兔VX2胸膜种植瘤CT影像学表现及CT灌注表现
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摘要
目的建立兔VX2胸膜种植瘤模型,观察CT影像学表现。研究CT灌注参数,分析胸膜肿瘤血液动力学改变。方法对10只兔VX2胸膜种植瘤模型,行CT影像学检查及CT灌注成像(CTPI)检查。CTPI分别测量灌注值(PV)、强化峰值增量(PEI)、达峰值时间(TTP)、血容量(BV)。结果胸膜种植瘤CT表现局限性胸膜增厚,呈结节状。壁层胸膜种植瘤PV、PEI、TTP、BV分别为:(33.45±6.76)m L/(min·m L),(39.50±10.05)Hu,(45.26±7.50)s和(30.97±9.52)m L/100g;脏层胸膜种植瘤分别为:(30.41±8.79)m L/(min·m L),(34.69±8.36)Hu,(45.11±6.75)s和(17.31±5.75)m L/100g。结论 CTPI能够准确直观地反映兔VX2胸腔种植瘤在生长过程中肿瘤的血供状况,量化分析病变的血流信息。
Objective CT imaging findings and CT perfusion parameters of rabbit VX2 pleura tumor models were observed,and hemodynamic changes of pleural tumors were analyzed.Method CT imaging and CT perfusion imaging(CTPI) were performed in 10 rabbit VX2 pleura implant models.The parameters of CTPI were divided into perfusion value(PV),enhanced peak increment(PEI),peak time(TTP) and blood volume(BV).Result CT imaging of VX2 pleural implants in rabbits were showed pleural nodule.The PV,PEI,TTP and BV of the pleura implant tumor were(33.45±6.76) m L/(min·m L),(39.50±10.05) Hu,(45.26±7.50) s and(30.97±9.52) m L/100 g;The PV,PEI,TTP and BV of the visceral pleura implant were(30.41± 8.79) m L/(min·m L),(34.69±8.36)Hu,(45.11±6.75)s and(17.31±5.75)m L/100 g.Conclusion CTPI parameters can explain the blood supply of rabbit VX2 pleural tumor during the growth process,and explain the blood flow information of the lesion.
Objective CT imaging findings and CT perfusion parameters of rabbit VX2 pleura tumor models were observed,and hemodynamic changes of pleural tumors were analyzed.Method CT imaging and CT perfusion imaging(CTPI) were performed in 10 rabbit VX2 pleura implant models.The parameters of CTPI were divided into perfusion value(PV),enhanced peak increment(PEI),peak time(TTP) and blood volume(BV).Result CT imaging of VX2 pleural implants in rabbits were showed pleural nodule.The PV,PEI,TTP and BV of the pleura implant tumor were(33.45±6.76) m L/(min·m L),(39.50±10.05) Hu,(45.26±7.50) s and(30.97±9.52) m L/100 g;The PV,PEI,TTP and BV of the visceral pleura implant were(30.41± 8.79) m L/(min·m L),(34.69±8.36)Hu,(45.11±6.75)s and(17.31±5.75)m L/100 g.Conclusion CTPI parameters can explain the blood supply of rabbit VX2 pleural tumor during the growth process,and explain the blood flow information of the lesion.
引文
[1]Chen S E,Pace M B.Malignant pleural mesothelioma[J].Amerjcan Joumal of Health-System Pharmacy,2012,69(5):377-385.
[2]Kent M,Rice D,Flores R.Diagnosis,Staging,and Surgical Treatment of Malignant Pleural Mesothelioma[J].Current Treatment Options in Oncology,2008,9(2-3):158-170.
[3]王玉艳,张弘,白桦,等.恶性胸膜间皮瘤临床特征及分子标记物与预防的关系[J].中华结核和呼吸杂志,2013,36(3):162-168.
[4]Helland A,Solberg S,Brustugun OT.Incidence and survival of malignant pleural mesothelioma in norwav:a population-based study of 1686 cases[J].J Thorac Oncol,2012,7(12):1858-1861.
[5]张明敏,张强,石宝琪,等.盐酸消融治疗对兔VX2肝种植瘤2周内疗效的CT灌注参数分析[J].包头医学院学报,2013,29(01):51-54.
[6]Qiang Zhang,Jun Guo,Hailong Qian,et al.Studies on Lung Cancer Angiogenesis Application of Interventional Therapt(A Report of 56 Cases)[J].CHINESE JOURNAL OF CLINICAL ONCOLOGY,2007,4(1):61-64.
[7]Qiang Zhang,Qi-bao SHI,Zhao-xin LIU,et al.Preliminary study of CT in combination with MRI perfusion imaging to assess hemodynamic changes during angiogenesis in a rabbit model of lung cancer[J].Onco Targets and Therapy,2013,6:685-692.
[8]Murayama S,Murakami J,Yoshimitsu K,et al.CT Diagnosis of Pleural Dissemillation without P1eural Effusion in Primary Lung cancer[J].Radiat Med,1996,14(3):117-119.
[9]Mori K,Hirose T,Machida s,et al.Helical computed Tomo-graphy Diagnosis of Pleural Dissemination jn Lung Cancer:Com-parison of T hick―section and Thin section Helical Computed Tomography[J].J Thorac Imaging,1998,13(3):21l-218.
[10]Mon K,Hlrose T,Machida s,et al.Djagnosis of Pleural Dissemination Lung Cancer by Thin-section CT,a Prospectiye Study[J].Nippon Ky6bu shikkan Gakkai zasshi,1996,34(11):1194-201.
[11]赵欣,张明敏,张强,等.兔VX2肝种植瘤盐酸消融治疗后骨髓抑制及肝功能并发症相关性分析[J].包头医学院学报,2014,30(01):24-25+29.
[2]Kent M,Rice D,Flores R.Diagnosis,Staging,and Surgical Treatment of Malignant Pleural Mesothelioma[J].Current Treatment Options in Oncology,2008,9(2-3):158-170.
[3]王玉艳,张弘,白桦,等.恶性胸膜间皮瘤临床特征及分子标记物与预防的关系[J].中华结核和呼吸杂志,2013,36(3):162-168.
[4]Helland A,Solberg S,Brustugun OT.Incidence and survival of malignant pleural mesothelioma in norwav:a population-based study of 1686 cases[J].J Thorac Oncol,2012,7(12):1858-1861.
[5]张明敏,张强,石宝琪,等.盐酸消融治疗对兔VX2肝种植瘤2周内疗效的CT灌注参数分析[J].包头医学院学报,2013,29(01):51-54.
[6]Qiang Zhang,Jun Guo,Hailong Qian,et al.Studies on Lung Cancer Angiogenesis Application of Interventional Therapt(A Report of 56 Cases)[J].CHINESE JOURNAL OF CLINICAL ONCOLOGY,2007,4(1):61-64.
[7]Qiang Zhang,Qi-bao SHI,Zhao-xin LIU,et al.Preliminary study of CT in combination with MRI perfusion imaging to assess hemodynamic changes during angiogenesis in a rabbit model of lung cancer[J].Onco Targets and Therapy,2013,6:685-692.
[8]Murayama S,Murakami J,Yoshimitsu K,et al.CT Diagnosis of Pleural Dissemillation without P1eural Effusion in Primary Lung cancer[J].Radiat Med,1996,14(3):117-119.
[9]Mori K,Hirose T,Machida s,et al.Helical computed Tomo-graphy Diagnosis of Pleural Dissemination jn Lung Cancer:Com-parison of T hick―section and Thin section Helical Computed Tomography[J].J Thorac Imaging,1998,13(3):21l-218.
[10]Mon K,Hlrose T,Machida s,et al.Djagnosis of Pleural Dissemination Lung Cancer by Thin-section CT,a Prospectiye Study[J].Nippon Ky6bu shikkan Gakkai zasshi,1996,34(11):1194-201.
[11]赵欣,张明敏,张强,等.兔VX2肝种植瘤盐酸消融治疗后骨髓抑制及肝功能并发症相关性分析[J].包头医学院学报,2014,30(01):24-25+29.