丹参有效成分防治恶性肿瘤作用机制的研究进展
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摘要
在世界范围内,癌症是非常重要的公共健康问题。在中国,癌症已成为疾病死因之首,发病率和病死率还在攀升。肿瘤在中医中隶属于"癥瘕""积聚"等范畴,血瘀在肿瘤的发生和进展过程中起重要作用。恶性肿瘤患者临床多表现出一些血瘀的证候,根据中医"有是症,用是药"的原则,在恶性肿瘤治疗上采用活血化瘀之法可以取得较好的疗效。活血化瘀代表药丹参的有效成分具有广泛抗肿瘤的生物活性,文章就其基础实验研究进展作一综述。
In the world, cancer has become a very important public health problem. In China, cancer has become the first cause of death, and the morbidity and mortality are still rising. In traditional Chinese medicine, tumor belongs to the ‘Zheng jia' and ‘amassment and accumulation' and other areas, and blood stasis plays an important role in the tumor occurrence and progress. Malignant tumor patients show a number of clinical evidence of blood stasis. According to the principle of ‘there is symptom, applying the drug', we can adopt the treatment of promoting blood circulation for removing blood stasis on malignant tumor in order to achieve a better effect. The effective components of Salvia miltiorrhiza on the promoting blood circulation for removing blood stasis has a wide range of anti-tumor biological activity, and this article will make a review on the basic experimental research progress.
In the world, cancer has become a very important public health problem. In China, cancer has become the first cause of death, and the morbidity and mortality are still rising. In traditional Chinese medicine, tumor belongs to the ‘Zheng jia' and ‘amassment and accumulation' and other areas, and blood stasis plays an important role in the tumor occurrence and progress. Malignant tumor patients show a number of clinical evidence of blood stasis. According to the principle of ‘there is symptom, applying the drug', we can adopt the treatment of promoting blood circulation for removing blood stasis on malignant tumor in order to achieve a better effect. The effective components of Salvia miltiorrhiza on the promoting blood circulation for removing blood stasis has a wide range of anti-tumor biological activity, and this article will make a review on the basic experimental research progress.
引文
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[3]张良登,张月,逯阳.活血化瘀中药防治恶性肿瘤复发与转移探讨.中华中医药学刊,2011,29(1):146-147
[4]楼招欢,杨波,沈炜,等.丹参二萜醌部位高速逆流色谱制备工艺及体外抗肿瘤活性研究.中草药,2015,46(5):679-682
[5]李伟,刘超,郭志敏,等.隐丹参酮通过抑制帽子依赖的翻译促进人肺癌细胞A549的凋亡.肿瘤防治研究,2016,43(7):550-554
[6]许冠华,雷俊华,金丽莎,等.隐丹参酮联合顺铂作用于非小细胞肺癌PC9细胞的体外研究.浙江中西医结合杂志,2014,24(12):1043-1045
[7]叶欢,阮君山,王少明,等.隐丹参酮抑制A549细胞复发转移的机制.海峡药学,2014,26(12):238-241
[8]孙蓓,叶因涛,王冬,等.二氢丹参酮对人肺癌GLC-82细胞的抑制作用及其机制研究.中国药房,2015,26(34):4775-4778
[9]简晓顺,刘相富,陈健清.丹参酮ⅡA抑制非小细胞肺癌NCI-H520细胞生长的研究.新医学,2013,44(5):347-350
[10]Zhang J,Wang J,Jiang J Y,et al.TanshinoneⅡA induces cytochrome c-mediated caspase cascade apoptosis in A549 human lung cancer cells via the JNK pathway.International Journal of Oncology,2014,45(2):683-690
[11]周生余,张发艳.丹参多酚酸盐对肺癌模型小鼠肺组织中VEGF和MMP-9表达的影响.中国药房,2016,27(25):3515-3517
[12]马齐襄,朱晓丹,胡凯文,等.253例原发性肺癌转移特征及中医证型分析.中华中医药杂志,2015,30(10):3659-3661
[13]Yu T,Zhou Z,Mu Y,et al.A novel anti-cancer agent,acetyltanshinoneⅡA,inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor.Cancer Letters,2014,346(1):94-103
[14]王跃华,郭章雄,朱志斌,等.丹参酮ⅡA抑制乳腺癌细胞转移的机制.黑龙江医学,2015,39(11):1209-1213
[15]赵丕文,臧金凤,陶仕英,等.丹参酮ⅡA抗乳腺癌T47 D细胞增殖的GPER途径研究.中国药理学通报,2015,31(10):1458-1462
[16]赵丕文,臧金凤,陶仕英,等.基因沉默技术研究丹参酮ⅡA抗雌激素受体阴性乳腺癌细胞增殖的GPER途径.中华中医药杂志,2016,31(11):4502-4506
[17]惠文涛,马小斌,昝瑛,等.丹参酮ⅡA磺酸钠对乳腺癌细胞株的作用及其机制研究.陕西医学杂志,2015,44(7):781-784
[18]朱智杰,刘兆国,周梁,等.隐丹参酮对人乳腺癌细胞MDAMB-231转移的影响及其分子机制.中国实验方剂学杂志,2014,20(11):160-165
[19]全军利,贺文兴,吴斯敏,等.隐丹参酮对乳腺癌MDAMB-231细胞自噬和侵袭迁移的影响.广西医科大学学报,2015,32(1):23-26
[20]易长胜,廖坤,余良忠,等.丹参素对乳腺癌MCF-7细胞株增殖影响及其分子机制.福建医药杂志,2015,37(5):56-58
[21]于庆生,经文善,宋加奎,等.丹参及其联合5-FU对人胃癌SGC-7901细胞凋亡的影响.世界中医药,2016,11(7):1315-1319
[22]赵雪峰,魏敬妙,李勇,等.丹参酮ⅡA诱导体外胃癌细胞的自噬.中成药,2014,36(1):10-14
[23]赵雪峰,魏敬妙,李勇,等.丹参酮ⅡA对胃癌细胞的抑制作用及其与NF-κB信号通路的关系.中国普通外科杂志,2014,23(4):483-487
[24]侯建红,张阳德.不同剂量丹参酮ⅡA对SGC7901胃癌细胞抑制作用的研究.中国现代医学杂志,2014,24(22):10-12
[25]王亚明,张桂东,尹清臣,等.丹参酮Ⅱa诱导人胃癌细胞MKN-45凋亡及对端粒酶活性的影响.中国生化药物杂志,2014,34(5):44-47,50
[26]徐俊丽.丹参酮ⅡA对人胃癌细胞SGC7901增殖凋亡的影响及其与COX-2表达的关系.医学临床研究,2015,32(8):1514-1517
[27]李萍,舒琦瑾.丹参酮ⅡA对人胃癌细胞株MKN-45体外侵袭和转移能力的影响.中华中医药学刊,2013,31(10):2318-2321
[28]宋烨.丹参酮Ⅰ和二氢丹参酮Ⅰ对人胃癌细胞MGC-803、乳腺癌细胞MCF-7的抗肿瘤活性研究.数理医药学杂志,2015,28(6):803-806
[29]邓凤春,于占江,杨钰,等.隐丹参酮对人胃癌细胞SGC-7901凋亡的影响及其机制.北京中医药大学学报,2015,38(7):457-461
[30]邓凤春,于占江,杨钰,等.隐丹参酮对人胃癌SGC-7901细胞增殖及血管内皮生长因子m RNA表达的影响.中国医药导报,2015,12(6):7-10
[31]Zhou L H,Hu Q,Sui H,et al.TanshinoneⅡ-a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer.Asian Pacific Journal of Cancer Prevention Apjcp,2012,13(9):4453-4458
[32]王炎,刘宣,周利红,等.丹参酮Ⅱ_A对裸鼠人肠癌血管新生的抑制作用.中国实验方剂学杂志,2013,19(3):167-171
[33]黄岩,王洁,常文军,等.STAT3磷酸化抑制剂隐丹参酮提高5-FU诱导的结直肠癌细胞凋亡.国际药学研究杂志,2016,43(2):296-300
[34]刘小微,王慧君,梁伟,等.从Akt/COX-2/P-gp信号通路研究丹参酚酸B逆转HCT-8/VCR细胞多药耐药的作用及机制.中国中西医结合消化杂志,2016,24(5):338-343
[35]Yuxian X,Feng T,Ren L,et al.TanshinoneⅡ-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo.Tumori,2009,95(6):789
[36]余丽芳,章必成,刘健,等.丹参体外诱导人肝癌细胞Hep G2凋亡的初步研究.湖北中医药大学学报,2016,18(4):8-11
[37]陈阳,赵秋宇,宋囡,等.丹参酮ⅡA诱导人肝癌Hep G2细胞凋亡的机制.中国老年学杂志,2015,35(5):1312-1315
[38]刘丽璇,吴灵飞,邓巍,等.丹参酮ⅡA对低氧条件下人肝癌Hep G2细胞增殖、凋亡的影响及与HIF-1α、VEGF和野生型P53蛋白表达的关系.中国病理生理杂志,2014,30(12):2155-2160
[39]Munagala R,Aqil F,Jeyabalan J,et al.TanshinoneⅡA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer.Cancer Letters,2015,356(2 Pt B):536-546
[40]Xu D,Lin T H,Li S,et al.Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells.Cancer Letters,2011,316(1):11-22
[41]Ye T,Zhu S,Zhu Y,et al.Cryptotanshinone induces melanoma cancer cells apoptosis via,ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion.Biomedicine&Pharmacotherapy,2016,82(8):319-326
[42]陈景,黄曙方,肖定璋,等.丹参酮ⅡA磺酸钠对胰腺癌BXPC-3细胞系增殖与细胞周期调控因子表达的影响.中国病理生理杂志,2013,29(1):112-115
[43]李慧,刘美,黎红佳,等.丹参酮ⅡA抑制髓系白血病细胞株增殖及诱导凋亡的研究.白血病·淋巴瘤,2014,23(6):334-338
[44]林洪生.恶性肿瘤中医诊疗指南.北京:人民卫生出版社,2014:24
[45]汤芷妮,骆云鹏,葛菲,等.活血化瘀抗肿瘤中草药作用机制的研究进展.中国药房,2016,27(8):1146-1149
[2]Chen W,Zheng R,Baade P D,et al.Cancer statistics in China,2015.CA:A Cancer Journal for Clinicians,2016,66(2):115-132
[3]张良登,张月,逯阳.活血化瘀中药防治恶性肿瘤复发与转移探讨.中华中医药学刊,2011,29(1):146-147
[4]楼招欢,杨波,沈炜,等.丹参二萜醌部位高速逆流色谱制备工艺及体外抗肿瘤活性研究.中草药,2015,46(5):679-682
[5]李伟,刘超,郭志敏,等.隐丹参酮通过抑制帽子依赖的翻译促进人肺癌细胞A549的凋亡.肿瘤防治研究,2016,43(7):550-554
[6]许冠华,雷俊华,金丽莎,等.隐丹参酮联合顺铂作用于非小细胞肺癌PC9细胞的体外研究.浙江中西医结合杂志,2014,24(12):1043-1045
[7]叶欢,阮君山,王少明,等.隐丹参酮抑制A549细胞复发转移的机制.海峡药学,2014,26(12):238-241
[8]孙蓓,叶因涛,王冬,等.二氢丹参酮对人肺癌GLC-82细胞的抑制作用及其机制研究.中国药房,2015,26(34):4775-4778
[9]简晓顺,刘相富,陈健清.丹参酮ⅡA抑制非小细胞肺癌NCI-H520细胞生长的研究.新医学,2013,44(5):347-350
[10]Zhang J,Wang J,Jiang J Y,et al.TanshinoneⅡA induces cytochrome c-mediated caspase cascade apoptosis in A549 human lung cancer cells via the JNK pathway.International Journal of Oncology,2014,45(2):683-690
[11]周生余,张发艳.丹参多酚酸盐对肺癌模型小鼠肺组织中VEGF和MMP-9表达的影响.中国药房,2016,27(25):3515-3517
[12]马齐襄,朱晓丹,胡凯文,等.253例原发性肺癌转移特征及中医证型分析.中华中医药杂志,2015,30(10):3659-3661
[13]Yu T,Zhou Z,Mu Y,et al.A novel anti-cancer agent,acetyltanshinoneⅡA,inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor.Cancer Letters,2014,346(1):94-103
[14]王跃华,郭章雄,朱志斌,等.丹参酮ⅡA抑制乳腺癌细胞转移的机制.黑龙江医学,2015,39(11):1209-1213
[15]赵丕文,臧金凤,陶仕英,等.丹参酮ⅡA抗乳腺癌T47 D细胞增殖的GPER途径研究.中国药理学通报,2015,31(10):1458-1462
[16]赵丕文,臧金凤,陶仕英,等.基因沉默技术研究丹参酮ⅡA抗雌激素受体阴性乳腺癌细胞增殖的GPER途径.中华中医药杂志,2016,31(11):4502-4506
[17]惠文涛,马小斌,昝瑛,等.丹参酮ⅡA磺酸钠对乳腺癌细胞株的作用及其机制研究.陕西医学杂志,2015,44(7):781-784
[18]朱智杰,刘兆国,周梁,等.隐丹参酮对人乳腺癌细胞MDAMB-231转移的影响及其分子机制.中国实验方剂学杂志,2014,20(11):160-165
[19]全军利,贺文兴,吴斯敏,等.隐丹参酮对乳腺癌MDAMB-231细胞自噬和侵袭迁移的影响.广西医科大学学报,2015,32(1):23-26
[20]易长胜,廖坤,余良忠,等.丹参素对乳腺癌MCF-7细胞株增殖影响及其分子机制.福建医药杂志,2015,37(5):56-58
[21]于庆生,经文善,宋加奎,等.丹参及其联合5-FU对人胃癌SGC-7901细胞凋亡的影响.世界中医药,2016,11(7):1315-1319
[22]赵雪峰,魏敬妙,李勇,等.丹参酮ⅡA诱导体外胃癌细胞的自噬.中成药,2014,36(1):10-14
[23]赵雪峰,魏敬妙,李勇,等.丹参酮ⅡA对胃癌细胞的抑制作用及其与NF-κB信号通路的关系.中国普通外科杂志,2014,23(4):483-487
[24]侯建红,张阳德.不同剂量丹参酮ⅡA对SGC7901胃癌细胞抑制作用的研究.中国现代医学杂志,2014,24(22):10-12
[25]王亚明,张桂东,尹清臣,等.丹参酮Ⅱa诱导人胃癌细胞MKN-45凋亡及对端粒酶活性的影响.中国生化药物杂志,2014,34(5):44-47,50
[26]徐俊丽.丹参酮ⅡA对人胃癌细胞SGC7901增殖凋亡的影响及其与COX-2表达的关系.医学临床研究,2015,32(8):1514-1517
[27]李萍,舒琦瑾.丹参酮ⅡA对人胃癌细胞株MKN-45体外侵袭和转移能力的影响.中华中医药学刊,2013,31(10):2318-2321
[28]宋烨.丹参酮Ⅰ和二氢丹参酮Ⅰ对人胃癌细胞MGC-803、乳腺癌细胞MCF-7的抗肿瘤活性研究.数理医药学杂志,2015,28(6):803-806
[29]邓凤春,于占江,杨钰,等.隐丹参酮对人胃癌细胞SGC-7901凋亡的影响及其机制.北京中医药大学学报,2015,38(7):457-461
[30]邓凤春,于占江,杨钰,等.隐丹参酮对人胃癌SGC-7901细胞增殖及血管内皮生长因子m RNA表达的影响.中国医药导报,2015,12(6):7-10
[31]Zhou L H,Hu Q,Sui H,et al.TanshinoneⅡ-a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer.Asian Pacific Journal of Cancer Prevention Apjcp,2012,13(9):4453-4458
[32]王炎,刘宣,周利红,等.丹参酮Ⅱ_A对裸鼠人肠癌血管新生的抑制作用.中国实验方剂学杂志,2013,19(3):167-171
[33]黄岩,王洁,常文军,等.STAT3磷酸化抑制剂隐丹参酮提高5-FU诱导的结直肠癌细胞凋亡.国际药学研究杂志,2016,43(2):296-300
[34]刘小微,王慧君,梁伟,等.从Akt/COX-2/P-gp信号通路研究丹参酚酸B逆转HCT-8/VCR细胞多药耐药的作用及机制.中国中西医结合消化杂志,2016,24(5):338-343
[35]Yuxian X,Feng T,Ren L,et al.TanshinoneⅡ-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo.Tumori,2009,95(6):789
[36]余丽芳,章必成,刘健,等.丹参体外诱导人肝癌细胞Hep G2凋亡的初步研究.湖北中医药大学学报,2016,18(4):8-11
[37]陈阳,赵秋宇,宋囡,等.丹参酮ⅡA诱导人肝癌Hep G2细胞凋亡的机制.中国老年学杂志,2015,35(5):1312-1315
[38]刘丽璇,吴灵飞,邓巍,等.丹参酮ⅡA对低氧条件下人肝癌Hep G2细胞增殖、凋亡的影响及与HIF-1α、VEGF和野生型P53蛋白表达的关系.中国病理生理杂志,2014,30(12):2155-2160
[39]Munagala R,Aqil F,Jeyabalan J,et al.TanshinoneⅡA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer.Cancer Letters,2015,356(2 Pt B):536-546
[40]Xu D,Lin T H,Li S,et al.Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells.Cancer Letters,2011,316(1):11-22
[41]Ye T,Zhu S,Zhu Y,et al.Cryptotanshinone induces melanoma cancer cells apoptosis via,ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion.Biomedicine&Pharmacotherapy,2016,82(8):319-326
[42]陈景,黄曙方,肖定璋,等.丹参酮ⅡA磺酸钠对胰腺癌BXPC-3细胞系增殖与细胞周期调控因子表达的影响.中国病理生理杂志,2013,29(1):112-115
[43]李慧,刘美,黎红佳,等.丹参酮ⅡA抑制髓系白血病细胞株增殖及诱导凋亡的研究.白血病·淋巴瘤,2014,23(6):334-338
[44]林洪生.恶性肿瘤中医诊疗指南.北京:人民卫生出版社,2014:24
[45]汤芷妮,骆云鹏,葛菲,等.活血化瘀抗肿瘤中草药作用机制的研究进展.中国药房,2016,27(8):1146-1149