等离子体聚合技术在制备生物材料中的应用
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摘要
近年来等离子体聚合技术在生物医学领域获得了越来越广泛的应用。首先介绍了等离子体聚合技术的仪器设计和沉积原理。之后总结了等离子聚合技术制备各种功能高分子薄膜的特点,以及它们在生物传感器、细胞培养载体以及抗蛋白吸附膜等领域的最新研究进展。最后讨论了等离子聚合技术将来的发展趋势。
Recently plasma polymerization techniques have been widely employed for biomedical applications.Both the instrument designs and the deposition mechanism of plasma polymerization are introduced firstly.The latest research progresses for various plasma deposited functional thin films are summarized,with particularly emphasis on their applications in biosensors,as supports for cell cultures,as well as,non-fouling coatings.The future trend of plasma polymerization techniques is also discussed.
Recently plasma polymerization techniques have been widely employed for biomedical applications.Both the instrument designs and the deposition mechanism of plasma polymerization are introduced firstly.The latest research progresses for various plasma deposited functional thin films are summarized,with particularly emphasis on their applications in biosensors,as supports for cell cultures,as well as,non-fouling coatings.The future trend of plasma polymerization techniques is also discussed.
引文
1迈克·A力伯曼,阿伦·J里登伯格.等离子体放电原理与材料处理[M].北京:科学出版社,2007
2 Bazaka K,Jacob M V,Crawford R J,et al.Plasma-assisted surface modification of organic biopolymers to prevent bacterial attachment[J].Acta Biomater,2011,7(5):2015
3 Chu P K,Chen J Y,Wang L P,et al.Plasma-surface modification of biomaterials[J].Mater Sci Eng R-Reports,2002,36(5-6):143
4 李笃信,贾德民.等离子体技术对高分子材料的表面改性[J].高分子材料科学与工程,1999,15(3):173
5 Leguijt C,Loelgen P,Eikelboom J A,et al.Low temperature surface passivation for silicon solar cells[J].Solar Energy Mater Solar Cells,1996,40(4):297
6 Choy K L.Chemical vapour deposition of coatings[J].Progress Mater Sci,2003,48(2):57
7 林晓,陈捷,徐纪平.等离子体聚合制备气体分离膜研究概况[J].功能高分子学报,1991,4(3):161
8 张丹霞,王保国,陈翠仙.等离子体技术在膜分离领域的应用[J].膜科学与技术,2002,22(4):65
9 Temenoff J S,Mikos A G.生物材料:生物学与材料科学的交叉[M].北京:科学出版社,2009
10 王正辉,萧翼之.高分子生物材料的研究进展[J].高分子材料科学与工程,2005,21(5):19
11 赵长生.生物医用高分子材料[M].北京:化学工业出版社,2009
12 Frch R,Chifen A N,Bousquet A,et al.Recent and expected roles of plasma-polymerized films for biomedical applications[J].Chem Vapor Deposition,2007,13(6-7):280
13 Desmet T,Morent R,De Geyter N,et al.Nonthermal plasma technology as a versatile strategy for polymeric biomaterials surface modification:A review[J].Biomacromolecules,2009,10(9):2351
14 黄永刚,陈敏,李长敏,等.低温等离子体技术在生物材料表面改性中的应用[J].材料导报,2004,18(2):72
15 Denes F.Macromolecular plasma-chemistry:An emerging field of polymer science[J].Prog Polym Sci,2004,29(8):815
16张富尧,张一烽,沈之荃.等离子体聚合[J].材料科学与工程,1988(4):11
17 Shi F F.Recent advances in polymer thin films prepared by plasma polymerization.Synthesis,structural characterization,properties and applications[J].Surf Coat Technol,1996,82(1-2):1
18 Merche D,Vandencasteele N,Reniers F.Atmospheric plasmas for thin film deposition:A critical review[J].Thin Solid Films,2012,520(13):4219
19 高晓莉,盛京.等离子体聚合及其研究进展[J].精细石油化工,1999(4):53
20 Yasuda H.Plasma polymerization[M].Orlando:Academic Press,1985
21 Friedrich J.Mechanisms of plasma polymerization-Reviewed from a chemical point of view[J].Plasma Processes Polym,2011,8(9):783
22 方振逵.等离子体聚合及其对聚烯烃表面性能的影响[J].高分子材料科学与工程,1998,14(6):15
23 Muguruma H.Plasma-polymerized films for biosensorsⅡ[J].TrAC Trends Analyt Chem,2007,26(5):433
24 Muguruma H.Plasma-polymerized films for biochip design[J].Plasma Processes Polym,2010,7:150
25 Akkahat P,Kiatkamjornwong S,Yusa S,et al.Development of a novel antifouling platform for biosensing probe immobilization from methacryloyloxyethyl phosphorylcholinecontaining copolymer brushes[J].Langmuir,2012,28(13):5872
26 Hiratsuka A,Karube I.Plasma polymerized films for sensor devices[J].Electroanalysis,2000,12(9):695
27 Siow K S,Britcher L,Kumar S,et al.Plasma methods for the generation of chemically reactive surfaces for biomolecule immobilization and cell colonization-A review[J].Plasma Processes Polym,2006,3(6-7):392
28 Cifuentes A,Borros S.Comparison of two different plasma surface-modification techniques for the covalent immobilization of protein monolayers[J].Langmuir,2013,29(22):6645
29 Muratsugu M,Kurosawa S,Kamo N.Adsorption and desorption of F(ab′)2Anti-hIgG on plasma-polymerized allylamine thin film:The application of the film to immunoassay[J].J Colloid Interf Sci,1991,147(2):378
30 Ardhaoui M,Bhatt S,Zheng M H,et al.Biosensor based on laccase immobilized on plasma polymerized allylamine/carbon electrode[J].Mater Sci Eng C,2013,33(6):3197
31 Yin Y,Bax D,Mckenzie D R,et al.Protein immobilization capacity and covalent binding coverage of pulsed plasma polymer surfaces[J].Appl Surf Sci,2010,256(16):4984
32 Rivolo P,Severino S M,Ricciardi S,et al.Protein immobilization on nanoporous silicon functionalized by RF activated plasma polymerization of acrylic acid[J].J Colloid Interf Sci,2014,416:73
33 Frch R,Zhang Z,Knoll W.Soft plasma treated surfaces:Tailoring of structure and properties for biomaterial applications[J].Plasma Processes Polym,2005,2(5):351
34 Zhang Z H,Chen Q,Knoll W,et al.Plasma polymer film structure and DNA probe immobilization[J].Macromolecules,2003,36(20):7689
35 Chu L Q,Knoll W,Forch R.Plasma polymerized epoxide functional surfaces for DNA probe immobilization[J].Biosensors Bioelectronics,2008,24(1):118
36 Kim H J,Bae I S,Cho S J,et al.Synthesis and characteristics of NH2-functionalized polymer films to align and immobilize DNA molecules[J].Nanoscale Res Lett,2012,7:1
37 Lopez-Perez P M,Da Silva R M,Sousa R A,et al.Plasmainduced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering:An in vitro study[J].Acta Biomater,2010,6(9):3704
38 谢芬艳,胡文娟,翁静.等离子体聚合胺基功能薄膜及其细胞吸附性研究[C]//第十三届全国等离子体科学技术会议.成都,2007
39 王海波,王进,王晓娜,等.等离子体聚合沉积聚烯丙胺薄膜改性医用不锈钢及内皮细胞粘附行为研究[J].功能材料,2008,39(7):1193
40 Antonini V,Torrengo S,Marocchi L,et al.Combinatorial plasma polymerization approach to produce thin films for testing cell proliferation[J].Colloids Surf B,2014,113:320
41 Mangindaan D,Kuo W H,Chang C C,et al.Plasma polymerization of amine-containing thin films and the studies on the deposition kinetics[J].Surf Coat Technol,2011,206(6):1299
42 石卿,苏延磊,姜忠义.材料表面抗蛋白质污染机理研究进展[J].中国科技论文在线,2010,5(3):172
43 Choukourov A,Polonskyi O,Hanus J,et al.PEO-Like coatings prepared by plasma-based techniques[J].Plasma Processes Polym,2009,6:21
44 Valsesia A,Colpo P,Meziani T,et al.Selective immobilization of protein clusters on polymeric nanocraters[J].Adv Funct Mater,2006,16(9):1242
45 Chu L,Knoll W,Frch R.Biologically multifunctional surfaces using plasma polymerization methods[J].Plasma Processes Polym,2006,3(6-7):498
46 O′mahony C C,Gubala V,Gandhiraman R P,et al.Improving the sensitivity of immunoassays with PEG-COOH-like film prepared by plasma-based technique[J].J Biomed Mater Res,2012,100(1):230
47 Valdes T I,Ciridon W,Ratner B D,et al.Surface modification of a perfluorinated ionomer using aglow discharge deposition method to control protein adsorption[J].Biomaterials,2008,29(10):1356
48 Yang Z,Wang J,Li X,et al.Interaction of platelets,fibrinogen and endothelial cells with plasma deposited PEOlike films[J].Appl Surf Sci,2012,258(8):3378
49 Chu L Q,Knoll W,Foerch R.Pulsed plasma polymerized di(ethylene glycol)monovinyl ether coatings for nonfouling surfaces[J].Chem Mater,2006,18(20):4840
50 陈瑞,刘玉洁,李欣,等.等离子体类聚氧乙烯薄膜的制备及性能研究[J].功能材料,2013,44(22):1
51 Bretagnol F,Lejeune M,Papadopoulou-Bouraoui A,et al.Fouling and non-fouling surfaces produced by plasma polymerization of ethylene oxide monomer[J].Acta Biomater,2006,2(2):165
52 Lee B S,Yoon O J,Cho W K,et al.Construction of protein-resistant pOEGMA films by helicon plasma-enhanced chemical vapor deposition[J].J Biomater Sci Polym Ed,2009,20(11):1579
53 任煜,邱夷平.低温等离子体对高聚物材料表面改性处理时效性的研究进展[J].材料导报,2007,21(1):56
54 Chu L Q,Knoll W,Forch R.Stabilization of plasma-polymerized allylamine films by ethanol extraction[J].Langmuir,2006,22(13):5548
55 Chu L Q,Forch R,Knoll W.Pulsed plasma polymerized maleic anhydride films in humid air and in aqueous solutions studied with optical waveguide spectroscopy[J].Langmuir,2006,22(6):2822
2 Bazaka K,Jacob M V,Crawford R J,et al.Plasma-assisted surface modification of organic biopolymers to prevent bacterial attachment[J].Acta Biomater,2011,7(5):2015
3 Chu P K,Chen J Y,Wang L P,et al.Plasma-surface modification of biomaterials[J].Mater Sci Eng R-Reports,2002,36(5-6):143
4 李笃信,贾德民.等离子体技术对高分子材料的表面改性[J].高分子材料科学与工程,1999,15(3):173
5 Leguijt C,Loelgen P,Eikelboom J A,et al.Low temperature surface passivation for silicon solar cells[J].Solar Energy Mater Solar Cells,1996,40(4):297
6 Choy K L.Chemical vapour deposition of coatings[J].Progress Mater Sci,2003,48(2):57
7 林晓,陈捷,徐纪平.等离子体聚合制备气体分离膜研究概况[J].功能高分子学报,1991,4(3):161
8 张丹霞,王保国,陈翠仙.等离子体技术在膜分离领域的应用[J].膜科学与技术,2002,22(4):65
9 Temenoff J S,Mikos A G.生物材料:生物学与材料科学的交叉[M].北京:科学出版社,2009
10 王正辉,萧翼之.高分子生物材料的研究进展[J].高分子材料科学与工程,2005,21(5):19
11 赵长生.生物医用高分子材料[M].北京:化学工业出版社,2009
12 Frch R,Chifen A N,Bousquet A,et al.Recent and expected roles of plasma-polymerized films for biomedical applications[J].Chem Vapor Deposition,2007,13(6-7):280
13 Desmet T,Morent R,De Geyter N,et al.Nonthermal plasma technology as a versatile strategy for polymeric biomaterials surface modification:A review[J].Biomacromolecules,2009,10(9):2351
14 黄永刚,陈敏,李长敏,等.低温等离子体技术在生物材料表面改性中的应用[J].材料导报,2004,18(2):72
15 Denes F.Macromolecular plasma-chemistry:An emerging field of polymer science[J].Prog Polym Sci,2004,29(8):815
16张富尧,张一烽,沈之荃.等离子体聚合[J].材料科学与工程,1988(4):11
17 Shi F F.Recent advances in polymer thin films prepared by plasma polymerization.Synthesis,structural characterization,properties and applications[J].Surf Coat Technol,1996,82(1-2):1
18 Merche D,Vandencasteele N,Reniers F.Atmospheric plasmas for thin film deposition:A critical review[J].Thin Solid Films,2012,520(13):4219
19 高晓莉,盛京.等离子体聚合及其研究进展[J].精细石油化工,1999(4):53
20 Yasuda H.Plasma polymerization[M].Orlando:Academic Press,1985
21 Friedrich J.Mechanisms of plasma polymerization-Reviewed from a chemical point of view[J].Plasma Processes Polym,2011,8(9):783
22 方振逵.等离子体聚合及其对聚烯烃表面性能的影响[J].高分子材料科学与工程,1998,14(6):15
23 Muguruma H.Plasma-polymerized films for biosensorsⅡ[J].TrAC Trends Analyt Chem,2007,26(5):433
24 Muguruma H.Plasma-polymerized films for biochip design[J].Plasma Processes Polym,2010,7:150
25 Akkahat P,Kiatkamjornwong S,Yusa S,et al.Development of a novel antifouling platform for biosensing probe immobilization from methacryloyloxyethyl phosphorylcholinecontaining copolymer brushes[J].Langmuir,2012,28(13):5872
26 Hiratsuka A,Karube I.Plasma polymerized films for sensor devices[J].Electroanalysis,2000,12(9):695
27 Siow K S,Britcher L,Kumar S,et al.Plasma methods for the generation of chemically reactive surfaces for biomolecule immobilization and cell colonization-A review[J].Plasma Processes Polym,2006,3(6-7):392
28 Cifuentes A,Borros S.Comparison of two different plasma surface-modification techniques for the covalent immobilization of protein monolayers[J].Langmuir,2013,29(22):6645
29 Muratsugu M,Kurosawa S,Kamo N.Adsorption and desorption of F(ab′)2Anti-hIgG on plasma-polymerized allylamine thin film:The application of the film to immunoassay[J].J Colloid Interf Sci,1991,147(2):378
30 Ardhaoui M,Bhatt S,Zheng M H,et al.Biosensor based on laccase immobilized on plasma polymerized allylamine/carbon electrode[J].Mater Sci Eng C,2013,33(6):3197
31 Yin Y,Bax D,Mckenzie D R,et al.Protein immobilization capacity and covalent binding coverage of pulsed plasma polymer surfaces[J].Appl Surf Sci,2010,256(16):4984
32 Rivolo P,Severino S M,Ricciardi S,et al.Protein immobilization on nanoporous silicon functionalized by RF activated plasma polymerization of acrylic acid[J].J Colloid Interf Sci,2014,416:73
33 Frch R,Zhang Z,Knoll W.Soft plasma treated surfaces:Tailoring of structure and properties for biomaterial applications[J].Plasma Processes Polym,2005,2(5):351
34 Zhang Z H,Chen Q,Knoll W,et al.Plasma polymer film structure and DNA probe immobilization[J].Macromolecules,2003,36(20):7689
35 Chu L Q,Knoll W,Forch R.Plasma polymerized epoxide functional surfaces for DNA probe immobilization[J].Biosensors Bioelectronics,2008,24(1):118
36 Kim H J,Bae I S,Cho S J,et al.Synthesis and characteristics of NH2-functionalized polymer films to align and immobilize DNA molecules[J].Nanoscale Res Lett,2012,7:1
37 Lopez-Perez P M,Da Silva R M,Sousa R A,et al.Plasmainduced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering:An in vitro study[J].Acta Biomater,2010,6(9):3704
38 谢芬艳,胡文娟,翁静.等离子体聚合胺基功能薄膜及其细胞吸附性研究[C]//第十三届全国等离子体科学技术会议.成都,2007
39 王海波,王进,王晓娜,等.等离子体聚合沉积聚烯丙胺薄膜改性医用不锈钢及内皮细胞粘附行为研究[J].功能材料,2008,39(7):1193
40 Antonini V,Torrengo S,Marocchi L,et al.Combinatorial plasma polymerization approach to produce thin films for testing cell proliferation[J].Colloids Surf B,2014,113:320
41 Mangindaan D,Kuo W H,Chang C C,et al.Plasma polymerization of amine-containing thin films and the studies on the deposition kinetics[J].Surf Coat Technol,2011,206(6):1299
42 石卿,苏延磊,姜忠义.材料表面抗蛋白质污染机理研究进展[J].中国科技论文在线,2010,5(3):172
43 Choukourov A,Polonskyi O,Hanus J,et al.PEO-Like coatings prepared by plasma-based techniques[J].Plasma Processes Polym,2009,6:21
44 Valsesia A,Colpo P,Meziani T,et al.Selective immobilization of protein clusters on polymeric nanocraters[J].Adv Funct Mater,2006,16(9):1242
45 Chu L,Knoll W,Frch R.Biologically multifunctional surfaces using plasma polymerization methods[J].Plasma Processes Polym,2006,3(6-7):498
46 O′mahony C C,Gubala V,Gandhiraman R P,et al.Improving the sensitivity of immunoassays with PEG-COOH-like film prepared by plasma-based technique[J].J Biomed Mater Res,2012,100(1):230
47 Valdes T I,Ciridon W,Ratner B D,et al.Surface modification of a perfluorinated ionomer using aglow discharge deposition method to control protein adsorption[J].Biomaterials,2008,29(10):1356
48 Yang Z,Wang J,Li X,et al.Interaction of platelets,fibrinogen and endothelial cells with plasma deposited PEOlike films[J].Appl Surf Sci,2012,258(8):3378
49 Chu L Q,Knoll W,Foerch R.Pulsed plasma polymerized di(ethylene glycol)monovinyl ether coatings for nonfouling surfaces[J].Chem Mater,2006,18(20):4840
50 陈瑞,刘玉洁,李欣,等.等离子体类聚氧乙烯薄膜的制备及性能研究[J].功能材料,2013,44(22):1
51 Bretagnol F,Lejeune M,Papadopoulou-Bouraoui A,et al.Fouling and non-fouling surfaces produced by plasma polymerization of ethylene oxide monomer[J].Acta Biomater,2006,2(2):165
52 Lee B S,Yoon O J,Cho W K,et al.Construction of protein-resistant pOEGMA films by helicon plasma-enhanced chemical vapor deposition[J].J Biomater Sci Polym Ed,2009,20(11):1579
53 任煜,邱夷平.低温等离子体对高聚物材料表面改性处理时效性的研究进展[J].材料导报,2007,21(1):56
54 Chu L Q,Knoll W,Forch R.Stabilization of plasma-polymerized allylamine films by ethanol extraction[J].Langmuir,2006,22(13):5548
55 Chu L Q,Forch R,Knoll W.Pulsed plasma polymerized maleic anhydride films in humid air and in aqueous solutions studied with optical waveguide spectroscopy[J].Langmuir,2006,22(6):2822