中青年焦虑症患者血尿酸水平与焦虑程度、神经递质及细胞因子分泌的相关性分析
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摘要
目的:研究中青年焦虑症患者血尿酸水平与焦虑程度、神经递质及细胞因子分泌的相关性。方法:选择我院2015年3月～2018年2月期间诊断为广泛性焦虑的中青年患者作为焦虑组,同期体检的健康者作为对照组。采集外周血后测定尿酸、神经递质及细胞因子的含量,采用汉密尔顿焦虑量表(HAMA)判断焦虑程度。结果:焦虑组的血尿酸水平明显高于对照组且HAMA评分越高,血尿酸水平的升高越显著;焦虑组的血5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)、白细胞介素-1α(IL-1α)、IL-17、干扰素-γ(IFN-γ)均明显高于对照组,神经肽Y(NPY)、IL-4、转化生长因子-β(TGF-β)含量均明显低于对照组;焦虑组的血尿酸水平与5-HT、NE、DA、IL-1α、IL-17、IFN-γ含量呈正相关,与NPY、IL-4、TGF-β含量呈负相关。结论:中青年焦虑症患者血尿酸水平的升高与焦虑程度的加重、神经递质及细胞因子分泌的异常有关。
Objective:To study the correlation of blood uric acid level with the degree of anxiety as well as the neurotransmitter and cytokine secretion in young and middle-aged patients with anxiety disorder.Methods:The young and middleaged patients diagnosed with generalized anxiety disorder in our hospital between March 2015 and February 2018 were selected as anxiety group,and healthy subjects receiving physical examination during the same period were selected as control group.Peripheral blood was collected to detect the contents of uric acid,neurotransmitters and cytokines,and Hamilton Anxiety Scale (HAMA)was adopted to judge the degree of anxiety.Results:The blood uric acid level of anxiety group was obviously higher than that of control group and the higher the HAMA scores,the more significant the rising of blood uric acid levels;blood 5-hydroxytryptamine (5-HT),norepinephrine (NE),dopamine (DA),interleukin-1α (IL-1α),IL-17 and interferon-γ (IFN-γ)contents of anxiety group were significantly higher than those of control group whereas neuropeptide Y (NPY),IL-4 and transforming growth factor-β (TGF-β)contents were significantly lower than those of control group;blood uric acid level of the anxiety group was positively correlated with 5-HT,NE,DA,IL-1α,IL-17 and IFN-γcontents,and negatively correlated with NPY,IL-4 and TGF-βcontents.Conclusion:The rise of blood uric acid level in young and middle-aged patients with anxiety disorder is related to the aggravation of anxiety degree as well as the abnormal secretion of neurotransmitters and cytokines.
Objective:To study the correlation of blood uric acid level with the degree of anxiety as well as the neurotransmitter and cytokine secretion in young and middle-aged patients with anxiety disorder.Methods:The young and middleaged patients diagnosed with generalized anxiety disorder in our hospital between March 2015 and February 2018 were selected as anxiety group,and healthy subjects receiving physical examination during the same period were selected as control group.Peripheral blood was collected to detect the contents of uric acid,neurotransmitters and cytokines,and Hamilton Anxiety Scale (HAMA)was adopted to judge the degree of anxiety.Results:The blood uric acid level of anxiety group was obviously higher than that of control group and the higher the HAMA scores,the more significant the rising of blood uric acid levels;blood 5-hydroxytryptamine (5-HT),norepinephrine (NE),dopamine (DA),interleukin-1α (IL-1α),IL-17 and interferon-γ (IFN-γ)contents of anxiety group were significantly higher than those of control group whereas neuropeptide Y (NPY),IL-4 and transforming growth factor-β (TGF-β)contents were significantly lower than those of control group;blood uric acid level of the anxiety group was positively correlated with 5-HT,NE,DA,IL-1α,IL-17 and IFN-γcontents,and negatively correlated with NPY,IL-4 and TGF-βcontents.Conclusion:The rise of blood uric acid level in young and middle-aged patients with anxiety disorder is related to the aggravation of anxiety degree as well as the abnormal secretion of neurotransmitters and cytokines.
引文
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16叶刚,汤臻,李歆,等.首发广泛性焦虑障碍患者外周血炎性细胞因子与焦虑症状的相关性[J].中华行为医学与脑科学杂志,2016,25(8):709-712.
17叶刚,汤臻,钱正康,等.首发广泛性焦虑障碍患者外周血炎性细胞因子与执行功能的相关性[J].精神医学杂志,2016,29(3):161-163.
18 Polacchini A,Girardi D,Falco A,et al.Distinct CCL2,CCL5,CCL11,CCL27,IL-17,IL-6,BDNF serum profiles correlate to different job-stress outcomes[J].Neurobiol Stress,2018,16(8):82-91.
19 Mandolesi G,Bullitta S,Fresegna D,et al.Interferon-γcauses mood abnormalities by altering cannabinoid CB1receptor function in the mouse striatum[J].Neurobiol Dis,2017,108:45-53.
20 Bahramabadi R,Fathollahi MS,Hashemi SM,et al.Serum levels of IL-6,IL-8,TNF-α,and TGF-βin chronic HBV-Infected patients:Effect of depression and anxiety[J].Lab Med,2017,49(1):41-46.
2廖梅梅,陈森.血尿酸水平与冠心病患者冠状动脉、颈动脉病变严重程度的相关性研究[J].实用心脑肺血管病杂志,2018,26(5):12-16.
3牛晓歌,张丁丁,张云,等.高血压患者尿酸、总胆固醇与动态动脉硬化指数的关系[J].中国动脉硬化杂志,2018,26(7):711-714.
4 Lambrinakou S,Katsa ME,Zyga S,et al.Correlations between nutrition habits,anxiety and metabolic parameters in greek healthy adults[J].Adv Exp Med Biol,2017,987:23-34.
5 Black CN,Bot M,Scheffer PG,et al.Uric acid in major depressive and anxiety disorders[J].J Affect Disord,2018,1(225):684-690.
6 Gupta A,Mohan RP,Gupta S,et al.Roles of serum uric acid,prolactin levels,and psychosocial factors in oral lichen planus[J].J Oral Sci,2017,59(1):139-146.
7王黛燕,张伟,郑天生,等.血清尿酸水平与中青年焦虑症的相关性研究[J].中华全科医学,2018,16(6):961-963.
8田超.45例焦虑症患者脑内神经递质变化特点研究[J].社区医学杂志,2018,16(2):35-36.
9和昱辰,张波,瞿玮,等.血清单胺类神经递质及其代谢产物在重度抑郁症及抑郁共病焦虑障碍诊断中的应用[J].第三军医大学学报,2014,36(8):806-810.
10 Rillich J,Stevenson PA.Serotonin mediates depression of aggression after acute and chronic social defeat stress in a model insect[J].Front Behav Neurosci,2018,8(12):233.
11 Babb JA,Linnros SE,Commons KG.Evidence for intact
5-HT1Areceptor-mediated feedback inhibition following sustained antidepressant treatment in a rat model of depression[J].Neuropharmacology,2018,141:139-147.
12 Berry JA,Phan A,Davis RL.Dopamine neurons mediate learning and forgetting through bidirectional modulation of a memory trace[J].Cell Rep,2018,25(3):651-662.
13曹林,沈丽华.焦虑症患者生活质量评分与血清中神经肽Y表达的相关性[J].中国老年学杂志,2018,38(9):2175-2176.
14 Lacey T,Sweeting J,Kingston R,et al.Neuropeptide Y impairs the acquisition of conditioned defeat in Syrian hamsters[J].Neurosci Lett,2018,9(690):214-218.
15 Sabban EL,Serova LI.Potential of Intranasal neuropeptide Y(NPY)and/or melanocortin 4receptor(MC4R)antagonists for preventing or treating PTSD[J].Mil Med,2018,183(suppl 1):408-412.
16叶刚,汤臻,李歆,等.首发广泛性焦虑障碍患者外周血炎性细胞因子与焦虑症状的相关性[J].中华行为医学与脑科学杂志,2016,25(8):709-712.
17叶刚,汤臻,钱正康,等.首发广泛性焦虑障碍患者外周血炎性细胞因子与执行功能的相关性[J].精神医学杂志,2016,29(3):161-163.
18 Polacchini A,Girardi D,Falco A,et al.Distinct CCL2,CCL5,CCL11,CCL27,IL-17,IL-6,BDNF serum profiles correlate to different job-stress outcomes[J].Neurobiol Stress,2018,16(8):82-91.
19 Mandolesi G,Bullitta S,Fresegna D,et al.Interferon-γcauses mood abnormalities by altering cannabinoid CB1receptor function in the mouse striatum[J].Neurobiol Dis,2017,108:45-53.
20 Bahramabadi R,Fathollahi MS,Hashemi SM,et al.Serum levels of IL-6,IL-8,TNF-α,and TGF-βin chronic HBV-Infected patients:Effect of depression and anxiety[J].Lab Med,2017,49(1):41-46.