研究婴幼儿常见下呼吸道感染性疾病与淋巴细胞亚群变化的关系
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摘要
目的研究婴幼儿常见下呼吸道感染性疾病与淋巴细胞亚群变化的关系。方法选取呼吸道感染性疾病患儿40例作为研究对象,根据疾病不同将其分为支气管炎、肺炎以及毛细支气管炎三组,其中支气管炎组11例、肺炎组21例、毛细支气管炎组8例,选取同期来我院进行健康体检的儿童15名作为参照对象,将其设置为健康组。观察四组淋巴细胞亚群变化情况,以及对婴幼儿下呼吸道感染性相关疾病与淋巴细胞亚群水平相关性进行分析。结果 CD_3~+、CD_3~+、CD_4~+、T4/T8以及CD_3~-、CD_(16)~+、CD_(56)~+水平与婴幼儿下呼吸道感染性相关疾病呈负相关;CD_3~+、CD_8~+与CD_3~-、CD_(19)~+水平与婴幼儿下呼吸道感染性相关疾病呈正相关。结论淋巴细胞亚群水平变化与婴幼儿常见下呼吸道感染性疾病发展与发生有着密切的联系,在临床诊治过程中加强对淋巴细胞亚群水平变化监测有助于临床中对于患儿病情的诊治。
Objective To study the relationship between common lower respiratory tract infections and lymphocyte subsets in infants and young children. Methods Forty children with respiratory tract infections were selected as subjects. They were divided into three groups according to different diseases: bronchitis, pneumonia and bronchiolitis. Among them, 11 were in the bronchitis group,21 in the pneumonia group, and 8 in the bronchiolitis group. For example, 15 children who were admitted to our hospital for health checkups at the same time were selected as reference targets and set as healthy groups. The changes of lymphocyte subsets in the four groups were observed, and the correlation between the lower respiratory tract infection-related diseases and lymphocyte subsets in infants and young children was analyzed. Results CD3+, CD3+, CD4+, T4/T8, and CD3-, CD16+, and CD56+ levels were negatively correlated with infantile lower respiratory tract infection-related diseases; CD3+, CD8+ and CD3-, CD19+ levels and infantile lower respiratory tract infection-related diseases Positive correlation. Conclusion The changes of lymphocyte subsets are closely related to the development and occurrence of common lower respiratory tract infections in infants and young children. Strengthening the monitoring of lymphocyte subsets during clinical diagnosis and treatment can help the diagnosis and treatment of children's diseases in clinic.
Objective To study the relationship between common lower respiratory tract infections and lymphocyte subsets in infants and young children. Methods Forty children with respiratory tract infections were selected as subjects. They were divided into three groups according to different diseases: bronchitis, pneumonia and bronchiolitis. Among them, 11 were in the bronchitis group,21 in the pneumonia group, and 8 in the bronchiolitis group. For example, 15 children who were admitted to our hospital for health checkups at the same time were selected as reference targets and set as healthy groups. The changes of lymphocyte subsets in the four groups were observed, and the correlation between the lower respiratory tract infection-related diseases and lymphocyte subsets in infants and young children was analyzed. Results CD3+, CD3+, CD4+, T4/T8, and CD3-, CD16+, and CD56+ levels were negatively correlated with infantile lower respiratory tract infection-related diseases; CD3+, CD8+ and CD3-, CD19+ levels and infantile lower respiratory tract infection-related diseases Positive correlation. Conclusion The changes of lymphocyte subsets are closely related to the development and occurrence of common lower respiratory tract infections in infants and young children. Strengthening the monitoring of lymphocyte subsets during clinical diagnosis and treatment can help the diagnosis and treatment of children's diseases in clinic.
引文
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[12]陶辰楠,李世敏,关丽娜.支气管肺癌患者外周血T淋巴细胞亚群表达情况及其与预后的关系研究[J].实用心脑肺血管病杂志,2018,26(3):44-47.
[13]王侠.支气管哮喘患儿血清免疫球蛋白E及T淋巴细胞亚群的动态变化分析[J].实用临床医药杂志,2016,20(19):195-196.
[14]刘方久,蒋琴,王欣.CRP、CD64及淋巴细胞亚群检测在呼吸系统感染性疾病诊断中的应用价值[J].解放军预防医学杂志,2018,36(3):327-329.
[15]贾民勇,王少芳,宋璐.外周血T淋巴细胞亚群检测在不同呼吸科疾病中的运用效果比较及其临床价值评价[J].临床肺科杂志,2018,23(4):732-735.
[2]谢志鸿,秦铁林.双黄连雾化吸入治疗呼吸道合胞病毒所致急性下呼吸道感染[J].内蒙古中医药,2017,36(1):54.
[3]Vivek M,Xie H,Pergam SA,et al.Does Detection of Respiratory Viral Infection in Upper Respiratory Tract(URT)Predict Lower Respiratory Tract(LRT)Disease in Hematopoietic Cell Transplant(HCT)Patients[J].Open Forum Infectious Diseases,2017,4(Suppl1):S9.
[4]王进雅,诸留珍,陆璐,等.淋巴细胞亚群在反复喘息婴幼儿血清中表达水平的研究[J].中外医疗,2016,35(35):32-35.
[5]董贺婷,季伟,顾文婧,等.2岁以下毛细支气管炎患儿临床特征与淋巴细胞亚群比值关系[J].中国实用儿科杂志,2016,31(12):920-924.
[6]缪华,刘晓蓉.不同呼吸道病毒感染与小儿哮喘发病及细胞因子、淋巴细胞亚群含量的关系[J].海南医学院学报,2017,23(8):1088-1091.
[7]刘元靖.匹多莫德治疗小儿反复下呼吸道感染的疗效及对患儿免疫功能的影响[J].临床研究,2016,24(12):34-35.
[8]吕淼.肺炎支原体肺炎患儿T淋巴细胞亚群改变的临床研究[J].中国现代药物应用,2018,12(10):46-47.
[9]罗婧,魏婷婷,许昆鹏.肺癌患者放疗前后血液TGF-β1变化与淋巴细胞亚群变化趋势相关性分析[J].中华放射肿瘤学杂志,2017,26(2):150-154.
[10]陈少艳,刘基铎,肖明锋.淋巴细胞亚群检测在感染性疾病中的应用[J].国际检验医学杂志,2017,38(2):206-208.
[11]江雨顺,刘达富.慢性阻塞性肺疾病患者外周血T淋巴细胞亚群和C反应蛋白变化的临床意义[J].白求恩医学杂志,2016,14(5):580-582.
[12]陶辰楠,李世敏,关丽娜.支气管肺癌患者外周血T淋巴细胞亚群表达情况及其与预后的关系研究[J].实用心脑肺血管病杂志,2018,26(3):44-47.
[13]王侠.支气管哮喘患儿血清免疫球蛋白E及T淋巴细胞亚群的动态变化分析[J].实用临床医药杂志,2016,20(19):195-196.
[14]刘方久,蒋琴,王欣.CRP、CD64及淋巴细胞亚群检测在呼吸系统感染性疾病诊断中的应用价值[J].解放军预防医学杂志,2018,36(3):327-329.
[15]贾民勇,王少芳,宋璐.外周血T淋巴细胞亚群检测在不同呼吸科疾病中的运用效果比较及其临床价值评价[J].临床肺科杂志,2018,23(4):732-735.