粘着斑激酶在神经系统疾病中的作用研究进展
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摘要
粘着斑激酶(focal adhesion kinase,FAK)是对动态调节细胞黏附结构至关重要的一种新型的非受体型蛋白酪氨酸激酶(non-receptor protein tyrosine kinase),通过与整合素(integrin)配体的结合实现酪氨酸位点的磷酸化而激活。有研究显示,FAK与神经系统发育、突触可塑性、神经系统疾病的发生发展密切相关。本文就近年来FAK在神经系统疾病中的作用作一综述。
Focal adhesion kinase( FAK) is one of novel non-receptor protein tyrosine kinases critical for the dynamic regulation of cell adhesion structures,which is activated through the phosphorylation of its tyrosine residue by ligands that bind to integrins. Some studies have demonstrated that FAK has close relationship with nervous system development,synaptic plasticity and the occurrence and development of nervous system diseases. The review summarized the functions of FAK in neurological diseases.
Focal adhesion kinase( FAK) is one of novel non-receptor protein tyrosine kinases critical for the dynamic regulation of cell adhesion structures,which is activated through the phosphorylation of its tyrosine residue by ligands that bind to integrins. Some studies have demonstrated that FAK has close relationship with nervous system development,synaptic plasticity and the occurrence and development of nervous system diseases. The review summarized the functions of FAK in neurological diseases.
引文
1 de Ruiter EJ,Willems SM.PTK2/FAK:a new predictive biomarker for response to radiotherapy in head and neck squamous cell carcinoma[J].Annals of Translational Medicine,2016,4(Suppl 1):S44
2 Navarro AI,Rico B.Focal adhesion kinase function in neuronal development[J].Current Opinion in Neurobiology,2014,?(27):89-95
3 Rico B,Beggs HE,Schahin-Reed D,et al.Control of axonal branching and synapse formation by focal adhesion kinase[J].Nat Neuroscience,2004,7(7):1059-1069
4 Chacón MR,Navarro AI,Cuesto G,et al.Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth[J].Development,2012,139(17):3200
5 Lim ST,Mikolon D,Stupack DG,et al.FERM control of FAK function:implications for cancer therapy[J].Cell Cycle,2008,7(15):2306-2314
6 Valiente M,Ciceri G,Rico B,et al.Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience,,2011,31(32):11678-11691
7 Robles E,Gomez TM.Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding[J].Nat Neuroscience,2006,9(10):1274-1283
8 Yang YC,Ma YL,Chen SK,et al.Focal adhesion kinase is required,but not sufficient,for the induction of long-term potentiation in dentate gyrus neurons in vivo.[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience,2003,23(10):4072-4080
9 Monje FJ,Kim EJ,Pollak DD,et al.Focal adhesion kinase regulates neuronal growth,synaptic plasticity,and hippocampus-dependent spatial learning and memory[J].Neurosignals,2012,20(1):1-14
10 Lian X,Wang XT,Wang WT,et al.Peripheral inflammation activated focal adhesion kinase signaling in spinal dorsal horn of mice[J].Journal of Neuroscience Research,2015,93(6):873-881
11 黄霞.PTZ点燃大鼠海马FAKp Y397动态表达其与苔藓纤维出芽关系[D].长沙:中南大学硕士学位论文,2014
12 Bernard-Trifilo JA,Kramár EA,Torp R,et al.Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology[J].Journal of Neurochemistry,2005,93(4):834-49
13 Reddy DS.Neurosteroids:Endogenous role in the human brain and therapeutic potentials[J].Progress in Brain Research,2010,186(186):113-137
14 Notenboom RGE.Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients[J].Brain,2006,129(1):96-107
15 Cooper SR,Jontes JD,Sotomayor M.Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy[J].Elife,2016,5,pii:e18529
16 Ribeiro A,Balasubramanian S,Hughes D,et al.β1-Integrin cytoskeletal signaling regulates sensory neuron response to matrix dimensionality[J].Neuroscience,2013,(248):67-78
17 Sosa LJ,Bergman J,Estrada-Bernal A,et al.Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance[J].Plo S One,2013,8(5):e64521
18 吴原.难治性癫痫患者脑组织中生长锥相关蛋白初步研究[D].重庆:重庆医科大学博士学位论文,2008
19 潘雪,顾峻菱,胡华斌,等.电流感觉阈值检测在2型糖尿病周围神经病变诊断中的应用[J].解放军医学杂志,2016,41(11):970-972
20 Yang SY,Lee JJ,Lee JH,et al.Secretagogin impacts insulin secretion in pancreatic beta cells by regulating actin dynamics and focal adhesion[J].Biochemical Journal,2016,473(12):1791-1803
21 陈丹丹,王雅,贾雅蕊,等.糖尿病神经病理性疼痛发生机制研究进展[J].中国疼痛医学杂志,2012,18(4):194-197
22 Tien SK,Duh JG.Tyrosine phosphorylation of focal adhension kinase(p125FAK)and paxillin in glomeruli from diabetic rat[J].1996,38(38):57-64
23 李霜,王圆圆,刘丽荣.黏着斑激酶在2型糖尿病大鼠肾组织中的表达变化及意义[J].中国病理生理杂志,2013,29(8):1400-1405
24 饶志方,王婉钢,程振玲,等.姜黄素治疗老年痴呆研究困境及其对策[J].中国药师,2016,19(8):1566-1568
25 Dourlen P,Fernandez-Gomez FJ,Dupont C,et al.Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology[J].Molecular Psychiatry,2016:1-10
26 Lachénmontes M,Gonzálezmorales A,Morentin XM,et al.An early dysregulation of FAK and MEK/ERK signaling pathways precedes theβ-amyloid deposition in the olfactory bulb of APP/PS1 mouse modelof Alzheimer's disease[J].Journal of Proteomics,2016(148):149-158
27 Steiner H.The catalytic core of gamma-secretase:presenilin revisited[J].Curr Alzheimer Res,2008,5(2):147-157
28 Mitra SK,Hanson DA,Schlaepfer DD.Focal adhesion kinase:in command and control of cell motility[J].Nat Rev Mol Cell Biol,2005,6:56-68
2 Navarro AI,Rico B.Focal adhesion kinase function in neuronal development[J].Current Opinion in Neurobiology,2014,?(27):89-95
3 Rico B,Beggs HE,Schahin-Reed D,et al.Control of axonal branching and synapse formation by focal adhesion kinase[J].Nat Neuroscience,2004,7(7):1059-1069
4 Chacón MR,Navarro AI,Cuesto G,et al.Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth[J].Development,2012,139(17):3200
5 Lim ST,Mikolon D,Stupack DG,et al.FERM control of FAK function:implications for cancer therapy[J].Cell Cycle,2008,7(15):2306-2314
6 Valiente M,Ciceri G,Rico B,et al.Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience,,2011,31(32):11678-11691
7 Robles E,Gomez TM.Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding[J].Nat Neuroscience,2006,9(10):1274-1283
8 Yang YC,Ma YL,Chen SK,et al.Focal adhesion kinase is required,but not sufficient,for the induction of long-term potentiation in dentate gyrus neurons in vivo.[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience,2003,23(10):4072-4080
9 Monje FJ,Kim EJ,Pollak DD,et al.Focal adhesion kinase regulates neuronal growth,synaptic plasticity,and hippocampus-dependent spatial learning and memory[J].Neurosignals,2012,20(1):1-14
10 Lian X,Wang XT,Wang WT,et al.Peripheral inflammation activated focal adhesion kinase signaling in spinal dorsal horn of mice[J].Journal of Neuroscience Research,2015,93(6):873-881
11 黄霞.PTZ点燃大鼠海马FAKp Y397动态表达其与苔藓纤维出芽关系[D].长沙:中南大学硕士学位论文,2014
12 Bernard-Trifilo JA,Kramár EA,Torp R,et al.Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology[J].Journal of Neurochemistry,2005,93(4):834-49
13 Reddy DS.Neurosteroids:Endogenous role in the human brain and therapeutic potentials[J].Progress in Brain Research,2010,186(186):113-137
14 Notenboom RGE.Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients[J].Brain,2006,129(1):96-107
15 Cooper SR,Jontes JD,Sotomayor M.Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy[J].Elife,2016,5,pii:e18529
16 Ribeiro A,Balasubramanian S,Hughes D,et al.β1-Integrin cytoskeletal signaling regulates sensory neuron response to matrix dimensionality[J].Neuroscience,2013,(248):67-78
17 Sosa LJ,Bergman J,Estrada-Bernal A,et al.Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance[J].Plo S One,2013,8(5):e64521
18 吴原.难治性癫痫患者脑组织中生长锥相关蛋白初步研究[D].重庆:重庆医科大学博士学位论文,2008
19 潘雪,顾峻菱,胡华斌,等.电流感觉阈值检测在2型糖尿病周围神经病变诊断中的应用[J].解放军医学杂志,2016,41(11):970-972
20 Yang SY,Lee JJ,Lee JH,et al.Secretagogin impacts insulin secretion in pancreatic beta cells by regulating actin dynamics and focal adhesion[J].Biochemical Journal,2016,473(12):1791-1803
21 陈丹丹,王雅,贾雅蕊,等.糖尿病神经病理性疼痛发生机制研究进展[J].中国疼痛医学杂志,2012,18(4):194-197
22 Tien SK,Duh JG.Tyrosine phosphorylation of focal adhension kinase(p125FAK)and paxillin in glomeruli from diabetic rat[J].1996,38(38):57-64
23 李霜,王圆圆,刘丽荣.黏着斑激酶在2型糖尿病大鼠肾组织中的表达变化及意义[J].中国病理生理杂志,2013,29(8):1400-1405
24 饶志方,王婉钢,程振玲,等.姜黄素治疗老年痴呆研究困境及其对策[J].中国药师,2016,19(8):1566-1568
25 Dourlen P,Fernandez-Gomez FJ,Dupont C,et al.Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology[J].Molecular Psychiatry,2016:1-10
26 Lachénmontes M,Gonzálezmorales A,Morentin XM,et al.An early dysregulation of FAK and MEK/ERK signaling pathways precedes theβ-amyloid deposition in the olfactory bulb of APP/PS1 mouse modelof Alzheimer's disease[J].Journal of Proteomics,2016(148):149-158
27 Steiner H.The catalytic core of gamma-secretase:presenilin revisited[J].Curr Alzheimer Res,2008,5(2):147-157
28 Mitra SK,Hanson DA,Schlaepfer DD.Focal adhesion kinase:in command and control of cell motility[J].Nat Rev Mol Cell Biol,2005,6:56-68