载抗肿瘤药物的壳聚糖纳米粒氨基化靶向修饰物的研究进展
摘要
目的:为寻找或开发更优的载抗肿瘤药物的壳聚糖纳米粒靶向修饰物提供参考。方法:以"壳聚糖""纳米粒""氨基""靶向修饰""抗肿瘤""Chitosan""Nanoparticles""Amino""Targeting modification""Antitumor"等为关键词,组合查询2005年1月-2018年3月在中国知网、万方、维普、Pub Med、Web of Science、Elsevier、Springer Link等数据库中的相关文献,对载抗肿瘤药物的壳聚糖纳米粒氨基化靶向修饰物从大分子和小分子配体两方面进行论述。结果与结论:共检索到相关文献300篇,其中有效文献36篇。对壳聚糖纳米粒表面的氨基进行修饰,可以获得具有主动寻靶作用的壳聚糖纳米粒,现有的靶向修饰配体有小分子的叶酸、生物素、乳糖酸、甘草酸等,大分子的透明质酸、鱼精蛋白、转铁蛋白、缬氨酸-精氨酸-甘氨酸-天冬氨酸-谷氨酸环肽、CD59特异性配体肽、促黄体生成素释放激素及MUC1等。未来研究重点应利用壳聚糖纳米粒氨基这一表面特性,寻找或开发出更优的壳聚糖纳米粒的靶向修饰物,进一步提高壳聚糖纳米粒对肿瘤细胞的靶向效率。
引文
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[2]LIN YS,LEE MY,YANG CH,et al.Active targeted drug delivery for microbes using nano-carriers[J].Curr Top Med Chem,2015,15(15):1525-1531.
[3]张程亮,孙纳.壳聚糖用于抗肿瘤治疗的研究进展[J].中国药房,2005,16(7):549-551.
[4]KHOEE S,SAADATINIA A,BAFKARY R.Ultrasoundassisted synthesis of p H-responsive nanovector based on PEG/chitosan coated magnetite nanoparticles for 5-FU delivery[J].Ultrason Sonochem,2017.DOI:10.1016/j.ultsonch.2017.04.025.
[5]林爱华,刘奕明,平其能.壳聚糖纳米粒表面游离氨基与纳米粒特性研究[J].药学学报,2007,42(3):323-328.
[6]WANG FQ,WANG Y,MA QZ,et al.Development and characterization of folic acid-conjugated chitosan nanoparticles for targeted and controlled delivery of gemcitabine in lung cancer therapeutics[J].Artif Cells Nanomed Biotechnol,2017,45(8):1530-1538.
[7]CHENG MR,ZHU WP,LI Q,et al.Anti-cancer efficacy of biotinylated chitosan nanoparticles in liver cancer[J].Oncotarget,2017,8(35):59068-59085.
[8]ZHA Q,WANG X,CHENG X,et al.Acid-degradable carboxymethyl chitosan nanogels via an ortho ester linkage mediated improved penetration and growth inhibition of 3-D tumor spheroids in vitro[J].Mater Sci Eng C Mater Biol Appl,2017.DOI:10.1016/j.msec.2017.04.098.
[9]WANG T,HOU J,SU C,et al.Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44[J].J Nanobiotechnology,2017.DOI:10.1186/s112951-016-0245-2.
[10]YANG P,LI B,YIN QF,et al.Carboxymethyl chitosan nanoparticles coupled with CD59-specific ligand peptide for targeted delivery of C-phycocyanin to He La cells[J].Tumour Biol,2017.DOI:10.1177/1010428317692267.
[11]YU X,HOU J,SHI Y,et al.Preparation and characterization of novel chitosan-protamine nanoparticles for nucleus-targeted anticancer drug delivery[J].Int J Nanomedicine,2016.DOI:10.2147/IJN.s117066.
[12]郭林峰,蒋宗林,李东红.叶酸受体介导靶向药物载体的研究进展[J].现代肿瘤医学,2013,21(5):1128-1131.
[13]CUI X,GUAN X,ZHONG S,et al.Multi-stimuli responsive smart chitosan-based microcapsules for targeted drug delivery and triggered drug release[J].Ultrason Sonochem,2017.DOI:10.1016/j.ultsonch.2017.03.011.
[14]汪小乐,简晓顺,庞廷媛,等.叶酸偶联壳聚糖载多西他赛纳米粒的制备[J].中国药房,2014,25(29):2740-2743.
[15]FATHI M,ZANGABAD PS,AGHANEJAD A,et al.Folate-conjugated thermosensitive O-maleoyl modified chitosan micellar nanoparticles for targeted delivery of erlotinib[J].Carbohydr Polym,2017.DOI:10.1016/j.carbpol.2017.05.007.
[16]TRIPODO G,MANDRACCHIA D,COLLINA S,et al.New perspectives in cancer therapy:the biotin-antitumor molecule conjugates[J].Angew Chem Int Ed,2014.DOI:10.4172/2161-0444.s1-004.
[17]CHEN HL,XIE LQ,QIN JW,et al.Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin[J].Colloids Surf B Biointerfaces,2015.DOI:10.1016/j.colsurfb.2015.11.033.
[18]ROGGENBUCK D,MYTILINAIOU MG,LAPIN SV,et al.Asialoglycoprotein receptor(ASGPR):a peculiar target of liver-specific autoimmunity[J].Auto Immun Highlights,2012,3(3):119-125.
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[25]李伟伟,高美华,张蓓,等.CD59配体肽真核表达系统的构建及对PC-3细胞活性的作用研究[J].细胞与分子免疫学杂志,2010,26(1):80-83.
[26]WANG Y,JIANG L,YIN Q,et al.The targeted antitumor effects of C-PC/CMC-CD59sp nanoparticles on He La cells in vitro and in vivo[J].J Cancer,2017,8(15):3001-3013.
[27]TONG HP,WANG LF,GUO YL,et al.Preparation of protamine cationic nanobubbles and experimental study of their physical properties and in vivo contrast enhancement[J].Ultrasound Med Biol,2013,39(11):2147-2157.
[28]王子臣.吉非替尼壳聚糖鱼精蛋白肺靶向纳米粒的制备及靶向性初步研究[D].锦州:锦州医科大学,2017.
[29]MATSUSAKA S,LENZ HJ.Pharmacogenomics of fluorouracil-based chemotherapy toxicity[J].Expert Opin Drug Metab Toxicol,2015,11(5):811-821.
[30]TIAN Q,ZHANG CN,WANG XH,et al.Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol)nanoparticles for liver-targeted delivery[J].Biomaterials,2010,31(17):4748-4756.
[31]AGRAWAL P,SINGH RP,SONALI,et al.TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy[J].Mater Sci Eng C Mater Biol Appl,2017.DOI:10.1016/j.msec.2017.02.008.
[32]CHEN Y,FENG S,LIU W,et al.Vitamin E succinategrafted-chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles loaded with paclitaxel for U87MG tumor therapy[J].Mol Pharm,2017,14(4):1190-1203.
[33]VARSHOSAZ J,HASSANZADEH F,ALIABADI HS,et al.Targeted delivery of doxorubicin to breast cancer cells by magnetic LHRH chitosan bioconjugated nanoparticles[J].Int J Biol Macromol,2016,93(Pt A):1192-1205.
[34]ESFANDYARI-MANESH M,MOHAMMADI A,ATYABI F,et al.Specific targeting delivery to MUC1 overexpressing tumors by albumin-chitosan nanoparticles conjugated to DNA aptamer[J].Int J Pharm,2016,515(1/2):607-615.
[35]DOOLITTLE E,PEIRIS PM,DORON G,et al.Spatiotemporal targeting of a dual-ligand nanoparticle to cancer metastasis[J].ACS Nano,2015,9(8):8012-8021.
[36]KAKIMOTO S,MORIYAMA T,TANABE T,et al.Dualligand effect of transferrin and transforming growth factor alpha on polyethyleneimine-mediated gene delivery.[J].J Control Release,2007,120(3):242-249.