血清药理学方法对药理、药效学和新药研发的贡献
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摘要
背景:对于复杂成分药物,尤其是复方中药,国内外诸多学者采用血清药理学方法进行药效评价及相关作用机制的研究,推动了药理药效学研究进展以及血清药理学技术方法本身的不断规范与完善。目的:对最近几年来中药血清药理学方法在各领域研究中的广泛应用作以综述,并对血清药理学方法的优势和不足进行评价。方法:应用计算机检索Pub Med数据库、中国知网数据库2012年1月至2017年6月发表的与血清药理学方法学相关,或采研究方法中应用了含药血清的研究,检索词为"血清药理学,含药血清,serum pharmacology,medicated serum,drug-containing serum"。依据纳入排除标准筛选检索到的2 977篇文献,共纳入58篇并分析。结果与结论:血清药理学方法可以较好地反映药物的药效及其作用环境,有助于研究中药药效物质及其在体内的过程,因此已被众多学者和专家所采用。近年来对血清供体、给药剂量、频次方案、血清采集、处理保存、加药比例等研究方案的探索优化中取得了显著进展,并已在心血管系统、呼吸系统、消化系统、神经系统、骨骼系统、泌尿系统、生殖系统、免疫系统、抗肿瘤、抗炎、抗菌、抗病毒等方向广泛应用,推动了药理学、药效学和新药研发等研究的发展进步。
BACKGROUND: Serum pharmacological methods have been used to evaluate the efficacy and related mechanisms of complex drug ingredients, especially Chinese herbal compounds, which promote the ongoing development of pharmacodynamics and serum pharmacological technologies. OBJECTIVE: To summarize the serum pharmacological methods applied in various fields, and to evaluate the advantages and disadvantages. METHODS: A computer-based retrieval of Pub Med and CNKI databases was performed for the articles related to serum pharmacology published from January 2012 to June 2017 with the keywords of "serum pharmacology, medicated serum, drug-containing serum" in English and Chinese, respectively. Totally 2 977 articles were collected and finally 58 eligible ones were included for result analysis according to the inclusion and exclusion criteria. RESULTS AND CONCLUSION: As serum pharmacology can reflect the efficacy and indications of medicines, and is helpful to study the effective compositions and in vivo course, it has been extensively used in various studies. In recent years, the studies on optimizing the serum donators, dosage, frequency, serum collection, serum storage and administration have achieved significant outcomes in the cardiovascular system, respiratory system, digestive system, nervous system, skeletal system, urinary system, reproductive system, immune system, anti-cancer, anti-inflammatory, antibacterial and antiviral treatments. Moreover, it is accompanied by the development of pharmacology, pharmacodynamics as well as new drug discovery
BACKGROUND: Serum pharmacological methods have been used to evaluate the efficacy and related mechanisms of complex drug ingredients, especially Chinese herbal compounds, which promote the ongoing development of pharmacodynamics and serum pharmacological technologies. OBJECTIVE: To summarize the serum pharmacological methods applied in various fields, and to evaluate the advantages and disadvantages. METHODS: A computer-based retrieval of Pub Med and CNKI databases was performed for the articles related to serum pharmacology published from January 2012 to June 2017 with the keywords of "serum pharmacology, medicated serum, drug-containing serum" in English and Chinese, respectively. Totally 2 977 articles were collected and finally 58 eligible ones were included for result analysis according to the inclusion and exclusion criteria. RESULTS AND CONCLUSION: As serum pharmacology can reflect the efficacy and indications of medicines, and is helpful to study the effective compositions and in vivo course, it has been extensively used in various studies. In recent years, the studies on optimizing the serum donators, dosage, frequency, serum collection, serum storage and administration have achieved significant outcomes in the cardiovascular system, respiratory system, digestive system, nervous system, skeletal system, urinary system, reproductive system, immune system, anti-cancer, anti-inflammatory, antibacterial and antiviral treatments. Moreover, it is accompanied by the development of pharmacology, pharmacodynamics as well as new drug discovery
引文
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