胰腺实性型浆液性囊腺瘤1例临床病理观察
摘要
目的探讨胰腺实性型浆液性囊腺瘤(solid-type serous cystadenoma,SSCA)的临床病理学特征。方法观察1例罕见的胰腺SSCA,结合文献分析其病理特征及鉴别诊断。结果患者为67岁男性,体检发现胰头占位。肿瘤肉眼实性、质韧,镜下境界清楚,呈结节状或分叶状,间质富含血管;肿瘤细胞呈紧密排列的实性巢、小腺泡、小腺管,局灶或散在可见小囊腔形成;肿瘤细胞呈立方或多边形,胞质丰富透明或淡嗜酸颗粒状,核小而圆,未见明显异型性及核分裂象。免疫表型:肿瘤细胞CK7、CK19、AAT、Inhibin-α、Calponin、MUC1、NSE均阳性,Ki-67增殖指数低,神经内分泌标记CgA、Syn、CD56及其他鉴别标记均阴性。术后随访22个月,未见复发或转移。结论 SSCA是胰腺浆液性囊性肿瘤的罕见亚型,患者手术切除预后良好,最终确诊依赖于病理检查。
引文
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[5] Katsourakis A,Dimitriou I,Noussios G,et al. Solid serous adenoma of the pancreas:a case report and review of the literature[J]. Case Rep Surg,2016,2016:3730249.
[6] Lee S D,Han S S,Hong E K. Solid serous cystic neoplasm of the pancreas with invasive growth[J]. J Hepatobiliary Pancreat Sci,2013,20(4):454-456.
[7]张宏艳,王志锋,马小龙,等.胰腺浆液性囊腺瘤的影像学类型与病理对照[J].放射学实践,2015,30(7):768-771.
[8] Reese S A,Traverso L W,Jacobs T W,et al. Solid serous adenoma of the pancreas:a rare variant within the family of pancreatic serous cystic neoplasms[J]. Pancreas,2006,33(1):96-99.
[9]谭洋,李霄,张智弘,等.富含黑色素的胰腺血管周上皮样细胞肿瘤1例临床病理观察[J].诊断病理学杂志,2016,23(11):845-849.
[10]黄曦,卢林明,汪向明,等.胰腺实性-假乳头状肿瘤11例临床病理分析[J].临床与实验病理学杂志,2015,31(9):1026-1030.
[2] Kishida Y,Matsubayashi H,Okamura Y,et al. A case of solidtype serous cystadenoma mimicking neuroendocrine tumor of the pancreas[J]. J Dig Dis,2014,15(4):211-215.
[3] Hayashi K,Fujimitsu R,Ida M,et al. CT differentiation of solid serous cystadenoma vs endocrine tumor of the pancreas[J]. Eur J Radiol,2012,81(3):e203-e208.
[4] Gabata T,Terayama N,Yamashiro M,et al. Solid serous cystadenoma of the pancreas:MR imaging with pathologic correlation[J].Abdom Imaging,2005,30(5):605-609.
[5] Katsourakis A,Dimitriou I,Noussios G,et al. Solid serous adenoma of the pancreas:a case report and review of the literature[J]. Case Rep Surg,2016,2016:3730249.
[6] Lee S D,Han S S,Hong E K. Solid serous cystic neoplasm of the pancreas with invasive growth[J]. J Hepatobiliary Pancreat Sci,2013,20(4):454-456.
[7]张宏艳,王志锋,马小龙,等.胰腺浆液性囊腺瘤的影像学类型与病理对照[J].放射学实践,2015,30(7):768-771.
[8] Reese S A,Traverso L W,Jacobs T W,et al. Solid serous adenoma of the pancreas:a rare variant within the family of pancreatic serous cystic neoplasms[J]. Pancreas,2006,33(1):96-99.
[9]谭洋,李霄,张智弘,等.富含黑色素的胰腺血管周上皮样细胞肿瘤1例临床病理观察[J].诊断病理学杂志,2016,23(11):845-849.
[10]黄曦,卢林明,汪向明,等.胰腺实性-假乳头状肿瘤11例临床病理分析[J].临床与实验病理学杂志,2015,31(9):1026-1030.