和肽素在急重症患者诊治中的应用进展
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摘要
<正>和肽素(copeptin)于1972年由Holwerda发现~([1]),是神经垂体分泌的、与精氨酸升压素(arginjne-vasopressin,AVP)同源的糖基化肽,与精氨酸升压素等摩尔释放~([2])。相关研究表明,在急性心力衰竭(AHF)、急性心肌梗死(AMI)、慢性阻塞性肺疾病急性加重(AECOPD)及脓毒症等急重症中,血浆和肽素水平明显升高,并与患者的病情、诊断及预后明显相关。本文简要综述和肽素在急重症患者诊治中的应用及其进展。
Copeptin is a glycosylation peptide secreted by the pituitary gland and homologous to arginine vasopressin.Its plasma level changes in the occurrence and development of acute and severe diseases such as myocardial ischemia,heart failure and sepsis.It has certain implications for the diagnosis,evaluation and prognosis of acute and severe diseases.And it is expected to become a new biological marker for clinical evaluation of acute and severe diseases.
Copeptin is a glycosylation peptide secreted by the pituitary gland and homologous to arginine vasopressin.Its plasma level changes in the occurrence and development of acute and severe diseases such as myocardial ischemia,heart failure and sepsis.It has certain implications for the diagnosis,evaluation and prognosis of acute and severe diseases.And it is expected to become a new biological marker for clinical evaluation of acute and severe diseases.
引文
[1]Holwerda DA.A glycopeptide from the posterior lobe of pig pituitaries.I.Isolation and characterization[J].Eur J Biochem,1972,28(3):334-339.
[2]Dobsa L,Edozien KC.Copeptin and its potential role in diagnosis and prognosis of various diseases[J].Biochem Med(Zagreb),2013,23(2):172-190.
[3]Bolignano D,Cabassi A,Fiaccadori E,et al.Copeptin(CTproAVP),a new tool for understanding the role of vasopressin in pathophysiology[J].Clin Chem Lab Med,2014,52(10):1447-1456.
[4]Yilman M,Erenler AK,Baydin A.Copeptin:a diagnostic factor for critical patients[J].Eur Rev Med Pharmacol Sci,2015,19(16):3030-3036.
[5]Lyngbakken MN,Myhre PL,RsjH,et al.Novel biomarkers of cardiovascular disease:Applications in clinical practice[J].Crit Rev Clin Lab Sci,2019,56(1):33-60.
[6]Folli C,Consonni D,Spessot M,et al.Diagnostic role of copeptin in patients presenting with chest pain in the emergency room[J].Eur J Intern Med,2013,24(2):189-193.
[7]Neuhold S,Huelsmann M,Strunk G,et al.Comparison of copeptin,type natriuretic peptide,and aminoterminal pro-B-type natriuretic peptide in patients with chronic heart failure:prediction of death at different stages of the disease[J].J Am Coll Cardiol,2008,52(4):266-272.
[8]Düngen HD,Tscholl V,Obradovic D,et al.Prognostic performance of serial in-hospital measurements of copeptin novel biomarkers among patients with worsening heart failure:results from the MOLITOR and multiple study[J].ESC Heart Fail,2018,5(2):288-296.
[9]Zhong Y,Wang R,Yan LL,et al.Copeptin in heart failure:Review and meta-analysis[J].Clin Chim Acta,2017,475:36-43.
[10]Khan SQ,Dhillon OS,O'Brien RJ,et al.C-Terminal provasopressin(Copeptin)as a novel and prognostic marker in acute myocardial infarction:Leicester Acute Myocardial Infarction Peptide(LAMP)Study[J].Circulation,2007,115(16):2103-2110.
[11]Tanana OS,Sukmanova IA,Ponomarenko IV,et al.The clinical significance of copeptin and matrix metalloproteinases in men with acute coronary syndrome[J].Kardiologiia,2017,57(S3):32-39.
[12]Mauermann E,Bolliger D,Seeberger E,et al.Incremental value of preoperative copeptin for predicting myocardial injury[J].Anesth Analg,2016,123(6):1363-1371.
[13]Bossone E,LaBounty TM,Eagle KA.Acute aortic syndromes:diagnosis and management,an update[J].Eur Heart J,2018,39(9):739-749d.
[14]Morello F,Oddi M,Cavalot G.et al.Prospective diagnostic and prognostic study of copeptin in suspected acute aortic syndromes[J].Sci Rep,2018,8(1):16713.
[15]华锋,王斌,崔恩海.和肽素对呼吸机相关性肺炎预后判断的临床意义[J].中华医院感染学杂志,2013,23(4):743-745.
[16]Stolz D,Christ-Crain M,Morgenthaler NG,et al.Copeptin,C-reactive protein,and procalcitonin as prognostic biomarkers in acute exacerbation of COPD[J].Chest,2007,131(4):1058-1067.
[17]Lin Q,Fu F,Chen H,et al.Copeptin in the assessment of acute lung injury and cardiogenic pulmonary edema[J].Respir Med,2012,106:1268-1277.
[18]Salt,Durukan P,Ozkan S,et al.Plasma copeptin levels in the patients with gastrointestinal bleeding[J].Am J Emerg Med,2017,35(10):1440-1443.
[19]中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南(2018年版)[J].现代医药卫生,2018,34(24):3897-3904.
[20]Kerbert AJC,Verspaget HW,NavarroA,et al.Copeptin in acute decompensation of liver cirrhosis:relationship with acute-on-chronic liver failure and short-term survival[J].Crit Care,2017,21(1):321.
[21]Jiang L,Feng B,Gao DN,et al.Plasma concentrations of copeptin,C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis[J].J Int Med Res,2015,43(2):188-195.
[22]Battista S,Audisio U,Galluzzo C,et al.Assessment of diagnostic and prognostic role of copeptin in the clinical setting of sepsis[J].Biomed Res Int,2016,2016:3624730.
[23]Zhang Q,Dong G,Zhao X,et al.Prognostic significance of hypotha-Lamic-pituitary-adrenal axis hormones in early sepsis:a study performed in the emergency department[J].Intensive Care Med,2014,40(10):1499-1508.
[24]张浩,任国庆,尹江宁,等.急性有机磷中毒患者和肽素的表达及其临床意义[J].实用医学杂志,2013,29(4):576-578.
[25]李敬,彭烨,马国营,等.和肽素、APACHEⅡ评分在急性百草枯中毒患者预后评估中的应用价值[J].实用医学杂志,2014,30(13):2072-2074.
[26]Zweifel C,Katan M,Schuetz P,et al.Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage[J].BMC Neurol,2010,26(10):1186-1188.
[27]Zhang RY,Liu J,Zhang Y,et al.Association between circulating copeptin level and mortality risk in patients with intracerebral hemorrhage:A systemic review and meta-analysis[J].Mol Neurobiol,2017,54(1):169-174.
[28]Wendt M,Ebinger M,Kunz A,et al.Copeptin levels in patients with acute ischemic stroke and stroke mimics[J].Stroke,2015,46(9):2426-2431.
[2]Dobsa L,Edozien KC.Copeptin and its potential role in diagnosis and prognosis of various diseases[J].Biochem Med(Zagreb),2013,23(2):172-190.
[3]Bolignano D,Cabassi A,Fiaccadori E,et al.Copeptin(CTproAVP),a new tool for understanding the role of vasopressin in pathophysiology[J].Clin Chem Lab Med,2014,52(10):1447-1456.
[4]Yilman M,Erenler AK,Baydin A.Copeptin:a diagnostic factor for critical patients[J].Eur Rev Med Pharmacol Sci,2015,19(16):3030-3036.
[5]Lyngbakken MN,Myhre PL,RsjH,et al.Novel biomarkers of cardiovascular disease:Applications in clinical practice[J].Crit Rev Clin Lab Sci,2019,56(1):33-60.
[6]Folli C,Consonni D,Spessot M,et al.Diagnostic role of copeptin in patients presenting with chest pain in the emergency room[J].Eur J Intern Med,2013,24(2):189-193.
[7]Neuhold S,Huelsmann M,Strunk G,et al.Comparison of copeptin,type natriuretic peptide,and aminoterminal pro-B-type natriuretic peptide in patients with chronic heart failure:prediction of death at different stages of the disease[J].J Am Coll Cardiol,2008,52(4):266-272.
[8]Düngen HD,Tscholl V,Obradovic D,et al.Prognostic performance of serial in-hospital measurements of copeptin novel biomarkers among patients with worsening heart failure:results from the MOLITOR and multiple study[J].ESC Heart Fail,2018,5(2):288-296.
[9]Zhong Y,Wang R,Yan LL,et al.Copeptin in heart failure:Review and meta-analysis[J].Clin Chim Acta,2017,475:36-43.
[10]Khan SQ,Dhillon OS,O'Brien RJ,et al.C-Terminal provasopressin(Copeptin)as a novel and prognostic marker in acute myocardial infarction:Leicester Acute Myocardial Infarction Peptide(LAMP)Study[J].Circulation,2007,115(16):2103-2110.
[11]Tanana OS,Sukmanova IA,Ponomarenko IV,et al.The clinical significance of copeptin and matrix metalloproteinases in men with acute coronary syndrome[J].Kardiologiia,2017,57(S3):32-39.
[12]Mauermann E,Bolliger D,Seeberger E,et al.Incremental value of preoperative copeptin for predicting myocardial injury[J].Anesth Analg,2016,123(6):1363-1371.
[13]Bossone E,LaBounty TM,Eagle KA.Acute aortic syndromes:diagnosis and management,an update[J].Eur Heart J,2018,39(9):739-749d.
[14]Morello F,Oddi M,Cavalot G.et al.Prospective diagnostic and prognostic study of copeptin in suspected acute aortic syndromes[J].Sci Rep,2018,8(1):16713.
[15]华锋,王斌,崔恩海.和肽素对呼吸机相关性肺炎预后判断的临床意义[J].中华医院感染学杂志,2013,23(4):743-745.
[16]Stolz D,Christ-Crain M,Morgenthaler NG,et al.Copeptin,C-reactive protein,and procalcitonin as prognostic biomarkers in acute exacerbation of COPD[J].Chest,2007,131(4):1058-1067.
[17]Lin Q,Fu F,Chen H,et al.Copeptin in the assessment of acute lung injury and cardiogenic pulmonary edema[J].Respir Med,2012,106:1268-1277.
[18]Salt,Durukan P,Ozkan S,et al.Plasma copeptin levels in the patients with gastrointestinal bleeding[J].Am J Emerg Med,2017,35(10):1440-1443.
[19]中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南(2018年版)[J].现代医药卫生,2018,34(24):3897-3904.
[20]Kerbert AJC,Verspaget HW,NavarroA,et al.Copeptin in acute decompensation of liver cirrhosis:relationship with acute-on-chronic liver failure and short-term survival[J].Crit Care,2017,21(1):321.
[21]Jiang L,Feng B,Gao DN,et al.Plasma concentrations of copeptin,C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis[J].J Int Med Res,2015,43(2):188-195.
[22]Battista S,Audisio U,Galluzzo C,et al.Assessment of diagnostic and prognostic role of copeptin in the clinical setting of sepsis[J].Biomed Res Int,2016,2016:3624730.
[23]Zhang Q,Dong G,Zhao X,et al.Prognostic significance of hypotha-Lamic-pituitary-adrenal axis hormones in early sepsis:a study performed in the emergency department[J].Intensive Care Med,2014,40(10):1499-1508.
[24]张浩,任国庆,尹江宁,等.急性有机磷中毒患者和肽素的表达及其临床意义[J].实用医学杂志,2013,29(4):576-578.
[25]李敬,彭烨,马国营,等.和肽素、APACHEⅡ评分在急性百草枯中毒患者预后评估中的应用价值[J].实用医学杂志,2014,30(13):2072-2074.
[26]Zweifel C,Katan M,Schuetz P,et al.Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage[J].BMC Neurol,2010,26(10):1186-1188.
[27]Zhang RY,Liu J,Zhang Y,et al.Association between circulating copeptin level and mortality risk in patients with intracerebral hemorrhage:A systemic review and meta-analysis[J].Mol Neurobiol,2017,54(1):169-174.
[28]Wendt M,Ebinger M,Kunz A,et al.Copeptin levels in patients with acute ischemic stroke and stroke mimics[J].Stroke,2015,46(9):2426-2431.