先心病患儿介入治疗中应用右美托咪定对心肌酶的影响
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摘要
目的探讨先心病患儿介入治疗中应用右美托咪定对心肌酶的影响。方法本次研究选取行先天性心脏病封堵术治疗的58例先心病患儿。通过采取随机数字表法将58例患儿均分为两组。观察组29例患儿采取右美托咪定联合氯胺酮辅助治疗,对照组29例患儿采取氯胺酮辅助治疗。结果观察组患儿术中心肌钙蛋白1、磷酸肌酸激酶以及磷酸肌酸激酶同工酶浓度明显优于与对照组,差异显著(P<0.05)。结论盐酸右美托咪定在先心病患儿介入治疗中可以改善心肌酶学,使先天性心脏病封堵术安全性得到显著提升,值得临床推广和广泛应用。
Objective To investigate the effect of dexmedetomidine on myocardial enzymes in interventional treatment of congenital heart disease. Methods This study selected 58 children with congenital heart disease who underwent congenital heart disease occlusion. 58 children were divided into two groups by random number table method. In observation group, 29 patients were treated with dexmedetomidine combined with ketamine, and 29 patients in the control group were treated with ketamine. Results The concentrations of cardiac troponin 1, phosphocreatine kinase and creatine kinase isoenzymes in the observation group were significantly better than those in the control group(P<0.05). Conclusion Dexmedetomidine hydrochloride can improve myocardial enzymology in the interventional treatment of congenital heart disease in children with congenital heart disease. It can significantly improve the safety of congenital heart disease occlusion. It is worthy of clinical promotion and wide application.
Objective To investigate the effect of dexmedetomidine on myocardial enzymes in interventional treatment of congenital heart disease. Methods This study selected 58 children with congenital heart disease who underwent congenital heart disease occlusion. 58 children were divided into two groups by random number table method. In observation group, 29 patients were treated with dexmedetomidine combined with ketamine, and 29 patients in the control group were treated with ketamine. Results The concentrations of cardiac troponin 1, phosphocreatine kinase and creatine kinase isoenzymes in the observation group were significantly better than those in the control group(P<0.05). Conclusion Dexmedetomidine hydrochloride can improve myocardial enzymology in the interventional treatment of congenital heart disease in children with congenital heart disease. It can significantly improve the safety of congenital heart disease occlusion. It is worthy of clinical promotion and wide application.
引文
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[2]王玉玺,徐昌顺,蔡铁良,等.右美托咪定与丙泊酚在脑功能区术中唤醒麻醉中对应激反应的影响[J].中国医药,2016,11(11):1644-1648.
[3]唐安山.右美托咪定对食管癌根治术中瑞芬太尼复合丙泊酚用量和麻醉效果的影响[J].河北医学,2016,22(9):1446-1449.
[4]黄珩,李萌,何艺,等.丙泊酚联合右美托咪啶对肺癌根治术患者镇痛及应激反应的影响[J].现代生物医学进展,2017,17(13):2495-2497.
[5]陈元良,徐丽丽,蓝志坚,等.七氟烷与丙泊酚联合右美托咪定对行腹腔镜胆囊切除术患者术后认知功能及氧化应激反应的影响[J].中华全科医学,2017,15(8):1283-1285.
[6]李熊刚,周亚.右美托咪定对神经外科手术患者血流动力学、麻醉恢复期遗忘程度及应激反应的影响[J].医学综述,2016,22(22):4571-4574.
[7]陈孟,何欢,李德春,等.右美托咪定联合脑电双频指数监测应用于肺癌根治术患者对全麻苏醒及拔管期血流动力学影响研究[J].河北医学,2017,23(7):1067-1070.
[8]朱月皓,李卫,刘文值.右美托咪定复合芬太尼、丙泊酚对行内镜下逆行胰胆管造影术中老年高血压患者心血管反应的影响[J].医学综述,2017,23(4):810-813.
[9]贺宏智,李小刚,胡华铂,等.右美托咪定对神经外科手术唤醒试验中应激反应的影响[J].西南国防医药,2016,26(9):996-999.
[10]秦鹏宇,马闻苛,张红伟,等.右美托咪定对开胸手术患者应激反应及血流动力学的影响[J].新乡医学院学报,2017,34(10):896-900.