介孔二氧化硅纳米材料在缓释递药系统中的研究进展
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摘要
药物载体能在一定程度上优化药物性能,可增强药物的缓释效应,使药物靶向作用于人体中某一部位。本文重点分析了载药纳米材料介孔二氧化硅在药物缓释给药系统中的研究与应用进展,综述了其作为一种新型的药物缓释载体材料,在材料合成、药物缓释给药系统的制备以及缓释性能影响的因素、应用等方面的研究进展并提出建议,为今后利用介孔二氧化硅载体制备缓释药物的研究及应用,提供方向性指导及理论依据。
The drug carriers can optimize performance of the drug to a certain degree,such as enhancing the sustained-release effect of the drug,or making the drug has the ability of targeting a certain part of the human body. This paper focuses on the research and application progress of mesoporous silica nanomaterials on drug delivery system. The paper also reviewed as new type of drug delivery material,material synthesis,preparation of drug sustained-release delivery system,the factories that affected the performance of drug sustained release system,and other aspects of the application and progress in mesoporous silica. Finally we presented theoretical basis and some recommendations about the future direction for the research and application of mesoporous silica in drug sustained release delivery system.
The drug carriers can optimize performance of the drug to a certain degree,such as enhancing the sustained-release effect of the drug,or making the drug has the ability of targeting a certain part of the human body. This paper focuses on the research and application progress of mesoporous silica nanomaterials on drug delivery system. The paper also reviewed as new type of drug delivery material,material synthesis,preparation of drug sustained-release delivery system,the factories that affected the performance of drug sustained release system,and other aspects of the application and progress in mesoporous silica. Finally we presented theoretical basis and some recommendations about the future direction for the research and application of mesoporous silica in drug sustained release delivery system.
引文
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[6]许磊,王公慰,魏迎旭,等. MCM-41介孔分子筛合成研究Ⅰ.水热合成法[J].催化学报,1999,20(3):247-250.
[7]曹渊,白英豪,夏之宁,等.硅基介孔材料在药物缓控释中的应用[J].中国药学杂志,2009,44(7):481-484.
[8]王振兴,丁士文,张美红,等.自组装合成纳米复合Ti O2-ZnO介孔材料及其光催化性能[J].化学学报,2005(3):243-248.
[9]施益峰.纳米浇铸法合成有序介孔高温陶瓷材料及金属硫化物、氮化物材料[D].上海:复旦大学,2007.
[10]刘治刚.纳米介孔分子筛用于吡格列酮长效缓释的研究[J].化工技术与开发,2013,42(11):24-26.
[11] JIA LJ,SHEN JY,LI ZY,et al. Successfully tailoring the pore size of mesoporous silica nanoparticles:Exploitation of delivery systems for poorly water-soluble drugs[J]. Int J Pharm,2012,439(1-2):81-91.
[12] SUMERLIN N,QU Z,PUJARA N,et al. Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol[J]. Colloids Surf B,2016,144:1-7.
[13] BRIGO L,SCOMPARIN E,et al. Mesoporous silica sub-micron spheres as drug dissolution enhancers:influence of drug and matrix chemistry on functionality and stability[J]. Mater Sci Eng C,2016,59:585-593.
[14] AZAIS T,TOURNE-PETEILH C,AUSSENAC F,et al. Solidstate NMR study of Ibuprofen Confmed in MCM-41 Material[J].Chem Mater,2006,18(26):6382-6390.
[15] HORCAJADA P,RAMILA A,et al. Influence of superficial organic modification of MCM-41 matrices on drug delivery rate.[J]. Solid State Sci,2006,8(10):1243-1249.
[16] IZQUIERDO-BARBA I,MARTINEZ,DOADRIO AL,et al.Release evaluation of drugs from ordered three-dimensional silica structures[J]. Eur J Pharm Sci,2005,26(5):365-373.
[17]王明启.磁性介孔氧化硅纳米颗粒载带短链核酸和蛋白药物及其生物医学应用[D].上海:上海交通大学,2013.
[18] GOSCIANSKA J,OLEJNIK A,PIETRZAK R. In vitro release of l-phenylalanine from ordered mesoporous materials[J]. Microporous and Mesoporous Mater,2013,177(complete):32-36.
[19] MARTIN A,GARCIA RA,KARAMAN DS,et al. Polyethyleneimine-functionalized large pore ordered silica materials for poorly water-soluble drug delivery[J]. J Mater Sci,2014,49(3):1437-1447.
[20]翟婷婷.介孔纳米硅材料负载难溶性药物的制备及优化[D].天津:天津大学,2014.
[21]田儒楠,郝凤奇,李景梅.氨丙基修饰M41作为胰岛素的缓释载体[J].吉林大学学报(理学版),2015,53(5):1039-1044.
[22] GOSCIANSKA A,OLEJNIK A,NOWAK I. APTES-functionalized mesoporous silica as a vehicle for antipyrine-adsorption and release studies[J]. Colloids Surf A,2017,533:187-196.
[23]林粤顺,周红军,周新华,等. pH值响应性毒死蜱/铜席夫碱配合物改性SBA-15的制备及缓释性能[J].无机化学学报,2017,33(3):446-454.
[24] HEIDEGGER S,GL D,SCHMIDT A,et al. Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery[J]. Nanoscale,2016(8):938-948.
[25]张凌宇.基于介孔二氧化硅多功能纳米材料的制备及生物应用[D].长春:东北师范大学,2015.
[26] GIRI S,BRIAN G,TREWYN S,et al. Stimuli-responsive controlled-release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles[J]. Angew Chem Int Edit,2005,44(32):5038-5044.
[27] CHEN Y,Yang W,et al. In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation[J]. Eur J,2013,85(3):406-412.
[28] DARVISHI B,FARAHMAND L,MAJIDZADEHA K. Stimuliresponsive mesoporous silica NPs as non-viral dual siRNA/chemotherapy carriers for triple negative breast cancer[J]. Mol Ther Nucl Acids,2017,7:164-180.
[29] CHENG SH,LI FC,SOURIS JS,et al. Visualizing dynamics of sub-hepatic distribution of nanoparticles using intravital multiphoton fluorescence microscopy[J]. ACS Nano,2016,6(5):4122-4131.
[30]李艳艳.阿莫西林/MCM-41载药体系的缓释作用研究[D].长春:长春理工大学,2012.
[31]刘治刚,王建刚,于世华,等. MCM-41的制备及用于吡拉西坦缓释性能研究[J].化工科技,2013,21(6):42-44.
[32] JIA L,SHEN J,Li Z,et al. In vitro and in vivo evaluation of paclitaxel-loaded mesoporous silica nanoparticles with three pore sizes[J]. Inter J Pharm,2013,445(1-2):12-19.
[33] HONG S,SHEN S,TAN DC,et al. High drug load,stable,manufacturable and bioavailable fenofibrate formulations in mesoporous silica:a comparison of spray drying versus solvent impregnation methods[J]. Drug Deliv,2016,23(1):316-327.
[34] ZHANG Y,ZHANG H,CHE E,et al. Development of novel mesoporous nanomatrix-supported lipid bilayers for oral sustained delivery of the water-insoluble drug,lovastatin[J]. Colloids Surf B,2015,128:77-85.
[35] ABD-ELRAHMAN AA,EL-NABARAWI MA,HASSAN DH,et al. Ketoprofen mesoporous silica nanoparticles SBA-15 hard gelatin capsules:preparation and in vitro/in vivo characterization[J]. Drug Deliv,2016,23(9):3387-3398.
[36]林妙阔,黄尔丹,黄向红,等.骨科钛板表面Ti O2纳米管阵列/MCM-41分子筛复合型药物载体的构建及负载阿仑磷酸钠缓释性能研究[J].福建医药杂志,2017,39(1):57-61.
[37] HONG S,SHEN S,TAN DC,et al. High drug load,stable,manufacturable and bioavailable fenofibrate formulations in mesoporous silica:a comparison of spray drying versus solvent impregnation methods[J]. Drug Deliv,2014,23(1):316-327.
[38] SUN WJ,王盈.利用介孔二氧化硅制备小剂量药物片剂[J].中国医药工业杂志,2018,49(6):773.
[2]张海东.药物在有序介孔氧化硅纳米孔道中组装与控缓释研究进展[J].材料导报,2009,23(15):88-91.
[3] VALLET-REGM,IZQUIERDO-BARBA I,RMILA A,et al.Phosphorous-doped MCM-41 as bioactive material[J]. Solid State Sci,2005,7(2):233-237.
[4] MORITZ M,GESZKE-MORITZ M,Mesoporous materials as multifunctional tools in biosciences:principles and applications[J]. Mater Sci Eng,2015,49:114-151.
[5]王炎,郑旭翰,姜兆平.有序介孔硅材料在生物医药领域中的应用[J].化学进展,2006,18(10):1345.
[6]许磊,王公慰,魏迎旭,等. MCM-41介孔分子筛合成研究Ⅰ.水热合成法[J].催化学报,1999,20(3):247-250.
[7]曹渊,白英豪,夏之宁,等.硅基介孔材料在药物缓控释中的应用[J].中国药学杂志,2009,44(7):481-484.
[8]王振兴,丁士文,张美红,等.自组装合成纳米复合Ti O2-ZnO介孔材料及其光催化性能[J].化学学报,2005(3):243-248.
[9]施益峰.纳米浇铸法合成有序介孔高温陶瓷材料及金属硫化物、氮化物材料[D].上海:复旦大学,2007.
[10]刘治刚.纳米介孔分子筛用于吡格列酮长效缓释的研究[J].化工技术与开发,2013,42(11):24-26.
[11] JIA LJ,SHEN JY,LI ZY,et al. Successfully tailoring the pore size of mesoporous silica nanoparticles:Exploitation of delivery systems for poorly water-soluble drugs[J]. Int J Pharm,2012,439(1-2):81-91.
[12] SUMERLIN N,QU Z,PUJARA N,et al. Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol[J]. Colloids Surf B,2016,144:1-7.
[13] BRIGO L,SCOMPARIN E,et al. Mesoporous silica sub-micron spheres as drug dissolution enhancers:influence of drug and matrix chemistry on functionality and stability[J]. Mater Sci Eng C,2016,59:585-593.
[14] AZAIS T,TOURNE-PETEILH C,AUSSENAC F,et al. Solidstate NMR study of Ibuprofen Confmed in MCM-41 Material[J].Chem Mater,2006,18(26):6382-6390.
[15] HORCAJADA P,RAMILA A,et al. Influence of superficial organic modification of MCM-41 matrices on drug delivery rate.[J]. Solid State Sci,2006,8(10):1243-1249.
[16] IZQUIERDO-BARBA I,MARTINEZ,DOADRIO AL,et al.Release evaluation of drugs from ordered three-dimensional silica structures[J]. Eur J Pharm Sci,2005,26(5):365-373.
[17]王明启.磁性介孔氧化硅纳米颗粒载带短链核酸和蛋白药物及其生物医学应用[D].上海:上海交通大学,2013.
[18] GOSCIANSKA J,OLEJNIK A,PIETRZAK R. In vitro release of l-phenylalanine from ordered mesoporous materials[J]. Microporous and Mesoporous Mater,2013,177(complete):32-36.
[19] MARTIN A,GARCIA RA,KARAMAN DS,et al. Polyethyleneimine-functionalized large pore ordered silica materials for poorly water-soluble drug delivery[J]. J Mater Sci,2014,49(3):1437-1447.
[20]翟婷婷.介孔纳米硅材料负载难溶性药物的制备及优化[D].天津:天津大学,2014.
[21]田儒楠,郝凤奇,李景梅.氨丙基修饰M41作为胰岛素的缓释载体[J].吉林大学学报(理学版),2015,53(5):1039-1044.
[22] GOSCIANSKA A,OLEJNIK A,NOWAK I. APTES-functionalized mesoporous silica as a vehicle for antipyrine-adsorption and release studies[J]. Colloids Surf A,2017,533:187-196.
[23]林粤顺,周红军,周新华,等. pH值响应性毒死蜱/铜席夫碱配合物改性SBA-15的制备及缓释性能[J].无机化学学报,2017,33(3):446-454.
[24] HEIDEGGER S,GL D,SCHMIDT A,et al. Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery[J]. Nanoscale,2016(8):938-948.
[25]张凌宇.基于介孔二氧化硅多功能纳米材料的制备及生物应用[D].长春:东北师范大学,2015.
[26] GIRI S,BRIAN G,TREWYN S,et al. Stimuli-responsive controlled-release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles[J]. Angew Chem Int Edit,2005,44(32):5038-5044.
[27] CHEN Y,Yang W,et al. In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation[J]. Eur J,2013,85(3):406-412.
[28] DARVISHI B,FARAHMAND L,MAJIDZADEHA K. Stimuliresponsive mesoporous silica NPs as non-viral dual siRNA/chemotherapy carriers for triple negative breast cancer[J]. Mol Ther Nucl Acids,2017,7:164-180.
[29] CHENG SH,LI FC,SOURIS JS,et al. Visualizing dynamics of sub-hepatic distribution of nanoparticles using intravital multiphoton fluorescence microscopy[J]. ACS Nano,2016,6(5):4122-4131.
[30]李艳艳.阿莫西林/MCM-41载药体系的缓释作用研究[D].长春:长春理工大学,2012.
[31]刘治刚,王建刚,于世华,等. MCM-41的制备及用于吡拉西坦缓释性能研究[J].化工科技,2013,21(6):42-44.
[32] JIA L,SHEN J,Li Z,et al. In vitro and in vivo evaluation of paclitaxel-loaded mesoporous silica nanoparticles with three pore sizes[J]. Inter J Pharm,2013,445(1-2):12-19.
[33] HONG S,SHEN S,TAN DC,et al. High drug load,stable,manufacturable and bioavailable fenofibrate formulations in mesoporous silica:a comparison of spray drying versus solvent impregnation methods[J]. Drug Deliv,2016,23(1):316-327.
[34] ZHANG Y,ZHANG H,CHE E,et al. Development of novel mesoporous nanomatrix-supported lipid bilayers for oral sustained delivery of the water-insoluble drug,lovastatin[J]. Colloids Surf B,2015,128:77-85.
[35] ABD-ELRAHMAN AA,EL-NABARAWI MA,HASSAN DH,et al. Ketoprofen mesoporous silica nanoparticles SBA-15 hard gelatin capsules:preparation and in vitro/in vivo characterization[J]. Drug Deliv,2016,23(9):3387-3398.
[36]林妙阔,黄尔丹,黄向红,等.骨科钛板表面Ti O2纳米管阵列/MCM-41分子筛复合型药物载体的构建及负载阿仑磷酸钠缓释性能研究[J].福建医药杂志,2017,39(1):57-61.
[37] HONG S,SHEN S,TAN DC,et al. High drug load,stable,manufacturable and bioavailable fenofibrate formulations in mesoporous silica:a comparison of spray drying versus solvent impregnation methods[J]. Drug Deliv,2014,23(1):316-327.
[38] SUN WJ,王盈.利用介孔二氧化硅制备小剂量药物片剂[J].中国医药工业杂志,2018,49(6):773.