甜梦口服液联合非典型抗精神病药物治疗对精神分裂症患者血清泌乳素和性激素水平的影响
|
摘要
目的探讨甜梦口服液联合非典型抗精神病药物治疗对精神分裂症患者血清泌乳素和性激素水平的影响。方法选择2014年2月至2017年8月山东省精神卫生中心接诊的240例精神分裂症患者为研究对象,按随机数字表法分为6组,每组40例,分别接受利培酮、阿立哌唑、喹硫平、利培酮联合甜梦口服液、阿立哌唑联合甜梦口服液、喹硫平联合甜梦口服液治疗,均连续治疗8周。比较治疗前后各组血清中泌乳素、睾酮、雌二醇的水平。结果治疗后利培酮组、阿立哌唑组、喹硫平组血清泌乳素水平明显高于治疗前[(16±9)μg/L比(10±6)μg/L、(16±7)μg/L比(11±4)μg/L、(16±6)μg/L比(10±5)μg/L],男性血清睾酮水平明显低于,女性血清睾酮水平明显高于治疗前[男性:(15±8)pmol/L比(21±9)pmol/L、(16±5)pmol/L比(20±8)pmol/L、(16±5)pmol/L比(20±8)pmol/L,女性:(2.4±0.8)pmol/L比(1.6±0.8)pmol/L、(2.3±0.6)pmol/L比(1.7±0.8)pmol/L、(2.2±0.5)pmol/L比(1.6±0.8)pmol/L],男性血清雌二醇水平明显高于,女性血清雌二醇水平明显低于治疗前[男性:(138±49)pmol/LL比(108±43)pmol/L、(131±35)pmol/L比(108±43)pmol/L、(130±32)pmol/L比(108±43)pmol/L,女性:(131±88)pmol/L比(300±120)pmol/L、(155±82)pmol/L比(300±119)pmol/L、(161±96)pmol/L比(302±121)pmol/L],差异均有统计学意义(均P<0.05)。利培酮组联合甜梦口服液组、阿立哌唑联合甜梦口服液组、喹硫平联合甜梦口服液组治疗后血清泌乳素、睾酮、雌二醇水平与治疗前比较,差异均无统计学意义(均P>0.05)。结论对精神分裂症患者采用甜梦口服液联合非典型抗精神病药物治疗能有效降低非典型抗精神病药物对患者血清泌乳素、性激素水平的影响。
Objective To investigate the effect of Tianmeng oral liquid combined with atypical antipsychotic drugs on serum prolactin and sex hormone in patients with schizophrenia. Methods Totally 240 patients with schizophrenia admitted in Shandong Mental Health Center from February 2014 to August 2017 were randomly divided into 6 groups(n = 40) taking risperidone, aripiprazole, quetiapine, risperidone combined with Tianmeng oral liquid, aripiprazole combined with Tianmeng oral liquid, quetiapine combined with Tianmeng oral liquid,respectively. Levels of serum prolactin, testosterone and estradiol were analyzed 8 weeks after treatment.Results After treatment, levels of serum prolactin in risperidone group, aripiprazole group and quetiapine group significantly increased compared to those before treatment [( 16 ± 9) μg/L vs( 10 ± 6) μg/L,(16 ± 7) μg/L vs(11 ± 4) μg/L,(16 ± 6) μg/L vs(10 ± 5)μg/L ]; level of serum testosterone significantly decreased in males and increased in females compared to those before treatment[ males:(15 ±8)pmol/L vs(21 ±9)pmol/L,(16 ±5)pmol/L vs(20±8)pmol/L,(16±5)pmol/L vs(20±8)pmol/L; females:(2.4±0.8)pmol/L vs(1.6±0. 8)pmol/L,(2. 3 ±0. 6)pmol/L vs(1. 7 ±0. 8)pmol/L,(2. 2 ±0. 5) pmol/L vs(1. 6 ±0. 8) pmol/L]; level of serum estradiol significantly increased in males and decreased in females compared to those before treatment[males:(138 ±49)pmol/L vs(108 士43) pmol/L,(131 ± 35) pmol/L vs(108 ±43) pmol/L,(130 ± 32) pmol/L vs(108 ±43)pmol/L; females:(131±88)pmol/L vs(300±120)pmol/L,(155±82)pmol/L vs(300±119)pmol/L,(161 ±96)pmol/L vs(302 ± 121)pmol/L](all P <0. 05). Levels of serum prolactin, testosterone and estradiol showed no significant differences before and after treatment in risperidone combined with Tianmeng oral liquid group, aripiprazole combined with Tianmeng oral liquid group and quetiapine combined with Tianmeng oral liquid group(all P > 0. 05). Conclusion Tianmeng oral liquid combined with atypical antipsychotic drugs treating schizophrenia can reduce the adverse effect of atypical antipsychotic drugs on serum prolactin and sex hormone.
Objective To investigate the effect of Tianmeng oral liquid combined with atypical antipsychotic drugs on serum prolactin and sex hormone in patients with schizophrenia. Methods Totally 240 patients with schizophrenia admitted in Shandong Mental Health Center from February 2014 to August 2017 were randomly divided into 6 groups(n = 40) taking risperidone, aripiprazole, quetiapine, risperidone combined with Tianmeng oral liquid, aripiprazole combined with Tianmeng oral liquid, quetiapine combined with Tianmeng oral liquid,respectively. Levels of serum prolactin, testosterone and estradiol were analyzed 8 weeks after treatment.Results After treatment, levels of serum prolactin in risperidone group, aripiprazole group and quetiapine group significantly increased compared to those before treatment [( 16 ± 9) μg/L vs( 10 ± 6) μg/L,(16 ± 7) μg/L vs(11 ± 4) μg/L,(16 ± 6) μg/L vs(10 ± 5)μg/L ]; level of serum testosterone significantly decreased in males and increased in females compared to those before treatment[ males:(15 ±8)pmol/L vs(21 ±9)pmol/L,(16 ±5)pmol/L vs(20±8)pmol/L,(16±5)pmol/L vs(20±8)pmol/L; females:(2.4±0.8)pmol/L vs(1.6±0. 8)pmol/L,(2. 3 ±0. 6)pmol/L vs(1. 7 ±0. 8)pmol/L,(2. 2 ±0. 5) pmol/L vs(1. 6 ±0. 8) pmol/L]; level of serum estradiol significantly increased in males and decreased in females compared to those before treatment[males:(138 ±49)pmol/L vs(108 士43) pmol/L,(131 ± 35) pmol/L vs(108 ±43) pmol/L,(130 ± 32) pmol/L vs(108 ±43)pmol/L; females:(131±88)pmol/L vs(300±120)pmol/L,(155±82)pmol/L vs(300±119)pmol/L,(161 ±96)pmol/L vs(302 ± 121)pmol/L](all P <0. 05). Levels of serum prolactin, testosterone and estradiol showed no significant differences before and after treatment in risperidone combined with Tianmeng oral liquid group, aripiprazole combined with Tianmeng oral liquid group and quetiapine combined with Tianmeng oral liquid group(all P > 0. 05). Conclusion Tianmeng oral liquid combined with atypical antipsychotic drugs treating schizophrenia can reduce the adverse effect of atypical antipsychotic drugs on serum prolactin and sex hormone.
引文
[1]Thornton AE,Procyshyn RM,Barr AM,et al.Cognition and plasma ratio of clozapine to N-desmethylclozapine in patients with clozapineresistant schizophrenia[J].Am J Psychiatry,2015,172(12):1259.DOI:10.1176/appi.ajp.2015.15070899.
[2]王龙书.奥氮平联合阿立哌唑对首发精神分裂症女性患者血糖及血脂水平的影响[J].中国医药,2017,12(10):1525-1528.DOI:10.3760/cma.j.issn.1673-4777.2017.10.021.Wang LS.Effect of olanzapine combined with aripiprazole on blood glucose and lipid levels in female patients with first episode of schizophrenia[J].China Medicine,2017,12(10):1525-1528.DOI:10.3760/cma.j.issn.1673-4777.2017.10.021.
[3]吴勇,平军娇,杜宝国,等.非典型抗精神病药对精神分裂症患者骨代谢的影响[J].临床精神医学杂志2017,27(4):272-274.DOI:10.3969/j.issn.1005-3220.2017.04.018.Wu Y,Ping JJ,Du BC,et al.The effects of atypical antipsychotics on bone metabolism in patients with schizophrenia[J].Journal of Clinical Psychological Medicine,2017,27(4):272-274.DOI:10.3969/j.issn.1005-3220.2017.04.018.
[4]孙玉涛.解郁安神方辅助阿立哌唑治疗精神分裂症急性激越症状临床观察[J].中国中医急症,2016,25(3):551-552.DOI:10.3969/j.isan.1004-745X.2016.03.061.Sun YT.Clinical observation of Jieyu Anshen prescription combined with aripiprazole in treatment of acute agitation symptoms of schizophrenia[J].Journal of Emergency in Traditional Chinese Medicine,2016,25(3):551-552.DOI:10.3969/j.issn.1004-745X.2016.03.061.
[5]谢姗姗,陈亚青,宁征远,等.芍药甘草颗粒对利培酮所致的女性精神分裂症高催乳素血症患者血清催乳素水平的影响[J].国际中医中药杂志,2016,38(9):790-792.DOI:10.3760/cma.j.issn.1673-4246.2016.09.007.Xie SS,Chen YQ,Ning ZY,et al.The effect of Shaoyao-Gancao grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone[J].International Journal of Traditional Chinese Medicine,2016,38(9):790-792.DOI:10.3760/cma.j.issn.1673-4246.2016.09.007.
[6]中华医学会精神病学分会.中国精神障碍分类与诊断标准第3版(精神障碍分类)[J].中华精神科杂志,2011,34(3):184-188.DOI:10.3760/j:issn:1006-7884.2001.03.028.Chinese Society of Psychiatry,Chinese Medical Association.Chinese classification and diagnostic standard for mental diseases(the 3rd edition)(classification of mental disorders)[J].Chinese Journal of Psychiatry,2011,34(3):184-188.DOI:10.3760/j:issn:1006-7884.2001.03.028.
[7]Slochl Jan,Jones PB,Plaistow J,et al.Multilevel ordinal factor analysis of the positive and negative syndrome scale(PANSS)[J].Int J Methods Psychiatr Res,2014,23(1):25-35.DOI:10.1002/mpr.1429.
[8]Lopez LV,Kane JM.Recommendations for the monitoring of serum concentrations of anlipsychotic drugs in the treatment of schizophrenia[J].J Clin Psychiatry,2015,76(9):1249-1250.DOI:10.4088/JCP.15ac10243.
[9]莫亚莉,夏泳,陶云海,等.3种非典型抗精神病药对首发精神分裂症患者血糖血脂、泌乳素、甲状腺激素的影响[J].中华全科医学,2017,15(3):479-482.DOI:10.16766/j.cnki.issn.1674-4152.2017.03.036.Mo YL,Xia Y,Tao YH,et al.Effects of three atypical antipsychotics on blood glucose and lipids,prolactin and thyroid hormone in firste-pisode schizophrenic patients[J].Chinese Journal of General Practice,2017,15(3):479-482.DOI:10.16766/j.cnki.issn.1674-4152.2017.03.036.
[10]陈敏,孙晓兰,殷月霞.精神分裂症患者用药前后甲状腺素催乳素及糖脂代谢水平观察[J].中国实用神经疾病杂志,2016,19(13):84-86.DOI:10.3969/j.issn.1673-5110.2016.13.050.Chen M,Sun XL,Yin YX.Levels of thyroxine prolactin and glucolipid metabolism before and after medication in patients with schizophrenia[J].Chinese Journal of Practical Nervous Diseases,2016,19(13):84-86.DOI:10.3969/j.issn.1673-5110.2016.13.050.
[11]Castillo-Sánchez M,Fàbregas-Escurriola M,Bergè-Baquero D,et al.Schizophrenia,antipsychotic drugs and cardiovascular risk:Descriptive study in primary care[J].Eur Psychiatry,2015,30(4):535-541.DOI:10.1016/j.eurpsy.2014.12.010.
[12]Tan ML,Dyck BA,Gabriele J,et al.SynapsinⅡgene expression in the dorsolateral prefrontal cortex of brain specimens from patients with schizophrenia and bipolar disorder:effect of lifetime intake of antipsychotic drugs[J].Pharmacogenomics J,2014,14(1):63-69.DOI:10.1038/tpj.2013.6.
[13]马春红.氨磺必利与利培酮治疗精神分裂症对照研究[J].中国实用神经疾病杂志,2015,18(13):121-122.DOI:10.3969/j.issn.1673-5110.2015.13.081.Ma CH.Comparative study on amisulpride and risperidone in treatment of schizophrenia[J].Chinese Journal of Practical Nervous Diseases,2015,18(13):121-122.DOI:10.3969/j.issn.1673-5110.2015.13.081.
[14]孔繁晔,王明明,雷洋,等.性激素水平检测在精神分裂症中的临床应用价值[J].中国性科学,2016,25(2):65-68.DOI:10.3969/j.issn.1672-1993.2016.02.022.Kong FY,Wang MM,Lei Y,et al.Clinical application value of sex hormone level detection in schizophrenia[J].The Chinese Journal of Human Sexuality,2016,25(2):65-68.DOI:10.3969/j.issn.1672-1993.2016.02.022.
[15]刘建君,孙菊水,沈鑫华,等.利培酮或喹硫平治疗女性首发精神分裂症患者12个月中血清催乳素及体重变化的随机对照研究[J].上海精神医学,2014,26(2):88-94.DOI:10.3969/j.issn.1002-0829.2014.02.005.Liu JJ,Sun JS,Shen XH,et al.Randomized controlled trial comparing changes in serum prolactin and weight among female patients with first-episode schizophrenia over 12 months of treatment with risperidone or quetiapine[J].Shanghai Archives of Psychiatry,2014,26(2):88-94.DOI:10.3969/j.issn.1002-0829.2014.02.005.
[16]徐开营,张慧芳,沈利,等.非典型抗梢神病药物对女性精神分裂症患者泌乳素水平的影响[J].中国实用神经疾病杂志,2014,17(8):68-69.Xu KY,Zhang HF,Shen L,et al.Influence of atypical antipsychotics on the level of prolactin in female schizophrenia[J].Chinese Journal of Practical Nervous Diseases,2014,17(8):68-69.
[17]张丽霞,张琛,朱俊敬.阿立哌唑利醅酮对女性精神分裂症患者睾酮的影响[J].中国实用神经疾病杂志,2015,18(10):111-112.DOI:10.3969/j.issn.1673-5110.2015.10.078.Zhang LX,Zhang C,Zhu JJ.Effect of aripiprazole and risperidone on testosterone in female patients with schizophrenia[J].Chinese Journal of Practical Nervous Diseases,2015,18(10):111-112.DOI:10.3969/j.issn.1673-5110.2015.10.078.
[18]夏松柏,虞冬辉.甜梦口服液联合帕罗西汀治疗围绝经期抑郁症的临床观察[J].中国药房,2017,28(3):344-347.DOI:10.6039/j.issn.1001-0408.2017.03.17.Xia SB,Yu DH.Clinical observation of Tianmeng oral liquid combined with paroxetine in the treatment of peri menopausal depression[J].China Pharmacy,2017,28(3):344-347.DOI:10.6039/j.issn.1001-0408.2017.03.17.
[19]赵佳,苏曼侠,方庆欣.甜梦口服液治疗慢性阻塞性肺疾病伴失眠的临床观察[J].中草药,2017,48(17):3587-3589.DOI:10.7501/j.issn.0253-2670.2017.17.021.Zhao J,Su MX,Fang QX.Clinical observation of Tianmeng oral Liquid in the treatment of chronic obstructive pulmonary disease with insomnia[J].Chinese Traditional and Herbal Drugs,2017,48(17):3587-3589.DOI:10.7501/j.issn.0253-2670.017.17.021.
[20]郝剑辉,杜秀生,张怡.甜梦口服液联合草酸艾司西酞普兰治疗抑郁症的疗效观察[J].现代药物与临床,2016,31(11):1818-1821.DOI:10.7501/j.issn.1674-5515.2016.11.031.Hao JH,Du XS,Zhang Y.Clinical observation of Tianmeng oral Liquid combined with escitalopram oxalate in treatment of depression[J].Drugs&Clinic,2016,31(11):1818-1821.DOI:10.7501/j.issn.1674-5515.2016.11.031.
[2]王龙书.奥氮平联合阿立哌唑对首发精神分裂症女性患者血糖及血脂水平的影响[J].中国医药,2017,12(10):1525-1528.DOI:10.3760/cma.j.issn.1673-4777.2017.10.021.Wang LS.Effect of olanzapine combined with aripiprazole on blood glucose and lipid levels in female patients with first episode of schizophrenia[J].China Medicine,2017,12(10):1525-1528.DOI:10.3760/cma.j.issn.1673-4777.2017.10.021.
[3]吴勇,平军娇,杜宝国,等.非典型抗精神病药对精神分裂症患者骨代谢的影响[J].临床精神医学杂志2017,27(4):272-274.DOI:10.3969/j.issn.1005-3220.2017.04.018.Wu Y,Ping JJ,Du BC,et al.The effects of atypical antipsychotics on bone metabolism in patients with schizophrenia[J].Journal of Clinical Psychological Medicine,2017,27(4):272-274.DOI:10.3969/j.issn.1005-3220.2017.04.018.
[4]孙玉涛.解郁安神方辅助阿立哌唑治疗精神分裂症急性激越症状临床观察[J].中国中医急症,2016,25(3):551-552.DOI:10.3969/j.isan.1004-745X.2016.03.061.Sun YT.Clinical observation of Jieyu Anshen prescription combined with aripiprazole in treatment of acute agitation symptoms of schizophrenia[J].Journal of Emergency in Traditional Chinese Medicine,2016,25(3):551-552.DOI:10.3969/j.issn.1004-745X.2016.03.061.
[5]谢姗姗,陈亚青,宁征远,等.芍药甘草颗粒对利培酮所致的女性精神分裂症高催乳素血症患者血清催乳素水平的影响[J].国际中医中药杂志,2016,38(9):790-792.DOI:10.3760/cma.j.issn.1673-4246.2016.09.007.Xie SS,Chen YQ,Ning ZY,et al.The effect of Shaoyao-Gancao grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone[J].International Journal of Traditional Chinese Medicine,2016,38(9):790-792.DOI:10.3760/cma.j.issn.1673-4246.2016.09.007.
[6]中华医学会精神病学分会.中国精神障碍分类与诊断标准第3版(精神障碍分类)[J].中华精神科杂志,2011,34(3):184-188.DOI:10.3760/j:issn:1006-7884.2001.03.028.Chinese Society of Psychiatry,Chinese Medical Association.Chinese classification and diagnostic standard for mental diseases(the 3rd edition)(classification of mental disorders)[J].Chinese Journal of Psychiatry,2011,34(3):184-188.DOI:10.3760/j:issn:1006-7884.2001.03.028.
[7]Slochl Jan,Jones PB,Plaistow J,et al.Multilevel ordinal factor analysis of the positive and negative syndrome scale(PANSS)[J].Int J Methods Psychiatr Res,2014,23(1):25-35.DOI:10.1002/mpr.1429.
[8]Lopez LV,Kane JM.Recommendations for the monitoring of serum concentrations of anlipsychotic drugs in the treatment of schizophrenia[J].J Clin Psychiatry,2015,76(9):1249-1250.DOI:10.4088/JCP.15ac10243.
[9]莫亚莉,夏泳,陶云海,等.3种非典型抗精神病药对首发精神分裂症患者血糖血脂、泌乳素、甲状腺激素的影响[J].中华全科医学,2017,15(3):479-482.DOI:10.16766/j.cnki.issn.1674-4152.2017.03.036.Mo YL,Xia Y,Tao YH,et al.Effects of three atypical antipsychotics on blood glucose and lipids,prolactin and thyroid hormone in firste-pisode schizophrenic patients[J].Chinese Journal of General Practice,2017,15(3):479-482.DOI:10.16766/j.cnki.issn.1674-4152.2017.03.036.
[10]陈敏,孙晓兰,殷月霞.精神分裂症患者用药前后甲状腺素催乳素及糖脂代谢水平观察[J].中国实用神经疾病杂志,2016,19(13):84-86.DOI:10.3969/j.issn.1673-5110.2016.13.050.Chen M,Sun XL,Yin YX.Levels of thyroxine prolactin and glucolipid metabolism before and after medication in patients with schizophrenia[J].Chinese Journal of Practical Nervous Diseases,2016,19(13):84-86.DOI:10.3969/j.issn.1673-5110.2016.13.050.
[11]Castillo-Sánchez M,Fàbregas-Escurriola M,Bergè-Baquero D,et al.Schizophrenia,antipsychotic drugs and cardiovascular risk:Descriptive study in primary care[J].Eur Psychiatry,2015,30(4):535-541.DOI:10.1016/j.eurpsy.2014.12.010.
[12]Tan ML,Dyck BA,Gabriele J,et al.SynapsinⅡgene expression in the dorsolateral prefrontal cortex of brain specimens from patients with schizophrenia and bipolar disorder:effect of lifetime intake of antipsychotic drugs[J].Pharmacogenomics J,2014,14(1):63-69.DOI:10.1038/tpj.2013.6.
[13]马春红.氨磺必利与利培酮治疗精神分裂症对照研究[J].中国实用神经疾病杂志,2015,18(13):121-122.DOI:10.3969/j.issn.1673-5110.2015.13.081.Ma CH.Comparative study on amisulpride and risperidone in treatment of schizophrenia[J].Chinese Journal of Practical Nervous Diseases,2015,18(13):121-122.DOI:10.3969/j.issn.1673-5110.2015.13.081.
[14]孔繁晔,王明明,雷洋,等.性激素水平检测在精神分裂症中的临床应用价值[J].中国性科学,2016,25(2):65-68.DOI:10.3969/j.issn.1672-1993.2016.02.022.Kong FY,Wang MM,Lei Y,et al.Clinical application value of sex hormone level detection in schizophrenia[J].The Chinese Journal of Human Sexuality,2016,25(2):65-68.DOI:10.3969/j.issn.1672-1993.2016.02.022.
[15]刘建君,孙菊水,沈鑫华,等.利培酮或喹硫平治疗女性首发精神分裂症患者12个月中血清催乳素及体重变化的随机对照研究[J].上海精神医学,2014,26(2):88-94.DOI:10.3969/j.issn.1002-0829.2014.02.005.Liu JJ,Sun JS,Shen XH,et al.Randomized controlled trial comparing changes in serum prolactin and weight among female patients with first-episode schizophrenia over 12 months of treatment with risperidone or quetiapine[J].Shanghai Archives of Psychiatry,2014,26(2):88-94.DOI:10.3969/j.issn.1002-0829.2014.02.005.
[16]徐开营,张慧芳,沈利,等.非典型抗梢神病药物对女性精神分裂症患者泌乳素水平的影响[J].中国实用神经疾病杂志,2014,17(8):68-69.Xu KY,Zhang HF,Shen L,et al.Influence of atypical antipsychotics on the level of prolactin in female schizophrenia[J].Chinese Journal of Practical Nervous Diseases,2014,17(8):68-69.
[17]张丽霞,张琛,朱俊敬.阿立哌唑利醅酮对女性精神分裂症患者睾酮的影响[J].中国实用神经疾病杂志,2015,18(10):111-112.DOI:10.3969/j.issn.1673-5110.2015.10.078.Zhang LX,Zhang C,Zhu JJ.Effect of aripiprazole and risperidone on testosterone in female patients with schizophrenia[J].Chinese Journal of Practical Nervous Diseases,2015,18(10):111-112.DOI:10.3969/j.issn.1673-5110.2015.10.078.
[18]夏松柏,虞冬辉.甜梦口服液联合帕罗西汀治疗围绝经期抑郁症的临床观察[J].中国药房,2017,28(3):344-347.DOI:10.6039/j.issn.1001-0408.2017.03.17.Xia SB,Yu DH.Clinical observation of Tianmeng oral liquid combined with paroxetine in the treatment of peri menopausal depression[J].China Pharmacy,2017,28(3):344-347.DOI:10.6039/j.issn.1001-0408.2017.03.17.
[19]赵佳,苏曼侠,方庆欣.甜梦口服液治疗慢性阻塞性肺疾病伴失眠的临床观察[J].中草药,2017,48(17):3587-3589.DOI:10.7501/j.issn.0253-2670.2017.17.021.Zhao J,Su MX,Fang QX.Clinical observation of Tianmeng oral Liquid in the treatment of chronic obstructive pulmonary disease with insomnia[J].Chinese Traditional and Herbal Drugs,2017,48(17):3587-3589.DOI:10.7501/j.issn.0253-2670.017.17.021.
[20]郝剑辉,杜秀生,张怡.甜梦口服液联合草酸艾司西酞普兰治疗抑郁症的疗效观察[J].现代药物与临床,2016,31(11):1818-1821.DOI:10.7501/j.issn.1674-5515.2016.11.031.Hao JH,Du XS,Zhang Y.Clinical observation of Tianmeng oral Liquid combined with escitalopram oxalate in treatment of depression[J].Drugs&Clinic,2016,31(11):1818-1821.DOI:10.7501/j.issn.1674-5515.2016.11.031.