端粒酶抑制剂的研究进展
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摘要
端粒酶是一种具有逆转录酶活性的核糖核蛋白复合体,在90%的肿瘤细胞中特异性表达,能合成重复序列添至端粒末端,维持端粒长度,端粒酶可作为抗肿瘤药物作用的一个重要靶点。近年来,端粒酶抑制剂作为一种潜在的抗肿瘤药物,可以帮助人们更好的对抗癌症。因此,本文根据近几年的相关文献,探讨端粒酶抑制剂的最新研究进展,为进一步抗肿瘤药物的研究提供参考。
Telomerase is a ribonucleoprotein polymer with reverse transcriptase activity, specifically expressed in 90% of tumor cells, which can synthesize repeat sequences to the end of telomere and maintain telomere length.Telomerase can be used as an important target of anti-tumor drugs.In recent years, telomerase inhibitors as a potential anti-tumor drug, provide new prospects for the treatment of malignant tumors. Therefore, this article reviews the relevant literatures in recent years, discusses the latest research progress of telomerase inhibitors, and provides a reference for the further research of anti-tumor drugs.
Telomerase is a ribonucleoprotein polymer with reverse transcriptase activity, specifically expressed in 90% of tumor cells, which can synthesize repeat sequences to the end of telomere and maintain telomere length.Telomerase can be used as an important target of anti-tumor drugs.In recent years, telomerase inhibitors as a potential anti-tumor drug, provide new prospects for the treatment of malignant tumors. Therefore, this article reviews the relevant literatures in recent years, discusses the latest research progress of telomerase inhibitors, and provides a reference for the further research of anti-tumor drugs.
引文
[1]O’Sullivan RJ, Karlseder J. Telomeres:protecting chromosomes against genome instability[J]. Nat Rev Mol Cell Biol,2010, 11(3):171-181.
[2]赵相轩,温锋,卢再鸣.端粒酶调控放射敏感性在恶性肿瘤治疗中的作用进展[J].肿瘤,2018,(05):498-501.
[3]Doksani Y, Wu JY, de Lange T, Zhuang X. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation[J].Cell,2013,155:345-56.
[4]营孙阳,熊加秀,麦洪旭,等.端粒酶调控研究进展[J].遗传,2016,38(4):289-299.
[5]刘惠芬,李峰,彭东旭,等.端粒、端粒酶及靶向抗衰老研究[J].现代预防医学,2017(3).
[6]颜呈呈,张悦.端粒酶抑制剂伊美司他治疗骨髓增殖性肿瘤的研究进展与展望[J].国际输血及血液学杂志,2017,40(1):41-45.
[7]Shammas M, Koley H R, Neri P, et al.Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo[J]. Leukemia,2008, 22(7):1410-8.
[8]邵文嘉,王武亮.端粒酶抑制剂XAV939联合奈达铂对HeLa细胞增殖和凋亡的影响[J].中国妇幼保健,2014,29(19):3135-3138.
[9]王燕利.XAV939对卵巢癌SKOV3细胞的生长抑制及顺铂增敏作用[D].郑州大学,2016.
[10]陈青.靶向端粒酶的新型芳基2H吡唑的设计合成与抗癌活性筛选[D].安徽医科大学,2013.
[11]何旭.以hTERT为靶点设计合成的新型二氢吡唑类化合物抑制人肝癌细胞株SMMC-7721增殖的作用机制研究[D].安徽医科大学,2015.
[12]赵婷婷.吡唑—酰腙类化合物作为端粒酶抑制剂的设计、合成及生物活性评价[D].南京大学,2013.
[13]杜会茹,蒋翠岚,黄文杰,等.3,6-二氨基咔唑衍生物的合成及与DNA的相互作用[J].精细化工,2015,32(2):0-0.
[14]黄文杰,张彩凌,杜会茹.咔唑类化合物在抗肿瘤方面的研究进展[J].精细与专用化学品,2018(7).
[15]Chang C C, Wu J Y, Chang T C. A Carbazole Derivative Synthesis for Stabilizing the Quadruplex Structure[J].Journal of the Chinese Chemical Society,2013, 50(2):185-188.
[16]马晓媛.1,2-二氢喹啉类化合物的合成及脂质体的抗肿瘤活性筛选研究[D].吉林大学,2016.
[17]Duan Y T, Yao Y F, Tang D J, et al. Synthesis and biological evaluation of quinoline-imidazole hybrids as potent telomerase inhibitors:a promising class of antitumor agents[J]. Rsc Advances, 2014, 4(39):20382-20392.
[18]Bryan C,Rice C,Hoffman H,et al.Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532[J].Structure,2015, 23(10):1934-1942.
[19]李牧,杜智敏.芦荟大黄素的药理作用研究进展[J].中国临床药理学杂志, 2015(9):765-768.
[20]Chen R, Zhang J, Hu Y, et al. Potential antineoplastic effects of Aloeemodin:acomprehensivereview[J].AmericanJournalofChinese Medicine,2014, 42(02):1450018.
[21]何敏,陶毅明.芦荟大黄素联用顺铂对MDA-MB-231乳腺癌细胞Caspase-3和端粒酶表达的影响[J].时珍国医国药,2015,27(1):79-81.
[22]张晓云,许博文,仝乐,等.蒜素抗肿瘤作用机制的研究进展[J].华北理工大学学报(医学版),2017,(02):165-168+164.
[23]刘跃欣.蒜素抑制人甲状腺乳头状癌TPC-1细胞的作用及机制[D].华北理工大学,2015.
[24]Sun L, Wang X. Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells[J]. World J Gastroenterol, 2003, 9(9):1930-1934.
[25]王钰涵.萝卜硫素的研究进展[J].当代化工研究,2017,(10):137-139.
[26]Moon DO, Kang SH, Kim KC, et al. Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway[J]. Cancer Lett,2010,295(2):260-266.
[27]韩玉芳,赵延兵,李俊,等.萝卜硫素诱导肝癌Huh-6细胞增殖和凋亡[J].河南科技大学学报(医学版),2017,(04):256-259.
[28]朱涛,张吉桂.萝卜硫素对人结肠癌HT-9细胞增殖、凋亡及PI3K/Akt信号通路的影响[J].天津中医药,2018,(10):774-777.
[29]朱涛,王永翠.萝卜硫素通过Traf6/TAK1信号通路介导人胃癌细胞凋亡的机制研究[J].天津中医药,2018,(09):710-713.
[30]李广志.青蒿素和姜黄素联用对人肝癌细胞株HepG2细胞增殖、凋亡以及端粒酶活性的影响[D].广西医科大学,2013.
[31]Lee JH, Chung IK.Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from h TERT[J]. Cancer Lett, 2010,290(1):76-86.
[32]黄小荣,梁昌盛,骆晓枫,等.姜黄素对人喉癌细胞株Hep-2增殖和端粒酶活性的影响[J].临床医学工程,2012,(02):195-198.
[33]王东,裘建明,杨关根,等.姜黄素对直肠癌细胞放疗增敏的机制研究[J].中华胃肠外科杂志,2015,(6):602-605.
[34]Buseman CM,Wright WE,Shay JW.Is telomerase a viable target in cancer?[J].Mutat Res,2012,730:90-7.
[2]赵相轩,温锋,卢再鸣.端粒酶调控放射敏感性在恶性肿瘤治疗中的作用进展[J].肿瘤,2018,(05):498-501.
[3]Doksani Y, Wu JY, de Lange T, Zhuang X. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation[J].Cell,2013,155:345-56.
[4]营孙阳,熊加秀,麦洪旭,等.端粒酶调控研究进展[J].遗传,2016,38(4):289-299.
[5]刘惠芬,李峰,彭东旭,等.端粒、端粒酶及靶向抗衰老研究[J].现代预防医学,2017(3).
[6]颜呈呈,张悦.端粒酶抑制剂伊美司他治疗骨髓增殖性肿瘤的研究进展与展望[J].国际输血及血液学杂志,2017,40(1):41-45.
[7]Shammas M, Koley H R, Neri P, et al.Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo[J]. Leukemia,2008, 22(7):1410-8.
[8]邵文嘉,王武亮.端粒酶抑制剂XAV939联合奈达铂对HeLa细胞增殖和凋亡的影响[J].中国妇幼保健,2014,29(19):3135-3138.
[9]王燕利.XAV939对卵巢癌SKOV3细胞的生长抑制及顺铂增敏作用[D].郑州大学,2016.
[10]陈青.靶向端粒酶的新型芳基2H吡唑的设计合成与抗癌活性筛选[D].安徽医科大学,2013.
[11]何旭.以hTERT为靶点设计合成的新型二氢吡唑类化合物抑制人肝癌细胞株SMMC-7721增殖的作用机制研究[D].安徽医科大学,2015.
[12]赵婷婷.吡唑—酰腙类化合物作为端粒酶抑制剂的设计、合成及生物活性评价[D].南京大学,2013.
[13]杜会茹,蒋翠岚,黄文杰,等.3,6-二氨基咔唑衍生物的合成及与DNA的相互作用[J].精细化工,2015,32(2):0-0.
[14]黄文杰,张彩凌,杜会茹.咔唑类化合物在抗肿瘤方面的研究进展[J].精细与专用化学品,2018(7).
[15]Chang C C, Wu J Y, Chang T C. A Carbazole Derivative Synthesis for Stabilizing the Quadruplex Structure[J].Journal of the Chinese Chemical Society,2013, 50(2):185-188.
[16]马晓媛.1,2-二氢喹啉类化合物的合成及脂质体的抗肿瘤活性筛选研究[D].吉林大学,2016.
[17]Duan Y T, Yao Y F, Tang D J, et al. Synthesis and biological evaluation of quinoline-imidazole hybrids as potent telomerase inhibitors:a promising class of antitumor agents[J]. Rsc Advances, 2014, 4(39):20382-20392.
[18]Bryan C,Rice C,Hoffman H,et al.Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532[J].Structure,2015, 23(10):1934-1942.
[19]李牧,杜智敏.芦荟大黄素的药理作用研究进展[J].中国临床药理学杂志, 2015(9):765-768.
[20]Chen R, Zhang J, Hu Y, et al. Potential antineoplastic effects of Aloeemodin:acomprehensivereview[J].AmericanJournalofChinese Medicine,2014, 42(02):1450018.
[21]何敏,陶毅明.芦荟大黄素联用顺铂对MDA-MB-231乳腺癌细胞Caspase-3和端粒酶表达的影响[J].时珍国医国药,2015,27(1):79-81.
[22]张晓云,许博文,仝乐,等.蒜素抗肿瘤作用机制的研究进展[J].华北理工大学学报(医学版),2017,(02):165-168+164.
[23]刘跃欣.蒜素抑制人甲状腺乳头状癌TPC-1细胞的作用及机制[D].华北理工大学,2015.
[24]Sun L, Wang X. Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells[J]. World J Gastroenterol, 2003, 9(9):1930-1934.
[25]王钰涵.萝卜硫素的研究进展[J].当代化工研究,2017,(10):137-139.
[26]Moon DO, Kang SH, Kim KC, et al. Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway[J]. Cancer Lett,2010,295(2):260-266.
[27]韩玉芳,赵延兵,李俊,等.萝卜硫素诱导肝癌Huh-6细胞增殖和凋亡[J].河南科技大学学报(医学版),2017,(04):256-259.
[28]朱涛,张吉桂.萝卜硫素对人结肠癌HT-9细胞增殖、凋亡及PI3K/Akt信号通路的影响[J].天津中医药,2018,(10):774-777.
[29]朱涛,王永翠.萝卜硫素通过Traf6/TAK1信号通路介导人胃癌细胞凋亡的机制研究[J].天津中医药,2018,(09):710-713.
[30]李广志.青蒿素和姜黄素联用对人肝癌细胞株HepG2细胞增殖、凋亡以及端粒酶活性的影响[D].广西医科大学,2013.
[31]Lee JH, Chung IK.Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from h TERT[J]. Cancer Lett, 2010,290(1):76-86.
[32]黄小荣,梁昌盛,骆晓枫,等.姜黄素对人喉癌细胞株Hep-2增殖和端粒酶活性的影响[J].临床医学工程,2012,(02):195-198.
[33]王东,裘建明,杨关根,等.姜黄素对直肠癌细胞放疗增敏的机制研究[J].中华胃肠外科杂志,2015,(6):602-605.
[34]Buseman CM,Wright WE,Shay JW.Is telomerase a viable target in cancer?[J].Mutat Res,2012,730:90-7.