九节根的化学成分研究
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摘要
目的:研究九节根的化学成分。方法:九节根用80%乙醇回流提取,提取液经减压浓缩得到浸膏,水部位应用D101大孔树脂、硅胶柱层析、ODS C18和Sephadex LH-20柱色谱分离得到8个化合物,并根据其理化性质和波谱分析来解析这些化合物的结构。结果:从九节根中分离得到8个化合物,分别鉴定为:asperulosidic acid(1)、6-methoxygeniposidic acid(2)、6α-hydroxygeniposide(3)、deacetylasperulosidic acid(4)、asperuloside(5)、蔗糖(6)、蔗糖乙酸酯(7)、葡萄糖乙酸酯(8)。结论:化合物1、2、4、5为首次从该植物中分离得到,化合物2、4为首次从该属植物中分离得到。
Objective: To study the chemical constituents from the roots of Psychotria rubra. Methods: The roots of Psychotria rubra were extracted with 80% ethanol for reflux,and the extracts were evaporated. Eight compounds were isolated by D101 macroporous resin,silica gel chromatography,ODS C18 and Sephadex LH-20 column chromatography from water part of extracts. Their structures were identified on the basis of physico-chemical characters and spectroscopic analysis. Results: Eight compounds were obtained from the roots from Psychotria rubra,and identified as asperulosidic acid( 1),6-methoxygeniposidic acid( 2),6α-hydroxygeniposide( 3),deacetylasperulosidic acid( 4),asperuloside( 5),sucrose( 6),1-O-acetyl-β-D-galactopyranose( 7) and 1-O-acetyl-β-D-glucoside( 8). Conclusion:Compounds 1,2,4,5 are isolated from Psychotria rubra for the first time,compounds 2,4 are isolated from Psychotria genus for the first time.
Objective: To study the chemical constituents from the roots of Psychotria rubra. Methods: The roots of Psychotria rubra were extracted with 80% ethanol for reflux,and the extracts were evaporated. Eight compounds were isolated by D101 macroporous resin,silica gel chromatography,ODS C18 and Sephadex LH-20 column chromatography from water part of extracts. Their structures were identified on the basis of physico-chemical characters and spectroscopic analysis. Results: Eight compounds were obtained from the roots from Psychotria rubra,and identified as asperulosidic acid( 1),6-methoxygeniposidic acid( 2),6α-hydroxygeniposide( 3),deacetylasperulosidic acid( 4),asperuloside( 5),sucrose( 6),1-O-acetyl-β-D-galactopyranose( 7) and 1-O-acetyl-β-D-glucoside( 8). Conclusion:Compounds 1,2,4,5 are isolated from Psychotria rubra for the first time,compounds 2,4 are isolated from Psychotria genus for the first time.
引文
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[2]南京中医药大学.中药大辞典[M].第二版.上海:上海科学技术出版社,2006.
[3]卢海啸,勾玲,李典鹏.九节木的抗阿尔茨海默病活性部位筛选[J].玉林师范学院学报,2015,36(5):43-47.
[4]卢海啸,李家洲,叶蓥,等.九节木地上部分抗抑郁作用的实验研究[J].玉林师范学院学报,2011,32(5):95-98.
[5]卢海啸,李家洲,叶蓥,等.山大颜抗抑郁作用实验研究[J].亚太传统医药,2012,8(5):37-38.
[6]卢海啸,李家洲,勾玲,等.九节木不同极性提取物对小鼠学习记忆能力的影响[J].中国实验方剂学杂志,2014,20(7):140-143.
[7]Lu HX,Liu LY,Li DP,et al.A new iridoid glycoside from the root of Psychotria rubra[J].Biochemical Systematics and Ecology,2014,57:133-136.
[8]Berger A,Fasshuber H,Schinnerl J,et al.Iridoids as chemical markers of false ipecac(Ronabea emetica),a previously confused medicinal plant[J].Journal of Ethnopharmacology,2011,138(3):756-761.
[9]Chu HB,Tan NH.Iridoid glycosides from Pedicularis dolichocymba Hand.-Mazz.[J].Journal of Integrative Plant Biology,2006,48(10):1250-1253.
[10]马河,李方丽,王芳,等.白花蛇舌草化学成分研究[J].中药材,2016,39(1):98-102.
[11]左月明,张忠立,王彦彦,等.杜仲叶环烯醚萜类化学成分研究[J].中药材,2014,37(2):252-254.
[12]王双燕,丁林芬,吴兴德,等.杜仲化学成分研究[J].中药材,2014,37(5):807-811.
[13]周乐,王宁,杨维霞,等.秦岭龙胆的化学成分研究[J].西北农林科技大学学报(自然科学版),2004,24(1):89-92.
[14]Seiichiro O,Masaru O.Synthesis of the penta-N,O-acetyl derivatives of some pseudo-3-amino 3-deoxy-dl-hexopyranoses and-dl-hexopyranosylamine derivatives[J].Carbohydrate Research,1989,189:323-330.