摘要
探讨睡眠相关中枢神经递质水平与阴阳变化在生理病理表现的相关性。认为参与睡眠—觉醒节律调控的众多神经递质,根据其作用和功能可分属不同的阴阳属性,即有抑制作用、促眠功能的为阴属类递质,有兴奋作用、促醒功能的为阳属类递质;神经递质含量的变化是阴阳消长转化的物质基础,且当递质含量的变化超出生理范围时,就会诱发病变,出现系列阴阳消长失调的临床症状;而阴阳失调是递质异常活动的结果,是疾病症状的外在表现。探讨睡眠相关中枢神经递质水平与阴阳变化在生理病理表现的相关性,将有助于寻找更安全有效的方法以提高临床治疗失眠的疗效。
The physiopathological correlation of the levels of sleep-associated neurotransmitters with Yin-yang alternation was discussed. It is indicated that the multiple sleep-awakening-rhythm associated neurotransmitters can be classified into Yin or Yang according to their action and function, i.e., the neurotransmitters with the inhibitory action and sleep-promoting function can be classified into Yin,and those with the excitatory action and awakening-promoting function can be classified into Yang. The changes in the contents of neurotransmitters result into the wax-wane and transformation of Yin and Yang, and clinical symptoms of disorder of Yin-yang transformation will appear if the levels of neurotransmitters are not in their normal range;the disorder of Yin and Yang is the result of the changes of neurotransmitter levels,and is the manifestation of the disease. The exploration of correlation of the levels of sleep-associated neurotransmitters with Yin-yang alternation will be helpful to find out a more effective and safer therapy for enhancing the therapeutic effect on insomnia treated with western medicine and Chinese medicine.
引文
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