甘丙肽与人类代谢综合征关系的研究进展
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摘要
人类代谢综合征是目前临床常见病,目前人类代谢综合征的发病机制虽然尚未明确,但其均与遗传、免疫、环境等各种因素有关。甘丙肽能够拮抗炎症的发生发展。甘丙肽与胰岛素抵抗、慢性炎症过程之间存在内在联系。同时甘丙肽还可以通过抗炎和调节血糖平衡,影响胰岛素抵抗发生发展。
At present, human metabolic syndrome is a common disease. The pathogenesis of human metabolic syndrome is not clear yet, but it is related to heredity, immunity, environment and so on. There is intrinsic relationship between galanin and insulin resistance and chronic inflammatory process. At the same time it can also regulate glucose homeostasis by galanin and anti-inflammatory effects of the development of insulin resistance.Key word:
At present, human metabolic syndrome is a common disease. The pathogenesis of human metabolic syndrome is not clear yet, but it is related to heredity, immunity, environment and so on. There is intrinsic relationship between galanin and insulin resistance and chronic inflammatory process. At the same time it can also regulate glucose homeostasis by galanin and anti-inflammatory effects of the development of insulin resistance.Key word:
引文
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[17] Timotin A,Pisarenko,Sidorova MMyocardial,et al.protection from ischemia/reperfusion injury by exogenous galanin fragment[J].Oncotarget,2017,8(13):21241-21252.
[18] Talero E,Sanchez-Fidalgo S,Calvo JR,et al.Chronic administration of galanin attenuates the TNBS-induced colitis in rats[J].Regul Pept,2007,141(1-3):96-104.
[19] McDonald AC,Schuijers JA,Gundlach AL,et al.Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNFalpha and GalR2 mRNA induced by chronic daily injections of an injurious vehicle[J].Bone,2007,40(4):895-903.
[20] Sandoval-Alzate HF,Agudelo-Zapata Y,González-Clavijo AM,et al.Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test[J].Sci Rep,2016,6:31661.
[21] Fang P,Yu M,Gu X,et al.Low levels of plasma galanin in obese subjects with hypertension[J].J Endocrinol Invest,2017,40(1):63-68.
[2] Pisarenko O,Timotin A,Sidorova M,et al.Cardioprotective properties of N-terminal galanin fragment (2-15) in experimental ischemia/reperfusion injury[J].Oncotarget,2017,8(60):101659-101671.
[3] 张真稳,方彭华.甘丙肽受体1正性调节胰岛素敏感性的作用[J].扬州大学学报(农业与生命科学版),2015,36(2):19-23.
[4] Zhang Z,Fang P,Shi M,et al.Elevated galanin may predict the risk of type 2 diabetes mellitus for development of Alzheimer's disease[J].Mech Ageing Dev,2015,150:20-6.
[5] Lu M,Sarruf DA,Talukdar S,et al.Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones[J].Nat Med,2011,17(5):618-622.
[6] Ramírez Alvarado MM,Sánchez Roitz C.Relationship between serum levels of C-reactive protein and alpha1-antitrypsin and insulin resistance in obese women[J].Invest Clin,2014,55:249-259.
[7] Mahajan A,Jaiswal A,Tabassum R,et al.Elevated levels of C-reactive protein as a risk factor for MetabolicSyndrome in Indians[J].Atherosclerosis,2012,220(1):275-81.
[8] Zhang Z,Fang P,Shi M,et al.Elevated galanin may predict the risk of type 2 diabetes mellitus for development of Alzheimer's disease[J].Mech Ageing Dev,2015,150:20-6.
[9] He B,Shi MY,Zhang L,et al.Beneficial effect of galanin on insulin sensitivity in muscle of type 2 diabetic rats[J].Physio Behav,2011,103(3-4):284-9.
[10] Jiang L,Shi MY,Guo L,et al.Effect of M35,a neuropeptide galanin antagonist on glucose uptake translated by glucose transporter 4 in trained rat skeletal muscle[J].Neurosci Lett,2009,467(2):178-81.
[11] Liang Y,Sheng S,Fang P,et al.Exercise-induced galanin release facilitated GLUT4 translocation in adipocytes of type 2 diabetic rats[J].Pharmacol biochem behav,2012,100(3):554-9.
[12] Zhang Z,Sheng S,Guo L,et al.Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats[J].Mol Cell Endocrinol,2012,361(1/2):213-218.
[13] Guo L,Shi M,Zhang L,et al.Galanin antagonist increases insulin resistance by reducing glucose transporter 4effect in adipocytes of rats[J].Gen Comp Endocrinol,2011,173(1):159-63.
[14] Simpson J,Sundler F,Humes DJ,et al.Post inflammatory damage to the enteric nervous system in diverticulardisease and its relationship to symptoms[J].Neurogastroenterol Motil,2009,21(8):847- e58.
[15] Ji RR,Zhang X,Zhang Q,et al.Central and peripheral expression of galanin in response to 4 inflammation[J].Neuroscience,1995,68(2):563-76.
[16] Qinyang W,Hultenby K,Adlan E,et al.Galanin in adjuvant arthritis in the rat[J].J Rheumatol,2004,31(2):302-7.
[17] Timotin A,Pisarenko,Sidorova MMyocardial,et al.protection from ischemia/reperfusion injury by exogenous galanin fragment[J].Oncotarget,2017,8(13):21241-21252.
[18] Talero E,Sanchez-Fidalgo S,Calvo JR,et al.Chronic administration of galanin attenuates the TNBS-induced colitis in rats[J].Regul Pept,2007,141(1-3):96-104.
[19] McDonald AC,Schuijers JA,Gundlach AL,et al.Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNFalpha and GalR2 mRNA induced by chronic daily injections of an injurious vehicle[J].Bone,2007,40(4):895-903.
[20] Sandoval-Alzate HF,Agudelo-Zapata Y,González-Clavijo AM,et al.Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test[J].Sci Rep,2016,6:31661.
[21] Fang P,Yu M,Gu X,et al.Low levels of plasma galanin in obese subjects with hypertension[J].J Endocrinol Invest,2017,40(1):63-68.