新型超分子水杨酸联合米诺环素胶囊与克林霉素磷酸酯凝胶治疗寻常性痤疮疗效观察
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摘要
目的:观察新型超分子水杨酸联合米诺环素与克林霉素磷酸酯治疗寻常性痤疮的临床疗效。方法:选取80例寻常性痤疮患者,随机分为新型超分子水杨酸联合米诺环素与克林霉素磷酸酯组(实验组),阿达帕林联合米诺环素与克林霉素磷酸酯组(对照组),每组各40例,分别于治疗前及治疗后2、4、8、12周观察临床疗效。结果:治疗12周后,两组患者炎性皮损数、非炎性皮损数及总皮损数较治疗前均明显减少。实验组与对照组的治疗总有效率虽无明显差异(P>0.05),但实验组的基愈率明显高于对照组(P<0.05),不良反应(干燥、脱屑、红斑、瘙痒、灼热)发生率低于对照组。从第4周开始实验组的总皮损减少速率明显快于对照组。结论:新型超分子水杨酸联合米诺环素、克林霉素磷酸酯治疗寻常性痤疮效果较好,不良反应少。
Objective To observe the efficacy of acne vulgaris treated with new supramolecular salicylic acid combined with minocycline and clindamycin phosphate. Methods A total of 80 patients with acne vulgais were participated in this study. 40 cases were treated with new supramolecular salicylic acid combined with minocycline and clindamycin phosphate(research group), while the other 40 cases were treated with adapalene gel combined with minocycline, clindamycin phosphate(control group). The evaluations of the two groups were compared at baseline and after 2,4,8,12 weeks of treatment by a single-blind investigator. Results After 12 weeks of treatment,both groups showd significant improvement, and both inflammatory as well as non-inflammatory lesions were effectively reduced. There have not different in total effective rate between research group and control group(P>0.05), however, the adverse reaction(dryness,peeling,erythem,burning and itching)of research group was less than control group. In addition, total lesion counts in research group were decreased faster than control group after 4 weeks of treatment. Conclusion New supramolecular salicylic acid combined with minocycline and clindamycin phosphate is effective in the treatment of acne vulgaris and is able to be better tolerated than adapalene gel.
Objective To observe the efficacy of acne vulgaris treated with new supramolecular salicylic acid combined with minocycline and clindamycin phosphate. Methods A total of 80 patients with acne vulgais were participated in this study. 40 cases were treated with new supramolecular salicylic acid combined with minocycline and clindamycin phosphate(research group), while the other 40 cases were treated with adapalene gel combined with minocycline, clindamycin phosphate(control group). The evaluations of the two groups were compared at baseline and after 2,4,8,12 weeks of treatment by a single-blind investigator. Results After 12 weeks of treatment,both groups showd significant improvement, and both inflammatory as well as non-inflammatory lesions were effectively reduced. There have not different in total effective rate between research group and control group(P>0.05), however, the adverse reaction(dryness,peeling,erythem,burning and itching)of research group was less than control group. In addition, total lesion counts in research group were decreased faster than control group after 4 weeks of treatment. Conclusion New supramolecular salicylic acid combined with minocycline and clindamycin phosphate is effective in the treatment of acne vulgaris and is able to be better tolerated than adapalene gel.
引文
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[11]Bernier C,Dreno B.[Minocycline][J].Ann Dermatol Venereol,2001,128(5):627-637.
[12]Pierard-Franchimont C,Goffin V,Arrese JE,et al.Lymecycline and minocycline in inflammatory acne:a randomized,double-blind intent-to-treat study on clinical and in vivo antibacterial efficacy[J].Skin Pharmacol Appl Skin Physiol,2002,15(2):112-119.
[13]Leyden JJ.A review of the use of combination therapies for the treatment of acne vulgaris[J].J Am Acad Dermatol,2003,49(3Suppl):S200-S210.
[14]Thiboutot D,Gollnick H,Bettoli V,et al.New insights into the management of acne:an update from the global alliance to improve outcomes in acne group[J].J Am Acad Dermatol,2009,60(5Suppl):S1-S50.
[15]Babayeva L,Akarsu S,Fetil E,et al.Comparison of tretinoin0.05%cream and 3%alcohol-based salicylic acid preparation in the treatment of acne vulgaris[J].J Eur Acad Dermatol Venereol,2011,25(3):328-333.
[16]Leyden JJ,Krochmal L,Yaroshinsky A.Two randomized,doubleblind,controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris[J].J Am Acad Dermatol,2006,54(1):73-81.
[17]Bowe WP,Shalita AR.Effective over-the-counter acne treatments[J].Semin Cutan Med Surg,2008,27(3):170-176.
[18]Alba MN,Gerenutti M,Yoshida VM,et al.Clinical comparison of salicylic acid peel and LED-Laser phototherapy for the treatment of Acne vulgaris in teenagers[J].J Cosmet Laser Ther,2017,19(1):49-53.
[19]Dayal S,Amrani A,Sahu P,et al.Jessner's solution vs.30%salicylic acid peels:a comparative study of the efficacy and safety in mild-tomoderate acne vulgaris[J].J Cosmet Dermatol,2017,16(1):43-51.
[20]De Souza A,Christiansen C,Jamie S.The use of salicylic acid in a new delivery system as a co-adjuvant topical treatment for acne vulgaris[J].Aesthet Surg J,2005,25(1):40-43.
[2]Akarsu S,Fetil E,Yucel F,et al.Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris[J].J Dermatol,2012,39(5):433-438.
[3]Nast A,Dreno B,Bettoli V,et al.European evidence-based(S3)guideline for the treatment of acne-update 2016-short version[J].JEur Acad Dermatol Venereol,2016,30(8):1261-1268.
[4]项蕾红.中国痤疮治疗指南(2 0 1 4修订版)[J].临床皮肤科杂志,2015,44(1):52-57.
[5]Hayashi N,Kawashima M.Efficacy of oral antibiotics on acne vulgaris and their effects on quality of life:a multicenter randomized controlled trial using minocycline,roxithromycin and faropenem[J].J Dermatol,2011,38(2):111-119.
[6]Jung GW,Tse JE,Guiha I,et al.Prospective,randomized,open-label trial comparing the safety,efficacy,and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne[J].J Cutan Med Surg,2013,17(2):114-122.
[7]Leyden J,Bergfeld W,Drake L,et al.A systemic type I 5 alphareductase inhibitor is ineffective in the treatment of acne vulgaris[J].J Am Acad Dermatol,2004,50(3):443-447.
[8]Stewart DM,Torok HM,Weiss JS,et al.Dose-ranging efficacy of new once-daily extended-release minocycline for acne vulgaris[J].Cutis,2006,78(4 Suppl):11-20.
[9]Eichenfield LF,Krakowski AC,Piggott C,et al.Evidence-based recommendations for the diagnosis and treatment of pediatric acne[J].Pediatrics,2013,131(Suppl 3):S163-S186.
[10]Ochsendorf F.Systemic antibiotic therapy of acne vulgaris[J].J Dtsch Dermatol Ges,2006,4(10):828-841.
[11]Bernier C,Dreno B.[Minocycline][J].Ann Dermatol Venereol,2001,128(5):627-637.
[12]Pierard-Franchimont C,Goffin V,Arrese JE,et al.Lymecycline and minocycline in inflammatory acne:a randomized,double-blind intent-to-treat study on clinical and in vivo antibacterial efficacy[J].Skin Pharmacol Appl Skin Physiol,2002,15(2):112-119.
[13]Leyden JJ.A review of the use of combination therapies for the treatment of acne vulgaris[J].J Am Acad Dermatol,2003,49(3Suppl):S200-S210.
[14]Thiboutot D,Gollnick H,Bettoli V,et al.New insights into the management of acne:an update from the global alliance to improve outcomes in acne group[J].J Am Acad Dermatol,2009,60(5Suppl):S1-S50.
[15]Babayeva L,Akarsu S,Fetil E,et al.Comparison of tretinoin0.05%cream and 3%alcohol-based salicylic acid preparation in the treatment of acne vulgaris[J].J Eur Acad Dermatol Venereol,2011,25(3):328-333.
[16]Leyden JJ,Krochmal L,Yaroshinsky A.Two randomized,doubleblind,controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris[J].J Am Acad Dermatol,2006,54(1):73-81.
[17]Bowe WP,Shalita AR.Effective over-the-counter acne treatments[J].Semin Cutan Med Surg,2008,27(3):170-176.
[18]Alba MN,Gerenutti M,Yoshida VM,et al.Clinical comparison of salicylic acid peel and LED-Laser phototherapy for the treatment of Acne vulgaris in teenagers[J].J Cosmet Laser Ther,2017,19(1):49-53.
[19]Dayal S,Amrani A,Sahu P,et al.Jessner's solution vs.30%salicylic acid peels:a comparative study of the efficacy and safety in mild-tomoderate acne vulgaris[J].J Cosmet Dermatol,2017,16(1):43-51.
[20]De Souza A,Christiansen C,Jamie S.The use of salicylic acid in a new delivery system as a co-adjuvant topical treatment for acne vulgaris[J].Aesthet Surg J,2005,25(1):40-43.