朊蛋白与神经变性病传播
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摘要
<正>近年来,朊蛋白(PrP)与神经变性病传播是此类疾病发病机制研究的一个关注点。目前认为,神经变性病是由于多种蛋白质构象改变所致,而特定的空间构象是蛋白质发挥其生物学功能的结构基础,对朊蛋白病(PrD)的研究业已发现,蛋白质的氨基酸序列虽未改变,但其空间结构或构象改变也能诱
引文
[1]Prusiner SB.Biology and genetics of prions causingneurodegeneration.Annu Rev Genet,2013,47:601-623.
[2]Hong T.Infectious and non-infectious dementia:Prion andAlzheimer's disease.Beijing:Science Press,2011:53-95.[洪涛.传染性与非传染性痴呆症:朊病毒病与阿尔茨海默病.北京:科学出版社,2011:53-95.]
[3]de Calignon A,Polydoro M,Suárez-Calvet M,William C,Adamowicz DH,Kopeikina KJ,Pitstick R,Sahara N,Ashe KH,Carlson GA,Spires-Jones TL,Hyman BT.Propagation of taupathology in a model of early Alzheimer's disease.Neuron,[2012,73:685-697.
[4]Manuelidis L.Infectious particles,stress,and induced prionamyloids:a unifying perspective.Virulence,2013,4:373-383.
[5]Liu L,Drouet V,Wu JW,Witter MP,Small SA,Clelland C,Duff K.Trans-synaptic spread of tau pathology in vivo.PLoSOne,2012,7:E31302.
[6]Luk KC,Lee VM.Modeling Lewy pathology propagation inParkinson's disease.Parkinsonism Relat Disord,2014,20Suppl 1:85-87.
[7]Watts JC,Giles K,Oehler A,Middleton L,Dexter DT,Gentleman SM,DeArmond SJ,Prusiner SB.Transmission ofmultiple system atrophy prions to transgenic mice.Proc NatlAcad Sci USA,2013,110:19555-19560.
[8]Hatzipetros T,Bogdanik LP,Tassinari VR,Kidd JD,MorenoAJ,Davis C,Osborne M,Austin A,Vieira FG,Lutz C,PerrinS.C57BL/6J congenic Prp-TDP43A315T mice developprogressive neurodegeneration in the myenteric plexus of thecolon without exhibiting key features of ALS.Brain Res,2013.[Epub ahead of print]
[9]Halliday M,Mallucci GR.Targeting the unfolded proteinresponse in neurodegeneration:a new approach to therapy.Neuropharmacology,2014,76 Pt A:169174.
[10]SikováZ.How structure shapes(dys)function:a perspective tounderstanding brain region-specific degeneration in priondisease.Prion,2013,7:291-293.
[11]Hallbeck M,Nath S,Marcusson J.Neuron-to-neurontransmission of neurodegenerative pathology.Neuroscientist,2013,19:560-566.
[12]Ordóez-Gutiérrez L,Torres JM,Gavín R,Antón M,Arroba-Espinosa AI,Espinosa JC,Vergara C,Del Río JA,WandosellF.Cellular prion protein modulatesβ-amyloid deposition inaged APP/PS1 transgenic mice.Neurobiol Aging,2013,34:2793-2804.
[13]Costanzo M,Zurzolo C.The cell biology of prion-like spread ofprotein aggregates:mechanisms and implication inneurodegeneration.Biochem J,2013,452:1-17.
[14]Lin Z,Zhao D,Yang L.Interaction between misfolded PrP andthe ubiquitin-proteasome system in prion-mediatedneurodegeneration.Acta Biochim Biophys Sin(Shanghai),2013,45:477-484.
[15]Olanow CW,Brundin P.Parkinson's disease and alphasynuclein:is Parkinson's disease a prion-like disorder?MovDisord,2013,28:31-40.
[16]Masuda-Suzukake M,Nonaka T,Hosokawa M,Oikawa T,AraiT,Akiyama H,Mann DM,Hasegawa M.Prion-like spreading ofpathologicalα-synuclein in brain.Brain,2013,136(Pt 4):1128-1138.
[17]Hilton KJ,Cunningham C,Reynolds RA,Perry VH.Earlyhippocampal synaptic loss precedes neuronal loss andassociates with early behavioural deficits in three distinct
[18]strains of prion disease.PLoS One,2013,8:E68062.Mohamed NV,Herrou T,Plouffe V,Piperno N,Leclerc N.Spreading of tau pathology in Alzheimer's disease by cell-to-
[19]cell transmission.Eur J Neurosci,2013,37:1939-1948.Clavaguera F,Akatsu H,Fraser G,Crowther RA,Frank S,Hench J,Probst A,Winkler DT,Reichwald J,Staufenbiel M,Ghetti B,Goedert M,Tolnay M.Brain homogenates from humantauopathies induce tau inclusions in mouse brain.Proc NatlAcad Sci USA,2013,110:9535-9540.
[20]Spillantini MG,Goedert M.Tau pathology andneurodegeneration.Lancet Neurol,2013,12:609-622.
[21]Verma A.Protein aggregates and regional disease spread inALS is reminiscent of prion-like pathogenesis.Neurol India,2013,61:107-110.
[22]Costanzo M,Zurzolo C.The cell biology of prion-like spread ofprotein aggregates:mechanisms and implication in
[23]neurodegeneration.Biochem J,2013,452:1-17.Natale G,Pompili E,Biagioni F,Paparelli S,Lenzi P,Fornai F.Histochemical approaches to assess cell-to-cell transmission ofmisfolded proteins in neurodegenerative diseases.Eur J[Histochem,2013,57:E5.
[24]Hofmann JP,Denner P,Nussbaum-Krammer C,Kuhn PH,Suhre MH,Scheibel T,Lichtenthaler SF,Schtzl HM,Bano D,Vorberg IM.Cell-to-cell propagation of infectious cytosolicprotein aggregates.Proc Natl Acad Sci USA,2013,110:5951-5956.2014-05-13
[2]Hong T.Infectious and non-infectious dementia:Prion andAlzheimer's disease.Beijing:Science Press,2011:53-95.[洪涛.传染性与非传染性痴呆症:朊病毒病与阿尔茨海默病.北京:科学出版社,2011:53-95.]
[3]de Calignon A,Polydoro M,Suárez-Calvet M,William C,Adamowicz DH,Kopeikina KJ,Pitstick R,Sahara N,Ashe KH,Carlson GA,Spires-Jones TL,Hyman BT.Propagation of taupathology in a model of early Alzheimer's disease.Neuron,[2012,73:685-697.
[4]Manuelidis L.Infectious particles,stress,and induced prionamyloids:a unifying perspective.Virulence,2013,4:373-383.
[5]Liu L,Drouet V,Wu JW,Witter MP,Small SA,Clelland C,Duff K.Trans-synaptic spread of tau pathology in vivo.PLoSOne,2012,7:E31302.
[6]Luk KC,Lee VM.Modeling Lewy pathology propagation inParkinson's disease.Parkinsonism Relat Disord,2014,20Suppl 1:85-87.
[7]Watts JC,Giles K,Oehler A,Middleton L,Dexter DT,Gentleman SM,DeArmond SJ,Prusiner SB.Transmission ofmultiple system atrophy prions to transgenic mice.Proc NatlAcad Sci USA,2013,110:19555-19560.
[8]Hatzipetros T,Bogdanik LP,Tassinari VR,Kidd JD,MorenoAJ,Davis C,Osborne M,Austin A,Vieira FG,Lutz C,PerrinS.C57BL/6J congenic Prp-TDP43A315T mice developprogressive neurodegeneration in the myenteric plexus of thecolon without exhibiting key features of ALS.Brain Res,2013.[Epub ahead of print]
[9]Halliday M,Mallucci GR.Targeting the unfolded proteinresponse in neurodegeneration:a new approach to therapy.Neuropharmacology,2014,76 Pt A:169174.
[10]SikováZ.How structure shapes(dys)function:a perspective tounderstanding brain region-specific degeneration in priondisease.Prion,2013,7:291-293.
[11]Hallbeck M,Nath S,Marcusson J.Neuron-to-neurontransmission of neurodegenerative pathology.Neuroscientist,2013,19:560-566.
[12]Ordóez-Gutiérrez L,Torres JM,Gavín R,Antón M,Arroba-Espinosa AI,Espinosa JC,Vergara C,Del Río JA,WandosellF.Cellular prion protein modulatesβ-amyloid deposition inaged APP/PS1 transgenic mice.Neurobiol Aging,2013,34:2793-2804.
[13]Costanzo M,Zurzolo C.The cell biology of prion-like spread ofprotein aggregates:mechanisms and implication inneurodegeneration.Biochem J,2013,452:1-17.
[14]Lin Z,Zhao D,Yang L.Interaction between misfolded PrP andthe ubiquitin-proteasome system in prion-mediatedneurodegeneration.Acta Biochim Biophys Sin(Shanghai),2013,45:477-484.
[15]Olanow CW,Brundin P.Parkinson's disease and alphasynuclein:is Parkinson's disease a prion-like disorder?MovDisord,2013,28:31-40.
[16]Masuda-Suzukake M,Nonaka T,Hosokawa M,Oikawa T,AraiT,Akiyama H,Mann DM,Hasegawa M.Prion-like spreading ofpathologicalα-synuclein in brain.Brain,2013,136(Pt 4):1128-1138.
[17]Hilton KJ,Cunningham C,Reynolds RA,Perry VH.Earlyhippocampal synaptic loss precedes neuronal loss andassociates with early behavioural deficits in three distinct
[18]strains of prion disease.PLoS One,2013,8:E68062.Mohamed NV,Herrou T,Plouffe V,Piperno N,Leclerc N.Spreading of tau pathology in Alzheimer's disease by cell-to-
[19]cell transmission.Eur J Neurosci,2013,37:1939-1948.Clavaguera F,Akatsu H,Fraser G,Crowther RA,Frank S,Hench J,Probst A,Winkler DT,Reichwald J,Staufenbiel M,Ghetti B,Goedert M,Tolnay M.Brain homogenates from humantauopathies induce tau inclusions in mouse brain.Proc NatlAcad Sci USA,2013,110:9535-9540.
[20]Spillantini MG,Goedert M.Tau pathology andneurodegeneration.Lancet Neurol,2013,12:609-622.
[21]Verma A.Protein aggregates and regional disease spread inALS is reminiscent of prion-like pathogenesis.Neurol India,2013,61:107-110.
[22]Costanzo M,Zurzolo C.The cell biology of prion-like spread ofprotein aggregates:mechanisms and implication in
[23]neurodegeneration.Biochem J,2013,452:1-17.Natale G,Pompili E,Biagioni F,Paparelli S,Lenzi P,Fornai F.Histochemical approaches to assess cell-to-cell transmission ofmisfolded proteins in neurodegenerative diseases.Eur J[Histochem,2013,57:E5.
[24]Hofmann JP,Denner P,Nussbaum-Krammer C,Kuhn PH,Suhre MH,Scheibel T,Lichtenthaler SF,Schtzl HM,Bano D,Vorberg IM.Cell-to-cell propagation of infectious cytosolicprotein aggregates.Proc Natl Acad Sci USA,2013,110:5951-5956.2014-05-13