输尿管肾源性腺瘤合并肾脏结核1例并文献复习
摘要
目的探讨输尿管肾源性腺瘤(nephrogenic adenoma,NA)的临床病理学和免疫表型特征。方法回顾性分析1例输尿管NA合并肾脏结核的临床资料及病理学特征,对其行HE及免疫组化En Vision法染色,并复习相关文献。结果患者男性,18岁。大体上输尿管腔内见狭窄区;镜下见黏膜下增生腺体形成小管状、乳头状结构,管腔大小形状不一,被覆单层立方上皮,黏膜下见慢性炎细胞浸润;肾脏结核改变。免疫表型:AMACR(P504s)(+);CK7(弱+);CK34βE12(局灶+);CD10、CK20、Villin、vimentin(-)。结论输尿管NA是非常少见的泌尿系统病变,需与息肉、移行细胞癌及腺癌鉴别,掌握其组织形态特征及免疫表型是正确诊断的关键。
引文
[1]Amin W,Parwani A V.Nephrogenic adenoma[J].Pathol Res Pract,2010,2016(10):659-62.
[2]Herlitz L C,Tong G X,Hamele-Bena D,Greenebaum E.Nephrogenic adenoma identified on urine cytology using PAX-2 immunos taining[J].Diagn Cytopathol,2008,36(1):47-49.
[3]Peeker R,Aldenborg F,Fall M.Nephrogenic adenoma-a study with special reference to clinical presentatinon[J].Br J Urol,1997,80(4):539-542.
[4]秦桂萍,华玉兰,侯海娜.膀胱肾源性腺瘤1例[J].临床与实验病理学杂志,2012,28(3):355-351.
[5]Gordetsky J,Gennaro K H,Selph J P,Rais-Bahrami S.Nephrogenic adenoma:clinical features,management,and diagnostic pitfalls[J].Urology,2016,95:29-33.
[6]Diolombi M,Ross H M,Mercalli F,et al.Nephrogenic adenoma:a report of 3 unusual cases infiltrating into perinephric adipose tissue[J].Am J Surg Pathol,2013,37(4):532.
[7]Khedaoui R,Encabo B,Tardio J C.Fibromyxoid nephrogenic adenoma protruding in a renal cortical cyst.A rare morphological variant in an outstanding location[J].Pathol Res Pract,2016,212(2):135-138.
[8]陈铌,陈雪芹,徐苗,等.肾源性腺瘤临床病理和免疫组化分析[J].临床与实验病理学杂志,2012,28(8):883-886.
[9]Herlitz L C,Tong G X,Hamclc-Bena D,et al.Nephrogenic adenoma identified on urnie PAX-2 immunostaining[J].Diagn Cytopathol,2008,36(1):47-49.
[10]Quinones W,Ziober A,Yao Y,et al.Immunohistochemical marers for the differential diagnosis of nephrogenic adenomas[J].Diagn Cytopathol,2013,17(1):41-44.
[11]Alexiev B A,Le Vea C M.Nephrogenic adenoma of the urinary tract:a revicw[J].Int J Surg Pathol,2012,20(2):123-131.
[12]Kuzaka B,Pudeko P,Powaa A,et al.Nephrogenic adenoma of the urinary bladder:a report of three cases and a review of the literature[J].Ann Transplant,2014,19:153-156.
[13]Lopez J I,Schiavo-Lena M,Corominas-Cishek A,et al.Nephrogenic adenoma of the urinary tract:clinical,histological,and immunohistochemical characteristics[J].Vicrchow Arch,2013,463(6):819-825.
[2]Herlitz L C,Tong G X,Hamele-Bena D,Greenebaum E.Nephrogenic adenoma identified on urine cytology using PAX-2 immunos taining[J].Diagn Cytopathol,2008,36(1):47-49.
[3]Peeker R,Aldenborg F,Fall M.Nephrogenic adenoma-a study with special reference to clinical presentatinon[J].Br J Urol,1997,80(4):539-542.
[4]秦桂萍,华玉兰,侯海娜.膀胱肾源性腺瘤1例[J].临床与实验病理学杂志,2012,28(3):355-351.
[5]Gordetsky J,Gennaro K H,Selph J P,Rais-Bahrami S.Nephrogenic adenoma:clinical features,management,and diagnostic pitfalls[J].Urology,2016,95:29-33.
[6]Diolombi M,Ross H M,Mercalli F,et al.Nephrogenic adenoma:a report of 3 unusual cases infiltrating into perinephric adipose tissue[J].Am J Surg Pathol,2013,37(4):532.
[7]Khedaoui R,Encabo B,Tardio J C.Fibromyxoid nephrogenic adenoma protruding in a renal cortical cyst.A rare morphological variant in an outstanding location[J].Pathol Res Pract,2016,212(2):135-138.
[8]陈铌,陈雪芹,徐苗,等.肾源性腺瘤临床病理和免疫组化分析[J].临床与实验病理学杂志,2012,28(8):883-886.
[9]Herlitz L C,Tong G X,Hamclc-Bena D,et al.Nephrogenic adenoma identified on urnie PAX-2 immunostaining[J].Diagn Cytopathol,2008,36(1):47-49.
[10]Quinones W,Ziober A,Yao Y,et al.Immunohistochemical marers for the differential diagnosis of nephrogenic adenomas[J].Diagn Cytopathol,2013,17(1):41-44.
[11]Alexiev B A,Le Vea C M.Nephrogenic adenoma of the urinary tract:a revicw[J].Int J Surg Pathol,2012,20(2):123-131.
[12]Kuzaka B,Pudeko P,Powaa A,et al.Nephrogenic adenoma of the urinary bladder:a report of three cases and a review of the literature[J].Ann Transplant,2014,19:153-156.
[13]Lopez J I,Schiavo-Lena M,Corominas-Cishek A,et al.Nephrogenic adenoma of the urinary tract:clinical,histological,and immunohistochemical characteristics[J].Vicrchow Arch,2013,463(6):819-825.