神经病理性疼痛动物模型研究进展
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摘要
神经病理性疼痛是临床上最为常见、最难治疗的慢性疼痛。为研究神经病理性疼痛发病机制和探索新的治疗方法,目前已制备出多种动物模型。总结和讨论中枢疼痛、周围神经损伤以及病变致周围神经痛等目前常用的研究神经病理性疼痛的动物模型及其特征。
Neuropathic pain is the most common but difficult to treat chronic pain in clinical practice. To study the pathogenesis of neuropathic pain and explore new treatments, a variety of animal models have been created. This article briefly summarizes and discusses the current animal models of neuropathic pain, including central pain, peripheral nerve injury and peripheral nerve pain caused by lesions and their characteristics.
Neuropathic pain is the most common but difficult to treat chronic pain in clinical practice. To study the pathogenesis of neuropathic pain and explore new treatments, a variety of animal models have been created. This article briefly summarizes and discusses the current animal models of neuropathic pain, including central pain, peripheral nerve injury and peripheral nerve pain caused by lesions and their characteristics.
引文
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[33] 杜俊英,房军帆,方剑乔,等.坐骨神经分支选择性损伤模型L4～6背根神经节水平不同时间P2X3 mRNA表达变化[J].解剖学报,2016(3):297-302.
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[36] 张劲军,魏明,赖英荣,等.非压迫性髓核导致大鼠背根神经节病理变化[J].中国神经精神疾病杂志,2009,35(5):280-284.
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[44] 罗道枢,陈磊,王玮,等.三叉神经根慢性压迫损伤对大鼠三叉神经尾侧亚核内WDR 神经元电活动的影响[J].神经解剖学杂志,2012(6):549-553.
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[2] Ralf B,Andreas B,Gunnar W.Neuropathic pain:diagnosis,pathophysiological mechanisms,and treatment[J].The Lancet,2010,9(8):807-819.
[3] He D,Grant B,Holden RR,et al.Methodology for self-report of rest pain (or spontaneous pain) vs evoked pain in chronic neuropathic conditions:a prospective observational pilot study[J].Pain Rep,2017,2(2):587.
[4] Leadley RM,Armstrong N,Lee YC,et al.Chronic diseases in the European Union:the prevalence and health cost implications of chronic pain [J].Pain Palliat Care Pharmacother,2012,26(4):310-325.
[5] 神经病理性疼痛诊疗专家组.神经病理性疼痛诊疗专家共识[S].中国疼痛医学杂志,2013(12):705-710.
[6] Cvijanovi M,Simi S,Bani Horvat S,et al.Contemporary treatment neuropathic pain [J].Med Pregl,2011,64(9/10):443-447.
[7] 严广斌.神经病理性疼痛[J].中华关节外科杂志(电子版),2017,11(4):446.
[8] Baron R,Eberhart L,Kern KU,et al .Tapentadol prolonged release for chronic pain:A review of clinical trials and 5 years of routine clinical practice data[J].Pain Pract,2016:9.
[9] Wasserman JK,Koeberle PD.Development and characterization of a hemorrhagic rat model of central post-stroke pain [J].Neuroscience,2009,161(1):173-183.
[10] 陈霄雷,林雷雷,邵璐斐,等.大鼠脊髓打击器研制及其制备的脊髓损伤模型稳定性评价[J].宁夏医科大学学报,2014(7):716-719.
[11] 段强,彭卫华,樊继军,等.大鼠完全性脊髓横断及坐骨神经损伤后运动终板变化[J].中国老年学杂志,2010(15):2176-2179.
[12] 孙德日,胡慧媛,朱悦.改良脊髓半横断损伤大鼠模型的建立及评价[J].中国医科大学学报,2017(3):223-226.
[13] Watson BD,Prado R,Dietrich WD,et al.Photochemically induced spinal cord injury in the rat [J].Brain research,1986,367(1-2):296-300.
[14] Hao JX,Xu XJ,Aldskogius,et al.Photochemically induced transient spinal is chemical induces behavioral hypersensitivity to mechanical and cold stimuli,but not to noxious heat stimuli in the rat[J].Exp.Neurol,1992,118(2):187-194.
[15] 何克林,马睿杰.脊髓损伤后疼痛的动物模型研究进展[J].中华中医药学刊,2016(8):1874-1876.
[16] 秦慧慧,王文春,葛杜鹃,等.改良钳夹型脊髓损伤大鼠模型的建立及神经功能评价[J].西南军医,2014(1):1-4.
[17] Kloos AD,Fisher LC,Detloff MR,et al.Stepwise motor and all- or - none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats [J].Experimental neurology,2005,191(2):251-265.
[18] 黄平,邹国耀,邹志远.置入内固定装置轻度持续性牵张对兔脊髓的潜在损伤[J].中国组织工程研究与临床康复,2011,15(4):695-698.
[19] Wang G,Thompson SM.Maladaptive homeostatic plasticity in a rodent model of central pain syndrome:thalamic hyperexcitability after spinothalamic tract lesions[J].The Journal of neuroscience:the official journal of the Society for Neuroscience,2008,28(46) :11959-11969.
[20] Hu SJ.An experimental model for chronic compression of dorsal root gangalion produced by intervertebral foramen stenosis in the rat[J].Pain,1998,77:15-23.
[21] 曹振昊,田云虎,马璐璐,等.慢性压迫背根神经节大鼠模型背根神经节Wnt5a的表达变化[J].中国修复重建外科杂志,2014(11):1392-1396.
[22] Shahid M,Subhan F,Ahmad N,et al.A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats[J].BMC Complement Altern Med,2017,17(1):293.
[23] Bennett GJ,Xie YK.A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man[J].Pain,1988,33(1):87-107.
[24] 马艳,张方博,刘欣,等.慢性压迫性损伤模型制备因素及模型评价方法的研究进展[J].医学研究杂志,2014(7):176-179.
[25] 沈立姿,房立丛,于津鹏,等.丝线、羊肠线及结扎道数对大鼠 CCI疼痛模型的影响[J].海南大学学报:自然科学版,2013,31(1):45-49.
[26] Yamato K,Kataoka T,Nishiyama Y,et al.Preventive and curative effects of radon inhalation on chronic constriction injury-induced neuropathic pain in mice[J].European Journal of Pain,2013,17(4):480-492.
[27] Ding XD,Wang W,Ding ZG,et al.Impact of Botox-A SNAP-25 protein expression and the mechanism of inhibitory neurotransmitter imbalance in chronic sciatic nerve pain rat model [J].Exp Ther Med,2017,13(6):2783-2786.
[28] Meymandi MS,Sepehri G,Abdolsamadi M,et al.The effects of co-administration of pregabalin and vitamin E on neuropathic pain induced by partial sciatic nerve ligation in male rats[J].Inflammopharmacology,2017,25(2):237-246.
[29] Kiguchi N,Sakaguchi H,Kadowaki Y,et al.Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation[J].J Pharmacol Sci,2017,133(1):53-56.
[30] 王江栓,李变锋.大鼠脊神经选择性结扎镜像痛模型的筛选建立[J].中国医学创新,2014,11(18):30-32.
[31] Li S,Cai J,Feng ZB,et al.BDNF contributes to spinal long-term potentiation and mechanical hypersensitivity via Fyn-mediated phosphorylation of NMDA receptor GluN2B Subunit at Tyrosine 1472 in rats following spinal nerve ligation[J].Neurochemical Research,2017:1-18.
[32] 江茜,王英,夏阳阳,等.神经病理性痛模型( SNI) 大鼠背根神经节P2X3的mRNA和蛋白表达变化[J].赣南医学院学报,2017(6):844-847.
[33] 杜俊英,房军帆,方剑乔,等.坐骨神经分支选择性损伤模型L4～6背根神经节水平不同时间P2X3 mRNA表达变化[J].解剖学报,2016(3):297-302.
[34] Metz AE,Yau HJ,Centeno MV,et al.Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain[J].PNAS,2009,106(7):2423-2428.
[35] 龙贤齐,王旭,任秀君,等.远近配穴电针对自体髓核移植大鼠脊髓p38丝裂原活化蛋白激酶及环磷酸腺苷表达的影响[J].针刺研究,2016(3):202-209.
[36] 张劲军,魏明,赖英荣,等.非压迫性髓核导致大鼠背根神经节病理变化[J].中国神经精神疾病杂志,2009,35(5):280-284.
[37] Mulleman D,Mammou S,Griffoul I,et al.Pathophysiology of disk-related sciatica.I:Evidence supporting a chemical component [J].Joint Bone Spine,2006,73(2):151-158.
[38] 冀丽丽,葛东宇,任秀君,等.电针对自体髓核移植大鼠脊髓后角小胶质细胞活性的影响[J].北京中医药大学学报,2016(5):399-405.
[39] 陆志东,陈志荣.硬膜外移植自体髓核大鼠背根神经节的非压迫性损伤[J].中国组织工程研究与临床康复,2010(2):294-297.
[40] 秦泗佳,王福,张奎启,等.SD大鼠三叉神经痛模型神经微循环变化[J].大连医科大学学报,2014(4):328-331.
[41] Luo DS,Zhang T,Zuo CX,et al.An Animal model for trigeminal neuralgia by compression of the trigeminal nerve root[J].Pain Physician,2013,42(10):1179-1179.
[42] 秦泗佳,张晓红,金海威,等.大鼠三叉神经痛模型中痛阈及胶质细胞源性神经营养因子的变化[J].华西口腔医学杂志,2015(1):16-20.
[43] 于映映,林凌,罗丽丽,等.三叉神经痛大鼠三叉神经根区Fyn的表达变化[J].神经解剖学杂志,2017(6):697-701.
[44] 罗道枢,陈磊,王玮,等.三叉神经根慢性压迫损伤对大鼠三叉神经尾侧亚核内WDR 神经元电活动的影响[J].神经解剖学杂志,2012(6):549-553.
[45] 郭永峰,丁纯,李明子,等.新型SD大鼠压迫性三叉神经痛动物模型建立及其作用研究[J].中国实用口腔科杂志,2016(5):295-299.
[46] 江翠华,张达颖,张学学.三叉神经痛动物模型制作研究进展[J].中国疼痛医学杂志,2014(6):430-433.
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