枸橼酸钠局部抗凝在重症医学科血液净化中的临床应用
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摘要
目的探讨枸橼酸钠局部抗凝在重症医学科血液净化中的临床应用效果和安全性。方法选取2016年12月至2018年12月在我院接受连续性血液净化治疗的危重患者60例,随机分为对照组和研究组各30例。对照组采用低分子肝素抗凝,研究组采用枸橼酸钠局部抗凝。对比两组的血液生化指标、凝血功能及不良反应情况。结果治疗后,两组患者的血液pH、 iCa2+、Na+水平无明显变化(P>0.05), HCO3-水平显著上升, Scr水平显著降低,且组间比较差异显著(P均<0.05)。治疗后,研究组的APTT、 PT、 TT均无明显变化(P>0.05),对照组的APTT、 PT、 TT明显上升,且组间比较差异显著(P均<0.05)。研究组治疗期间的不良反应发生率显著低于对照组(P <0.05)。结论在重症医学科血液净化中应用枸橼酸钠局部抗凝的效果显著,患者出血风险明显降低,值得临床推广。
Objective To explore the clinical application effect and safety of local anticoagulation of sodium citrate in blood purification of intensive care unit. Methods 60 critically ill patients receiving continuous blood purification therapy in our hospital from December 2016 to December 2018 were selected and randomly divided into control group and study group, with 30 cases in each group. The control group used low molecular weight heparin for anticoagulation, and the study group received local anticoagulation of sodium citrate.The blood biochemical indicators, coagulation function and adverse reactions were compared between the two groups. Results After treatment, the blood pH, i Ca2+, and Na+levels of two groups did not change significantly(P >0.05), the HCO3-level increased significantly,and the Scr level decreased significantly, with significant difference between the two groups(all P <0.05). After treatment, the APTT, PT and TT did not change significantly in the study group(P >0.05), while the APTT, PT and TT in the control group increased significantly, with significant difference between the two groups(all P <0.05). The incidence of adverse reactions of the study group was significantly lower than that of the control group(P <0.05). Conclusions Local anticoagulation of sodium citrate in blood purification of intensive care unit has significant effect, and significantly reduces the bleeding risk of patients, which is worthy of clinical promotion.
Objective To explore the clinical application effect and safety of local anticoagulation of sodium citrate in blood purification of intensive care unit. Methods 60 critically ill patients receiving continuous blood purification therapy in our hospital from December 2016 to December 2018 were selected and randomly divided into control group and study group, with 30 cases in each group. The control group used low molecular weight heparin for anticoagulation, and the study group received local anticoagulation of sodium citrate.The blood biochemical indicators, coagulation function and adverse reactions were compared between the two groups. Results After treatment, the blood pH, i Ca2+, and Na+levels of two groups did not change significantly(P >0.05), the HCO3-level increased significantly,and the Scr level decreased significantly, with significant difference between the two groups(all P <0.05). After treatment, the APTT, PT and TT did not change significantly in the study group(P >0.05), while the APTT, PT and TT in the control group increased significantly, with significant difference between the two groups(all P <0.05). The incidence of adverse reactions of the study group was significantly lower than that of the control group(P <0.05). Conclusions Local anticoagulation of sodium citrate in blood purification of intensive care unit has significant effect, and significantly reduces the bleeding risk of patients, which is worthy of clinical promotion.
引文
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