应用经颅多普勒超声评价神经血管耦合功能的研究进展
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摘要
<正>神经血管耦合(neurovascular coupling,NVC)是颅神经代谢的基础,很多神经系统疾病的早期,如卒中、小血管病变、神经变性病等存在一定程度的NVC功能障碍。因此,通过检查并及早发现NVC功能异常对神经系统疾病的早期诊断尤为重要。目前,检查NVC的方法有功能MRI、单光子发射体层摄影、正电子成像及氙清除技术等,但其均要求受试者制动,对时间分辨率较差,而且检查费用较昂贵,
引文
[1]Malojcic B,Giannakopoulos P,Sorond FA,et al.Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease[J].BMC Med,2017,15(1):27.
[2]Keage HA,Churches OF,Kohler M,et al.Cerebrovascular function in aging and dementia:a systematic review of transcranial doppler studies[J].Dement Geriatr Cogn Dis Extra,2012,2(1):258-270.
[3]De Silva TM,Faraci FM.Microvascular dysfunction and cognitive impairment[J].Cell Mol Neurobiol,2016,36(2):241-258.
[4]Toth P,Tarantini S,Ashpole NM,et al.IGF-1 deficiency impairs neurovascular coupling in mice:implications for cerebromicrovascular aging[J].Aging Cell,2015,14(6):1034-1044.
[5]Toth P,Tarantini S,Springo Z,et al.Aging exacerbates hypertension-induced cerebral microhemorrhages in mice:role of resveratrol treatment in vasoprotection[J].Aging Cell,2015,14(3):400-408.
[6]Hage B,Alwatban MR,Barney E,et al.Functional transcranial doppler ultrasound for measurement of hemispheric lateralization during visual memory and visual search cognitive tasks[J].IEEE Trans Ultrason Ferroelectr Freq Control,2016,63(12):2001-2007.
[7]Iadecola C.The pathobiology of vascular dementia[J].Neuron,2013,80(4):844-866.
[8]Cai W,Zhang K,Li P,et al.Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases:an aging effect[J].Ageing Res Rev,2017,34:77-87.
[9]Ainslie PN,Hoiland RL.Transcranial Doppler ultrasound:valid,invalid,or both?[J].J Appl Physiol(1985),2014,117(10):1081-1083.
[10]Demarin V,Morovic S.Ultrasound subclinical markers in assessing vascular changes in cognitive decline and dementia[J].J Alzheimers Dis,2014,42 Suppl 3:S259-S266.
[11]Xiong YY,Mok V,Wong A,et al.Evaluation of age-related w hite m atter changes using transcranial D oppler ultrasonography[J].J Neuroimaging,2013,23(1):53-57.
[12]Ruitenberg A,den Heijer T,Bakker SL,et al.Cerebral hypoperfusion and clinical onset of dementia:the Rotterdam study[J].Ann Neurol,2005,57(6):789-794.
[13]Shim Y,Yoon B,Shim DS,et al.Cognitive correlates of cerebral vasoreactivity on transcranial doppler in older adults[J].J Stroke Cerebrovasc Dis,2015,24(6):1262-1269.
[14]Marmarelis VZ,Shin DC,Tarumi T,et al.Comparison of model-based indices of cerebral autoregulation and vasomotor reactivity using transcranial doppler versus near-infrared spectroscopy in patients with amnestic mild cognitive impairment[J].J Alzheimers Dis,2017,56(1):89-105.
[15]Sattel H,Forstl H,Biedert S.Senile dementia of Alzheimer type and multi-infarct dementia investigated by transcranial Doppler sonography[J].Dementia,1996,7(1):41-46.
[16]Vicenzini E,Ricciardi MC,Altieri M,et al.Cerebrovascular reactivity in degenerative and vascular dem entia:a transcranial doppler study[J].Eur Neurol,2007,58(2):84-89.
[17]Kisler K,Nelson AR,Montagne A,et al.Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease[J].Nat Rev Neurosci,2017,18(7):419-434.
[18]Dittrich R,Ringelstein EB.Occurrence and clinical impact of microembolic signals(MES)in patients with chronic cardiac diseases and atheroaortic plaques-a systematic review[J].Curr Vasc Pharmacol,2008,6(4):329-334.
[19]Purandare N,Burns A.Cerebral emboli in the genesis of dementia[J].J Neurol Sci,2009,283(1-2):17-20.
[20]Purandare N,Burns A,Morris J,et al.Association of cerebral emboli with accelerated cognitive deterioration in Alzheimer's disease and vascular dementia[J].Am J Psychiatry,2012,169(3):300-308.
[21]Phillips AA,Chan FH,Zheng MM,et al.Neurovascular coupling in humans:Physiology,methodological advances and clinical implications[J].J Cereb Blood Flow Metab,2016,36(4):647-664.
[22]Portegies ML,de Bruijn RF,Hofman A,et al.Cerebral vasomotor reactivity and risk of mortality:the Rotterdam study[J].Stroke,2014,45(1):42-47.
[23]Smolinski L,Czlonkowska A.Cerebral vasomotor reactivity in neurodegenerative diseases[J].Neurol Neurochir Pol,2016,50(6):455-462.
[24]Camargo CH,Martins EA,Lange MC,et al.Abnormal cerebrovascular reactivity in patients with Parkinson's disease[J].Parkinsons Dis,2015,2015:523041.
[25]Uzuner N,Ozkan S,Cinar N.Cerebrovascular reactivity in multiple sclerosis patients[J].Mult Scler,2007,13(6):737-741.
[26]Likitjaroen Y,Suwanwela NC,Phanthumchinda K.Vasoreactivity induced by acetazolamide in patients with vascular dementia versus Alzheimer's disease[J].J Neurol Sci,2009,283(1/2):32-35.
[27]Anzola GP,Galluzzi S,Mazzucco S,et al.Autonomic dysfunction in mild cognitive impairment:a transcranial doppler study[J].Acta Neurol Scand,2011,124(6):403-409.
[28]Aaslid R,Markwalder TM,Nornes H.Noninvasive transcranial doppler ultrasound recording of flow velocity in basal cerebral arteries[J].J Neurosurg,1982,57(6):769-774.
[29]Hodgson JC,Hudson JM.Atypical speech lateralization in adults with developmental coordination disorder demonstrated using functional transcranial Doppler ultrasound[J].J Neuropsychol,2017,11(1):1-13.
[30]Lupo M,Troisi E,Chiricozzi FR,et al.Inability to process negative emotions in cerebellar damage:a functional transcranial Doppler sonographic study[J].Cerebellum,2015,14(6):663-669.
[31]Connaughton VM,Amiruddin A,Clunies-Ross KL,et al.Assessing hemispheric specialization for processing arithmetic skills in adults:a functional transcranial doppler ultrasonography(f TCD)study[J].J Neuropsychol,2017,283:33-41.
[32]Payne H,Gutierrez-Sigut E,Subik J,et al.Stimulus rate increases lateralisation in linguistic and non-linguistic tasks measured by functional transcranial doppler sonography[J].Neuropsychologia,2015,72:59-69.
[33]Osbun JW,Kim LJ.Internal carotid artery stenting for intracranial atherosclerosis[J].Methodist Debakey Cardiovasc J,2014,10(4):245-250.
[34]Mills M,Alwatban M,Hage B,et al.Cerebral hemodynamics during scene viewing:Hemispheric lateralization predicts temporal gaze behavior associated with distinct modes of visual processing[J].J Exp Psychol Hum Percept Perform,2017,43(7):1291-1302.
[35]Montoro CI,Duschek S,de Guevara CM,et al.Patterns of cerebral blood flow modulation during painful stimulation in fibromyalgia:a transcranial Doppler sonography study[J].Pain Med,2016,17(12):2256-2267.
[36]Pinaya WH,Fraga FJ,Haratz SS,et al.Comparing methods for determining motor-hand lateralization based on f TCDsignals[J].J Med Syst,2015,39(2):4.
[37]Kim SS,Kim TH,Lee BH.Effects of action observational training on cerebral hemodynamic changes of stroke survivors:a f TCD study[J].J Phys Ther Sci,2014,26(3):331-334.
[38]Meyer GF,Spray A,Fairlie JE,et al.Inferring common cognitive mechanisms from brain blood-flow lateralization data:a new methodology for fTCD analysis[J].Front Psychol,2014,5:552.
[39]Reyes Del Paso GA,Montoro CI,Duschek S.Reaction time,cerebral blood flow,and heart rate responses in fibromyalgia:Evidence of alterations in attentional control[J].J Clin Exp Neuropsychol,2015,37(4):414-428.
[40]Kolodny E,Fellgiebel A,Hilz MJ,et al.Cerebrovascular involvement in Fabry disease:current status of knowledge[J].Stroke,2015,46(1):302-313.
[41]Anzola GP,Galluzzi S,Mazzucco S,et al.Autonomic dysfunction in mild cognitive impairment:a transcranial doppler study[J].Acta Neurol Scand,2011,124(6):403-409.
[42]Gucuyener DO,Yenilmez C,Ayranci U,et al.An analysis of changes in cerebral blood flood velocities in depressive pseudo-dementia and Alzheimer disease patients[J].Neurologist,2010,16(6):358-363.
[43]Matteis M,Silvestrini M,Troisi E,et al.Cerebral hemodynamic patterns during stimuli tasks in multi-infarct and Alzheimer types of dementia[J].Acta Neurol Scand,1998,97(6):374-380.
[44]Asil T,Uzuner N.Differentiation of vascular dementia and Alzheimer disease:a functional transcranial doppler ultrasonographic study[J].J Ultrasound Med,2005,24(8):1065-1070.
[2]Keage HA,Churches OF,Kohler M,et al.Cerebrovascular function in aging and dementia:a systematic review of transcranial doppler studies[J].Dement Geriatr Cogn Dis Extra,2012,2(1):258-270.
[3]De Silva TM,Faraci FM.Microvascular dysfunction and cognitive impairment[J].Cell Mol Neurobiol,2016,36(2):241-258.
[4]Toth P,Tarantini S,Ashpole NM,et al.IGF-1 deficiency impairs neurovascular coupling in mice:implications for cerebromicrovascular aging[J].Aging Cell,2015,14(6):1034-1044.
[5]Toth P,Tarantini S,Springo Z,et al.Aging exacerbates hypertension-induced cerebral microhemorrhages in mice:role of resveratrol treatment in vasoprotection[J].Aging Cell,2015,14(3):400-408.
[6]Hage B,Alwatban MR,Barney E,et al.Functional transcranial doppler ultrasound for measurement of hemispheric lateralization during visual memory and visual search cognitive tasks[J].IEEE Trans Ultrason Ferroelectr Freq Control,2016,63(12):2001-2007.
[7]Iadecola C.The pathobiology of vascular dementia[J].Neuron,2013,80(4):844-866.
[8]Cai W,Zhang K,Li P,et al.Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases:an aging effect[J].Ageing Res Rev,2017,34:77-87.
[9]Ainslie PN,Hoiland RL.Transcranial Doppler ultrasound:valid,invalid,or both?[J].J Appl Physiol(1985),2014,117(10):1081-1083.
[10]Demarin V,Morovic S.Ultrasound subclinical markers in assessing vascular changes in cognitive decline and dementia[J].J Alzheimers Dis,2014,42 Suppl 3:S259-S266.
[11]Xiong YY,Mok V,Wong A,et al.Evaluation of age-related w hite m atter changes using transcranial D oppler ultrasonography[J].J Neuroimaging,2013,23(1):53-57.
[12]Ruitenberg A,den Heijer T,Bakker SL,et al.Cerebral hypoperfusion and clinical onset of dementia:the Rotterdam study[J].Ann Neurol,2005,57(6):789-794.
[13]Shim Y,Yoon B,Shim DS,et al.Cognitive correlates of cerebral vasoreactivity on transcranial doppler in older adults[J].J Stroke Cerebrovasc Dis,2015,24(6):1262-1269.
[14]Marmarelis VZ,Shin DC,Tarumi T,et al.Comparison of model-based indices of cerebral autoregulation and vasomotor reactivity using transcranial doppler versus near-infrared spectroscopy in patients with amnestic mild cognitive impairment[J].J Alzheimers Dis,2017,56(1):89-105.
[15]Sattel H,Forstl H,Biedert S.Senile dementia of Alzheimer type and multi-infarct dementia investigated by transcranial Doppler sonography[J].Dementia,1996,7(1):41-46.
[16]Vicenzini E,Ricciardi MC,Altieri M,et al.Cerebrovascular reactivity in degenerative and vascular dem entia:a transcranial doppler study[J].Eur Neurol,2007,58(2):84-89.
[17]Kisler K,Nelson AR,Montagne A,et al.Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease[J].Nat Rev Neurosci,2017,18(7):419-434.
[18]Dittrich R,Ringelstein EB.Occurrence and clinical impact of microembolic signals(MES)in patients with chronic cardiac diseases and atheroaortic plaques-a systematic review[J].Curr Vasc Pharmacol,2008,6(4):329-334.
[19]Purandare N,Burns A.Cerebral emboli in the genesis of dementia[J].J Neurol Sci,2009,283(1-2):17-20.
[20]Purandare N,Burns A,Morris J,et al.Association of cerebral emboli with accelerated cognitive deterioration in Alzheimer's disease and vascular dementia[J].Am J Psychiatry,2012,169(3):300-308.
[21]Phillips AA,Chan FH,Zheng MM,et al.Neurovascular coupling in humans:Physiology,methodological advances and clinical implications[J].J Cereb Blood Flow Metab,2016,36(4):647-664.
[22]Portegies ML,de Bruijn RF,Hofman A,et al.Cerebral vasomotor reactivity and risk of mortality:the Rotterdam study[J].Stroke,2014,45(1):42-47.
[23]Smolinski L,Czlonkowska A.Cerebral vasomotor reactivity in neurodegenerative diseases[J].Neurol Neurochir Pol,2016,50(6):455-462.
[24]Camargo CH,Martins EA,Lange MC,et al.Abnormal cerebrovascular reactivity in patients with Parkinson's disease[J].Parkinsons Dis,2015,2015:523041.
[25]Uzuner N,Ozkan S,Cinar N.Cerebrovascular reactivity in multiple sclerosis patients[J].Mult Scler,2007,13(6):737-741.
[26]Likitjaroen Y,Suwanwela NC,Phanthumchinda K.Vasoreactivity induced by acetazolamide in patients with vascular dementia versus Alzheimer's disease[J].J Neurol Sci,2009,283(1/2):32-35.
[27]Anzola GP,Galluzzi S,Mazzucco S,et al.Autonomic dysfunction in mild cognitive impairment:a transcranial doppler study[J].Acta Neurol Scand,2011,124(6):403-409.
[28]Aaslid R,Markwalder TM,Nornes H.Noninvasive transcranial doppler ultrasound recording of flow velocity in basal cerebral arteries[J].J Neurosurg,1982,57(6):769-774.
[29]Hodgson JC,Hudson JM.Atypical speech lateralization in adults with developmental coordination disorder demonstrated using functional transcranial Doppler ultrasound[J].J Neuropsychol,2017,11(1):1-13.
[30]Lupo M,Troisi E,Chiricozzi FR,et al.Inability to process negative emotions in cerebellar damage:a functional transcranial Doppler sonographic study[J].Cerebellum,2015,14(6):663-669.
[31]Connaughton VM,Amiruddin A,Clunies-Ross KL,et al.Assessing hemispheric specialization for processing arithmetic skills in adults:a functional transcranial doppler ultrasonography(f TCD)study[J].J Neuropsychol,2017,283:33-41.
[32]Payne H,Gutierrez-Sigut E,Subik J,et al.Stimulus rate increases lateralisation in linguistic and non-linguistic tasks measured by functional transcranial doppler sonography[J].Neuropsychologia,2015,72:59-69.
[33]Osbun JW,Kim LJ.Internal carotid artery stenting for intracranial atherosclerosis[J].Methodist Debakey Cardiovasc J,2014,10(4):245-250.
[34]Mills M,Alwatban M,Hage B,et al.Cerebral hemodynamics during scene viewing:Hemispheric lateralization predicts temporal gaze behavior associated with distinct modes of visual processing[J].J Exp Psychol Hum Percept Perform,2017,43(7):1291-1302.
[35]Montoro CI,Duschek S,de Guevara CM,et al.Patterns of cerebral blood flow modulation during painful stimulation in fibromyalgia:a transcranial Doppler sonography study[J].Pain Med,2016,17(12):2256-2267.
[36]Pinaya WH,Fraga FJ,Haratz SS,et al.Comparing methods for determining motor-hand lateralization based on f TCDsignals[J].J Med Syst,2015,39(2):4.
[37]Kim SS,Kim TH,Lee BH.Effects of action observational training on cerebral hemodynamic changes of stroke survivors:a f TCD study[J].J Phys Ther Sci,2014,26(3):331-334.
[38]Meyer GF,Spray A,Fairlie JE,et al.Inferring common cognitive mechanisms from brain blood-flow lateralization data:a new methodology for fTCD analysis[J].Front Psychol,2014,5:552.
[39]Reyes Del Paso GA,Montoro CI,Duschek S.Reaction time,cerebral blood flow,and heart rate responses in fibromyalgia:Evidence of alterations in attentional control[J].J Clin Exp Neuropsychol,2015,37(4):414-428.
[40]Kolodny E,Fellgiebel A,Hilz MJ,et al.Cerebrovascular involvement in Fabry disease:current status of knowledge[J].Stroke,2015,46(1):302-313.
[41]Anzola GP,Galluzzi S,Mazzucco S,et al.Autonomic dysfunction in mild cognitive impairment:a transcranial doppler study[J].Acta Neurol Scand,2011,124(6):403-409.
[42]Gucuyener DO,Yenilmez C,Ayranci U,et al.An analysis of changes in cerebral blood flood velocities in depressive pseudo-dementia and Alzheimer disease patients[J].Neurologist,2010,16(6):358-363.
[43]Matteis M,Silvestrini M,Troisi E,et al.Cerebral hemodynamic patterns during stimuli tasks in multi-infarct and Alzheimer types of dementia[J].Acta Neurol Scand,1998,97(6):374-380.
[44]Asil T,Uzuner N.Differentiation of vascular dementia and Alzheimer disease:a functional transcranial doppler ultrasonographic study[J].J Ultrasound Med,2005,24(8):1065-1070.