中药对肠道菌群的调节作用
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摘要
肠道菌群作为人体庞大的微生态系统与许多疾病的发生密切相关。临床研究和动物实验表明,中药可维持肠道微生态的平衡,对肠道菌群的调节作用也逐渐被阐释。该文通过归纳总结近5年来的文献,以中药对肠道菌群的调节作用为线索,从肠道菌群的研究方法和中药有效成分、提取物及复方调节肠道菌群的相关研究等方面进行了综述,为中药在肠道菌群调节方面的研究与开发提供参考。
As a large micro-ecosystem in the human body,the intestinal microbiota is closely associated with the occurrence of many diseases.The clinical investigations and animal experiments have showed that traditional Chinese medicine(TCM) could maintain the balance of the intestinal micro-ecological system.This review summarized the research methods and literatures on the regulation effects of TCM,including different effective ingredients,extracts and Chinese herbal formulae,on intestinal microflora in recent five years,in order to provide a reference for the further research and development of TCM.
As a large micro-ecosystem in the human body,the intestinal microbiota is closely associated with the occurrence of many diseases.The clinical investigations and animal experiments have showed that traditional Chinese medicine(TCM) could maintain the balance of the intestinal micro-ecological system.This review summarized the research methods and literatures on the regulation effects of TCM,including different effective ingredients,extracts and Chinese herbal formulae,on intestinal microflora in recent five years,in order to provide a reference for the further research and development of TCM.
引文
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[11]何梦晓,蔡海莹,毛悦.茶多酚和茶皂素对感染鸡球虫肉仔鸡生长性能、肠道微生物和抗氧化性能的影响[J].扬州大学学报:农业与生命科学版,2017,38(2):32.
[12]张蔚,江曙,钱大玮,等.芒柄花苷与人体肠道细菌的相互作用研究[J].药学学报,2014,49(8):1162.
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[15]Xie M,Chen G,Wan P,et al.Modulating effects of dicaffeoylquinic acids from Ilex Kudingcha on intestinal microecology in vitro[J].J Agr Food Chem,2017,65(47):10185.
[16]Zhang X,Zhao Y,Xu J,et al.Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats[J].Sci Rep,2015,5(6):14405.
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[20]Yan H,Lu J,Wang Y,et al.Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats[J].Phytomedicine,2017,26:45.
[21]Shi L L,Li Y,Wang Y,et al.MDG-1,an ophiopogon polysaccharide,regulate gut microbiota in high-fat diet-induced obese C57BL/6 mice[J].Int J Biol Macromol,2015,81:576.
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[23]何旭云,贺姣姣,郑宁宁,等.黄芪多糖对肥胖小鼠的减肥作用与调节肠道菌群的关系研究[J].世界中医药,2016,11(11):2379.
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[26]张在强,邓晓东,石莹,等.夹江石斛多糖提取物对小鼠肠道菌群的影响研究[J].现代预防医学,2017,44(1):57.
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