COX-2和EGFR在尖锐湿疣组织中的表达及意义
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摘要
目的探讨环氧化酶-2 (COX-2)、表皮生长因子受体(EGFR)在尖锐湿疣(CA)组织中的表达及意义。方法采用免疫组化(SP法)方法检测65例CA患者皮损与30例正常皮肤表皮组织中COX-2、EGFR的表达情况,并作对照研究。结果 COX-2和EGFR在CA组织中阳性率分别为95.38%和61.54%,CA组织中COX-2和EGFR的阳性率与正常组织相比,两者间的差异均有统计学意义(P <0.05)。结论 COX-2、EGFR在CA组织中表达均显著高于正常皮肤组,说明两者可能参与CA的发生和发展。
Objective To investigate the expression expression and significance of cyclooxygenase-2(COX-2) and epidermal growth factor receptor(EGFR) in condyloma acuminatum(CA). Methods COX-2 and EGFR proteins were detected by Immunohistochemistry(SP method) in 65 CA tissues and30 normal skin tissues. Results COX-2 and EGFR protein positive rates were 95.38%, 61.54% in CA tissues respectively. The positive rates of COX-2 and EGFR in CA tissues were significantly different from those in normal tissues.(P < 0.05). Conclusion The expressions of COX-2 and EGFR in CA tissues were significantly higher than those in normal skin tissues, suggesting that COX-2 and EGFR may be involved in the occurrence and development of CA.
Objective To investigate the expression expression and significance of cyclooxygenase-2(COX-2) and epidermal growth factor receptor(EGFR) in condyloma acuminatum(CA). Methods COX-2 and EGFR proteins were detected by Immunohistochemistry(SP method) in 65 CA tissues and30 normal skin tissues. Results COX-2 and EGFR protein positive rates were 95.38%, 61.54% in CA tissues respectively. The positive rates of COX-2 and EGFR in CA tissues were significantly different from those in normal tissues.(P < 0.05). Conclusion The expressions of COX-2 and EGFR in CA tissues were significantly higher than those in normal skin tissues, suggesting that COX-2 and EGFR may be involved in the occurrence and development of CA.
引文
[1]Subbaramaiah K,Dannenberg AJ.Cyclooxygenase 2:a molecular target for cancer prevention and treatment[J].Trends Pharmacol Sci,2003,24(2):96-102.
[2]Ranger GS1,Thomas V,Jewell A,et al.Elevated cyclooxygenase-2expression correlates with Distant metastases in breast cancer[J].Anticancer Res,2004,24(4):2349-2351.
[3]Subbaramaiah K,Dannenberg AJ.Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins:evidence of a corepressor/coactivator exchange[J].Cancer Res,2007,67(8):3976-3985.
[4]Hee Seung Kim,Taehun Kim,Mi-Kyung Kim,et al.Cyclooxygenase-1 and-2:Molecular Targets for Cervical Neoplasia[J].J Cancer Prev,2013,18(2):123-134.
[5]黄朝霞,王荣跃,黄永刚,等.尖锐湿疣组织中COX-2的表达及意义[J].中国妇幼保健,2011,26(3):398-399.
[6]李海,邓志勇,陈金珍.环氧化酶-2在尖锐湿疣组织中的表达及意义[J].中国中西医结合皮肤性病学杂志,2009,8(5):292-293.
[7]Maiorano E,Favia G,Maisonneuve P,et al.Prognostic implications of epidermal growth factor receptor immunoreactivity in squamous cell carcinoma of the oral mucosa[J].J Pathol,1998,185(2):167-174.
[8]Tomakidi P,Cheng H,Kohl A,et al.Modulation of the epidermal growth factor receptor by the human papillomavirus type 16E5protein in raft cultures of human keratinocytes[J].Eur J Cell Biol,2000,79(6):407-412.
[9]Grünwald V,Hidalgo M.Developing inhibitors of epidermal growth factor receptor for cancer treatment[J].J Natl Cancer Inst,2003,95(12):851-867.
[10]陈海霞,肖君刚.表皮生长因子受体和PTEN蛋白在尖锐湿疣皮损中的检测及意义[J].中国皮肤性病学杂志,2006,20(10):592-594.
[11]Suprynowicz FA,Krawczyk E,Hebert JD,et al.The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification[J].J Virol,2010,84(20):10619-10629.
[12]Buchanan FG,Wang D,Bargiacchi F,et al.Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor[J].J Biol Chem,2003,278(37):35451-35457.
[13]Moraitis D,Du B,De Lorenzo MS,et al.Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers:evidence for the role of epidermal growth factor receptor and its ligands[J].Cancer Res,2005,65(2):664-670.
[2]Ranger GS1,Thomas V,Jewell A,et al.Elevated cyclooxygenase-2expression correlates with Distant metastases in breast cancer[J].Anticancer Res,2004,24(4):2349-2351.
[3]Subbaramaiah K,Dannenberg AJ.Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins:evidence of a corepressor/coactivator exchange[J].Cancer Res,2007,67(8):3976-3985.
[4]Hee Seung Kim,Taehun Kim,Mi-Kyung Kim,et al.Cyclooxygenase-1 and-2:Molecular Targets for Cervical Neoplasia[J].J Cancer Prev,2013,18(2):123-134.
[5]黄朝霞,王荣跃,黄永刚,等.尖锐湿疣组织中COX-2的表达及意义[J].中国妇幼保健,2011,26(3):398-399.
[6]李海,邓志勇,陈金珍.环氧化酶-2在尖锐湿疣组织中的表达及意义[J].中国中西医结合皮肤性病学杂志,2009,8(5):292-293.
[7]Maiorano E,Favia G,Maisonneuve P,et al.Prognostic implications of epidermal growth factor receptor immunoreactivity in squamous cell carcinoma of the oral mucosa[J].J Pathol,1998,185(2):167-174.
[8]Tomakidi P,Cheng H,Kohl A,et al.Modulation of the epidermal growth factor receptor by the human papillomavirus type 16E5protein in raft cultures of human keratinocytes[J].Eur J Cell Biol,2000,79(6):407-412.
[9]Grünwald V,Hidalgo M.Developing inhibitors of epidermal growth factor receptor for cancer treatment[J].J Natl Cancer Inst,2003,95(12):851-867.
[10]陈海霞,肖君刚.表皮生长因子受体和PTEN蛋白在尖锐湿疣皮损中的检测及意义[J].中国皮肤性病学杂志,2006,20(10):592-594.
[11]Suprynowicz FA,Krawczyk E,Hebert JD,et al.The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification[J].J Virol,2010,84(20):10619-10629.
[12]Buchanan FG,Wang D,Bargiacchi F,et al.Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor[J].J Biol Chem,2003,278(37):35451-35457.
[13]Moraitis D,Du B,De Lorenzo MS,et al.Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers:evidence for the role of epidermal growth factor receptor and its ligands[J].Cancer Res,2005,65(2):664-670.