阻塞性睡眠呼吸暂停并发阿尔茨海默病的研究进展
摘要
<正>阻塞性睡眠呼吸暂停(Obstructive Sleep Apnoea,OSA)是常见的与睡眠相关呼吸障碍性疾病,以反复发作的上呼吸道部分或完全阻塞为特征[1]。OSA诱导的长期慢性缺氧可能引起认知功能障碍及并发神经退行性疾病[2]。阿尔茨海默病(Alzheimer′s disease,AD)是21世纪重要的公共健康挑战之一,影响着越来越多的人口。研究发现,睡眠异常可能作为AD的生物标志物,成为降低AD风险的潜在治疗和预防策略[3]。本文
引文
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[2] DISSEL S,ANGADI V,KIRSZENBLAT L,et al.Sleep restores behavioral plasticity to Drosophila mutants[J].Curr Biol,2015,25(10):1270-1281.
[3] CEDERNAES J,OSORIO R S,VARGA A W,et al.Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer′s disease[J].Sleep Med Rev,2017,31:102-111.
[4] D′ROZARIO A L,CROSS N E,VAKULIN A,et al.Quantitative electroencephalogram measures in adult obstructive sleep apnea-potential biomarkers of neurobehavioural functioning[J].Sleep Med Rev,2017,36:29-42.
[5] JU Y E,FINN M B,SUTPHEN C L,et al.Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid[J].Ann Neurol,2016,80(1):154-159.
[6] MANDER B A,WINER J R,JAGUST W J,et al.Sleep:A Novel mechanistic pathway,biomarker,and treatment target in the pathology of Alzheimer?s disease[J].Trends Neurosci,2016,39(8):552-566.
[7] JU Y E,LUCEY B P,HOLTZMAN D M.Sleep and Alzheimer disease pathology——a bidirectional relationship[J].Nat Rev Neurol,2014,10(2):115-119.
[8] CARVALHO D Z,GERHARDT G J,DELLAGUSTIN G,et al.Loss of sleep spindle frequency deceleration in Obstructive Sleep Apnea[J].Clin Neurophysiol,2014,125(2):306-312.
[9] NARDONE R,BERGMANN J,BRIGO F,et al.Cortical afferent inhibition reflects cognitive impairment in obstructive sleep apnea syndrome:a TMS study[J].Sleep Med,2016,24(8):51-56.
[10] LIGUORI C,MERCURI N B,IZZI F,et al.Obstructive sleep apnea is associated with early but possibly modifiable Alzheimer?s disease biomarkers changes[J].Sleep,2017,40(5):11.
[11] CHENG S,STARK CD,STARK RJ.Sleep apnoea and the neurologist[J].Pract Neurol,2017,17(1):21-27.
[12] LIGUORI C,CHIARAVALLOTI A,IZZI F,et al.Sleep apnoeas may represent a reversible risk factor for amyloid-β pathology[J].Brain,2017,140(12):e75.
[13] DAULATZAI M A.Evidence of neurodegeneration in obstructive sleep apnea:relationship between obstructive sleep apnea and cognitive dysfunction in the elderly[J].J Neurosci Res,2015,93(12):1778-1794.
[14] LAVIE L.Oxidative stress in obstructive sleep apnea and intermittent hypoxia——revisited——the bad ugly and good:implications to the heart and brain[J].Sleep Med Rev,2015,20:27-45.
[15] HENEKA M T,CARSON M J,EL KHOURY J,et al.Neuroinflammation in Alzheimer?s disease[J].Lancet Neurol,2015,14(4):388-405.
[16] SHERPA A D,XIAO F,JOSEPH N,et al.Activation of β-adrenergic receptors in rat visual cortex expands astrocytic processes and reduces extracellular space volume[J].Synapse,2016,70(8):307-316.
[17] BERNARDI G,CECCHETTI L,SICLARI F,et al.Sleep reverts changes in human gray and white matter caused by wake-dependent training[J].Neuroimage,2016,129:367-377.
[18] SMITH A J,YAO X,DIX J A,et al.Test of the ‘glymphatic′ hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma[J].Elife,2017,6:1-16.
[19] ATZORI M,CUEVAS-OLGUIN R,ESQUIVEL-RENDON E,et al.Locus ceruleus norepinephrine release:a central regulator of CNS spatio-temporal activation?[J].Front Synaptic Neurosci,2016,8:1-26.