硒与病毒性疾病的相关性
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摘要
病毒性疾病具有广泛的传播性与流行性,给人们健康带来严重的危害,已成为目前研究热点之一。硒是人体必需微量元素,与病毒性疾病发病和传播密切相关。本文综述了当前国内外硒与病毒性疾病的研究进展,包括硒与克山病、艾滋病、病毒性肝炎、流感和手足口病等疾病的关系及相关研究,并在此基础上分析了硒干预病毒性疾病的作用机制,探索了硒及不同硒蛋白作为预防药物开发、相关病毒性疾病治疗和药物筛选靶标的可能性。
Viral disease has great communicability and epidemicity and brings serious harm to peoples health, which has become one of the research hotspots currently. As an essential trace element, selenium is involved in viral infections,virulence and the development of many viral diseases. This review summarized the recent progress of selenium and viral diseases researches, including Keshan disease, AIDS, viral hepatitis, flu and hand, foot and mouth disease. The intervention effect and underlying mechanism of selenium in viral diseases were also discussed. This review also aimed at analyzing the roles of selenium and selenoproteins in viral diseases development, and exploring the potential of selenium and selenoproteins as preventive agents or the target for viral diseases treatment and drug-screening.
Viral disease has great communicability and epidemicity and brings serious harm to peoples health, which has become one of the research hotspots currently. As an essential trace element, selenium is involved in viral infections,virulence and the development of many viral diseases. This review summarized the recent progress of selenium and viral diseases researches, including Keshan disease, AIDS, viral hepatitis, flu and hand, foot and mouth disease. The intervention effect and underlying mechanism of selenium in viral diseases were also discussed. This review also aimed at analyzing the roles of selenium and selenoproteins in viral diseases development, and exploring the potential of selenium and selenoproteins as preventive agents or the target for viral diseases treatment and drug-screening.
引文
[1]Ryan-Harshman M,Aldoori W.The relevance of selenium to immunity,cancer,and infectious/inflammatory diseases[J].Can J Diet Pract Res,2005,66(2):98-102.
[2]Steinbrenner H,Al-Quraishy S,Dkhil MA,et al.Dietary selenium in adjuvant therapy of viral and bacterial infections[J].Adv Nutr,2015,6(1):73-82.
[3]Harthill M.Review:micronutrient selenium deficiency influences evolution of some viral infectious diseases[J].Biol Trace Elem Res,2011,143(3):1325-1336.
[4]徐辉碧,黄开勋,刘琼.硒的化学、生物化学及其在生命科学中的应用[M].第2版.武汉:华中科技大学出版社,2009.Xu HB,Huang KX,Liu Q.Selenium:its chemistry,biochemistry and application in life science[M].2nd Edition.Wuhan:Huazhong university of science and technology press,2009.
[5]Beck MA,Levander OA.Dietary oxidative stress and the potentiation of viral infection[J].Annu Rev Nutr,1998,18:93-116.
[6]曹丹阳,周令望,张淑芹,等.柯萨奇病毒B4'致低硒鼠心肌损伤的实验研究[J].中华地方病学杂志,2002,21(2):100-102.Cao DY,Zhou LW,Zhang SQ,et al.The experimental research on myocardial injury induced by CVB4’in Se-deficient mice[J].Chin J Endemiol,2002,21(2):100-102.
[7]Hatfield DL,Berry MJ,Gladyshev VN.Selenium:It’s molecular biology and role in human health[M].3rd Edition.New York:Springer,2012.
[8]Look MP,Rockstroh JK,Rao GS,et al.Serum selenium,plasma glutathione(GSH)and erythrocyte glutathione peroxidase(GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1(HIV-1)-infection[J].Eur J Clin Nutr,1997,51(4):266-272.
[9]刘琼,姜亮,田静,等.硒蛋白的分子生物学及与疾病的关系[J].化学进展,2009,21(5):818-830.Liu Q,Jiang L,Tian J,et al.The molecular biology of selenoproteins and their effects on diseases[J].Progress in Chemistry,2009,21(5):818-830.
[10]石乃玉,夏亦明,施燕红.硒有效防治病毒感染性疾病进展[J].中华实验和临床病毒学杂志,2005,19(1):90-91.Shi NY,Xia YM,Shi YH.Selenium is effective in preventing and treating viral infectious diseases[J].Chinese J Exp Clin Virol,2005,19(1):90-91.
[11]Stone CA,Kawai K,Kupka R,et al.Role of selenium in HIV infection[J].Nutr Rev,2010,68(11):671-681.
[12]Hori K,Hatfield D,Maldarelli F,et al.Selenium supplementation suppresses tumor necrosis factor alpha-induced human immunodeficiency virus type 1 replication in vitro[J].AIDS Res Hum Retroviruses,1997,13(15):1325-1332.
[13]Yu SY,Zhu YJ,Li WG.Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong[J].Biol Trace Elem Res,1997,56(1):117-124.
[14]Khan MS,Dilawar S,Ali I,et al.The possible role of selenium concentration in hepatitis B and C patients[J].Saudi J Gastroenterol,2012,18(2):106-110.
[15]He SX,Wu B,Chang XM,et al.Effects of selenium on peripheral blood mononuclear cell membrane fluidity,interleukin-2 production and interleukin-2 receptor expression in patients with chronic hepatitis[J].World J Gastroenterol,2004,10(23):3531-3533.
[16]Abediankenari S,Ghasemi M,Nasehi MM,et al.Determination of trace elements in patients with chronic hepatitis B[J].Acta medica Iranica,2011,49(10):667-669.
[17]Cheng Z,Zhi X,Sun G,et al.Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines[J].J Med Virol,2016,88(4):653-663.
[18]Girodon F,Galan P,Monget AL,et al.Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients:a randomized controlled trial.MIN.VIT.AOX.geriatric network[J].Arch Intern Med,1999,159(7):748-754.
[19]Erkeko g lu P,A??l A,Ceyhan M,et al.Selenium levels,selenoenzyme activities and oxidant/antioxidant parameters in H1N1-infected children[J].Turk J Pediatr,2013,55(3):271-282.
[20]Sheridan PA,Zhong N,Carlson BA,et al.Decreased selenoprotein expression alters the immune response during influenza virus infection in mice[J].J Nutr,2007,137(6):1466-1471.
[21]Yu L,Sun L,Nan Y,et al.Protection from H1N1 influenza virus infections in mice by supplementation with selenium:a comparison with selenium-deficient mice[J].Biol Trace Elem Res,2011,141(1-3):254-261.
[22]Jaspers I,Zhang W,Brighton LE,et al.Selenium deficiency alters epithelial cell morphology and responses to influenza[J].Free Radic Biol Med,2007,42(12):1826-1837.
[23]Li Y,Lin Z,Guo M,et al.Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus[J].Int J Nanomedicine,2017,12:5733-5743.
[24]黄飞雁,张东晓,许少坚,等.缺硒饲养ICR小鼠加快肠道病毒71型在体内的复制研究[J].热带医学杂志,2013,13(1):47-50.Huang FY,Zhang DX,Xu SJ,et al.Deficiency of selenium in the feeding for ICR mice accelerates enterovirus 71 replication[J].J Trop Med,2013,13(1):47-50.
[25]黄飞雁,张仁利,张起文,等.硒代蛋氨酸与亚硒酸钠对EV71在体内外增值的影响[J].中国热带医学,2014,14(7):792-794,868.Huang FY,Zhang RL,Zhang QW,et al.Effect of selenomethionine and sodium selenite on proliferation of EV71 in vitro and in vivo[J].China Trop Med,2014,14(7):792-794,868.
[26]Broome CS,Mc Ardle F,Kyle JA,et al.An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status[J].Am J Clin Nutr,2004,80(1):154-162.
[27]Verma S,Molina Y,Lo YY,et al.In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity[J].Virol J,2008,5:66.
[28]Verma S,Hoffmann FW,Kumar M,et al.Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses[J].J Immunol,2011,186(6):2127-2137.
[2]Steinbrenner H,Al-Quraishy S,Dkhil MA,et al.Dietary selenium in adjuvant therapy of viral and bacterial infections[J].Adv Nutr,2015,6(1):73-82.
[3]Harthill M.Review:micronutrient selenium deficiency influences evolution of some viral infectious diseases[J].Biol Trace Elem Res,2011,143(3):1325-1336.
[4]徐辉碧,黄开勋,刘琼.硒的化学、生物化学及其在生命科学中的应用[M].第2版.武汉:华中科技大学出版社,2009.Xu HB,Huang KX,Liu Q.Selenium:its chemistry,biochemistry and application in life science[M].2nd Edition.Wuhan:Huazhong university of science and technology press,2009.
[5]Beck MA,Levander OA.Dietary oxidative stress and the potentiation of viral infection[J].Annu Rev Nutr,1998,18:93-116.
[6]曹丹阳,周令望,张淑芹,等.柯萨奇病毒B4'致低硒鼠心肌损伤的实验研究[J].中华地方病学杂志,2002,21(2):100-102.Cao DY,Zhou LW,Zhang SQ,et al.The experimental research on myocardial injury induced by CVB4’in Se-deficient mice[J].Chin J Endemiol,2002,21(2):100-102.
[7]Hatfield DL,Berry MJ,Gladyshev VN.Selenium:It’s molecular biology and role in human health[M].3rd Edition.New York:Springer,2012.
[8]Look MP,Rockstroh JK,Rao GS,et al.Serum selenium,plasma glutathione(GSH)and erythrocyte glutathione peroxidase(GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1(HIV-1)-infection[J].Eur J Clin Nutr,1997,51(4):266-272.
[9]刘琼,姜亮,田静,等.硒蛋白的分子生物学及与疾病的关系[J].化学进展,2009,21(5):818-830.Liu Q,Jiang L,Tian J,et al.The molecular biology of selenoproteins and their effects on diseases[J].Progress in Chemistry,2009,21(5):818-830.
[10]石乃玉,夏亦明,施燕红.硒有效防治病毒感染性疾病进展[J].中华实验和临床病毒学杂志,2005,19(1):90-91.Shi NY,Xia YM,Shi YH.Selenium is effective in preventing and treating viral infectious diseases[J].Chinese J Exp Clin Virol,2005,19(1):90-91.
[11]Stone CA,Kawai K,Kupka R,et al.Role of selenium in HIV infection[J].Nutr Rev,2010,68(11):671-681.
[12]Hori K,Hatfield D,Maldarelli F,et al.Selenium supplementation suppresses tumor necrosis factor alpha-induced human immunodeficiency virus type 1 replication in vitro[J].AIDS Res Hum Retroviruses,1997,13(15):1325-1332.
[13]Yu SY,Zhu YJ,Li WG.Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong[J].Biol Trace Elem Res,1997,56(1):117-124.
[14]Khan MS,Dilawar S,Ali I,et al.The possible role of selenium concentration in hepatitis B and C patients[J].Saudi J Gastroenterol,2012,18(2):106-110.
[15]He SX,Wu B,Chang XM,et al.Effects of selenium on peripheral blood mononuclear cell membrane fluidity,interleukin-2 production and interleukin-2 receptor expression in patients with chronic hepatitis[J].World J Gastroenterol,2004,10(23):3531-3533.
[16]Abediankenari S,Ghasemi M,Nasehi MM,et al.Determination of trace elements in patients with chronic hepatitis B[J].Acta medica Iranica,2011,49(10):667-669.
[17]Cheng Z,Zhi X,Sun G,et al.Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines[J].J Med Virol,2016,88(4):653-663.
[18]Girodon F,Galan P,Monget AL,et al.Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients:a randomized controlled trial.MIN.VIT.AOX.geriatric network[J].Arch Intern Med,1999,159(7):748-754.
[19]Erkeko g lu P,A??l A,Ceyhan M,et al.Selenium levels,selenoenzyme activities and oxidant/antioxidant parameters in H1N1-infected children[J].Turk J Pediatr,2013,55(3):271-282.
[20]Sheridan PA,Zhong N,Carlson BA,et al.Decreased selenoprotein expression alters the immune response during influenza virus infection in mice[J].J Nutr,2007,137(6):1466-1471.
[21]Yu L,Sun L,Nan Y,et al.Protection from H1N1 influenza virus infections in mice by supplementation with selenium:a comparison with selenium-deficient mice[J].Biol Trace Elem Res,2011,141(1-3):254-261.
[22]Jaspers I,Zhang W,Brighton LE,et al.Selenium deficiency alters epithelial cell morphology and responses to influenza[J].Free Radic Biol Med,2007,42(12):1826-1837.
[23]Li Y,Lin Z,Guo M,et al.Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus[J].Int J Nanomedicine,2017,12:5733-5743.
[24]黄飞雁,张东晓,许少坚,等.缺硒饲养ICR小鼠加快肠道病毒71型在体内的复制研究[J].热带医学杂志,2013,13(1):47-50.Huang FY,Zhang DX,Xu SJ,et al.Deficiency of selenium in the feeding for ICR mice accelerates enterovirus 71 replication[J].J Trop Med,2013,13(1):47-50.
[25]黄飞雁,张仁利,张起文,等.硒代蛋氨酸与亚硒酸钠对EV71在体内外增值的影响[J].中国热带医学,2014,14(7):792-794,868.Huang FY,Zhang RL,Zhang QW,et al.Effect of selenomethionine and sodium selenite on proliferation of EV71 in vitro and in vivo[J].China Trop Med,2014,14(7):792-794,868.
[26]Broome CS,Mc Ardle F,Kyle JA,et al.An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status[J].Am J Clin Nutr,2004,80(1):154-162.
[27]Verma S,Molina Y,Lo YY,et al.In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity[J].Virol J,2008,5:66.
[28]Verma S,Hoffmann FW,Kumar M,et al.Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses[J].J Immunol,2011,186(6):2127-2137.