针刺百会、神门联合丙戊酸钠治疗癫痫
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摘要
目的探究针刺百会、神门联合丙戊酸钠在治疗癫痫中的效果。方法选取2015年5月-2017年5月于我院进行确诊并进行治疗的60例癫痫患者为研究对象,按照随机数字表法将其分为观察组和对照组,各30例,对照组单纯使用丙戊酸钠治疗,观察组在对照组基础上加用针刺百会、神门,治疗结束后对2组的临床治疗有效率、治疗后癫痫发作次数、持续时间、治疗中不良反应发生率及治疗后癫痫患者生活质量量表(QOLIE-31)得分进行对比。结果观察组治疗有效率为93.33%,明显优于对照组的73.33%(P <0.05);2组患者治疗后癫痫发作次数及持续时间均较治疗前降低(P <0.05),观察组治疗后2周发作次数平均为(2.6±0.6)次,平均持续时间为(2.1±0.6)min,低于对照组的(5.1±1.1)次和(5.1±0.4)min,差异具有统计学意义(P <0.05);观察组不良反应发生率为10.00%,低于对照组的23.33%,差异具有统计学意义(P <0.05);治疗后观察组QOLIE-31得分(81.2±6.2)分,高于对照组的(70.6±5.9)分,差异具有统计学意义(P <0.05)。结论针刺百会、神门联合丙戊酸钠可起到协同增效作用,通过刺激人体脑部特定区域,修复受损神经细胞,达到安神通络,定痫醒脑的治疗效果。
Objective To investigate the effect of acupuncture at Baihui and Shenmen acupoints combined with sodium valproate in the treatment of epilepsy. Methods 60 patients with epilepsy who were diagnosed and treated in our hospital from May 2015 to May 2017 as subjects were divided into observation group and control group according to random number table method, 30 cases in each group. The control group was treated with sodium valproate for epilepsy only. The observation group was given acupuncture Baihui amd Shenmenon on the basis of the control group. After treatment, the effective rate, the number of seizures, the duration, the incidence of adverse reactions and the quality of life(QOLIE-31) of the patients with epilepsy after treatment were compared between the two groups. Results The effective rate of the observation group was 93.33%, while the control group was 73.33%(P <0.05), the difference was statistically significant(P<0.05). The average number of seizures 2 weeks after treatment in the observation group was(2.6±0.6) and the mean duration was(2.1±0.6) min, which was significantly lower than that in the control group(5.1±1.1) and(5.1±0.4) min(P <0.05). The incidence of adverse reactions in the observation group was 10.00%, which was lower than that of the control group(23.33%), the difference was statistically significant(P <0.05). After treatment, the QOLIE-31 score of the observation group was(81.2±6.2), which was higher than that of the control group(70.6±5.9), and the difference was statistically significant(P<0.05). Conclusion The effect of acupuncture at Baihui and Shenmen combined with sodium valproate in the treatment of epilepsy is worthy of affirmation, which not only can improve the therapeutic effect, but also reduce the incidence of adverse reactions and is worthy of clinical promotion.
Objective To investigate the effect of acupuncture at Baihui and Shenmen acupoints combined with sodium valproate in the treatment of epilepsy. Methods 60 patients with epilepsy who were diagnosed and treated in our hospital from May 2015 to May 2017 as subjects were divided into observation group and control group according to random number table method, 30 cases in each group. The control group was treated with sodium valproate for epilepsy only. The observation group was given acupuncture Baihui amd Shenmenon on the basis of the control group. After treatment, the effective rate, the number of seizures, the duration, the incidence of adverse reactions and the quality of life(QOLIE-31) of the patients with epilepsy after treatment were compared between the two groups. Results The effective rate of the observation group was 93.33%, while the control group was 73.33%(P <0.05), the difference was statistically significant(P<0.05). The average number of seizures 2 weeks after treatment in the observation group was(2.6±0.6) and the mean duration was(2.1±0.6) min, which was significantly lower than that in the control group(5.1±1.1) and(5.1±0.4) min(P <0.05). The incidence of adverse reactions in the observation group was 10.00%, which was lower than that of the control group(23.33%), the difference was statistically significant(P <0.05). After treatment, the QOLIE-31 score of the observation group was(81.2±6.2), which was higher than that of the control group(70.6±5.9), and the difference was statistically significant(P<0.05). Conclusion The effect of acupuncture at Baihui and Shenmen combined with sodium valproate in the treatment of epilepsy is worthy of affirmation, which not only can improve the therapeutic effect, but also reduce the incidence of adverse reactions and is worthy of clinical promotion.
引文
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[14]LI J L, ZHOU J, CHEN Z H, et al. Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole[J]. Journal of Natural Products, 2015, 78(7):1548-1555.
[15]张华.拉莫三嗪联合丙戊酸钠治疗难治性癫痫部分性发作的临床研究[J].中国临床药理学杂志, 2016,32(12):1085-1087.
[16]郭迎树,王春虎,张运克.化痰逐瘀汤联合丙戊酸钠片治疗癫痫全面性强直-阵挛发作的临床观察[J].中成药,2015, 37(10):2149-2152.
[17]刘梅.醒脑静联合拉莫三嗪、丙戊酸钠治疗老年脑卒中继发性癫痫患者的疗效观察[J].辽宁中医杂志, 2017,65(3):551-553.
[18]张风林,柳惠青,姚玮,等.经颅磁刺激联合医痫丸辅助治疗颅脑外伤继发性癫痫效果观察[J].山东医药, 2017,57(20):52-54.
[19]曾令虹,栗刚.针灸治疗偏头痛患者的效果及其对血清基质金属蛋白酶-2活性的影响[J].辽宁中医杂志, 2015,58(10):1971-1974.
[20]李龙宽,谢娟,张玲敏,等.左乙拉西坦及奥卡西平对癫痫患儿丙戊酸钠及其代谢产物2-丙基-2-戊烯酸血药浓度的影响[J].中国医院药学杂志, 2016, 36(1):41-45.
[2]路蝉伊,刘立雄,张云峰,等.癫痫发病机制的研究进展[J].解放军医学院学报, 2014, 35(8):876-880.
[3]张玉婷,孙美珍.成人癫痫患者生活质量及其影响因素的调查分析[J].中西医结合心脑血管病杂志, 2015,26(17):1932-1934.
[4]王秀锋,陈晏,李蕾,等.中国北方成人癫痫患者生活质量的影响因素及性别差异[J].中华神经科杂志, 2017,50(1):34-39.
[5]张海英,罗兰,马金花.癫痫患者常见心理问题及护理[J].母婴世界, 2017, 8(9):250-251.
[6]韩小年,马莉,张宏丽,等.丙戊酸钠致59例不良反应情况分析[J].中国医院药学杂志, 2015, 35(1):57-60.
[7]王越,刘金民,李淑芳,等.癫痫中医证型及证候要素分布规律的文献研究[J].环球中医药, 2013, 6(1):16-19.
[8]兰志新,朱叶萍,姜昆,等.郭立中从通阳泄浊治疗癫痫[J].长春中医药大学学报, 2015, 31(4):717-719.
[9]LEE M R, SHENG W H, HUNG C C, et al. Mycobacterium abscessus Complex Infections in Humans[J]. Emerging Infectious Diseases, 2015, 21(9):1638-1646.
[10]PORPORATTI A L, COSTA Y M, STUGINSKIBARBOSA J,et al. Acupuncture therapeutic protocols for the management of temporomandibular disorders[J]. Dermatologic Surgery,2015, 16(1):771-773.
[11]LING W, LI Y, JIANG W, et al. Common Mechanism of Pathogenesis in Gastrointestinal Diseases Implied by Consistent Efficacy of Single Chinese Medicine Formula:A PRISMA-Compliant Systematic Review and MetaAnalysis[J]. Medicine, 2015, 94(27):e1111.
[12]贾妮.拉莫三嗪联合丙戊酸钠治疗小儿癫痫的临床研究[J].中国临床药理学杂志, 2016, 32(14):1293-1295.
[13]GAO J, WANG Q, XIAN S, et al. The effect of moxibustion on alleviating menstrual pain in a population of young nursing students:A prospective randomized cross-over pilot study[J]. Complementary Therapies in Medicine, 2015,23(6):773-781.
[14]LI J L, ZHOU J, CHEN Z H, et al. Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole[J]. Journal of Natural Products, 2015, 78(7):1548-1555.
[15]张华.拉莫三嗪联合丙戊酸钠治疗难治性癫痫部分性发作的临床研究[J].中国临床药理学杂志, 2016,32(12):1085-1087.
[16]郭迎树,王春虎,张运克.化痰逐瘀汤联合丙戊酸钠片治疗癫痫全面性强直-阵挛发作的临床观察[J].中成药,2015, 37(10):2149-2152.
[17]刘梅.醒脑静联合拉莫三嗪、丙戊酸钠治疗老年脑卒中继发性癫痫患者的疗效观察[J].辽宁中医杂志, 2017,65(3):551-553.
[18]张风林,柳惠青,姚玮,等.经颅磁刺激联合医痫丸辅助治疗颅脑外伤继发性癫痫效果观察[J].山东医药, 2017,57(20):52-54.
[19]曾令虹,栗刚.针灸治疗偏头痛患者的效果及其对血清基质金属蛋白酶-2活性的影响[J].辽宁中医杂志, 2015,58(10):1971-1974.
[20]李龙宽,谢娟,张玲敏,等.左乙拉西坦及奥卡西平对癫痫患儿丙戊酸钠及其代谢产物2-丙基-2-戊烯酸血药浓度的影响[J].中国医院药学杂志, 2016, 36(1):41-45.