成纤维细胞生长因子23对心脏重构的影响
摘要
FGF23是一个由骨分泌的调节磷酸盐的激素,受FGF受体及Kltho蛋白调节,作用于肾脏和甲状旁腺的FGFs受体/Klotho蛋白复合物,减少肾脏磷酸盐的吸收、活性维生素D的合成以及甲状旁腺激素的分泌,维持体内血磷酸盐及矿物质内环境平衡。
引文
[1]Liu S,Guo R,Simpson LG,Xiao ZS,Burnham CE,Quarles LD.Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX[J].J Biol Chem(2003)278(39):37419-26.
[2]管旭,赵景宏.Klotho与FGF信号通路关系的研究进展[J].解放军医药杂志,2014,26(10):109-113.
[3]任晓曼,董中亮,卜舒扬,等.Klotho在动物肾脏疾病中的作用机制[J].畜牧与兽医,2017,49(10):131-134.
[4]Neuburg S,Dussold C,Gerber C,Wang X,Francis C,Qi L,et al.Genetic background influences cardiac phenotype in murine chronic kidney disease.Nephrol Dial Transplant(2017).
[5]Faul C,Amaral AP,Oskouei B,Hu MC,Sloan A,Isakova T,et al.FGF23 induces left ventricular hypertrophy.J Clin Invest(2011)121(11):4393-408.
[6]Richter M,Lautze HJ,Walther T,Braun T,Kostin S,Kubin T.The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation.J Heart Lung Transplant(2015)34:1211-4.
[2]管旭,赵景宏.Klotho与FGF信号通路关系的研究进展[J].解放军医药杂志,2014,26(10):109-113.
[3]任晓曼,董中亮,卜舒扬,等.Klotho在动物肾脏疾病中的作用机制[J].畜牧与兽医,2017,49(10):131-134.
[4]Neuburg S,Dussold C,Gerber C,Wang X,Francis C,Qi L,et al.Genetic background influences cardiac phenotype in murine chronic kidney disease.Nephrol Dial Transplant(2017).
[5]Faul C,Amaral AP,Oskouei B,Hu MC,Sloan A,Isakova T,et al.FGF23 induces left ventricular hypertrophy.J Clin Invest(2011)121(11):4393-408.
[6]Richter M,Lautze HJ,Walther T,Braun T,Kostin S,Kubin T.The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation.J Heart Lung Transplant(2015)34:1211-4.