不同作用机制镇痛药物用于创伤骨科的临床效果分析
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摘要
目的研究不同作用机制镇痛药物用于创伤骨科的临床效果。方法选择我院2017年1月至2017年12月收治的60例创伤骨科患者,按照治疗方式不同分为三组各20例。研究组采用地佐辛治疗,对照A组采用双氯芬酸钠治疗,对照B组采用曲马多治疗,对比三组的治疗结果。结果治疗前,三组的疼痛评分比较差异无统计学意义(P>0.05);治疗12 h、 1 d、 2 d及3d后,研究组的疼痛评分均低于对照A组、对照B组(P <0.05)。研究组的不良反应发生率为5.00%,明显低于对照A组的35.00%及对照B组的35.00%(P <0.05)。结论地佐辛、双氯芬酸钠、曲马多应用于创伤骨科中均具有一定效果,其中地佐辛效果更好,可快速缓解疼痛,避免不良反应产生,为预后提供保障。
Objective To study the clinical effect of analgesic drugs with different mechanisms in traumatic orthopedics. Methods 60 cases of traumatic orthopedic patients admitted to our hospital from January 2017 to December 2017 were selected and divided into three groups according to different treatment methods, with 20 cases in each group. The study group was treated with dezocine, the control group A was treated with diclofenac sodium, and the control group B was treated with tramadol. The treatment effects were compared among the three groups. Results Before treatment, no statistical difference was found in the pain scores among the three groups(P >0.05). 12 h, 1 d, 2 d and 3 d after treatment, the pain scores of the study group were lower than those of the control group A and control group B(P <0.05). The incidence of adverse reactions of the study group was 5.00%, significantly lower than 35.00% of the control group A and 35.00% of the control group B(P <0.05). Conclusions Dezocine, diclofenac sodium and tramadol in the application of orthopedic trauma have certain effects. Dezocine has better effect, can quickly relieve the pain, avoid the adverse reactions, and provide a guarantee for prognosis.
Objective To study the clinical effect of analgesic drugs with different mechanisms in traumatic orthopedics. Methods 60 cases of traumatic orthopedic patients admitted to our hospital from January 2017 to December 2017 were selected and divided into three groups according to different treatment methods, with 20 cases in each group. The study group was treated with dezocine, the control group A was treated with diclofenac sodium, and the control group B was treated with tramadol. The treatment effects were compared among the three groups. Results Before treatment, no statistical difference was found in the pain scores among the three groups(P >0.05). 12 h, 1 d, 2 d and 3 d after treatment, the pain scores of the study group were lower than those of the control group A and control group B(P <0.05). The incidence of adverse reactions of the study group was 5.00%, significantly lower than 35.00% of the control group A and 35.00% of the control group B(P <0.05). Conclusions Dezocine, diclofenac sodium and tramadol in the application of orthopedic trauma have certain effects. Dezocine has better effect, can quickly relieve the pain, avoid the adverse reactions, and provide a guarantee for prognosis.
引文
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[8]陈琳,王艳玲,王建珍.骨科手术中帕瑞昔布钠复合地佐辛超前镇痛效果观察[J].山东医药, 2015, 55(5):49-51.
[9]周树立,刘志勋,罗天放.不同作用机制镇痛药物用于创伤骨科的临床效果分析[J].北方药学, 2018, 15(8):128-129.
[10]程文娟,刘文勋,杨敏,等.地佐辛的镇痛作用及其对术后谵妄和躁动的影响[J].中国新药与临床杂志, 2018, 37(2):70-74.
[2]罗晓东,李宝丰.丙帕他莫联合曲马多在骨科手术围手术期镇痛效果的研究[J].检验医学与临床, 2015, 12(11):1614-1615.
[3]付鹏.帕瑞昔布钠注射液对急性腰椎间盘突出手术患者的镇痛作用[J].中国临床药理学杂志, 2016, 32(22):2063-2065, 2093.
[4] Marzok MA, El-khodery SA. Comparative analgesic and seda tive ef fects of tramadol, tramadol-lidocaine and lidocaine for caudal epidural analgesia in donkeys(Equus asinus)[J]. Vet Anaesth Analg, 2015,42(2):215-219.
[5]许宏辉,应江明.苏芬太尼与帕瑞昔布钠对骨科手术术后自控镇痛的效果比较分析[J].浙江创伤外科, 2015, 20(4):816-818.
[6]张军,侯立朝,鲁彦斌,等.骨科术后疼痛的原因分析及对策研究[J].现代生物医学进展, 2016, 16(27):5370-5372, 5400.
[7]钭伟国,周俊,刘喜燕,等.地佐辛抑制下肢手术止血带反应的临床研究[J].浙江创伤外科, 2015, 20(6):1253-1254.
[8]陈琳,王艳玲,王建珍.骨科手术中帕瑞昔布钠复合地佐辛超前镇痛效果观察[J].山东医药, 2015, 55(5):49-51.
[9]周树立,刘志勋,罗天放.不同作用机制镇痛药物用于创伤骨科的临床效果分析[J].北方药学, 2018, 15(8):128-129.
[10]程文娟,刘文勋,杨敏,等.地佐辛的镇痛作用及其对术后谵妄和躁动的影响[J].中国新药与临床杂志, 2018, 37(2):70-74.