产时应用抗生素预防B族溶血性链球菌母婴垂直传播的效果分析
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摘要
目的探析产时应用抗生素对于预防B族溶血性链球菌阳性孕妇垂直传染新生儿的临床效果。方法于南阳医学高等专科学院第三附属医院妇产科选取92例B族溶血性链球菌(GBS)检查结果为阳性的孕妇,根据随机数字表法将其平均分为两组(对照组与预防组),每组各46例。对照组孕妇给予常规护理干预,不进行任何预防治疗;预防组孕妇给予常规护理与抗生素预防治疗。比较两组母婴结局情况,并检测新生儿GBS带菌情况与血常规异常情况。结果预防组产妇胎膜早破的发生率(2.17%)显著低于对照组(13.04%),差异有统计学意义(P<0.05);两组新生儿结局比较,差异无统计学意义(P>0.05);预防组新生儿GBS带菌率以及血常规异常发生率均显著低于对照组,差异有统计学意义(P<0.05)。结论对GBS阳性孕妇进行抗生素预防治疗的效果确切,可减少母婴垂直传播,预防新生儿感染GBS相关疾病。
Objective To explore the clinical effect of antibiotics on preventing vertical infection of newborns in pregnant women with group B hemolytic streptococcus. Methods 92 pregnant women with positive results of group B hemolytic streptococcus(GBS)were selected from Gynecology and Obstetrics Department of the hospital. According to the random number table method,they were divided into two groups(control group and prevention group),with 46 cases in each group. The pregnant women in the control group were given routine nursing intervention without any preventive treatment,while the pregnant women in the prevention group were given routine nursing and antibiotic preventive treatment. Maternal and infant outcomes were compared between the two groups,and GBS carrier and abnormal blood routine were detected in newborns. Results The incidence of premature rupture of membranes in the prevention group(2.17%)was significantly lower than that in the control group(13.04%). The difference was statistically significant(P<0.05).There was no significant difference in neonatal outcomes between the two groups(P>0.05).The GBS carrier rate and abnormal blood routine rate in the prevention group were significantly lower than those in the control group(P<0.05). Conclusion Antibiotic prophylaxis for GBS positive pregnant women is effective,which can reduce vertical transmission between mother and infant,and prevent GBS infection in newborns.
Objective To explore the clinical effect of antibiotics on preventing vertical infection of newborns in pregnant women with group B hemolytic streptococcus. Methods 92 pregnant women with positive results of group B hemolytic streptococcus(GBS)were selected from Gynecology and Obstetrics Department of the hospital. According to the random number table method,they were divided into two groups(control group and prevention group),with 46 cases in each group. The pregnant women in the control group were given routine nursing intervention without any preventive treatment,while the pregnant women in the prevention group were given routine nursing and antibiotic preventive treatment. Maternal and infant outcomes were compared between the two groups,and GBS carrier and abnormal blood routine were detected in newborns. Results The incidence of premature rupture of membranes in the prevention group(2.17%)was significantly lower than that in the control group(13.04%). The difference was statistically significant(P<0.05).There was no significant difference in neonatal outcomes between the two groups(P>0.05).The GBS carrier rate and abnormal blood routine rate in the prevention group were significantly lower than those in the control group(P<0.05). Conclusion Antibiotic prophylaxis for GBS positive pregnant women is effective,which can reduce vertical transmission between mother and infant,and prevent GBS infection in newborns.
引文
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[3]姜静,杨蒙蒙,高丽君,等.妊娠晚期B族溶血性链球菌诊治研究进展[J].现代妇产科进展,2016,25(8):624-627.
[4]林开婷,管翠,陈坚,等.妊娠晚期孕妇B族溶血性链球菌感染对孕产妇凝血功能及母婴结局的影响[J].中华医院感染学杂志,2017,27(19):4511-4514.
[5]张倩,严涵,张凤.妊娠晚期生殖道B族溶血性链球菌(GBS)感染及对妊娠结局的影响分析[J].河北医学,2018,24(4):84-88.
[2]熊丽丽,田晓予,郭凤仙.妊娠晚期孕妇B族溶血性链球菌感染对妊娠结局影响的临床研究[J].中华医院感染学杂志,2015,25(23):5482-5484.
[3]姜静,杨蒙蒙,高丽君,等.妊娠晚期B族溶血性链球菌诊治研究进展[J].现代妇产科进展,2016,25(8):624-627.
[4]林开婷,管翠,陈坚,等.妊娠晚期孕妇B族溶血性链球菌感染对孕产妇凝血功能及母婴结局的影响[J].中华医院感染学杂志,2017,27(19):4511-4514.
[5]张倩,严涵,张凤.妊娠晚期生殖道B族溶血性链球菌(GBS)感染及对妊娠结局的影响分析[J].河北医学,2018,24(4):84-88.