家蚕——新的内分泌干扰物筛选靶标
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摘要
内分泌干扰物对人类及环境的影响日益严重,如何建立快速有效的筛选方法,从复杂的周围环境中鉴别出具有内分泌干扰活性的物质,指导人们尽量规避不必要的暴露风险,成了当前环境学家的重要任务。本文以鳞翅目昆虫的模式物种家蚕为对象,介绍了其内分泌系统组成及相关激素的作用,分析了作为内分泌干扰物筛选靶标的优势,阐述了候选的测试端点及依据,从理论和方法不同角度探讨了家蚕成为一种新的内分泌干扰物筛选靶标的可行性。
The influence of endocrine disrupting-chemicals(EDCs) on human and environment is becoming more and more serious. The challenging tasks for environmental experts are establishing an efficient and rapid screening method to identify the active EDCs from complex environment,and guiding people to avoid unnecessary exposure risk. The article introduces the composition of endocrine system and their associated hormones of silkworm(bombyx mori). The advantages of silkworm as an ideal candidate for testing EDCs and candidate measurement endpoints are detailed analysis. The feasibility of silkworm as a new EDC test species are also discussed from the perspective of theory and methods.
The influence of endocrine disrupting-chemicals(EDCs) on human and environment is becoming more and more serious. The challenging tasks for environmental experts are establishing an efficient and rapid screening method to identify the active EDCs from complex environment,and guiding people to avoid unnecessary exposure risk. The article introduces the composition of endocrine system and their associated hormones of silkworm(bombyx mori). The advantages of silkworm as an ideal candidate for testing EDCs and candidate measurement endpoints are detailed analysis. The feasibility of silkworm as a new EDC test species are also discussed from the perspective of theory and methods.
引文
[1]康亦珂,汝少国,王蔚.环境内分泌干扰物快速筛选方法研究进展[J].科技导报,2010,28(12):99-103Tang Y K,Ru S G,Wang W.Progress in the rapid screening of endocrine disrupting chemical[J].Science&Technology Review,2010,28(12):99-103(in Chinese)
[2]鲁兴萌.蚕桑高新技术研究与进展[M].中国农业大学出版社,2012:161-195
[3]庄大桓,项美华,戴祝英,等.昆虫保幼激素和蜕皮激素在家蚕不同发育阶段的生物活性效应[J].蚕业科学,1984,10(3):139-144
[4]崔为正,张友英,刘余发,等.保幼激素和蜕皮激素混合使用对家蚕发育和产丝量的影响[J].蚕业科学,1993,19(4):236-238
[5]矶部稔,后藤俊夫,庄大桓.家蚕滞育激素的化学[J].国外农学-蚕业,1982,3:9-13
[6]吕鸿声.家蚕(Bombyx moeri L.)卵态滞育的激素生理学研究[C].中国昆虫学会学术讨论会会刊,1962
[7]Nagasawa H,Kataoka H,Isogai A,et al.Amino-terminal amino acid sequence of the silkworm prothoracicotropic hormone:Homology with insulin[J].Science,1984,226(4680):1344-1345
[8]牟志美,崔为正,张友英.保幼激素和蜕皮激素配合处理对家蚕后部丝腺细胞超微结构的影响[J].蚕业科学,1996,22(2):125-127
[9]吴友良.日本家蚕人工饲料育的现状及研究历史[J].江苏蚕业,1981(2):46-51
[10]蔡幼民,王红林,刘大柏,等.家蚕人工饲料育试验(初报)[J].江苏蚕业,1975,6(1):19-24
[11]姚耀涛,冯建琴,沈建华,等.蚕品种对人工饲料育的适应性试验分析[J].中国蚕业,2005,26(3):85-86
[12]Xia Q Y,Zhou Z Y,Lu C,et al.A draft sequence for the genome of the domesticated silkworm(Bombyx mori)[J].Science,2004,306(5703):1937-1940
[13]Xia Q,Wang J,Zhou Z,et al.The genome of a lepidopteran model insect,the silkworm Bombyx mori[J].Insect Biochemistry and Molecular Biology,2008,38(12):1036-1345
[14]袁红霞.环境内分泌干扰物4-壬基苯酚对无脊椎动物家蚕的生殖毒性及分子机理研究[D].苏州:苏州大学,2013Yuan H X.Reproductive toxicity and its molecular mechanism of environmental endocrine disruptor 4-nonylphenol to the invertebrated Bombyx mori[D].Suzhou:Suzhou University,2013
[2]鲁兴萌.蚕桑高新技术研究与进展[M].中国农业大学出版社,2012:161-195
[3]庄大桓,项美华,戴祝英,等.昆虫保幼激素和蜕皮激素在家蚕不同发育阶段的生物活性效应[J].蚕业科学,1984,10(3):139-144
[4]崔为正,张友英,刘余发,等.保幼激素和蜕皮激素混合使用对家蚕发育和产丝量的影响[J].蚕业科学,1993,19(4):236-238
[5]矶部稔,后藤俊夫,庄大桓.家蚕滞育激素的化学[J].国外农学-蚕业,1982,3:9-13
[6]吕鸿声.家蚕(Bombyx moeri L.)卵态滞育的激素生理学研究[C].中国昆虫学会学术讨论会会刊,1962
[7]Nagasawa H,Kataoka H,Isogai A,et al.Amino-terminal amino acid sequence of the silkworm prothoracicotropic hormone:Homology with insulin[J].Science,1984,226(4680):1344-1345
[8]牟志美,崔为正,张友英.保幼激素和蜕皮激素配合处理对家蚕后部丝腺细胞超微结构的影响[J].蚕业科学,1996,22(2):125-127
[9]吴友良.日本家蚕人工饲料育的现状及研究历史[J].江苏蚕业,1981(2):46-51
[10]蔡幼民,王红林,刘大柏,等.家蚕人工饲料育试验(初报)[J].江苏蚕业,1975,6(1):19-24
[11]姚耀涛,冯建琴,沈建华,等.蚕品种对人工饲料育的适应性试验分析[J].中国蚕业,2005,26(3):85-86
[12]Xia Q Y,Zhou Z Y,Lu C,et al.A draft sequence for the genome of the domesticated silkworm(Bombyx mori)[J].Science,2004,306(5703):1937-1940
[13]Xia Q,Wang J,Zhou Z,et al.The genome of a lepidopteran model insect,the silkworm Bombyx mori[J].Insect Biochemistry and Molecular Biology,2008,38(12):1036-1345
[14]袁红霞.环境内分泌干扰物4-壬基苯酚对无脊椎动物家蚕的生殖毒性及分子机理研究[D].苏州:苏州大学,2013Yuan H X.Reproductive toxicity and its molecular mechanism of environmental endocrine disruptor 4-nonylphenol to the invertebrated Bombyx mori[D].Suzhou:Suzhou University,2013