少肌症的早期筛查与干预
摘要
少肌症(Sarcopenia)是一种以肌肉质量、肌肉力量以及肌肉功能下降为主要特征的中老年人高发病征,发病率随着年龄增长而增高~([1])。在亚洲,使用不同的sarcopenia的诊断标准,sarcopenia的患病率为2.5%～45.7%不等~([2])。在欧洲使用最低流行率估计的定义,sarcopenia的患病率为11.1%~([3])。在国际研究中,80岁以上老年人sarcopenia的患病率最高可达50%~([4])。sarcopenia的预后不良,若能早期发现可疑患者,及时进行干预,将能有效地节省资源和经费,促进中老年人的生活质量的提高。因此,本文对sarcopenia的早期筛查和干预的研究进展进行综述,分析其优劣势,寻找可靠实用的方法,以期寻找适用于国内中老年人群sarcopenia的早期筛查和干预方法。
引文
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[5]Kyung Mook Choi.Sarcopenia and Sarcopenic Obesity[J].Endocrinology and Metabolism,2013,28(2):86-89.
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[7]薛瑜,王鸥,邢小平.肌少症筛查工具[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(5):483-490.
[8]Malmstrom T K,Morley J E.SARC-F:A SimpleQuestionnaire to Rapidly Diagnose Sarcopenia[J].Journal of the American Medical Directors Association,2013,14(8):531-532.
[9]Bahat G,Yilmaz O,Kili C,et al.Performance of Sarc-F in Regard to Sarcopenia Definitions,Muscle Mass and Functional Measures[J].Journal of Nutrition Health&Aging,2018,22(8):898-903.
[10]Kemmler W,Sieber C,Freiberger E,et al.The SARC-FQuestionnaire:Diagnostic Overlap with Established Sarcopenia Definitions in Older German Men with Sarcopenia[J].Gerontology,2017,63(5):411-416.
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[15]Chumlea W C,Cesari M,Evans W J,et al.International working group on Sarcopenia[J].Journal of Nutrition Health&Aging,2011,15(6):450-455.
[16]游杰,薄亚聪,王萌萌,等.BMI诊断某社区汉族老年人肌肉衰减综合征的价值[J].郑州大学学报(医学版),2017,52(2):201-204.
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[22]Marina Mourtzakis,Carla M.M.Prado,Jessica R.Lieffers,et al.A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care[J].Applied Physiology Nutrition and Metabolism,2008,33(5):997-1006.
[23]韦朝联,陈俊强.L3骨骼肌质量指数对胃癌患者营养风险评估及预后影响的研究[D].广西:广西医科大学,2015.
[24]Santos V,Gomes I C,Bueno D R,et al.Obesity,sarcopenia,sarcopenic obesity and reduced mobility in Brazilian older people aged 80 years and over.[J].Einstein,2017,15(4):435-440.
[25]Aggio D A,Sartini C,Papacosta O,et al.P135 Association of objectively measured physical activity and sedentary time with sarcopenia,severe sarcopenia and sarcopenic obesity in older men[J].Journal of Epidemiology&Community Health,2016,70(Suppl 1):A113.1-A113.
[26]Bann D,Chen H,Bonell C,et al.Socioeconomic differences in the benefits of structured physical activity compared with!!!!!!!!!!!!!!!!!!!!!!healtheducationonthepreventionofmajormobilitydisability inolder adults:the LIFE study[J].Journal ofEpidemiology&Community Health,2016,70(9):930-933.
[27]Trouwborst I,Verreijen A,Memelink R,et al.Exercise and Nutrition Strategies to Counteract Sarcopenic Obesity[J].Nutrients,2018,10(5):605.
[28]Chen,Hung‐Ting,Chung,Yu‐Chun,Chen,Yu‐Jen,et al.Effects of Different Types of Exercise on Body Composition,Muscle Strength,and IGF‐1 in the Elderly with Sarcopenic Obesity[J].Journal of the AmericanGeriatrics Society,2017,65(4):827-832.
[29]赵永军,张育民,郭艳花.抗阻运动与推拿防治骨骼肌衰减征研究进展[J].中国老年学杂志,2017,37(2):509-513.
[30]徐韬.老年人少肌症与营养治疗进展[J].《中国老年保健医学》杂志,2017,15(2):71-72.
[31]Carliene van Dronkelaar MSc,Aafke?van Velzen BSc,Maya Abdelrazek?BSc,et al.Minerals and Sarcopenia;The Role of Calcium,Iron,Magnesium,Phosphorus,Potassium,Selenium,Sodium,and Zinc on Muscle Mass,Muscle Strength,and Physical Performance in Older Adults:A Systematic Review[J].Journal of the American Medical Directors Association,2018,19(1):6-11.
[32]Cruz-Jentoft AJ,Landi F,Schneider SM,et al.Prevalence of and interventions for sarcopenia in ageing adults:a systematic review.Report of the International Sarcopenia Initiative(EWGSOP andIWGS)[J].Age Ageing,2014,43(6):748-759
[33]Rossi A P,D'Introno A,Rubele S,et al.The Potential ofβ-Hydroxy-β-Methylbutyrate as a New Strategy for the Management of Sarcopenia and Sarcopenic Obesity[J].Drugs&Aging,2017,34(11):1-8.
[34]Carlienevan Dronkelaar?MSc,Aafkevan VelzenBSc,Maya Abdelrazek BSc,et al.Minerals and Sarcopenia;The Role of Calcium,Iron,Magnesium,Phosphorus,Potassium,Selenium,Sodium,and Zinc on Muscle Mass,MuscleStrength,and Physical Performance in Older Adults:ASystematic Review[J].Journal of the American Medical Directors Association,2018,19(1):6-11.
[35]夏维波,付勤,王鸥,等.肌少症治疗进展与趋势[J].中华骨质疏松和骨矿盐疾病杂志,2016,9(3):251-256.
[36]Garcia-Contreras C,Vazquez-Gomez M,Torres-Rovira L,etal.Characterization of Ageing-and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity[J].International Journal of Molecular Sciences,2018,19(3):823.
[37]Batsis JA,Villareal DT.?Sarcopenic obesity in older adults:aetiology,?epidemiology and treatment strategies[J].Nature Reviews.Endocrinology,?2018,14(9):513-537.
[38]Nieschlag E.Current topics in testosterone replacement of hypogonadal men[J].Best Pract Res Clin Endocrinol Metab,2015,29:77-90.
[39]Kemmler w,Teschler M,weissenfels A,willert S,Bebenek M,von Stengel S.Whole-Body EMS to Fight Sarcopenic Obesitya Review with Emphasis on Body Fat[J].Dtsch Z Sportmed.2017,68:170-177.
[40]Kemmler W,Teschler M,Weissenfels A,et al.Wholebody electromyostimulation to fight sarcopenic obesity in community dwelling older women at risk.Results of the randomized controlledFORMOsAsarcopenic obesity study[J].Osteoporosis International,2016,27(11):1-10.
[41]Wittmann K,Sieber C,Von Stengel S,et al.Impact of whole body electromyostimulation on cardiometabolic risk factors in older women with sarcopenic obesity:the randomized controlled FORMOsAsarcopenic obesity study.[J].Clinical Interventions in Aging,2016,11:1697-1706.
[2]Wu Y H,Hwang A C,Liu L K,et al.Sex differences of sarcopenia in Asian populations:The implications in diagnosis and management[J].Journal of Clinical Gerontology&Geriatrics,2016,7(2):37-43.
[3]Ethgen O,Beaudart C,Buckinx F,et al.The Future Prevalence of Sarcopenia in Europe:A Claim for Public Health Action[J].CalcifiedTissueInternational,2017,100(3):1-6.
[4]Murray Té,Williams D,Lee M J.Erratum to:Osteoporosis obesity,and sarcopenia on abdominal CT:a review of epidemiology,diagnostic criteria,and management strategiesforthereportingradiologist[J].Abdominal Radiology,2017(2045):1-1.
[5]Kyung Mook Choi.Sarcopenia and Sarcopenic Obesity[J].Endocrinology and Metabolism,2013,28(2):86-89.
[6]Anker S D,Morley J E,Von H S.Welcome to the ICD-10code for sarcopenia.[J].Journal of Cachexia Sarcopenia&Muscle,2016,7(5):512-514.
[7]薛瑜,王鸥,邢小平.肌少症筛查工具[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(5):483-490.
[8]Malmstrom T K,Morley J E.SARC-F:A SimpleQuestionnaire to Rapidly Diagnose Sarcopenia[J].Journal of the American Medical Directors Association,2013,14(8):531-532.
[9]Bahat G,Yilmaz O,Kili C,et al.Performance of Sarc-F in Regard to Sarcopenia Definitions,Muscle Mass and Functional Measures[J].Journal of Nutrition Health&Aging,2018,22(8):898-903.
[10]Kemmler W,Sieber C,Freiberger E,et al.The SARC-FQuestionnaire:Diagnostic Overlap with Established Sarcopenia Definitions in Older German Men with Sarcopenia[J].Gerontology,2017,63(5):411-416.
[11]Cruzjentoft A J,Baeyens J P,Bauer J M,et al.Sarcopenia:European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People[J].Age&Ageing,2010,39(4):412-423.
[12]Studenski S A,Peters K W,Alley D E,et al.The FNIHSarcopenia Project:Rationale,Study Description,Conference Recommendations,and Final Estimates[J].Journals of Gerontology,2014,69(5):547-558.
[13]Chen L K,Liu L K,Woo J,et al.Sarcopenia in Asia:Consensus Report of the Asian Working Group for Sarcopenia[J].Journal of the American Medical Directors Association,2014,15(2):95-101.
[14]CM Santos,JMD Dias,GAR Samora,et al.?Prevalence of obesity,sarcopenic obesity andassociated factors:A FIBRANetwork study[J].Fisioterapia em Movimento,2017,30(1):161-169.
[15]Chumlea W C,Cesari M,Evans W J,et al.International working group on Sarcopenia[J].Journal of Nutrition Health&Aging,2011,15(6):450-455.
[16]游杰,薄亚聪,王萌萌,等.BMI诊断某社区汉族老年人肌肉衰减综合征的价值[J].郑州大学学报(医学版),2017,52(2):201-204.
[17]Steffl M,Chrudimsky J,Tufano J J.Using relative handgrip strength to identify children at risk of sarcopenic obesity[J].Plos One,2017,12(5):e0177006.
[18]Goodman M J,Ghate S R,Panagiotis M,et al.Development of a practical screening tool to predict low muscle mass using NHANES 1999-2004[J].Journal of Cachexia Sarcopenia&Muscle,2013,4(3):187-197.
[19]周仙杰,李军,鲁飞翔,等.肌肉衰减综合征诊断标准及诊断指标测量方法研究进展[J].山东医药,2016,56(27):107-109.
[20]Timothyé.Murray,WilliamsD,LeeMJ.Osteoporosis,obesity,and sarcopenia on abdominal CT:a review of epidemiology,diagnostic criteria,and management strategies for the reporting radiologist[J].Abdominal Radiology,2017,42(2045):1-11.
[21]曹平,姚佳,朱娜,等.肌肉减少症评价肝硬化患者营养状况及其影响因素[J].中国药物与临床,2017,17(12):1737-1739.
[22]Marina Mourtzakis,Carla M.M.Prado,Jessica R.Lieffers,et al.A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care[J].Applied Physiology Nutrition and Metabolism,2008,33(5):997-1006.
[23]韦朝联,陈俊强.L3骨骼肌质量指数对胃癌患者营养风险评估及预后影响的研究[D].广西:广西医科大学,2015.
[24]Santos V,Gomes I C,Bueno D R,et al.Obesity,sarcopenia,sarcopenic obesity and reduced mobility in Brazilian older people aged 80 years and over.[J].Einstein,2017,15(4):435-440.
[25]Aggio D A,Sartini C,Papacosta O,et al.P135 Association of objectively measured physical activity and sedentary time with sarcopenia,severe sarcopenia and sarcopenic obesity in older men[J].Journal of Epidemiology&Community Health,2016,70(Suppl 1):A113.1-A113.
[26]Bann D,Chen H,Bonell C,et al.Socioeconomic differences in the benefits of structured physical activity compared with!!!!!!!!!!!!!!!!!!!!!!healtheducationonthepreventionofmajormobilitydisability inolder adults:the LIFE study[J].Journal ofEpidemiology&Community Health,2016,70(9):930-933.
[27]Trouwborst I,Verreijen A,Memelink R,et al.Exercise and Nutrition Strategies to Counteract Sarcopenic Obesity[J].Nutrients,2018,10(5):605.
[28]Chen,Hung‐Ting,Chung,Yu‐Chun,Chen,Yu‐Jen,et al.Effects of Different Types of Exercise on Body Composition,Muscle Strength,and IGF‐1 in the Elderly with Sarcopenic Obesity[J].Journal of the AmericanGeriatrics Society,2017,65(4):827-832.
[29]赵永军,张育民,郭艳花.抗阻运动与推拿防治骨骼肌衰减征研究进展[J].中国老年学杂志,2017,37(2):509-513.
[30]徐韬.老年人少肌症与营养治疗进展[J].《中国老年保健医学》杂志,2017,15(2):71-72.
[31]Carliene van Dronkelaar MSc,Aafke?van Velzen BSc,Maya Abdelrazek?BSc,et al.Minerals and Sarcopenia;The Role of Calcium,Iron,Magnesium,Phosphorus,Potassium,Selenium,Sodium,and Zinc on Muscle Mass,Muscle Strength,and Physical Performance in Older Adults:A Systematic Review[J].Journal of the American Medical Directors Association,2018,19(1):6-11.
[32]Cruz-Jentoft AJ,Landi F,Schneider SM,et al.Prevalence of and interventions for sarcopenia in ageing adults:a systematic review.Report of the International Sarcopenia Initiative(EWGSOP andIWGS)[J].Age Ageing,2014,43(6):748-759
[33]Rossi A P,D'Introno A,Rubele S,et al.The Potential ofβ-Hydroxy-β-Methylbutyrate as a New Strategy for the Management of Sarcopenia and Sarcopenic Obesity[J].Drugs&Aging,2017,34(11):1-8.
[34]Carlienevan Dronkelaar?MSc,Aafkevan VelzenBSc,Maya Abdelrazek BSc,et al.Minerals and Sarcopenia;The Role of Calcium,Iron,Magnesium,Phosphorus,Potassium,Selenium,Sodium,and Zinc on Muscle Mass,MuscleStrength,and Physical Performance in Older Adults:ASystematic Review[J].Journal of the American Medical Directors Association,2018,19(1):6-11.
[35]夏维波,付勤,王鸥,等.肌少症治疗进展与趋势[J].中华骨质疏松和骨矿盐疾病杂志,2016,9(3):251-256.
[36]Garcia-Contreras C,Vazquez-Gomez M,Torres-Rovira L,etal.Characterization of Ageing-and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity[J].International Journal of Molecular Sciences,2018,19(3):823.
[37]Batsis JA,Villareal DT.?Sarcopenic obesity in older adults:aetiology,?epidemiology and treatment strategies[J].Nature Reviews.Endocrinology,?2018,14(9):513-537.
[38]Nieschlag E.Current topics in testosterone replacement of hypogonadal men[J].Best Pract Res Clin Endocrinol Metab,2015,29:77-90.
[39]Kemmler w,Teschler M,weissenfels A,willert S,Bebenek M,von Stengel S.Whole-Body EMS to Fight Sarcopenic Obesitya Review with Emphasis on Body Fat[J].Dtsch Z Sportmed.2017,68:170-177.
[40]Kemmler W,Teschler M,Weissenfels A,et al.Wholebody electromyostimulation to fight sarcopenic obesity in community dwelling older women at risk.Results of the randomized controlledFORMOsAsarcopenic obesity study[J].Osteoporosis International,2016,27(11):1-10.
[41]Wittmann K,Sieber C,Von Stengel S,et al.Impact of whole body electromyostimulation on cardiometabolic risk factors in older women with sarcopenic obesity:the randomized controlled FORMOsAsarcopenic obesity study.[J].Clinical Interventions in Aging,2016,11:1697-1706.