur J Physiol,2001,443(2):227-233.
[30]Nilius B,Vriens J,Prenen J,et al.TRPV4 calcium en-trychannel:a paradigm for gating diversity[J].Am JPhysiol Cell Physiol,2004,286:C 195-C 205.
[31]Vennekens R,Owsianik G,Nilius B.Vanilloid transientreceptor potential cation channels:an overview[J].CurrPharm Des,2008,14(1):18-31.
[32]Vriens J,Appendino G,Nilius B.Pharmacology of vanil-loid transient receptor potential cation channels[J].MolPharmacol,2009,75(6):1262-1279.
[33]Plant TD,Strotmann R.TRPV4:A Multifunctional Nonse-lective Cation Channel with Complex Regulation[J].Handb Exp Pharmacol,2007,179:189-205.
[34]Kanju P,Liedtke W.Pleiotropic function of TRPV4 ionchannels in the central nervous system[J].Exp Physiol,2016,101(12):1472-1476.
[35]Shibasaki K,Suzuki M,Mizuno A,et al.Effects of bodytemperature on neural activity in the hippocampus:regu-lation of resting membrane potentials by transient recep-tor potential vanilloid 4[J].J Neurosci,2007,27:1566-1575.
[36]Baets J,De Jonghe P.TRPV4 neuropathies:calciumchannel inhibition as atherapeutic target?[J]Neurology,2011,76(10):856-857.
[37]Liu L,Chen L,Liedtke W,et al.Changes in osmolalitysensitize the response to capsaicin in trigeminal sensoryneurons[J].J Neurophysiol,2007,97(3):2001-2015.
[38]Lin L,Liu C,Chen L,et al.Hypotonicity modulates tetro-dotoxin-sensitive sodium current in trigeminal ganglionneurons[J].Mol Pain,2011,7:27-32.
[39]Chen L,Liu C,Liu L,et al.Changes in osmolality modu-late sodium voltage-gated channels in trigerninal gangli-on neurons[J].Neurosci Res,2009,64:199-207.
[40]Chen L,Liu C,Liu L.The modulation of voltage-gatedpotassiunm channels by anisotonicity in trigeminal gangli-on neurons[J].Neuroscience,2008,1,54:482-295.
[41]Chen L,Liu C,Liu L.Changes in Osmolality Modulate Voltage-gated Calcium Channels in Trigeminal GanglionNeurons[J].Brain Res,2008,1208:56-66.
[42]Chen L,Liu C,Liu L.Osmolality-induced tuning of ac-tion potentials intrigeminal ganglion neurons[J].NeurosciLett,2009,452:79-83.
[43]Pryazhnikov E,Khiroug L.Sub-micromolar increase in[Ca2+]itriggers delayed exocytosis of ATP in cultured as-trocytes[J].Glia,2008,56(1):38-49.
[44]Zonta M,Angulo MC,Gobbo S,et al.Neuron-to-astrocytesignaling is central to the dynamic control of brain mi-crocirculation[J].Nat Neurosci,2003,6(1):43-50.
[45]Straub SV,Nelson MT.Astrocytic calcium signaling:Theinformation currency coupling neuronal activity to the ce-rebral microcirculation[J].Trends Cardiovasc Med,2007,17(6):183-190.
[46]Girouard H,Bonev AD,Hannah RM,et al.Astrocyticend-foot Ca2+and BK channels determine both arteriolar dila-tion and constriction[J].Proc Natl Acad Sci USA,2010,107(8):3811-3816.
[47]Li L,Yin J,Liu C,et al.Hypertonic stimulation inhibitssynaptic transmission in hippocampal slices through de-creasing pre-synaptic voltage-gated calcium current[J].Neurosci Lett,2012,507:l06-111.
[48]李林.TRPV4受体在脑缺血再灌注损伤中的作用及其分子机制研究[D].南京医科大学博士学位论文,2014.
[49]Bubolz AH,Mendoza SA,Zheng X,et al.Activation of en-dothelial TRPV4 mediates flow-induced dilation in hu-man coronary arterioles:role of Ca2+entry and mitochon-drial ROS signaling[J].Am J Physiol Heart Circ Physi-ol,2012,302:H634-H642.
[50]王大磊,刘晓莉,乔德才.大鼠力竭运动中丘脑底核和皮层神经元电活动的变化[J].中国应用生理学杂志,2011,27(4):427-431.
[51]李裕和.运动性脑缺氧与中枢疲劳[J].广州体育学院学报,1997,17(2):49-52.