同型半胱氨酸和超敏C反应蛋白在急性冠脉综合征危险分层中的应用
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摘要
目的探讨血浆同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)水平在急性冠脉综合征(ACS)危险分层中的应用。方法病例组选取ACS患者71例,并按GRACE危险评分软件对其进行危险分层,另选取体检健康者89例作为健康对照组,检测Hcy和hs-CRP。结果 Hcy在各危险分层组与健康对照组之间差异均有统计学意义(P<0.05),但在各危险分层之间差异均无统计学意义(P>0.05);hs-CRP在中危组、高危组与健康对照组差异有统计学意义(P<0.05),低危组与健康对照组、中危组与高危组的差异无统计学意义(P>0.05),高危组与低危组、低危组与中危组的差异有统计学意义(P<0.05)。结论 Hcy和hs-CRP的检测在ACS的早期诊断中均具有一定参考意义,hs-CRP水平可以提示患者疾病的危险程度,但Hcy目前在此方面暂无显著的意义,仍需进一步深入的研究。
Objective To discuss the application of plasma homocysteine(Hcy) and high-sensitivity C-reactive protein(hs-CRP) levels in risk stratification of acute coronary syndrome(ACS).Methods 71 patients with ACS were included in disease group and subjected to risk stratification according to GRACE risk score software.Another 89 healthy people who had undergone physical examination served as health control group.Their plasma Hcy and hs-CRP were detected.Results Differences of plasma Hcy between each group of risk stratification and health control group demonstrated statistical significance(P<0.05),while there was no statistically significant difference among risk stratification groups(P>0.05).Differences of plasma hs-CRP between health control group and midium risk group or high risk group showed statistical significance(P<0.05),while there were no statistical significant differences in low risk group and the health control group,midium risk group and high risk group(P>0.05).Compared with high and low risk groups or low and midium risk groups,the differences between them were found to be statistically significant(P<0.05).Conclusion Hcy and hs-CRP detection both possess certain referential meaning in early diagnosis.Hs-CRP level may indicate risk degree of disease.However,Hcy currently shows no obvious significance in this respect and further thorough research should be undertaken.
Objective To discuss the application of plasma homocysteine(Hcy) and high-sensitivity C-reactive protein(hs-CRP) levels in risk stratification of acute coronary syndrome(ACS).Methods 71 patients with ACS were included in disease group and subjected to risk stratification according to GRACE risk score software.Another 89 healthy people who had undergone physical examination served as health control group.Their plasma Hcy and hs-CRP were detected.Results Differences of plasma Hcy between each group of risk stratification and health control group demonstrated statistical significance(P<0.05),while there was no statistically significant difference among risk stratification groups(P>0.05).Differences of plasma hs-CRP between health control group and midium risk group or high risk group showed statistical significance(P<0.05),while there were no statistical significant differences in low risk group and the health control group,midium risk group and high risk group(P>0.05).Compared with high and low risk groups or low and midium risk groups,the differences between them were found to be statistically significant(P<0.05).Conclusion Hcy and hs-CRP detection both possess certain referential meaning in early diagnosis.Hs-CRP level may indicate risk degree of disease.However,Hcy currently shows no obvious significance in this respect and further thorough research should be undertaken.
引文
[1]章结楼,叶山东.糖尿病视网膜病变危险因素分析[J].中国临床保健杂志,2008,11(3):249-251.
[2]邢艇,袁如玉.急性冠脉综合征患者GRACE评分与血运重建的相互关系[J].天津医科大学学报,2010,6:235-237.
[3]曾迎春,王立军,邹前福.临床诊断急性心肌梗死3个常用“金指标”的价值对比分析[J].医学检验杂志,2010,7(5):430-431.
[4]邓争荣,杨贵琦,陈新义.同型半胱氨酸与高血压病,冠心病的相关性[J].西安交通大学学报:医学版,2002,23(5):469-482.
[5]Tang EW,Wong CK,Herbison P,et al.Global Registry of Acute Coronary Events(GRACE)hospital discharge risk score accurate-ly predicts long-term mortality post acute coronary syndrome[J].Am Heart J,2007,153(1):29-35.
[6]吴梅君.超敏C-反应蛋白、同型半胱氨酸、D-二聚体水平与急性冠脉综合征的关系[J].浙江实用医学,2011,16(5):333-334.
[7]赵云慧,秦毅,刘相星.C-反应蛋白在急性冠脉综合征危险分层中的价值[J].中国煤炭工业医学杂志,2009,9(12):1482-1483.
[8]王琦武,唐建华,黄学成,等.急性冠脉综合征患者同型半胱氨酸水平及其与炎症关系的探讨[J].广西医学,2009,31(2):211-212.
[9]周晓云,杨海,陈远东,等.急性冠脉综合征与同型半胱氨酸、超敏C反应蛋白的相关性研究[J].临床医学,2011,24(6):3452.
[10]王宇.血浆同型半胱氨酸临床常用检测方法及影响因素[J].检验医学与临床,2010,7(24):2808-2810.
[11]Joseph J,Joseph L,Devi S,et al.Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and dias-tolic dysfunction[J].J Heart Lung Transplant,2008,27(11):1237-1241.
[2]邢艇,袁如玉.急性冠脉综合征患者GRACE评分与血运重建的相互关系[J].天津医科大学学报,2010,6:235-237.
[3]曾迎春,王立军,邹前福.临床诊断急性心肌梗死3个常用“金指标”的价值对比分析[J].医学检验杂志,2010,7(5):430-431.
[4]邓争荣,杨贵琦,陈新义.同型半胱氨酸与高血压病,冠心病的相关性[J].西安交通大学学报:医学版,2002,23(5):469-482.
[5]Tang EW,Wong CK,Herbison P,et al.Global Registry of Acute Coronary Events(GRACE)hospital discharge risk score accurate-ly predicts long-term mortality post acute coronary syndrome[J].Am Heart J,2007,153(1):29-35.
[6]吴梅君.超敏C-反应蛋白、同型半胱氨酸、D-二聚体水平与急性冠脉综合征的关系[J].浙江实用医学,2011,16(5):333-334.
[7]赵云慧,秦毅,刘相星.C-反应蛋白在急性冠脉综合征危险分层中的价值[J].中国煤炭工业医学杂志,2009,9(12):1482-1483.
[8]王琦武,唐建华,黄学成,等.急性冠脉综合征患者同型半胱氨酸水平及其与炎症关系的探讨[J].广西医学,2009,31(2):211-212.
[9]周晓云,杨海,陈远东,等.急性冠脉综合征与同型半胱氨酸、超敏C反应蛋白的相关性研究[J].临床医学,2011,24(6):3452.
[10]王宇.血浆同型半胱氨酸临床常用检测方法及影响因素[J].检验医学与临床,2010,7(24):2808-2810.
[11]Joseph J,Joseph L,Devi S,et al.Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and dias-tolic dysfunction[J].J Heart Lung Transplant,2008,27(11):1237-1241.