摘要
目的旨在探讨新发脑梗死后患者认知损害及抑郁的发生情况。方法选择2016年5月~2017年10月来我院就诊的新发脑梗死患者156例,采用汉密尔顿抑郁量表(HAMD)评价患者的抑郁症状,并将患者分为非抑郁组和抑郁组,采用蒙特利尔认知评估量表(MoCA)和简易精神状态评价量表(MMSE)评价患者认知功能水平,并根据MoCA评分结果将患者分为认知正常组、轻度认知损害组和重度认知损害组,评估脑梗死后患者抑郁和认知障碍的发生情况,并分析两者的相互关系。结果认知正常组、轻度认知损害组和重度认知损害组的MoCA、MMSE和HAMD评分差异有统计学意义(P<0.05),非抑郁组的MMSE各项评分皆高于抑郁组,差异有统计学意义(P<0.05)。认知损害与抑郁在定向、回忆能力及语言能力方面存在交互作用,且交互作用有统计学意义(P<0.05)。结论脑梗死后患者可能并发抑郁和认知功能障碍,两者之间存在一定的交互关系。
Objective To investigate the occurrence of cognitive impairment and depression in patients with new-onset cerebral infarction. Methods A total of 156 patients with new-onset cerebral infarction admitted in our hospital from May 2016 to October 2017 were enrolled. The Hamilton Depression Table(HAMD) was used to evaluate the depressive symptoms and the patients were divided into non-depression group and depression group. The Montreal Cognitive Assessment Scale(MoCA) and the Mini-Mental State Assessment Scale(MMSE) were used to evaluate the cognitive function of patients, and the patients were divided into cognitive normal group, mild cognitive impairment group and severe cognitive impairment group according to MoCA score. The incidence of depression and cognitive impairment in patients after cerebral infarction was assessed, and the relationship between the two groups was analyzed. Results The differences in MoCA, MMSE and HAMD scores between the cognitive normal group, mild cognitive impairment group and severe cognitive impairment group were statistically significant(P<0.05). The MMSE scores in the non-depressed group were higher than those in the depression group, and the difference was statistically significant(P<0.05). There was an interaction between cognitive impairment and depression in orientation, recall ability and language ability, and the difference in the interaction was statistically significant(P<0.05). Conclusion Patients with cerebral infarction may have depression and cognitive dysfunction, and there is a certain interaction between them.
引文
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